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chr12:27,587,038-29,432,481

Best TWAS P=1.4e-13 · Best GWAS P=4.74e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC91	0.08	0.06	lasso	6	0.07	9.4e-09	-6.7	5.6	2.5e-08	-0.87	0.33	0.67	FALSE
2	GTEx	Artery Aorta	RP11-967K21.1	0.07	0.02	lasso	7	0.01	7.9e-02	3.3	5.8	6.0e-09	-0.83	0.06	0.82	FALSE
3	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	-6.9	-7.1	1.7e-12	0.85	0.13	0.87	FALSE
4	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	-7.3	7.4	1.4e-13	-0.96	0.04	0.96	TRUE
5	GTEx	Colon Transverse	CCDC91	0.11	0.01	lasso	6	0.00	4.6e-01	-6.8	-5.9	3.6e-09	0.80	0.09	0.74	FALSE
6	GTEx	Heart Atrial Appendage	CCDC91	0.10	0.06	lasso	8	0.04	4.4e-03	-6.9	-6.4	1.3e-10	0.85	0.04	0.92	FALSE
7	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	-7.3	7.3	3.8e-13	-0.91	0.04	0.93	FALSE
8	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	-6.8	6.4	2.2e-10	-0.90	0.06	0.80	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	-7.5	-6.7	2.6e-11	0.87	0.03	0.97	FALSE
10	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	-7.3	-7.1	1.6e-12	0.85	0.06	0.89	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	-6.7	-6.7	2.3e-11	0.94	0.18	0.82	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC91	0.06	0.02	blup	174	0.04	2.9e-05	2.4	-5.4	6.0e-08	0.79	0.42	0.55	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC91	0.09	0.01	blup	170	0.02	1.0e-03	-7.0	-5.2	2.6e-07	0.75	0.18	0.68	FALSE
14	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	-6.8	-6.8	1.1e-11	0.91	0.07	0.91	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC91	0.40	0.12	blup	175	0.14	4.9e-13	-7.0	-6.4	2.0e-10	0.72	0.09	0.91	FALSE