Best TWAS P=7.61e-08 · Best GWAS P=1.37e-07 conditioned to 0.404
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM76B | 0.06 | 0.02 | lasso | 3 | 0.01 | 8.1e-03 | -5.1 | 5.3 | 9.0e-08 | 0.80 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AP001877.1 | 0.29 | 0.24 | lasso | 7 | 0.25 | 5.0e-07 | -5.1 | -5.3 | 1.3e-07 | -0.85 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Colon Transverse | CEP57 | 0.12 | 0.11 | lasso | 3 | 0.11 | 6.8e-06 | -5.1 | -5.2 | 1.7e-07 | -0.83 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CEP57 | 0.14 | 0.14 | lasso | 3 | 0.10 | 6.0e-07 | -5.1 | -5.1 | 3.1e-07 | -0.83 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Esophagus Muscularis | CEP57 | 0.15 | 0.05 | enet | 21 | 0.06 | 9.0e-05 | -5.1 | -5.2 | 1.9e-07 | -0.81 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Esophagus Muscularis | AP001877.1 | 0.17 | 0.09 | lasso | 6 | 0.10 | 6.2e-07 | -5.1 | -5.4 | 7.6e-08 | -0.92 | 0.04 | 0.96 | TRUE |
| 7 | GTEx | Liver | FAM76B | 0.43 | 0.08 | enet | 32 | 0.13 | 1.4e-04 | -5.2 | -5.3 | 1.3e-07 | -0.64 | 0.03 | 0.93 | FALSE |
| 8 | GTEx | Liver | CEP57 | 0.24 | 0.10 | enet | 23 | 0.01 | 2.1e-01 | -5.1 | -5.3 | 1.4e-07 | -0.73 | 0.04 | 0.82 | FALSE |
| 9 | GTEx | Lung | CEP57 | 0.12 | 0.05 | enet | 16 | 0.04 | 4.4e-04 | -5.1 | -5.4 | 8.7e-08 | -0.76 | 0.03 | 0.97 | FALSE |
| 10 | GTEx | Muscle Skeletal | CEP57 | 0.15 | 0.18 | lasso | 9 | 0.18 | 1.8e-17 | -5.2 | -5.1 | 2.8e-07 | -0.79 | 0.02 | 0.97 | FALSE |
| 11 | GTEx | Nerve Tibial | CEP57 | 0.15 | 0.08 | lasso | 6 | 0.07 | 1.9e-05 | -5.1 | -5.3 | 1.5e-07 | -0.83 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Pancreas | CEP57 | 0.19 | 0.10 | lasso | 13 | 0.08 | 3.6e-04 | -5.1 | -5.4 | 8.5e-08 | -0.79 | 0.03 | 0.96 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | CEP57 | 0.14 | 0.06 | enet | 10 | 0.05 | 9.6e-04 | -3.9 | -5.1 | 3.0e-07 | -0.73 | 0.03 | 0.96 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | CEP57 | 0.19 | 0.14 | enet | 24 | 0.16 | 4.1e-13 | -5.1 | -5.3 | 1.4e-07 | -0.89 | 0.03 | 0.97 | FALSE |
| 15 | GTEx | Small Intestine Terminal Ileum | AP001877.1 | 0.34 | 0.14 | lasso | 22 | 0.11 | 1.8e-03 | -5.1 | -5.2 | 2.2e-07 | -0.70 | 0.03 | 0.87 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | AP001877.1 | 0.17 | 0.27 | lasso | 12 | 0.27 | 3.6e-35 | -5.2 | -5.2 | 2.0e-07 | -0.76 | 0.03 | 0.97 | FALSE |
| 17 | YFS | Blood | FAM76B | 0.14 | 0.25 | lasso | 10 | 0.26 | 8.1e-83 | -5.2 | 5.2 | 1.7e-07 | 0.75 | 0.03 | 0.97 | FALSE |