[Hub]/) : Traits : Whole body water mass :

chr17:41,946,180-43,913,030

Best TWAS P=2.56e-18 · Best GWAS P=4.95e-20 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous DCAKD 0.21 0.09 lasso 6 0.14 6.1e-12 5.8 6.5 1.1e-10 -0.35 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous ACBD4 0.10 0.06 enet 8 0.06 1.8e-05 -7.2 -8.2 2.9e-16 0.52 0.52 0.36 FALSE
3 GTEx Adrenal Gland PLEKHM1 0.21 0.00 enet 20 0.08 1.0e-03 4.6 6.2 4.7e-10 -0.13 0.08 0.13 FALSE
4 GTEx Artery Aorta NMT1 0.14 0.08 lasso 2 0.12 3.9e-07 -4.9 -5.9 4.3e-09 0.50 0.92 0.04 FALSE
5 GTEx Artery Aorta DCAKD 0.22 0.16 enet 26 0.19 1.1e-10 -4.4 7.5 8.3e-14 -0.46 0.92 0.07 FALSE
6 GTEx Artery Aorta GJC1 0.24 0.16 lasso 6 0.14 2.2e-08 5.0 5.5 3.7e-08 -0.02 1.00 0.00 TRUE
7 GTEx Artery Coronary NMT1 0.13 0.06 enet 7 0.11 1.5e-04 5.8 -7.2 6.5e-13 0.53 0.12 0.25 TRUE
8 GTEx Artery Tibial NMT1 0.11 0.09 lasso 5 0.10 6.3e-08 -5.0 -6.3 3.1e-10 0.36 0.98 0.01 FALSE
9 GTEx Artery Tibial DCAKD 0.27 0.21 lasso 8 0.20 6.6e-16 -4.4 5.3 9.3e-08 -0.43 1.00 0.00 FALSE
10 GTEx Artery Tibial ACBD4 0.10 0.09 lasso 2 0.08 4.8e-07 -7.3 -7.3 2.5e-13 0.58 0.80 0.12 FALSE
11 GTEx Artery Tibial HEXIM1 0.13 0.08 lasso 2 0.05 1.8e-04 5.7 5.7 1.0e-08 -0.58 0.81 0.15 FALSE
12 GTEx Brain Cerebellar Hemisphere ACBD4 0.43 0.12 lasso 8 0.18 1.7e-05 -6.7 -6.0 1.7e-09 0.37 0.11 0.43 FALSE
13 GTEx Brain Cerebellar Hemisphere CTD-2020K17.4 0.23 0.02 enet 20 0.11 1.1e-03 -6.6 -6.3 2.6e-10 0.46 0.03 0.16 FALSE
14 GTEx Brain Cerebellum ADAM11 0.17 0.19 enet 8 0.18 4.4e-06 4.2 5.7 1.5e-08 -0.13 0.48 0.03 FALSE
15 GTEx Brain Cerebellum DCAKD 0.40 0.06 enet 20 0.24 1.4e-07 -4.3 5.9 3.1e-09 -0.39 0.80 0.06 FALSE
16 GTEx Brain Cerebellum ACBD4 0.40 0.06 lasso 8 0.17 1.0e-05 6.4 -6.2 6.4e-10 0.27 0.09 0.14 FALSE
17 GTEx Brain Hippocampus CCDC43 0.23 0.09 enet 9 0.16 1.8e-04 -6.7 5.6 2.4e-08 -0.46 0.05 0.29 FALSE
18 GTEx Breast Mammary Tissue KANSL1 0.31 0.00 enet 9 0.11 2.6e-06 3.1 -6.0 2.4e-09 0.08 0.00 0.00 TRUE
19 GTEx Breast Mammary Tissue DCAKD 0.16 0.13 lasso 7 0.13 2.9e-07 -5.8 5.6 1.8e-08 -0.59 0.92 0.08 FALSE
20 GTEx Breast Mammary Tissue (Male) DCAKD 0.36 0.29 lasso 8 0.33 1.4e-08 -4.3 5.9 3.5e-09 -0.58 0.42 0.44 FALSE
21 GTEx Breast Mammary Tissue (Female) FZD2 0.10 0.08 lasso 2 0.05 1.1e-02 5.7 5.9 3.1e-09 -0.07 0.04 0.13 FALSE
22 GTEx Cells EBV-transformed lymphocytes GJC1 0.34 0.33 lasso 4 0.33 2.3e-11 5.0 5.1 3.0e-07 0.01 1.00 0.00 FALSE
23 GTEx Cells Transformed fibroblasts PLCD3 0.23 0.04 lasso 5 0.08 1.3e-06 2.4 5.9 2.9e-09 -0.48 0.95 0.01 FALSE
24 GTEx Cells Transformed fibroblasts GJC1 0.41 0.40 enet 32 0.44 8.7e-36 4.9 5.1 3.0e-07 -0.02 1.00 0.00 TRUE
25 GTEx Cells Transformed fibroblasts HEXIM1 0.11 0.10 lasso 2 0.08 1.6e-06 5.7 5.8 8.9e-09 -0.58 0.74 0.20 FALSE
26 GTEx Colon Transverse DCAKD 0.28 0.18 lasso 8 0.26 1.5e-12 -4.3 5.8 5.0e-09 -0.41 0.99 0.01 FALSE
27 GTEx Esophagus Gastroesophageal Junction NMT1 0.24 0.21 lasso 4 0.22 2.8e-08 4.6 -7.1 1.5e-12 0.54 0.53 0.42 FALSE
28 GTEx Esophagus Gastroesophageal Junction DCAKD 0.42 0.36 lasso 7 0.37 3.8e-14 -5.8 6.0 2.6e-09 -0.58 0.96 0.04 FALSE
29 GTEx Esophagus Mucosa ADAM11 0.19 0.14 lasso 4 0.12 1.2e-08 5.7 5.7 1.1e-08 -0.07 0.99 0.00 FALSE
30 GTEx Esophagus Mucosa DCAKD 0.33 0.32 enet 20 0.35 5.6e-24 -4.4 5.7 1.5e-08 -0.51 1.00 0.00 FALSE
31 GTEx Esophagus Mucosa ACBD4 0.14 0.10 lasso 4 0.10 4.5e-07 6.3 -6.7 2.7e-11 0.13 0.59 0.08 FALSE
32 GTEx Esophagus Muscularis DCAKD 0.27 0.29 lasso 5 0.30 2.1e-18 -4.4 5.2 2.2e-07 -0.47 1.00 0.00 FALSE
33 GTEx Heart Left Ventricle DCAKD 0.17 0.17 lasso 3 0.17 2.3e-09 -4.4 5.8 6.0e-09 -0.55 0.98 0.01 FALSE
34 GTEx Lung HIGD1B 0.09 0.04 lasso 3 0.04 2.2e-04 5.5 -5.3 8.9e-08 -0.01 0.78 0.01 FALSE
35 GTEx Lung DCAKD 0.22 0.05 enet 27 0.10 5.2e-08 4.6 5.7 1.5e-08 -0.44 0.96 0.03 FALSE
36 GTEx Muscle Skeletal PLCD3 0.18 0.10 enet 8 0.10 1.7e-10 6.3 6.6 5.2e-11 -0.12 1.00 0.00 FALSE
37 GTEx Muscle Skeletal DCAKD 0.12 0.06 enet 16 0.07 9.9e-08 -5.8 6.5 6.5e-11 -0.54 0.88 0.12 FALSE
38 GTEx Nerve Tibial DCAKD 0.35 0.29 enet 21 0.30 1.6e-21 4.6 5.6 1.9e-08 -0.42 1.00 0.00 FALSE
39 GTEx Nerve Tibial ACBD4 0.21 0.10 lasso 5 0.11 4.2e-08 -6.7 -8.1 6.6e-16 0.47 0.92 0.07 FALSE
40 GTEx Pancreas NMT1 0.19 0.12 enet 18 0.07 8.0e-04 -4.9 -5.3 1.3e-07 0.27 0.33 0.09 FALSE
41 GTEx Prostate NMT1 0.43 0.28 lasso 6 0.25 5.3e-07 4.8 -5.2 1.9e-07 0.36 0.58 0.11 FALSE
42 GTEx Skin Not Sun Exposed Suprapubic DCAKD 0.30 0.21 lasso 6 0.20 5.0e-11 -5.8 6.3 2.4e-10 -0.58 1.00 0.00 FALSE
43 GTEx Skin Sun Exposed Lower leg DCAKD 0.33 0.20 enet 30 0.31 2.4e-26 -4.4 6.0 2.2e-09 -0.27 1.00 0.00 TRUE
44 GTEx Skin Sun Exposed Lower leg ACBD4 0.06 0.05 lasso 4 0.02 3.8e-03 6.4 -8.1 5.3e-16 0.33 0.19 0.08 FALSE
45 GTEx Stomach DCAKD 0.29 0.17 enet 25 0.20 9.4e-10 -4.4 6.9 7.1e-12 -0.48 0.57 0.42 FALSE
46 GTEx Thyroid PLCD3 0.12 0.01 enet 20 0.07 8.2e-06 6.3 5.7 1.2e-08 -0.04 0.77 0.01 TRUE
47 GTEx Thyroid DCAKD 0.25 0.26 enet 17 0.27 9.4e-21 -5.8 5.5 4.0e-08 -0.57 1.00 0.00 FALSE
48 GTEx Thyroid ACBD4 0.20 0.16 enet 23 0.15 1.2e-11 -7.2 -8.7 2.6e-18 0.51 1.00 0.00 TRUE
49 METSIM Adipose C17orf104 0.05 0.02 bslmm 404 0.04 4.2e-06 5.0 -5.9 3.9e-09 0.11 0.91 0.00 FALSE
50 YFS Blood FZD2 0.15 0.12 bslmm 362 0.13 1.8e-39 5.7 5.3 9.0e-08 -0.08 0.57 0.43 FALSE
51 YFS Blood HEXIM2 0.02 0.01 bslmm 279 0.01 1.0e-05 5.8 -6.4 2.0e-10 0.61 0.59 0.36 TRUE
52 YFS Blood NMT1 0.02 0.01 lasso 6 0.01 5.0e-03 6.5 -7.1 1.3e-12 0.37 0.28 0.03 FALSE
53 The Cancer Genome Atlas Bladder Urothelial Carcinoma LOC644172 0.08 0.00 blup 79 0.04 3.2e-04 2.9 5.3 1.1e-07 -0.51 0.07 0.27 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma LOC644172 0.14 0.07 enet 10 0.12 1.2e-23 1.5 5.2 2.4e-07 -0.35 1.00 0.00 FALSE
55 The Cancer Genome Atlas Breast Invasive Carcinoma MGC57346 0.02 0.00 blup 62 0.02 2.2e-05 1.7 5.2 2.3e-07 -0.53 0.04 0.59 FALSE
56 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma LOC644172 0.19 -0.01 blup 81 0.03 1.3e-02 1.7 5.9 2.9e-09 -0.47 0.02 0.56 FALSE
57 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DCAKD 0.07 0.07 lasso 4 0.07 1.4e-08 -5.8 7.0 1.9e-12 -0.56 0.06 0.94 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma ACBD4 0.08 0.04 enet 9 0.04 6.9e-06 -7.2 -6.9 4.0e-12 0.50 0.95 0.01 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma LOC644172 0.04 0.00 enet 15 0.02 4.0e-03 -9.2 6.2 8.0e-10 -0.60 0.00 0.76 FALSE
60 The Cancer Genome Atlas Brain Lower Grade Glioma NMT1 0.08 0.04 blup 83 0.05 3.5e-06 -4.4 -5.6 2.5e-08 0.37 0.96 0.02 FALSE
61 The Cancer Genome Atlas Lung Adenocarcinoma NMT1 0.04 0.00 blup 81 0.01 1.9e-02 -4.9 -6.7 2.5e-11 0.27 0.03 0.70 FALSE
62 The Cancer Genome Atlas Lung Adenocarcinoma PLCD3 0.04 0.01 blup 64 0.01 2.3e-02 6.3 -6.0 1.6e-09 0.27 0.05 0.08 FALSE
63 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HEXIM1 0.06 0.01 blup 47 0.03 3.3e-03 3.0 5.7 9.6e-09 -0.24 0.01 0.10 FALSE
64 The Cancer Genome Atlas Pancreatic Adenocarcinoma NMT1 0.23 0.08 blup 82 0.12 1.1e-05 4.6 -7.2 6.3e-13 0.55 0.05 0.90 FALSE
65 The Cancer Genome Atlas Prostate Adenocarcinoma ACBD4 0.04 0.01 enet 7 0.03 2.2e-04 4.6 -6.7 2.1e-11 0.44 0.09 0.13 FALSE
66 The Cancer Genome Atlas Prostate Adenocarcinoma LOC644172 0.15 0.01 blup 77 0.06 1.0e-06 6.5 6.1 8.7e-10 -0.40 0.19 0.29 FALSE
67 The Cancer Genome Atlas Prostate Adenocarcinoma NMT1 0.09 0.08 lasso 3 0.09 1.1e-09 4.6 -5.4 6.4e-08 0.46 0.91 0.09 FALSE
68 The Cancer Genome Atlas Testicular Germ Cell Tumors LOC644172 0.20 0.01 enet 12 0.06 4.5e-03 -3.2 5.3 1.1e-07 -0.47 0.06 0.08 FALSE
69 The Cancer Genome Atlas Thyroid Carcinoma C17orf104 0.07 0.02 blup 37 0.04 6.2e-05 5.7 -5.2 1.9e-07 0.09 0.01 0.98 FALSE
70 The Cancer Genome Atlas Thyroid Carcinoma HEXIM1 0.05 0.05 blup 47 0.04 8.5e-05 -9.2 8.4 4.2e-17 -0.84 0.00 1.00 FALSE
71 The Cancer Genome Atlas Thyroid Carcinoma NMT1 0.18 0.19 enet 20 0.20 3.8e-19 -4.9 -5.8 6.2e-09 0.40 1.00 0.00 FALSE
72 The Cancer Genome Atlas Thyroid Carcinoma PLCD3 0.24 0.16 lasso 5 0.20 2.8e-19 6.3 6.9 4.8e-12 -0.15 1.00 0.00 FALSE