Best TWAS P=2.89e-08 · Best GWAS P=8e-10 conditioned to 3.74e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PRMT6 | 0.19 | 0.16 | lasso | 6 | 0.16 | 5.4e-19 | 5.1 | -5.2 | 2.6e-07 | -0.08 | 0.59 | 0.41 | FALSE |
2 | GTEx | Adipose Subcutaneous | PRMT6 | 0.17 | 0.10 | enet | 6 | 0.11 | 5.1e-09 | 5.0 | -5.2 | 1.9e-07 | -0.09 | 0.63 | 0.37 | FALSE |
3 | GTEx | Colon Transverse | PRMT6 | 0.29 | 0.24 | lasso | 7 | 0.19 | 1.4e-09 | 5.0 | -5.3 | 1.3e-07 | -0.09 | 0.62 | 0.38 | FALSE |
4 | GTEx | Esophagus Mucosa | PRMT6 | 0.33 | 0.23 | lasso | 7 | 0.29 | 1.4e-19 | 5.1 | -5.2 | 2.3e-07 | -0.08 | 0.61 | 0.39 | FALSE |
5 | GTEx | Liver | PRMT6 | 0.60 | 0.52 | lasso | 6 | 0.58 | 1.0e-19 | 5.0 | -5.3 | 1.1e-07 | -0.08 | 0.60 | 0.40 | FALSE |
6 | GTEx | Muscle Skeletal | PRMT6 | 0.32 | 0.16 | enet | 13 | 0.16 | 2.8e-15 | 5.1 | -5.5 | 2.9e-08 | -0.08 | 0.59 | 0.40 | TRUE |
7 | GTEx | Thyroid | PRMT6 | 0.19 | 0.17 | enet | 14 | 0.19 | 1.7e-14 | 5.1 | -5.3 | 9.3e-08 | -0.08 | 0.61 | 0.39 | FALSE |
8 | METSIM | Adipose | PRMT6 | 0.21 | 0.20 | lasso | 9 | 0.21 | 1.1e-30 | 5.1 | -5.1 | 2.7e-07 | -0.08 | 0.62 | 0.38 | FALSE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRMT6 | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.0e-08 | 5.1 | -5.2 | 1.6e-07 | -0.09 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Esophageal Carcinoma | PRMT6 | 0.33 | 0.26 | lasso | 3 | 0.25 | 2.0e-08 | 5.0 | -5.2 | 1.5e-07 | -0.09 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRMT6 | 0.11 | 0.12 | enet | 7 | 0.12 | 2.3e-13 | 5.1 | -5.3 | 1.4e-07 | -0.09 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRMT6 | 0.09 | 0.08 | blup | 36 | 0.08 | 3.3e-06 | 5.1 | -5.4 | 5.4e-08 | -0.09 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PRMT6 | 0.17 | 0.17 | enet | 6 | 0.19 | 1.5e-13 | 5.1 | -5.1 | 3.0e-07 | -0.09 | 0.01 | 0.99 | FALSE |