TWAS hub - C5orf42

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.036	0.0170	1.1e-03	0.034	0.023	0.038	0.019	0.040	4.7e-05	7.7e-04	1.7e-05	0.00190	1.2e-05
2	GTEx	Cells Transformed fibroblasts	0.111	0.0550	3.0e-03	0.000	NA	0.004	NA	0.000	3.4e-01	NA	1.6e-01	NA	3.0e-01
3	GTEx	Whole Blood	0.067	0.0380	5.3e-03	0.005	NA	0.014	NA	0.002	1.1e-01	NA	1.8e-02	NA	1.8e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.110	0.0369	8.1e-05	0.005	0.029	0.016	0.027	0.005	7.2e-02	9.7e-05	3.5e-03	0.00018	7.3e-02
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.043	0.0320	5.4e-03	0.048	0.023	0.033	NA	0.039	3.3e-04	9.9e-03	2.5e-03	NA	1.1e-03
6	TCGA	Rectum Adenocarcinoma	0.747	0.1020	2.1e-03	-0.005	0.029	0.002	NA	-0.004	4.5e-01	7.2e-02	2.8e-01	NA	4.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Exposure to tobacco smoke outside home	5.7	7.6	14.4	-1.8	-3.8	-3.2	0.1	-2.8	-3.1
Leg predicted mass (right)	5.5	29.2	66.4	6.3	1.7	7.2	0.5	8.2	3.8
Sitting height	5.4	38.5	118.8	7.0	2.8	5.8	-0.0	10.9	4.6
Leg fat-free mass (right)	5.4	28.6	64.2	6.2	1.8	7.1	0.6	8.0	3.8
Leg fat-free mass (left)	5.0	26.3	58.5	6.0	1.4	6.9	0.5	7.7	3.6
Leg predicted mass (left)	4.9	26.0	58.1	5.9	1.5	6.9	0.5	7.6	3.5
Whole body water mass	4.5	25.8	66.4	5.9	1.1	6.5	0.8	8.2	3.1
Whole body fat-free mass	4.4	25.0	64.8	5.7	1.0	6.5	0.8	8.1	3.0
Arm predicted mass (right)	4.1	21.0	55.4	5.0	1.2	6.0	1.0	7.4	2.6
Ever had prostate specific antigen (PSA) test	4.1	4.7	14.2	1.7	0.2	3.8	1.8	2.3	1.6
Basal metabolic rate	4.0	22.1	52.7	5.7	1.1	6.2	0.9	7.3	2.9
Impedance of leg (right)	3.9	18.8	40.8	-4.8	-1.9	-5.9	-1.4	-6.4	-2.7
Impedance of leg (left)	3.8	18.7	41.3	-4.8	-1.4	-6.1	-1.1	-6.4	-2.8
Trunk fat-free mass	3.8	21.7	63.2	5.3	0.4	5.8	0.6	7.9	2.4
Trunk predicted mass	3.8	21.8	63.7	5.2	0.5	5.8	0.6	8.0	2.4
Ever depressed for a whole week	3.8	4.7	15.2	3.9	0.6	1.0	2.3	2.1	1.3
Arm fat-free mass (right)	3.7	19.0	48.6	5.1	0.9	5.7	1.3	7.0	2.2
Height	3.3	63.3	162.2	7.8	2.2	8.7	-2.3	12.7	8.5
Standing height	3.3	32.4	93.3	5.7	1.6	6.0	-1.9	9.7	5.1
Average weekly fortified wine intake	3.2	3.8	7.9	-2.1	-0.4	-2.4	0.2	-2.8	-2.1
Arm predicted mass (left)	3.0	15.4	37.8	4.7	0.8	5.2	0.9	6.2	1.9
Arm fat-free mass (left)	2.9	14.5	35.6	4.6	0.6	5.0	1.1	6.0	1.8
Comparative height size at age 10	2.6	14.1	37.5	4.4	1.0	4.3	0.0	6.1	2.9
Depression (Nagel 2018)	2.5	3.7	18.2	1.1	1.5	-0.3	4.3	-0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	9.7	3.1	0.5	0.8	2.0	1.4	1.4
Pain all over the body in last month	2.4	2.6	7.7	2.8	1.1	0.7	2.1	1.1	0.7
Neck or shoulder pain in last month	2.4	3.4	15.4	0.1	1.5	-0.6	3.9	-1.4	-0.7
Illnesses of siblings: Diabetes	2.4	2.9	6.7	-1.8	2.2	-1.1	0.1	-2.6	-1.1
Unable to work because of sickness or disability	2.4	3.1	10.9	1.6	1.6	0.4	3.3	1.3	-0.6
Frequency of depressed mood in last 2 weeks	2.3	3.2	16.8	1.2	0.8	0.1	4.1	-0.2	-0.1
Weight	2.3	11.3	20.9	4.6	1.5	4.5	0.8	4.2	2.4
Illnesses of mother	2.3	2.8	7.2	-2.0	-2.7	-1.0	-0.9	-1.9	-0.7
Medication: Bendroflumethiazide	2.3	3.5	6.7	1.1	1.7	2.6	1.7	2.3	1.6
Mouth/teeth dental problems	2.1	3.1	11.3	-1.6	-1.3	-1.3	-3.4	-1.3	-0.0
Age at last live birth	2.1	3.1	5.4	-1.9	-0.6	-2.2	-0.9	-1.9	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	10.3	0.4	-0.3	-1.8	3.2	-0.5	-0.8
Miserableness	2.1	3.7	14.4	1.1	1.0	-1.7	3.8	-0.6	-1.4
Alcohol drinker status: Previous	2.1	2.4	5.9	1.0	2.4	0.1	1.9	1.7	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	12.9	1.2	0.2	-0.5	3.6	0.1	-0.9
Medication for cholesterol	1.9	2.9	6.6	-1.7	-1.1	-2.2	-0.5	-2.6	-1.2
Body Mass Index (BMI) (2010)	1.8	2.5	6.4	0.9	2.5	1.4	0.1	2.0	1.4
Pulse rate	1.8	3.0	5.7	-1.7	-0.8	-1.9	0.0	-2.3	-2.4
Overall health rating	1.8	3.8	9.3	3.0	0.7	1.0	1.9	2.6	1.3
Mood swings	1.8	3.2	14.2	0.9	0.6	-1.1	3.8	0.1	-1.7
Irritability	1.8	3.0	13.5	0.6	1.0	0.2	3.7	-0.6	-1.7
Impedance of whole body	1.8	9.4	22.4	-3.5	-0.3	-4.0	-2.3	-4.7	-0.5
Depressed Affect (Nagel 2018)	1.7	3.6	13.9	0.5	1.1	-1.8	3.7	-0.7	-1.6
Neuroticism (2016)	1.7	2.4	12.7	1.1	0.7	0.1	3.6	0.3	-0.1
Hearing difficulty/problems with background noise	1.7	2.7	12.3	1.7	-0.3	0.5	3.5	-0.4	-0.5
Happiness	1.7	2.1	4.7	0.9	0.5	1.8	0.5	2.2	1.8
Health satisfaction	1.7	2.2	9.0	2.0	-0.1	-0.3	3.0	-0.2	0.3
Alcohol intake frequency.	1.7	3.9	8.8	1.1	1.9	1.3	2.9	3.0	0.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.6	1.5	-1.4	-0.9	2.4	0.1	-1.5
Supplements: Zinc	1.6	1.7	3.9	1.7	0.4	0.7	-0.7	1.6	2.0
Exposure to tobacco smoke at home	1.6	1.8	6.2	-0.5	-2.5	-1.1	0.4	-1.4	-0.9
Number of self-reported non-cancer illnesses	1.6	2.7	12.6	1.2	0.4	-0.1	3.6	-0.4	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	4.1	-0.2	-0.8	-2.0	2.0	-0.6	-1.5
Ulcerative Colitis (UC)	1.5	2.8	4.6	-2.0	-1.6	-1.6	0.8	-2.1	-1.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	2.1	1.2	1.1	0.9	1.4	1.4
Severe depression (siblings)	1.5	1.7	6.4	1.2	-0.4	1.5	2.5	0.2	0.1
Neuroticism score	1.5	3.1	15.4	1.3	0.9	0.1	3.9	-0.6	-0.4
Hip circumference	1.5	6.6	14.4	3.8	2.7	3.0	1.0	2.1	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.0	2.6	1.2	0.5	1.9	0.6	1.1
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	8.1	2.9	0.3	0.4	1.6	0.4	0.8
Medication: Blood pressure	1.5	2.6	7.6	-0.7	2.2	2.8	1.0	1.1	0.6
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	5.0	-0.2	1.2	1.1	-2.2	0.5	1.7
Cholesterol lowering medication	1.5	2.2	3.9	2.0	1.4	1.2	1.9	1.4	0.5
Basal cell carcinoma (self-reported)	1.5	1.8	2.9	-1.0	-1.7	-0.5	-1.7	-1.2	-1.5
Bipolar Disorder (2011)	1.4	1.4	4.2	-2.1	0.4	-0.4	-0.8	-1.7	-0.5
Hearing difficulty/problems: Yes	1.4	2.2	10.6	1.4	-0.5	0.2	3.3	-0.4	-0.5
Medication: Lansoprazole	1.4	1.6	3.7	-1.5	0.4	-0.7	0.7	-1.6	-1.9
Breast cancer (self-reported)	1.4	1.7	2.7	1.3	-0.9	-1.6	1.6	-1.1	-1.1
Financial situation satisfaction	1.4	1.7	4.6	2.1	-0.4	-0.5	2.1	0.7	0.5
Neuroticism (Nagel 2018)	1.3	3.1	14.5	1.2	0.9	-0.6	3.8	-0.6	-0.8
Schizophrenia vs Biploar Disorder	1.3	1.8	7.6	-0.2	-0.7	0.7	-2.8	0.6	1.2
Fasting Glucose	1.3	1.5	3.2	0.6	0.0	1.6	-1.6	1.8	0.7
Neuroticism	1.3	3.2	16.1	1.2	0.5	0.0	4.0	-1.0	-0.6
Fed-up feelings	1.3	2.4	10.1	0.2	0.7	-1.6	3.2	-0.1	-1.2
Qualifications: A levels/AS levels or equivalent	1.3	2.8	7.7	-0.3	-2.8	-1.3	-0.4	-1.6	-2.2
Mouth/teeth dental problems: Dentures	1.3	2.2	7.2	-2.7	0.6	-0.5	0.9	-0.3	-2.1
Emphysema/chronic bronchitis	1.3	1.5	3.1	1.4	0.9	-0.3	1.7	1.6	0.4
Suffer from ‘nerves’	1.3	2.1	5.0	1.9	2.2	0.9	1.1	1.0	0.9
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.9	-0.1	-1.1	-0.6	1.6	-1.7	-1.4
Supplements: Vitamin C	1.3	1.5	6.2	-0.9	0.0	-0.9	-2.5	0.8	0.6
Loneliness, isolation	1.3	1.8	8.1	0.3	-0.5	-0.5	2.8	-1.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	7.6	1.5	0.2	1.2	2.8	0.6	0.3
Medication: Atorvastatin	1.3	1.6	4.3	1.5	-0.1	1.4	2.1	1.0	0.0
Sensitivity / hurt feelings	1.2	2.0	8.5	0.8	0.5	1.4	2.9	-0.1	0.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	1.2	0.4	1.7	0.1	0.6	1.7
Serious illness, injury or assault to yourself	1.2	1.4	4.2	1.4	0.0	0.3	2.0	1.5	-0.4
High blood pressure	1.2	3.4	10.1	0.7	1.0	3.2	0.6	2.7	1.2
Hair/balding pattern: Pattern 4	1.2	2.8	8.1	0.8	0.0	1.0	2.8	2.6	-0.7
Commuting to job workplace: Public transport	1.2	1.4	3.9	-0.2	1.2	0.7	-2.0	0.8	1.3
Medication: Paracetamol	1.2	1.9	4.2	1.0	1.4	0.9	1.7	2.1	0.5
Breast Cancer	1.1	2.6	6.4	-2.5	-0.5	-0.9	-2.2	-1.0	-1.5
Waist Hip Ratio (WHR)	1.1	4.9	9.3	-3.0	-2.3	-1.0	-1.6	-3.0	-1.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.1	-1.1	-0.7	-1.8	-0.6	-1.5	-0.5
High blood pressure (mother)	1.1	1.6	5.3	0.3	2.3	0.3	1.1	1.6	-0.4
Had menopause	1.1	1.4	4.5	0.7	1.4	2.1	0.5	1.1	-0.0
Financial difficulties in last 2 years	1.1	1.5	7.5	1.1	0.4	-0.2	2.7	-0.1	-0.5
Impedance of arm (right)	1.1	5.0	11.1	-2.4	-0.2	-2.6	-2.4	-3.3	0.0
Prospective memory result	1.1	1.4	4.6	1.4	-0.8	2.1	0.1	0.9	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	6.1	1.3	-0.5	0.9	2.5	0.4	-1.0
Pulse wave reflection index	1.1	1.3	4.4	0.4	0.3	0.6	-1.4	0.9	2.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.5	1.0	-2.1	-2.0	-1.1	-0.4	-0.3
Ever had bowel cancer screening	1.1	1.3	2.5	0.3	1.6	1.6	0.5	1.5	0.6
Arm fat mass (left)	1.1	4.5	9.4	3.1	1.6	3.0	0.8	1.5	1.7
Average weekly champagne plus white wine intake	1.1	1.6	5.1	-0.1	-0.6	2.3	0.3	2.0	-0.2
Diastolic blood pressure, automated reading	1.1	3.3	6.3	1.9	0.7	1.9	-0.8	2.5	2.2
Vascular/heart problems diagnosed by doctor	1.1	3.0	6.7	-0.8	-1.3	-2.6	-1.1	-2.6	-1.2
Major Depression (MDD)	1.0	1.2	5.8	1.0	0.4	0.0	2.4	0.5	-0.2
Rheumatoid Arthritis	1.0	1.3	4.1	-0.4	-2.0	0.5	0.0	1.2	-1.4
Diabetes (mother)	1.0	1.3	4.8	0.7	1.3	-0.6	2.2	0.1	-0.5
Current tobacco smoking	1.0	1.6	5.6	1.3	0.0	2.4	0.9	1.2	0.4
Age when periods started (menarche)	1.0	2.3	5.2	-2.3	-0.9	-1.5	-0.9	-1.7	-1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.2	-0.8	1.1	-1.2	1.0	-1.5	-0.8
Medication: Atenolol	1.0	1.3	2.4	0.8	1.3	1.2	0.2	1.5	1.2
Trunk fat mass	1.0	4.1	8.4	2.8	1.8	2.9	0.6	1.4	1.9
Number of incorrect matches in round	1.0	1.6	2.9	-1.7	-1.3	1.4	1.0	-0.9	-1.2
Number of live births	1.0	1.5	3.2	0.8	1.7	0.3	1.8	-0.0	1.3
Loud music exposure frequency	1.0	1.1	2.8	-0.5	-0.8	-0.1	0.9	-1.7	-1.5
Number of full brothers	1.0	1.2	6.2	-0.8	-2.5	-0.4	-0.1	-0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.2	1.1	1.1	-0.8	0.7	1.0	1.5
Medication: Seretide 50 evohaler	1.0	1.2	2.2	1.0	-1.5	-1.0	0.6	-0.8	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	5.5	0.3	2.3	-0.1	0.3	-0.5	0.9
Pain experienced in last month	1.0	1.7	5.4	-1.7	-1.2	-0.4	-2.3	-0.0	0.1
Hand grip strength (left)	0.9	2.3	4.2	-1.9	-2.0	0.6	-1.8	-0.2	-1.6
Relative age of first facial hair	0.9	1.8	4.6	0.1	2.1	0.7	-1.5	0.7	1.7
Pack years adult smoking proportion	0.9	1.4	2.4	-0.0	-1.5	-1.6	0.7	-1.5	-1.1
Hand grip strength (right)	0.9	2.3	6.7	-0.8	-2.6	1.1	-1.6	0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	2.7	1.4	1.6	1.6	0.9	1.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.9	0.9	1.3	0.5	2.2	0.7	-0.4
Had other major operations	0.9	1.1	3.8	1.3	0.6	-2.0	0.1	-0.7	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.1	1.7	0.6	1.8	1.2	1.3	1.6
Allergy	0.9	2.1	5.1	0.7	-0.4	2.0	-2.3	0.7	1.5
Noisy workplace	0.9	1.1	2.3	-1.4	-0.1	0.0	1.5	-1.3	-0.7
Peak expiratory flow (PEF)	0.9	2.2	3.7	-0.1	-1.9	-1.5	0.8	-1.7	-1.9
Comparative body size at age 10	0.9	2.5	5.3	0.5	1.4	2.3	-1.3	1.9	1.4
Number of children fathered	0.9	1.1	2.6	1.1	1.4	-0.3	1.6	0.1	0.6
Qualifications: College or University degree	0.9	2.7	8.8	0.2	-3.0	0.4	-2.4	-0.0	-1.2
Medication: Omeprazole	0.9	1.1	3.1	0.1	-0.8	-1.5	1.7	-0.2	-0.7
Hypertension (Self-reported)	0.9	2.4	7.4	0.1	0.8	2.7	0.4	2.4	0.7
Average weekly red wine intake	0.9	1.4	4.7	1.5	-0.8	-0.5	-2.2	-0.2	0.6
Long-standing illness, disability or infirmity	0.9	1.3	3.5	0.8	1.2	-1.4	1.9	0.2	-0.7
Osteoarthritis (self-reported)	0.9	1.2	3.2	1.1	-0.3	0.2	1.8	-1.2	-1.1
High cholesterol (Self-reported)	0.9	1.6	4.0	-0.3	0.7	-0.0	2.0	-1.4	-1.7
Fractured/broken bones in last 5 years	0.9	1.2	3.8	-0.5	-1.4	-0.5	2.0	-0.2	-0.8
Pack years of smoking	0.9	1.3	2.2	-0.3	-1.3	-1.5	0.9	-1.2	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.1	0.5	-2.0	-1.8	-0.7	-0.4	-1.7
Age at First Birth	0.8	1.1	2.2	-1.4	-0.2	-0.5	-1.5	-0.8	-1.4
LDL Cholesterol	0.8	1.3	3.3	1.8	1.3	0.4	1.1	0.6	0.8
Medication for hormone replacement therapy	0.8	0.9	1.6	0.9	0.8	0.7	-0.6	1.3	1.1
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	-0.9	0.2	0.3	-1.0	-1.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.5	0.5	1.5	-0.7	1.6	-1.1	-0.2
Time employed in main current job	0.8	0.9	2.4	0.9	1.1	0.3	0.9	1.6	0.2
Arm fat mass (right)	0.8	3.4	8.2	2.9	1.4	2.5	0.9	1.1	1.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.7	1.9	-1.1	0.0	-0.1	0.3	0.7
Blood clot in the leg (DVT)	0.8	1.0	1.9	-0.0	0.4	-1.1	1.4	-1.4	-0.9
Medication: Amlodipine	0.8	1.1	3.0	-1.5	-0.3	1.7	-1.1	0.3	-0.1
Leg fat percentage (right)	0.8	2.8	12.0	-0.1	0.2	-1.3	1.2	-3.5	-1.3
Pulse rate, automated reading	0.8	2.6	4.8	-0.8	-1.4	-2.0	-1.4	-1.5	-2.2
Number of full sisters	0.8	0.9	2.3	0.8	0.6	1.1	1.5	0.9	-0.5
Had major operations	0.8	0.9	2.4	-1.1	-1.6	-0.8	0.0	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.4	0.9	-1.0	1.0	-1.2	2.1	1.2
Illnesses of father: None of the above (group 1)	0.8	0.9	3.3	0.9	1.8	0.0	0.7	0.8	0.6
Leg fat percentage (left)	0.8	2.9	11.6	-0.0	0.5	-1.3	1.4	-3.4	-1.3
Heart disease (siblings)	0.8	1.0	4.3	0.1	-0.2	-2.1	0.5	-1.0	-0.5
Prostate Cancer	0.7	1.0	2.2	-0.8	-1.2	-1.1	-0.5	-1.5	-0.6
Triglycerides	0.7	1.2	2.4	-0.4	0.3	-1.4	1.6	-1.4	-0.8
Ulcerative Colitis	0.7	1.0	3.2	-1.8	-0.9	0.7	-0.2	-0.8	-0.9
Cardiovascular Disease	0.7	2.3	6.3	0.6	1.6	2.5	1.4	1.6	0.6
Respiratory disease	0.7	1.6	3.2	-0.0	0.8	-1.8	1.8	-0.6	-1.4
Lung FVC	0.7	3.7	8.9	-2.1	-0.8	-2.1	1.6	-1.2	-3.0
Medication: Co-codamol	0.7	0.8	1.6	0.6	1.3	1.3	0.9	0.2	-0.8
Diabetes (father)	0.7	0.8	3.8	-0.0	-0.3	-1.9	-0.9	-0.5	0.0
Chronic bronchitis/emphysema (father)	0.7	0.9	1.4	-0.9	0.1	0.7	-1.0	-1.1	1.2
Medication: Cholesterol lowering	0.7	1.1	2.0	-1.3	0.8	0.6	1.3	-1.4	-0.3
Impedance of arm (left)	0.7	3.2	6.6	-2.0	0.5	-1.6	-2.6	-2.1	1.2
Length of working week for main job	0.7	0.8	1.7	1.3	-0.9	-1.0	1.0	0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	-0.5	-1.4	-1.2	-1.1	-1.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.5	-0.7	1.2	0.4	1.6	-0.1	-0.6
Wheeze or whistling in the chest in last year	0.7	1.2	3.7	0.1	-1.9	-1.4	0.8	-0.7	-0.7
Shortness of breath walking on level ground	0.7	0.9	1.7	1.1	-0.1	0.6	1.3	1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.9	0.4	0.7	-1.1	1.7	-0.2	-0.6
Migraine (self-reported)	0.7	0.8	2.8	-0.2	0.5	-1.7	-1.1	-0.5	-0.6
Chest pain or discomfort	0.7	1.0	2.1	1.4	0.3	1.2	0.8	0.9	1.0
Family relationship satisfaction	0.7	0.9	2.0	0.9	0.5	0.7	0.5	1.4	1.2
Medication: Aspirin	0.7	0.9	2.8	-0.2	1.1	1.7	0.8	0.7	0.4
Medication: Aspirin	0.7	0.9	2.1	-0.1	1.3	1.4	1.1	0.5	0.1
Medication: Gliclazide	0.7	0.7	2.3	0.6	-0.7	-0.9	0.7	0.1	-1.5
Guilty feelings	0.7	1.1	4.3	1.0	-0.3	1.1	2.1	-0.1	0.3
Ever taken oral contraceptive pill	0.7	0.8	2.0	0.1	-0.4	1.1	-0.7	0.9	1.4
Alcohol drinker status: Never	0.7	0.8	3.3	0.5	0.5	0.1	1.8	0.7	-0.8
Risk taking	0.7	1.1	3.0	-0.2	-1.7	0.0	1.6	0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.3	-0.7	-1.9	-1.3	0.5	-0.2	-2.3
Irritable Bowel Disease (IBD)	0.6	1.5	4.2	-2.1	-1.1	-0.5	-1.0	-1.2	-1.0
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.8	-0.4	0.8	-1.3	1.1	0.1
Crohns Disease (2012)	0.6	1.0	5.8	-0.4	-0.0	0.4	-2.4	0.4	0.0
Lupus	0.6	0.9	3.9	0.3	-2.0	-0.1	-0.4	-1.2	-0.4
BMI	0.6	3.5	8.2	2.9	1.5	2.5	1.8	1.0	0.6
Lung FEV1/FVC ratio	0.6	2.8	6.4	2.5	-0.1	0.1	-2.5	-0.4	2.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.9	-0.3	1.7	0.3	1.0	-0.1	0.4
Medication: Metformin	0.6	0.9	3.6	-0.1	-1.9	0.3	0.3	-0.9	-0.8
Relative age voice broke	0.6	1.0	2.3	0.0	0.8	-0.9	-1.4	0.6	1.5
Forced vital capacity (FVC)	0.6	2.4	10.3	0.3	-0.1	1.2	1.5	3.2	-0.3
Illnesses of siblings	0.6	0.8	2.6	1.0	-1.6	0.1	-0.1	0.6	0.9
Medication: Paracetamol	0.6	1.1	2.2	0.6	1.5	0.5	1.3	1.3	0.5
Glaucoma (self-reported)	0.6	0.7	1.6	0.1	-0.6	-1.2	1.0	0.5	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.8	3.0	0.2	-0.1	0.1	1.7	-1.1	0.5
Worry too long after embarrassment	0.6	1.1	3.7	0.1	-1.0	0.6	1.1	-1.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.9	0.6	-0.8	-0.1	1.4	-0.7	-1.2
Mean time to correctly identify matches	0.6	1.2	3.4	0.7	-0.7	1.9	1.4	0.4	0.7
Heart disease (mother)	0.6	0.7	1.6	1.3	0.3	-0.3	-1.0	1.1	0.3
Whole body fat mass	0.6	2.5	5.5	2.3	1.1	2.3	0.9	0.9	1.1
Eye problems/disorders: Cataract	0.6	0.7	1.5	-0.9	-1.2	-0.0	-0.9	0.1	-1.0
Smoking status: Current	0.6	1.0	4.2	0.8	-0.0	2.0	0.3	0.9	0.4
Hearing aid user	0.6	0.7	1.5	-1.2	0.8	0.1	0.7	0.4	-1.2
Worry (Nagel 2018)	0.5	1.0	2.9	1.7	0.5	0.5	1.4	0.6	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	0.5	1.4	1.1	0.1	0.6	0.0
Crohns Disease (2017)	0.5	1.2	5.5	-1.0	-0.2	0.7	-2.3	0.3	-0.3
Mean Putamen Volume	0.5	0.6	1.5	1.2	0.4	0.7	-0.4	1.0	0.5
Systolic Blood Pressure	0.5	2.4	6.7	0.6	0.6	2.1	-0.2	2.6	1.6
Number of treatments/medications taken	0.5	1.0	2.4	-1.3	0.5	-0.1	1.1	-0.2	-1.6
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.3	-1.3	0.3	1.2	0.4	-1.0
Stomach or abdominal pain in last month	0.5	0.6	1.6	1.0	0.1	0.0	1.3	0.9	-0.1
Body mass index (BMI)	0.5	2.1	4.7	2.2	1.0	2.0	1.7	-0.1	0.2
Medication: Ramipril	0.5	0.6	1.5	-0.1	0.5	1.2	-0.0	0.9	0.9
Asthma	0.5	0.9	2.0	0.8	1.2	-1.0	1.4	0.0	-0.5
Tense / ‘highly strung’	0.5	0.8	3.5	0.6	-0.0	0.8	1.9	-0.2	-0.2
High blood pressure (siblings)	0.5	0.7	2.3	-0.9	1.5	0.9	0.3	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.7	7.2	0.1	-0.5	1.3	1.0	2.7	-0.4
Knee pain experienced in last month	0.5	0.8	2.9	-0.3	1.2	0.3	-0.5	-1.7	0.3
Qualifications: nursing, teaching	0.5	0.8	2.4	0.9	1.0	0.7	-0.3	0.3	1.6
Commuting to job workplace: Walk	0.5	0.6	2.3	-0.1	1.5	-0.4	-0.3	0.4	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-0.6	0.7	-1.0	1.0	-0.5	-0.5
Asthma (self-reported)	0.5	1.0	2.4	0.9	1.3	-0.9	1.5	0.0	-0.5
Osteoporosis (self-reported)	0.5	0.6	2.2	-0.4	0.6	0.8	1.5	0.1	-0.3
Ever smoked	0.5	0.9	3.1	1.4	-0.3	0.7	1.8	-0.2	-0.0
Age started oral contraceptive pill	0.5	0.6	1.3	-1.0	0.9	0.7	1.2	-0.1	-0.2
Myopia	0.5	0.8	4.3	-2.1	0.4	-0.2	0.2	-0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	-0.7	-0.9	-0.6	0.6	-1.1	-0.7
Bipolar Disorder (2018)	0.4	0.6	1.6	-0.4	1.3	1.0	0.5	-0.3	-0.8
Reaction Time	0.4	0.8	2.5	0.0	-1.0	1.0	1.6	-0.4	0.1
Heel T-Score	0.4	2.9	9.9	2.1	3.1	0.7	1.7	0.4	0.1
Allergy or Eczema	0.4	1.1	4.5	0.1	0.2	-1.0	2.1	-0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	0.1	-0.9	0.7	1.5	0.1	-1.1
Chronotype (morning person)	0.4	1.0	2.0	-1.4	1.3	-0.6	-0.6	-1.4	0.1
Average weekly spirits intake	0.4	0.6	1.4	-0.6	-0.7	0.3	0.8	-0.6	-1.2
Vitamin and mineral supplements	0.4	0.5	1.4	-0.1	1.0	1.2	0.6	0.1	-0.4
Trunk fat percentage	0.4	1.8	3.7	1.4	1.9	1.5	0.6	-0.9	1.2
Maternal smoking around birth	0.4	0.6	2.2	-0.7	-0.6	-0.2	0.2	-1.5	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.9	-0.2	0.2	-0.8	1.7	-0.6	-0.9
Multivitamins +/- minerals	0.4	0.5	1.5	1.0	-0.7	-0.4	1.2	-0.1	0.0
Medication: Levothyroxine sodium	0.4	0.7	2.0	0.3	0.3	0.7	-1.4	1.3	0.3
Alcohol usually taken with meals	0.4	0.7	1.5	1.2	-1.2	-0.9	-0.4	-0.2	0.2
Heart attack	0.4	0.4	0.8	-0.6	-0.9	-0.4	0.6	-0.8	-0.5
Father’s age at death	0.4	0.6	2.6	0.1	-1.6	-0.5	0.2	-0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.6	0.5	-1.3	-0.8	-0.0	-0.6	-0.0
Lung cancer (father)	0.4	0.5	1.6	0.3	0.8	1.3	0.6	0.4	0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	0.6	0.1	0.8	-1.2	0.4	0.6
Headache pain in last month	0.4	0.7	2.0	-0.0	-0.0	-1.0	0.6	-1.1	-1.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	-0.1	-0.9	-0.3	-1.4	-1.0	0.5
Medication: Allopurinol	0.4	0.6	1.4	-1.2	1.1	0.6	0.6	0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	-1.4	-0.3	-0.2	0.0	-0.9	0.1
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.8	-0.8	-0.9	-0.0	-0.3	-0.9
Smoking status: Previous	0.4	0.7	2.5	0.1	0.3	-0.4	1.6	-1.0	-0.5
Arm fat percentage (left)	0.4	1.6	3.5	1.9	1.4	1.3	0.9	-0.7	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.9	-0.1	0.9	0.9	0.8	-0.6	0.1
Friendships satisfaction	0.4	0.5	0.9	0.6	0.6	0.8	0.3	0.9	0.9
Back pain experienced in last month	0.4	0.5	1.5	1.2	0.3	-0.8	1.0	0.0	0.1
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	0.6	-1.1	-0.2	0.2	0.8	-0.5
Medication: Blood pressure	0.4	0.8	1.9	1.1	-0.5	1.1	0.4	1.4	0.3
Medication: Lisinopril	0.4	0.5	1.8	-1.3	-0.3	-0.2	-0.8	0.4	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.2	0.7	0.1	0.7	-0.5	0.8	1.1
Average weekly beer plus cider intake	0.4	0.5	1.5	-0.2	1.2	1.0	0.6	-0.3	0.4
Supplements: Calcium	0.4	0.4	1.0	0.1	0.2	0.6	-1.0	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.0	0.3	-0.6	1.0	-1.0	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	1.7	0.2	-1.3	0.2	0.4	-0.2	0.1
Ovarian Cancer	0.3	0.4	1.1	-0.1	-0.3	0.5	0.5	-0.9	-1.0
HbA1C	0.3	0.3	0.7	0.8	-0.9	0.1	0.5	0.2	0.2
Schizophrenia (2014)	0.3	0.6	1.9	0.7	-0.8	0.7	-1.4	0.0	0.5
Blood Red Count	0.3	3.0	10.7	-1.2	-0.7	-1.5	-1.7	-3.3	-0.4
Blood White Count	0.3	2.0	4.7	-0.7	-1.0	-0.3	2.1	-1.2	-2.2
Systolic blood pressure, automated reading	0.3	0.9	2.5	-0.2	0.7	1.0	-0.1	1.6	1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	0.4	-0.7	1.0	0.1	0.6	0.3
Angina	0.3	0.4	1.3	0.8	-0.0	-0.4	1.1	0.3	-0.2
Taking other prescription medications	0.3	0.5	1.9	-0.8	0.5	0.2	0.4	-0.4	-1.4
Supplements: Glucosamine	0.3	0.4	0.9	0.9	0.3	0.6	-0.2	0.6	0.9
Waist circumference	0.3	1.0	2.7	1.6	0.6	1.6	0.2	-0.4	0.6
Past tobacco smoking	0.3	0.5	2.0	-0.6	-0.2	0.3	-1.4	0.7	0.2
Nervous feelings	0.3	0.5	1.2	0.6	-0.4	-0.4	0.9	-1.1	-0.8
Qualifications: None of the above	0.3	0.7	2.1	0.4	1.5	0.3	0.9	0.8	0.7
Diabetes (self-reported)	0.3	0.5	2.3	-0.2	-0.2	-0.3	1.5	-0.2	-0.6
Fluid intelligence score	0.3	0.6	1.3	0.3	-1.1	-0.4	-0.9	0.6	-1.0
Arm fat percentage (right)	0.3	1.2	2.3	1.4	1.0	0.7	1.0	-1.5	0.6
Alcohol intake versus 10 years previously	0.3	0.4	1.7	0.1	-1.3	-0.1	0.6	0.6	-0.5
Falls in the last year	0.3	0.4	1.0	1.0	0.0	-0.9	0.4	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.2	0.4	-0.5	0.8	0.7	2.1	-0.1
Breastfed as a baby	0.3	0.4	1.0	1.0	-1.0	0.0	0.5	0.3	-0.4
Gout (self-reported)	0.3	0.4	0.8	-0.5	0.4	0.9	0.9	0.7	-0.0
Birth weight	0.3	0.7	1.6	1.2	-0.4	1.2	-0.1	1.0	0.5
Body fat percentage	0.3	1.2	4.0	0.9	1.3	0.3	0.9	-2.0	0.3
Age at first live birth	0.3	0.5	1.5	-1.2	0.6	-0.5	-0.8	0.1	-0.4
Pulse wave peak to peak time	0.3	0.3	1.4	-0.2	0.1	-0.4	1.2	0.3	-0.3
Eye problems/disorders: None of the above	0.3	0.4	1.2	0.3	0.7	-0.3	-0.0	-0.6	1.1
Angina (self-reported)	0.3	0.3	0.9	0.9	0.3	-0.5	0.9	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	-0.8	0.2	-0.2	-1.2	-0.1	0.4
Leg fat mass (right)	0.3	1.2	3.2	1.8	0.5	1.4	1.3	-0.0	0.2
Leg pain on walking	0.3	0.4	1.0	0.9	0.1	-0.1	1.0	-0.1	0.8
Diabetes diagnosed by doctor	0.3	0.5	2.5	0.0	-0.4	0.4	1.6	-0.1	-0.5
Mineral and other dietary supplements	0.3	0.5	1.2	0.6	1.1	-0.1	1.1	0.2	-0.1
Wears glasses or contact lenses	0.3	0.4	1.5	-0.1	-0.2	-0.1	0.4	1.2	-0.7
Mother’s age at death	0.3	0.3	0.8	-0.9	-0.0	-0.8	0.7	-0.3	-0.4
Commuting to job workplace: Cycle	0.3	0.4	1.5	-0.7	-1.2	-0.3	-0.0	0.4	-0.3
Leg fat mass (left)	0.3	1.3	3.4	1.9	0.8	1.4	1.2	0.1	0.3
HDL Cholesterol	0.2	0.3	0.8	0.6	-0.1	0.4	-0.9	0.3	0.6
Primary Biliary Cirrhosis	0.2	0.3	1.2	-1.1	0.6	-0.3	0.4	0.0	-0.2
Blood Eosinophil Count	0.2	1.2	4.8	0.4	-0.4	1.3	2.2	0.2	-0.3
Blood Platelet Count	0.2	2.5	5.7	1.0	1.2	1.2	-1.1	2.4	2.1
Smoking Status	0.2	0.6	1.8	-0.2	-0.1	1.1	1.4	-0.4	-0.5
Hypothyroidism (self reported)	0.2	0.5	1.1	-1.0	-0.7	-0.0	-1.0	0.2	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.0	0.3	-0.2	-0.7	-0.7	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.5	-0.3	-0.5	-0.0	0.8	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.3	0.1	-0.6	-0.6	0.7	-0.1
Depression (self-reported)	0.2	0.2	0.6	0.8	-0.3	-0.4	0.5	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.2	-0.1	-0.8	0.6	0.4	1.5	-0.4
Birth weight of first child	0.2	0.4	1.0	0.6	0.6	0.1	0.7	1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-1.1	-0.2	-0.5	0.3	-0.7	-1.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	0.5	0.5	-0.5	0.1	0.7	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.7	0.1	-1.3	0.1	-0.0	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.2	-0.8	0.2	0.5	0.4	-0.3
Number of operations (self-reported)	0.2	0.3	0.9	0.9	0.3	-0.1	0.8	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	1.1	0.1	0.7	1.1	0.1	0.0	-0.5
Schizophrenia (2018)	0.1	0.1	0.3	0.5	-0.2	0.5	-0.2	0.3	-0.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.0	0.3	0.4	0.6	-0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	-0.1	0.2	-0.5	0.7	-0.1	-0.3
Hair Pigment	0.1	3.2	7.7	0.2	-1.7	2.8	-0.6	2.7	1.0
Tanning	0.1	0.9	2.5	1.6	0.2	0.2	0.6	1.0	1.2
Medication: Simvastatin	0.1	0.2	0.4	-0.1	0.7	0.5	0.6	-0.4	-0.1
Worrier / anxious feelings	0.1	0.3	0.5	0.7	0.2	0.7	0.1	0.7	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.0	-0.3	0.5	0.2	-0.6	1.0	-0.2
Medication: Ibuprofen	0.1	0.1	0.3	0.2	0.0	-0.4	-0.4	0.6	-0.3

Hub : Genes

C5orf42

Models

Trait associations