Best TWAS P=3.59e-08 · Best GWAS P=1.15e-12 conditioned to 2.02e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | 5.2 | -5.2 | 1.5e-07 | 0.13 | 0.96 | 0.04 | FALSE |
| 2 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | 5.3 | -5.3 | 1.5e-07 | 0.12 | 0.50 | 0.06 | FALSE |
| 3 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 3.6 | 5.5 | 4.8e-08 | 0.06 | 0.91 | 0.09 | FALSE |
| 4 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 5.5 | 5.5 | 3.6e-08 | 0.10 | 0.80 | 0.20 | TRUE |
| 5 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | 5.3 | -5.3 | 1.4e-07 | 0.13 | 0.80 | 0.04 | TRUE |