[Hub]/) : Traits : Basal metabolic rate : ← →

chr2:23,453,834-29,344,127

Best TWAS P=6.23e-37 · Best GWAS P=1.6e-34 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-12.3	12.7	6.2e-37	-0.99	0.00	0.96	TRUE
60	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	7.6	9.8	9.0e-23	-0.64	0.91	0.09	TRUE
29	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	7.6	-7.5	4.5e-14	-0.05	0.04	0.91	TRUE
8	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	6.4	7.2	8.9e-13	-0.23	0.04	0.05	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	6.2	-6.7	2.6e-11	0.09	0.00	1.00	TRUE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-5.0	-6.4	1.7e-10	0.01	0.00	0.70	TRUE
34	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	4.5	-6.3	3.3e-10	0.15	0.35	0.40	TRUE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	8.2	5.9	3.5e-09	-0.04	0.04	0.04	TRUE
22	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	1.7	-5.9	4.5e-09	0.12	0.37	0.45	TRUE
12	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-1.6	-5.8	7.6e-09	0.06	0.04	0.49	TRUE
5	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-2.4	-5.7	1.3e-08	-0.01	0.06	0.16	TRUE
38	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	2.8	-5.4	8.1e-08	0.43	0.25	0.04	TRUE
44	YFS	Blood	MRPL33	0.02	0.01	blup	385	0.01	6.4e-05	5.8	-5.3	1.4e-07	0.22	0.97	0.00	TRUE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	-1.3	5.2	1.6e-07	-0.47	0.01	0.83	TRUE
59	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	7.8	10.5	1.2e-25	-0.70	0.41	0.59	FALSE
33	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	7.6	10.4	1.9e-25	-0.69	0.67	0.33	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	8.2	10.2	2.2e-24	-0.40	0.19	0.14	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	8.4	9.4	5.0e-21	-0.54	0.02	0.27	FALSE
32	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	4.4	-8.5	1.7e-17	0.85	0.05	0.94	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-9.8	-8.3	8.1e-17	0.54	0.00	0.99	FALSE
30	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	5.7	8.3	1.4e-16	-0.36	0.20	0.08	FALSE
19	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	5.7	-7.9	2.8e-15	0.82	0.01	0.97	FALSE
31	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	5.7	-7.8	8.9e-15	0.80	0.03	0.96	FALSE
17	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	5.7	-7.4	1.9e-13	0.74	0.94	0.06	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	5.0	7.2	4.9e-13	-0.63	0.43	0.49	FALSE
27	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	4.3	-7.2	6.0e-13	0.77	0.04	0.80	FALSE
21	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-6.5	-7.0	3.0e-12	0.02	0.24	0.26	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-6.4	6.7	1.8e-11	-0.04	0.35	0.04	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-7.5	6.6	4.0e-11	-0.03	0.92	0.08	FALSE
13	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-6.2	-6.6	5.0e-11	-0.06	0.08	0.67	FALSE
16	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	1.7	-6.5	5.7e-11	0.05	0.10	0.16	FALSE
35	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	3.6	-6.5	7.8e-11	0.72	0.08	0.57	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	4.3	-6.5	8.1e-11	0.72	0.28	0.72	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-6.4	6.4	1.6e-10	-0.03	0.36	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	4.2	6.3	2.2e-10	-0.75	0.48	0.52	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	3.1	6.2	4.2e-10	-0.55	0.02	0.34	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-4.7	-6.1	1.1e-09	0.06	0.27	0.22	FALSE
37	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	5.7	-6.0	2.0e-09	0.67	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-4.7	-5.9	3.2e-09	0.05	1.00	0.00	FALSE
25	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	-1.9	-5.9	3.6e-09	0.43	0.29	0.07	FALSE
20	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	5.7	-5.8	5.7e-09	0.65	0.73	0.26	FALSE
4	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	5.7	-5.8	6.2e-09	0.65	0.45	0.27	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	-6.1	-5.7	1.1e-08	0.08	0.11	0.09	FALSE
18	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-3.2	-5.7	1.1e-08	0.01	0.06	0.26	FALSE
24	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-3.7	-5.7	1.1e-08	0.01	0.52	0.02	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	5.7	-5.7	1.1e-08	0.67	0.02	0.09	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	4.4	-5.6	2.1e-08	0.64	0.43	0.30	FALSE
6	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	4.2	-5.6	2.4e-08	0.66	0.29	0.12	FALSE
39	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-6.2	-5.6	2.4e-08	0.00	0.86	0.14	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	5.7	-5.5	2.8e-08	0.65	0.04	0.70	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-4.7	5.5	5.2e-08	-0.08	0.42	0.06	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	4.4	-5.4	5.9e-08	0.66	0.03	0.51	FALSE
7	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	5.0	-5.4	8.4e-08	0.62	0.99	0.00	FALSE
36	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	4.2	5.4	8.4e-08	-0.52	0.96	0.03	FALSE
45	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	4.4	-5.3	1.0e-07	0.61	0.99	0.00	FALSE
26	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	5.7	-5.3	1.3e-07	0.61	0.28	0.61	FALSE
10	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	5.0	-5.2	1.5e-07	0.61	0.95	0.04	FALSE
11	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	5.7	-5.2	1.5e-07	0.66	0.87	0.13	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-3.5	-5.2	1.8e-07	0.01	0.02	0.97	FALSE
28	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-6.1	-5.2	2.3e-07	-0.08	0.04	0.87	FALSE
51	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf18	0.20	0.02	blup	30	0.06	6.7e-03	4.8	5.2	2.6e-07	-0.04	0.01	0.40	FALSE