Best TWAS P=4.87e-14 · Best GWAS P=1.82e-10 conditioned to 0.653
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CTNNAL1 | 0.10 | 0.00 | lasso | 7 | 0.06 | 1.3e-07 | -4.3 | -6.6 | 3.7e-11 | -0.63 | 0.39 | 0.58 | FALSE |
2 | GTEx | Adipose Subcutaneous | IKBKAP | 0.08 | 0.08 | lasso | 4 | 0.07 | 4.6e-06 | 6.4 | 6.1 | 1.0e-09 | 1.00 | 0.00 | 1.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | CTNNAL1 | 0.22 | 0.20 | enet | 14 | 0.22 | 7.1e-18 | 5.3 | -6.0 | 1.7e-09 | -0.89 | 0.34 | 0.66 | FALSE |
4 | GTEx | Adipose Visceral Omentum | CTNNAL1 | 0.20 | 0.16 | lasso | 7 | 0.15 | 2.6e-08 | 5.3 | -5.6 | 2.3e-08 | -0.92 | 0.11 | 0.89 | FALSE |
5 | GTEx | Artery Aorta | IKBKAP | 0.15 | 0.14 | lasso | 4 | 0.15 | 1.9e-08 | 6.4 | 6.3 | 2.2e-10 | 0.97 | 0.00 | 1.00 | FALSE |
6 | GTEx | Artery Aorta | CTNNAL1 | 0.17 | 0.06 | lasso | 6 | 0.05 | 9.5e-04 | -4.3 | -6.8 | 1.4e-11 | -0.48 | 0.18 | 0.58 | FALSE |
7 | GTEx | Artery Tibial | IKBKAP | 0.13 | 0.12 | enet | 11 | 0.13 | 2.0e-10 | 3.2 | 5.3 | 1.4e-07 | 0.67 | 0.33 | 0.67 | FALSE |
8 | GTEx | Artery Tibial | CTNNAL1 | 0.37 | 0.18 | lasso | 6 | 0.31 | 9.9e-25 | 5.6 | -6.2 | 6.0e-10 | -0.72 | 0.08 | 0.92 | FALSE |
9 | GTEx | Breast Mammary Tissue (Male) | CTNNAL1 | 0.20 | -0.01 | lasso | 4 | -0.01 | 5.9e-01 | 4.0 | -5.3 | 1.1e-07 | -0.67 | 0.03 | 0.62 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | IKBKAP | 0.20 | 0.19 | lasso | 5 | 0.18 | 1.0e-13 | 6.4 | 5.5 | 2.9e-08 | 0.99 | 0.00 | 1.00 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | CTNNAL1 | 0.22 | 0.08 | enet | 21 | 0.19 | 2.1e-14 | 5.6 | -5.7 | 1.2e-08 | -0.70 | 0.04 | 0.96 | FALSE |
12 | GTEx | Esophagus Muscularis | IKBKAP | 0.16 | 0.14 | lasso | 7 | 0.11 | 4.8e-07 | 6.4 | 6.6 | 4.1e-11 | 0.98 | 0.00 | 1.00 | FALSE |
13 | GTEx | Lung | IKBKAP | 0.11 | 0.11 | lasso | 5 | 0.10 | 1.9e-08 | 6.4 | 6.5 | 9.8e-11 | 0.99 | 0.00 | 1.00 | FALSE |
14 | GTEx | Muscle Skeletal | CTNNAL1 | 0.42 | 0.14 | lasso | 7 | 0.27 | 7.6e-27 | -4.3 | -6.8 | 1.0e-11 | -0.63 | 0.92 | 0.07 | FALSE |
15 | GTEx | Nerve Tibial | IKBKAP | 0.13 | 0.16 | lasso | 7 | 0.14 | 3.7e-10 | 6.4 | 6.5 | 7.3e-11 | 0.99 | 0.00 | 1.00 | FALSE |
16 | GTEx | Pancreas | CTNNAL1 | 0.41 | 0.18 | lasso | 9 | 0.19 | 2.6e-08 | 5.6 | -7.3 | 3.6e-13 | -0.85 | 0.09 | 0.91 | TRUE |
17 | GTEx | Pituitary | IKBKAP | 0.29 | 0.24 | lasso | 9 | 0.23 | 2.0e-06 | 6.4 | 5.9 | 2.9e-09 | 0.93 | 0.00 | 0.98 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | CTNNAL1 | 0.12 | 0.09 | lasso | 5 | 0.09 | 1.2e-07 | 5.6 | -5.9 | 3.7e-09 | -0.96 | 0.01 | 0.99 | FALSE |
19 | GTEx | Spleen | CTNNAL1 | 0.66 | 0.06 | enet | 84 | 0.18 | 2.8e-05 | 5.6 | -6.1 | 1.0e-09 | -0.50 | 0.02 | 0.90 | FALSE |
20 | GTEx | Whole Blood | CTNNAL1 | 0.14 | 0.07 | lasso | 6 | 0.07 | 9.4e-07 | -4.3 | -5.8 | 8.8e-09 | -0.05 | 0.49 | 0.32 | FALSE |
21 | METSIM | Adipose | IKBKAP | 0.08 | 0.01 | blup | 648 | 0.03 | 1.7e-05 | 6.4 | 6.1 | 8.4e-10 | 0.58 | 0.01 | 0.99 | FALSE |
22 | YFS | Blood | CTNNAL1 | 0.15 | 0.07 | enet | 29 | 0.08 | 2.8e-26 | -4.3 | -5.6 | 1.9e-08 | -0.17 | 0.99 | 0.01 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTNNAL1 | 0.29 | 0.06 | enet | 12 | 0.12 | 8.8e-14 | 5.6 | -6.0 | 2.2e-09 | -0.72 | 0.06 | 0.94 | FALSE |
24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CTNNAL1 | 0.21 | 0.02 | lasso | 3 | 0.06 | 2.1e-03 | 5.6 | -6.9 | 4.4e-12 | -0.72 | 0.01 | 0.85 | FALSE |
25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CTNNAL1 | 0.09 | 0.00 | blup | 83 | 0.04 | 1.0e-04 | -4.3 | -7.5 | 4.9e-14 | -0.47 | 0.02 | 0.48 | TRUE |