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chr12:106,649,988-108,064,952

Best TWAS P=9.07e-11 · Best GWAS P=3.5e-10 conditioned to 0.651

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Thyroid	RP11-412D9.4	0.10	0.10	enet	7	0.12	9.3e-10	6.1	6.5	9.1e-11	-0.95	0.01	0.99	TRUE
13	GTEx	Skin Sun Exposed Lower leg	C12orf23	0.06	0.04	lasso	3	0.03	8.0e-04	-6.3	6.5	9.8e-11	-0.98	0.01	0.99	FALSE
7	GTEx	Cells Transformed fibroblasts	RP11-412D9.4	0.12	0.10	lasso	4	0.09	2.1e-07	-5.9	6.4	1.3e-10	-0.91	0.01	0.99	FALSE
10	GTEx	Nerve Tibial	C12orf23	0.09	0.12	enet	10	0.12	1.1e-08	-6.3	6.4	1.3e-10	-0.97	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-412D9.4	0.22	0.13	lasso	5	0.13	5.1e-11	-5.9	6.4	1.4e-10	-0.94	0.01	0.99	FALSE
4	GTEx	Artery Tibial	RP11-412D9.4	0.06	0.05	lasso	3	0.06	2.9e-05	-6.3	6.4	1.5e-10	-0.93	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	MTERFD3	0.02	0.01	lasso	4	0.01	1.3e-03	-5.9	6.4	1.9e-10	-0.89	0.02	0.91	FALSE
14	GTEx	Testis	RP11-412D9.4	0.25	0.24	lasso	5	0.20	3.7e-09	-6.3	6.3	2.4e-10	-0.99	0.00	1.00	FALSE
11	GTEx	Nerve Tibial	RP11-412D9.4	0.18	0.18	enet	11	0.20	5.6e-14	-5.9	6.3	3.3e-10	-0.95	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue	RP11-412D9.4	0.23	0.26	lasso	4	0.26	9.7e-14	-6.3	6.1	9.7e-10	-0.97	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C12orf23	0.06	0.05	enet	8	0.05	5.0e-03	-6.3	6.1	1.2e-09	-0.93	0.01	0.74	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	MTERFD3	0.08	0.06	lasso	6	0.05	7.1e-04	-5.9	5.9	3.2e-09	-0.90	0.01	0.76	FALSE
12	GTEx	Pancreas	RP11-412D9.4	0.09	0.06	enet	12	0.06	1.2e-03	-6.3	5.8	5.3e-09	-0.85	0.02	0.96	FALSE
8	GTEx	Colon Sigmoid	RP11-412D9.4	0.17	0.06	lasso	3	0.07	1.4e-03	5.6	5.7	1.3e-08	-0.78	0.06	0.69	FALSE
6	GTEx	Breast Mammary Tissue (Female)	RP11-412D9.4	0.20	0.14	lasso	4	0.13	9.0e-05	-6.3	5.7	1.4e-08	-0.95	0.01	0.96	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf23	0.03	0.05	enet	7	0.05	2.2e-10	5.5	5.7	1.4e-08	-0.81	0.11	0.89	FALSE
1	GTEx	Adipose Subcutaneous	C12orf23	0.07	0.02	lasso	4	0.02	5.5e-03	-6.3	5.6	1.7e-08	-0.90	0.01	0.96	FALSE
9	GTEx	Lung	C12orf23	0.04	0.03	lasso	2	0.02	9.9e-03	-5.2	5.4	5.2e-08	-0.76	0.04	0.86	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf23	0.03	0.01	blup	50	0.01	2.2e-02	-6.3	5.4	6.0e-08	-0.86	0.01	0.82	FALSE
3	GTEx	Artery Tibial	C12orf23	0.15	0.10	enet	21	0.15	8.1e-12	6.1	5.4	8.0e-08	-0.80	0.04	0.96	FALSE