[Hub]/) : Traits : Basal metabolic rate :

chr2:15,703-1,384,725

Best TWAS P=1.39e-15 · Best GWAS P=9.89e-61 conditioned to 4.49e-50

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TMEM18 0.32 0.21 lasso 9 0.25 4.7e-20 5.8 7.2 5.7e-13 -0.20 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous AC092159.2 0.29 0.14 lasso 14 0.19 4.2e-15 4.8 7.1 1.5e-12 -0.15 1.00 0.00 FALSE
3 GTEx Adipose Visceral Omentum TMEM18 0.23 0.14 lasso 4 0.17 5.7e-09 5.6 5.6 2.3e-08 -0.12 0.99 0.00 FALSE
4 GTEx Adipose Visceral Omentum AC092159.2 0.29 0.11 enet 41 0.14 1.5e-07 5.6 7.9 3.0e-15 -0.09 0.92 0.00 FALSE
5 GTEx Artery Aorta TMEM18 0.32 0.16 lasso 5 0.15 1.4e-08 5.8 6.6 4.5e-11 -0.17 1.00 0.00 FALSE
6 GTEx Artery Aorta AC092159.2 0.29 0.19 enet 9 0.23 9.7e-13 5.5 6.9 6.2e-12 -0.16 1.00 0.00 FALSE
7 GTEx Artery Tibial TMEM18 0.35 0.08 enet 28 0.19 9.2e-15 5.5 7.7 9.7e-15 -0.17 1.00 0.00 FALSE
8 GTEx Artery Tibial AC092159.2 0.38 0.24 lasso 5 0.30 5.6e-24 6.7 7.7 2.0e-14 -0.16 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts AC092159.2 0.26 0.17 enet 5 0.21 1.8e-15 5.6 5.7 9.3e-09 -0.13 1.00 0.00 FALSE
10 GTEx Esophagus Mucosa TMEM18 0.37 0.20 lasso 7 0.20 2.3e-13 5.8 5.9 2.8e-09 -0.17 1.00 0.00 FALSE
11 GTEx Esophagus Mucosa AC092159.2 0.27 0.18 enet 5 0.20 2.5e-13 5.6 6.4 1.3e-10 -0.16 1.00 0.00 FALSE
12 GTEx Esophagus Muscularis TMEM18 0.37 0.20 lasso 8 0.18 2.0e-11 6.7 8.0 1.4e-15 -0.26 1.00 0.00 TRUE
13 GTEx Esophagus Muscularis AC092159.2 0.26 0.16 enet 7 0.20 5.3e-12 6.7 7.6 2.8e-14 -0.29 1.00 0.00 FALSE
14 GTEx Heart Atrial Appendage TMEM18 0.26 0.16 lasso 7 0.09 5.0e-05 5.8 6.3 2.6e-10 -0.21 0.83 0.07 FALSE
15 GTEx Heart Left Ventricle TMEM18 0.22 0.19 lasso 7 0.16 8.3e-09 5.6 7.4 1.7e-13 -0.16 0.99 0.00 FALSE
16 GTEx Heart Left Ventricle AC092159.2 0.35 0.24 lasso 6 0.23 2.3e-12 5.6 6.8 9.1e-12 -0.17 1.00 0.00 FALSE
17 GTEx Lung TMEM18 0.13 0.11 lasso 2 0.10 4.5e-08 5.6 5.6 1.8e-08 -0.14 0.99 0.00 FALSE
18 GTEx Lung AC092159.2 0.22 0.17 lasso 3 0.18 1.1e-13 5.6 6.0 2.0e-09 -0.11 1.00 0.00 FALSE
19 GTEx Muscle Skeletal TMEM18 0.40 0.30 lasso 7 0.33 2.0e-33 6.7 6.8 8.1e-12 -0.15 1.00 0.00 FALSE
20 GTEx Muscle Skeletal AC092159.2 0.46 0.34 enet 18 0.39 1.1e-40 6.7 6.8 1.2e-11 -0.14 1.00 0.00 FALSE
21 GTEx Nerve Tibial AC092159.2 0.18 0.09 lasso 5 0.10 1.5e-07 6.7 6.8 1.1e-11 -0.13 0.99 0.00 FALSE
22 GTEx Skin Sun Exposed Lower leg AC092159.2 0.18 0.10 enet 15 0.13 1.4e-10 6.7 5.4 6.3e-08 -0.06 0.99 0.00 FALSE
23 METSIM Adipose TMEM18 0.20 0.12 lasso 6 0.12 9.2e-17 5.6 6.2 4.3e-10 -0.15 1.00 0.00 FALSE
24 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM18 0.11 0.01 blup 74 0.04 1.3e-03 5.8 6.5 1.1e-10 -0.21 0.11 0.04 FALSE