Best TWAS P=5.84e-18 · Best GWAS P=7.88e-16 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOSTRIN | 0.14 | 0.13 | lasso | 4 | 0.12 | 1.9e-14 | -8.1 | 8.6 | 5.8e-18 | -0.97 | 0.00 | 1.00 | TRUE |
2 | GTEx | Adrenal Gland | NOSTRIN | 0.21 | 0.09 | lasso | 4 | 0.09 | 4.1e-04 | 6.3 | 6.4 | 1.8e-10 | -0.40 | 0.42 | 0.22 | FALSE |
3 | GTEx | Lung | NOSTRIN | 0.09 | 0.06 | lasso | 4 | 0.07 | 7.1e-06 | 7.4 | 6.7 | 2.2e-11 | -0.39 | 0.15 | 0.81 | FALSE |
4 | GTEx | Pancreas | NOSTRIN | 0.30 | 0.12 | enet | 17 | 0.08 | 3.3e-04 | -6.0 | 5.8 | 5.8e-09 | -0.47 | 0.24 | 0.68 | FALSE |
5 | GTEx | Stomach | NOSTRIN | 0.15 | 0.04 | enet | 9 | 0.09 | 6.8e-05 | 7.4 | 7.9 | 2.5e-15 | -0.58 | 0.17 | 0.78 | FALSE |
6 | GTEx | Testis | NOSTRIN | 0.43 | 0.17 | enet | 17 | 0.32 | 1.0e-14 | -5.4 | 6.9 | 4.6e-12 | -0.68 | 0.08 | 0.92 | FALSE |
7 | METSIM | Adipose | NOSTRIN | 0.07 | 0.09 | lasso | 6 | 0.08 | 1.6e-12 | 7.4 | 7.4 | 1.6e-13 | -0.59 | 0.18 | 0.82 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NOSTRIN | 0.03 | 0.01 | blup | 55 | 0.02 | 9.5e-05 | -5.8 | 6.5 | 9.2e-11 | -0.37 | 0.02 | 0.95 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | G6PC2 | 0.32 | 0.07 | blup | 29 | 0.06 | 3.8e-04 | -5.6 | -7.1 | 9.4e-13 | 0.79 | 0.02 | 0.81 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | NOSTRIN | 0.25 | 0.01 | blup | 55 | 0.08 | 2.0e-03 | -5.8 | 5.1 | 2.9e-07 | -0.25 | 0.01 | 0.62 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | G6PC2 | 0.47 | 0.23 | enet | 8 | 0.28 | 4.4e-32 | -5.6 | -6.4 | 1.3e-10 | 0.79 | 0.06 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOSTRIN | 0.12 | 0.13 | lasso | 7 | 0.14 | 4.5e-15 | -5.8 | 6.8 | 1.4e-11 | -0.43 | 0.04 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | G6PC2 | 0.56 | 0.13 | blup | 29 | 0.16 | 2.1e-09 | -5.6 | -6.8 | 7.2e-12 | 0.75 | 0.03 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOSTRIN | 0.08 | 0.01 | enet | 6 | 0.04 | 2.1e-05 | 6.0 | 6.7 | 2.3e-11 | -0.32 | 0.01 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NOSTRIN | 0.05 | 0.00 | blup | 55 | 0.01 | 1.1e-02 | -5.8 | 6.4 | 1.9e-10 | -0.38 | 0.01 | 0.72 | FALSE |
16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOSTRIN | 0.17 | 0.07 | lasso | 2 | 0.08 | 4.3e-04 | 5.7 | 6.2 | 5.5e-10 | -0.44 | 0.01 | 0.95 | FALSE |
17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | G6PC2 | 0.22 | 0.01 | enet | 4 | 0.08 | 3.1e-06 | -5.6 | -5.3 | 8.8e-08 | 0.71 | 0.05 | 0.70 | FALSE |
18 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NOSTRIN | 0.27 | 0.04 | lasso | 3 | 0.08 | 2.8e-03 | 6.3 | 5.9 | 3.7e-09 | -0.44 | 0.01 | 0.60 | FALSE |