Best TWAS P=3.89e-13 · Best GWAS P=5.91e-17 conditioned to 8.66e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C5orf42 | 0.04 | 0.05 | lasso | 3 | 0.04 | 1.1e-03 | -7.5 | 7.3 | 3.9e-13 | -0.92 | 0.00 | 0.94 | TRUE |
| 3 | GTEx | Esophagus Muscularis | LMBRD2 | 0.13 | 0.07 | enet | 21 | 0.08 | 1.8e-05 | 3.8 | -5.3 | 9.9e-08 | -0.04 | 0.28 | 0.05 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | WDR70 | 0.06 | 0.03 | lasso | 8 | 0.03 | 3.5e-03 | -6.1 | 6.6 | 4.0e-11 | -0.72 | 0.38 | 0.42 | FALSE |
| 6 | GTEx | Whole Blood | C5orf42 | 0.07 | 0.00 | enet | 16 | 0.01 | 1.8e-02 | -8.4 | 6.2 | 6.7e-10 | -0.68 | 0.01 | 0.88 | FALSE |
| 4 | GTEx | Nerve Tibial | WDR70 | 0.17 | 0.07 | lasso | 3 | 0.05 | 1.4e-04 | 5.9 | 5.7 | 1.2e-08 | -0.43 | 0.40 | 0.03 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | C5orf42 | 0.04 | 0.03 | lasso | 4 | 0.04 | 1.2e-05 | -6.5 | 5.7 | 1.5e-08 | -0.65 | 0.40 | 0.48 | FALSE |
| 5 | GTEx | Whole Blood | NUP155 | 0.05 | 0.01 | enet | 14 | 0.04 | 1.1e-04 | -8.4 | 5.5 | 4.4e-08 | -0.61 | 0.00 | 0.95 | FALSE |