TWAS
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Models
Genes
Traits
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Traits
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Basal metabolic rate
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chr12:101,575,652-103,148,974
Best TWAS P=3.59e-08 · Best GWAS P=1.15e-12 conditioned to 2.02e-12
101.6M
101.8M
102M
102.2M
102.4M
102.6M
102.8M
103M
103.2M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
YFS
Blood
DRAM1
0.33
0.13
enet
101
0.19
1.6e-58
5.5
5.5
3.6e-08
0.10
0.80
0.20
TRUE
5
The Cancer Genome Atlas
Stomach Adenocarcinoma
CCDC53
0.04
0.07
lasso
4
0.06
2.1e-05
5.3
-5.3
1.4e-07
0.13
0.80
0.04
TRUE
3
METSIM
Adipose
DRAM1
0.12
0.03
enet
24
0.08
1.1e-12
3.6
5.5
4.8e-08
0.06
0.91
0.09
FALSE
1
GTEx
Cells Transformed fibroblasts
CCDC53
0.10
0.18
lasso
1
0.17
1.5e-12
5.2
-5.2
1.5e-07
0.13
0.96
0.04
FALSE
2
GTEx
Spleen
CCDC53
0.25
0.19
lasso
11
0.16
5.8e-05
5.3
-5.3
1.5e-07
0.12
0.50
0.06
FALSE