Hub : Genes

FAM76B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.055 0.0230 3.7e-03 0.022 0.012 0.000 0.013 0.013 9.2e-04 1.2e-02 3.3e-01 8.8e-03 8.1e-03
2 GTEx Liver 0.434 0.1000 7.6e-05 0.078 NA 0.134 NA 0.109 3.5e-03 NA 1.4e-04 NA 6.0e-04
3 YFS Blood 0.137 0.0179 0.0e+00 0.254 0.230 0.254 0.254 0.255 1.4e-82 7.3e-74 1.7e-82 1.6e-82 8.1e-83

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.3 0.6 -0.1 0.4
Bipolar Disorder or Schizophrenia 0.8 1.9 2.1 -1.3 1.4 -1.4
Depressed Affect (Nagel 2018) 0.0 0.1 0.1 0.3 0.3 0.3
Depression (Nagel 2018) 0.4 0.7 1.2 1.1 -0.1 0.8
Intelligence (Savage-Jansen 2018) 9.4 28.8 31.3 -5.4 5.1 -5.6
Neuroticism (Nagel 2018) 0.8 1.9 2.7 1.6 -0.8 1.5
Schizophrenia (2018) 2.0 4.1 4.4 -2.1 1.9 -2.1
Schizophrenia vs Biploar Disorder 2.4 3.2 4.8 -2.2 1.5 -1.6
Worry (Nagel 2018) 5.4 11.4 13.1 3.2 -3.3 3.6
Alzheimer’s Disease (in mother) 2.6 3.0 3.5 -1.9 1.5 -1.8
Alzheimer’s Disease (in father) 0.3 0.3 0.5 0.4 0.7 0.6
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 -0.4 0.9 0.0
Crohns Disease (2017) 0.0 0.1 0.2 0.1 -0.5 0.3
Irritable Bowel Disease (IBD) 0.4 0.9 1.4 -1.2 -0.1 -1.1
Ulcerative Colitis (UC) 0.5 0.9 1.4 -1.0 -0.4 -1.2
Major Depression (MDD) 0.8 1.0 2.0 0.9 -0.3 1.4
Reaction Time 0.7 1.3 1.9 1.4 -0.8 1.2
Verbal and Numeric Reasoning (VNR) 8.1 19.3 19.9 -4.4 4.3 -4.5
Breast Cancer 4.6 11.1 11.6 -3.4 3.3 -3.3
Ovarian Cancer 0.1 0.2 0.2 0.5 0.0 0.5
Prostate Cancer 0.4 0.6 1.2 0.7 -0.1 1.1
Age at First Birth 1.4 2.1 2.7 -1.4 1.3 -1.6
Bipolar Disorder (2011) 0.3 0.3 0.6 0.2 -0.5 -0.8
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 0.0 0.0 0.3
Coronary Artery Disease (CAD) 1.9 2.3 2.6 1.5 -1.5 1.6
Crohns Disease (2012) 0.4 0.6 0.8 -0.9 0.6 -0.8
Mean Putamen Volume 1.0 1.1 1.3 -1.1 1.0 -1.1
Fasting Glucose 0.3 0.3 0.8 0.5 -0.1 0.9
HbA1C 0.0 0.0 0.1 -0.1 0.2 0.3
HDL Cholesterol 0.0 0.1 0.2 0.4 -0.1 0.3
LDL Cholesterol 2.9 4.7 6.5 2.5 -1.6 2.2
Lupus 0.4 0.6 0.9 -0.9 0.8 -0.3
Neuroticism (2016) 0.8 1.2 1.9 1.3 0.1 1.4
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.1 -0.6 -0.1
Rheumatoid Arthritis 4.9 6.7 8.8 2.8 -1.9 3.0
Schizophrenia (2014) 1.4 3.1 3.6 -1.9 1.6 -1.8
Triglycerides 1.0 1.6 2.7 1.4 -0.1 1.6
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 0.4 -0.2 0.8
Ulcerative Colitis 0.3 0.5 0.9 -0.5 -0.9 -0.6
Blood Eosinophil Count 0.1 1.1 1.7 1.3 -0.4 1.2
Blood Platelet Count 0.8 9.1 10.8 3.2 -3.3 2.5
Blood Red Count 2.0 19.5 29.2 -5.1 1.8 -5.4
Blood White Count 0.5 3.6 4.3 2.1 -1.6 2.1
Heel T-Score 0.3 2.7 3.2 -1.6 1.5 -1.8
BMI 0.1 0.6 1.6 0.1 1.3 0.3
Height 1.3 25.5 28.9 -5.4 4.5 -5.2
Waist Hip Ratio (WHR) 0.5 2.4 5.3 1.3 0.1 2.3
Systolic Blood Pressure 1.5 7.3 9.5 3.1 -2.4 2.6
Smoking Status 3.0 7.1 9.8 2.9 -1.8 3.1
Allergy or Eczema 0.2 0.6 1.2 0.1 -1.1 -0.8
Cardiovascular Disease 2.2 7.4 10.3 3.2 -1.7 3.0
Hypothyroidism (self reported) 0.6 1.4 2.3 -1.4 -0.0 -1.5
Respiratory disease 2.2 4.8 6.1 2.5 -2.0 2.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.2 1.0 -0.7 1.1
Lung FEV1/FVC ratio 0.1 0.7 1.1 -0.9 0.1 -1.1
Lung FVC 0.0 0.1 0.2 -0.4 0.3 -0.2
Neuroticism 0.5 1.3 1.9 1.3 -0.6 1.4
Chronotype (morning person) 1.1 2.6 4.3 2.1 -0.7 1.7
Hair Pigment 0.1 3.6 3.8 -2.0 1.8 -1.9
Tanning 0.4 5.2 7.2 2.1 -1.9 2.7
Hand grip strength (left) 1.4 3.6 5.3 -2.3 0.6 -2.3
Number of treatments/medications taken 3.2 5.7 8.0 2.6 -1.5 2.8
Average weekly spirits intake 0.1 0.2 0.3 0.5 -0.4 0.4
Sensitivity / hurt feelings 0.7 1.3 1.5 1.2 -0.9 1.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 0.6 0.3 0.7
Hearing difficulty/problems: Yes 0.7 1.0 1.2 -1.0 1.0 -1.1
Relative age of first facial hair 1.5 3.1 4.3 -1.6 2.1 -1.6
Other serious medical condition/disability diagnosed by doctor 1.7 2.3 3.8 -2.0 0.8 -1.5
Ever used hormone-replacement therapy (HRT) 8.8 11.2 12.3 3.5 -3.2 3.3
Ever had hysterectomy (womb removed) 5.3 6.0 6.2 2.4 -2.5 2.4
Systolic blood pressure, automated reading 2.0 5.9 7.8 2.8 -2.1 2.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 2.0 -1.2 1.2 -1.4
Angina 0.1 0.2 0.3 -0.4 0.6 -0.2
Medication for hormone replacement therapy 0.6 0.7 1.7 1.3 -0.5 0.4
Vitamin and mineral supplements 0.4 0.5 0.7 0.8 -0.5 0.8
Supplements: Zinc 1.1 1.2 1.8 -1.4 0.1 -1.3
Medication: Co-codamol 8.0 9.2 14.8 3.2 -1.5 3.9
Medication: Metformin 0.2 0.2 0.3 -0.6 0.5 -0.3
Diabetes (father) 1.9 2.4 3.5 1.9 -0.8 1.8
Diabetes (mother) 0.3 0.4 0.8 -0.9 -0.1 -0.6
Severe depression (siblings) 0.9 1.0 1.7 -0.7 1.3 -0.8
Pack years adult smoking proportion 1.8 2.7 4.5 1.2 -1.5 2.1
Impedance of leg (right) 5.8 27.9 28.6 5.3 -5.3 5.2
Leg fat-free mass (left) 2.2 11.8 13.1 -3.4 3.6 -3.3
Trunk fat percentage 1.4 5.7 8.0 2.8 -1.3 2.8
Hand grip strength (right) 1.7 4.6 6.5 -2.6 0.9 -2.6
Townsend deprivation index at recruitment 0.2 0.3 0.6 -0.8 0.5 -0.4
Current tobacco smoking 2.3 3.7 5.2 2.0 -1.4 2.3
Average weekly fortified wine intake 0.3 0.4 0.7 -0.6 -0.8 -0.3
Maternal smoking around birth 1.6 2.3 3.5 1.5 -1.0 1.9
Fed-up feelings 0.1 0.1 0.3 0.1 0.4 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 4.3 5.8 7.6 2.5 -1.9 2.8
Relative age voice broke 0.2 0.3 0.4 -0.4 0.6 -0.7
Taking other prescription medications 1.1 1.6 1.9 1.2 -1.3 1.4
Age when periods started (menarche) 0.0 0.1 0.1 -0.4 0.2 -0.2
Bilateral oophorectomy (both ovaries removed) 5.1 5.9 6.5 2.5 -2.4 2.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.6 0.2 -1.3 0.2
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 3.8 -1.0 2.0 -1.4
Qualifications: CSEs or equivalent 0.3 0.4 0.6 0.6 -0.8 0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.7 0.1 -0.3
High blood pressure 3.0 8.4 11.8 3.4 -2.1 3.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.0 -0.3 -0.8 -1.0
Multivitamins +/- minerals 0.6 0.8 1.3 -0.7 1.1 -0.8
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.3 -0.1 0.6
Supplements: Glucosamine 0.1 0.2 0.5 0.7 -0.0 0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.0 1.0 -0.8 0.6
Medication: Atenolol 0.2 0.3 0.7 -0.3 0.8 -0.2
Medication: Levothyroxine sodium 0.3 0.5 1.2 -1.1 -0.0 -0.6
Sitting height 0.7 5.1 7.1 -2.6 1.1 -2.7
Chronic bronchitis/emphysema (father) 1.3 1.5 1.8 1.2 -1.1 1.4
High blood pressure (mother) 0.9 1.2 1.7 0.9 -1.0 1.3
Body mass index (BMI) 0.1 0.4 0.4 0.5 0.6 0.7
Impedance of leg (left) 4.3 20.8 21.0 4.6 -4.6 4.5
Leg predicted mass (left) 2.3 11.9 13.3 -3.4 3.6 -3.3
Trunk fat mass 0.3 1.4 2.2 1.4 -0.0 1.5
Waist circumference 0.2 0.8 1.2 0.6 0.9 1.1
Number of incorrect matches in round 6.4 10.7 14.0 3.2 -2.8 3.7
Past tobacco smoking 0.7 1.3 2.1 -1.1 0.7 -1.4
Alcohol usually taken with meals 2.6 4.2 5.5 -2.0 1.8 -2.3
Nervous feelings 3.4 6.3 8.2 2.6 -2.0 2.9
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 1.9 1.0 -0.3 1.4
Hearing difficulty/problems with background noise 0.1 0.2 0.6 -0.1 0.7 -0.4
Hair/balding pattern: Pattern 2 1.6 2.0 3.1 -1.8 0.9 -1.5
Had menopause 4.4 5.4 5.6 2.4 -2.3 2.3
Had other major operations 1.3 1.6 2.3 -1.5 0.8 -1.4
Forced vital capacity (FVC) 0.6 2.2 3.5 -1.3 1.2 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.6 0.3 -0.7 -0.0
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 1.8 -1.3 1.2 -1.3
Qualifications: None of the above 18.6 39.8 48.9 6.4 -5.5 7.0
Financial difficulties in last 2 years 3.3 4.4 7.7 -2.2 0.7 -2.8
Mouth/teeth dental problems 0.4 0.6 1.2 1.1 -0.2 0.8
Heart attack 0.3 0.4 0.9 -0.6 0.1 -1.0
Allergy 0.8 1.9 2.9 -1.5 1.7 -0.8
Pain all over the body in last month 0.0 0.0 0.1 -0.4 0.1 0.1
Diabetes (self-reported) 0.5 0.7 1.2 0.9 -0.5 1.1
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 2.8 1.1 -1.7 0.9
Medication: Ramipril 0.9 1.2 1.6 1.2 -0.8 1.2
Medication: Simvastatin 1.0 1.5 2.7 1.0 -1.6 0.9
Fluid intelligence score 5.5 11.4 12.4 -3.2 3.5 -3.4
Illnesses of siblings 2.7 3.7 5.4 -2.3 1.6 -1.9
Neuroticism score 0.8 1.7 2.6 1.2 -1.0 1.6
Weight 0.4 1.7 3.0 -1.1 1.7 -1.0
Impedance of arm (right) 1.3 6.2 7.1 2.7 -2.2 2.5
Arm fat percentage (right) 0.8 3.3 4.8 2.2 -0.5 2.2
Trunk fat-free mass 2.8 15.9 16.1 -4.0 4.0 -4.0
Hip circumference 0.2 0.8 1.3 -0.6 1.2 -0.8
Time employed in main current job 0.1 0.1 0.1 0.3 0.3 -0.1
Alcohol intake versus 10 years previously 4.5 6.8 9.9 2.5 -2.0 3.2
Father’s age at death 1.3 1.7 2.7 -1.1 1.1 -1.6
Worrier / anxious feelings 10.0 18.9 21.6 4.3 -4.0 4.6
Frequency of tiredness / lethargy in last 2 weeks 3.6 5.9 6.9 2.5 -2.1 2.6
Falls in the last year 1.5 2.0 3.5 1.9 -0.8 1.4
Hair/balding pattern: Pattern 3 0.7 1.0 2.1 1.0 0.0 1.4
Number of live births 1.9 2.7 3.6 1.9 -1.4 1.6
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 5.4 -1.8 1.4 -2.3
Pulse rate 0.3 0.6 0.8 0.6 -0.9 0.7
Happiness 7.3 8.9 10.5 -3.1 2.5 -3.2
Noisy workplace 0.7 0.8 1.2 0.7 -1.1 0.9
Qualifications: A levels/AS levels or equivalent 17.6 38.9 45.6 -6.6 5.3 -6.8
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 5.8 -1.9 1.5 -2.4
Mouth/teeth dental problems: Dentures 7.6 12.8 17.1 3.2 -4.1 3.3
Asthma 2.0 4.0 5.2 2.3 -1.7 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.7 -0.5 1.7 -0.3
Medication: Cholesterol lowering 0.5 0.8 1.2 0.7 -1.1 0.8
Depression (self-reported) 0.1 0.1 0.2 -0.3 -0.5 -0.2
Medication: Lansoprazole 3.4 3.9 5.2 2.3 -1.7 1.9
Prospective memory result 0.6 0.7 0.8 0.9 -0.9 0.7
Lung cancer (father) 1.3 1.5 2.2 1.5 -0.9 1.3
Illnesses of mother 1.0 1.2 1.9 1.4 -0.6 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 6.4 -2.2 2.1 -2.5
Pulse wave Arterial Stiffness index 1.8 2.0 2.2 1.5 -1.4 1.4
Impedance of arm (left) 1.5 7.1 8.3 2.9 -2.5 2.6
Arm fat mass (right) 0.1 0.5 0.6 0.8 0.6 0.8
Trunk predicted mass 2.9 16.6 16.7 -4.1 4.1 -4.0
Standing height 0.8 7.6 9.1 -2.9 2.3 -3.0
Length of working week for main job 0.1 0.1 0.2 0.0 -0.4 -0.3
Exposure to tobacco smoke at home 3.3 3.7 4.9 2.0 -2.2 1.5
Breastfed as a baby 5.1 6.3 8.8 -2.6 1.8 -3.0
Tense / ‘highly strung’ 1.4 2.4 3.0 1.6 -1.2 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.8 -1.3 0.7 -0.9
Hair/balding pattern: Pattern 4 1.2 3.0 3.6 1.8 -1.9 1.6
Birth weight of first child 0.7 1.3 2.3 1.5 -0.7 1.1
Peak expiratory flow (PEF) 0.4 0.9 1.3 -1.0 0.6 -1.1
Pulse wave reflection index 0.0 0.0 0.0 -0.1 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 1.7 2.0 4.0 1.1 -2.0 1.0
Loud music exposure frequency 0.3 0.3 0.6 -0.6 0.0 -0.8
Qualifications: O levels/GCSEs or equivalent 9.1 14.5 18.5 -3.8 3.3 -4.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.0 -0.7 1.0 -0.9
Blood clot in the leg (DVT) 0.4 0.5 0.9 1.0 -0.5 0.6
Medication: Paracetamol 4.7 7.8 8.7 2.8 -2.7 2.9
Headache pain in last month 0.3 0.5 1.0 1.0 0.6 0.4
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 4.7 -1.9 1.1 -2.2
Glaucoma (self-reported) 0.2 0.3 0.5 -0.7 -0.5 -0.1
Gout (self-reported) 0.8 1.1 1.7 -1.3 -0.7 -1.0
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.1 -1.4 -0.3 -1.4
Medication: Amlodipine 1.4 2.0 3.0 1.7 -1.4 1.1
Medication: Ventolin 100micrograms inhaler 3.4 4.3 6.5 2.5 -1.0 2.4
Birth weight 0.2 0.4 0.8 0.0 -0.9 -0.6
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.3 0.5 -0.1 0.4
High blood pressure (siblings) 2.5 3.6 5.3 2.3 -1.6 1.8
Forced vital capacity (FVC), Best measure 1.1 4.0 4.8 -1.9 1.8 -2.2
Body fat percentage 1.8 7.3 10.4 3.0 -1.5 3.2
Leg fat percentage (right) 3.6 12.9 17.4 4.0 -2.4 4.2
Arm fat-free mass (right) 1.9 9.9 10.3 -3.2 3.1 -3.2
Exposure to tobacco smoke outside home 1.5 2.0 2.8 1.5 -1.7 1.0
Comparative body size at age 10 0.1 0.2 0.5 0.1 0.7 -0.1
Number of full brothers 0.2 0.3 0.5 -0.7 0.1 -0.6
Worry too long after embarrassment 0.4 0.6 0.8 0.9 -0.7 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 -0.7 0.3 -0.4
Wheeze or whistling in the chest in last year 0.9 1.6 2.2 1.2 -1.2 1.5
Number of children fathered 3.8 4.2 6.1 2.5 -1.1 2.4
Reason for reducing amount of alcohol drunk: Health precaution 7.2 8.4 9.8 3.0 -2.5 3.1
Age at first live birth 6.9 12.2 16.1 -3.7 2.6 -4.0
Pulse wave peak to peak time 1.9 2.2 2.3 -1.5 1.5 -1.5
Health satisfaction 0.2 0.3 0.8 -0.9 0.1 -0.3
Shortness of breath walking on level ground 0.2 0.3 0.4 -0.6 0.6 -0.3
Qualifications: College or University degree 14.0 44.2 50.2 -7.1 6.2 -6.6
Eye problems/disorders: None of the above 1.2 1.4 1.8 1.1 -1.1 1.3
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.0 -1.0 2.0 -0.6
Emphysema/chronic bronchitis 5.5 6.2 8.3 2.6 -1.9 2.9
Medication for pain relief, constipation, heartburn 4.6 7.9 10.1 -3.0 2.0 -3.2
Neck or shoulder pain in last month 0.7 1.0 1.3 -1.0 1.1 -0.8
Medication: Blood pressure 2.3 4.0 6.0 2.3 -0.8 2.4
Angina (self-reported) 0.1 0.2 0.3 -0.4 0.6 -0.2
Migraine (self-reported) 1.0 1.3 2.4 -0.9 1.5 -0.8
Medication: Ibuprofen 0.7 0.8 2.2 -0.3 1.5 -0.2
Medication: Allopurinol 0.8 1.1 2.2 -1.5 -0.5 -0.9
Medication: Omeprazole 4.6 5.5 8.7 2.2 -1.7 2.9
Medication: Seretide 50 evohaler 0.3 0.4 0.5 -0.7 0.4 -0.7
Mean time to correctly identify matches 1.1 2.1 3.1 1.8 -1.0 1.5
Heart disease (mother) 0.2 0.2 0.4 -0.1 0.6 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.0 -0.9 0.3 -1.0
Whole body fat mass 0.3 1.3 2.0 1.3 0.1 1.4
Leg fat mass (right) 0.6 2.4 3.8 1.8 -0.5 1.9
Arm predicted mass (right) 2.0 10.2 11.4 -3.4 3.0 -3.2
Pulse rate, automated reading 2.7 8.9 10.0 2.6 -3.1 3.2
Alcohol intake frequency. 0.0 0.1 0.1 0.2 -0.3 0.3
Comparative height size at age 10 0.1 0.5 0.7 -0.8 0.4 -0.8
Number of full sisters 0.1 0.1 0.3 0.5 -0.1 -0.1
Suffer from ‘nerves’ 1.6 2.6 3.1 1.4 -1.8 1.7
Overall health rating 1.3 2.8 4.2 1.7 -1.1 2.0
Chest pain or discomfort 0.0 0.0 0.1 -0.2 -0.2 0.1
Had major operations 3.9 4.6 7.8 -1.5 2.8 -1.9
Age at last live birth 7.4 10.7 14.6 -3.5 2.3 -3.8
Family relationship satisfaction 11.4 14.0 17.0 -4.1 3.0 -4.0
Leg pain on walking 0.5 0.7 1.1 1.0 -0.3 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 0.0 0.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 0.6 -0.3 0.5
Illness, injury, bereavement, stress in last 2 years 3.2 3.9 7.0 1.7 -1.3 2.6
Medication: Aspirin 0.7 0.9 1.7 1.3 -0.5 0.9
Supplements: Vitamin C 0.8 1.0 1.3 -1.0 0.9 -1.1
Knee pain experienced in last month 0.9 1.4 2.2 1.5 -0.9 1.1
Hypertension (Self-reported) 2.7 7.4 11.3 3.4 -1.7 2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 3.4 1.3 -0.9 1.8
Illnesses of father: Heart disease 0.2 0.2 0.3 -0.5 0.4 -0.5
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.5 0.1 -0.3
Smoking status: Previous 1.5 2.2 2.7 1.6 -1.1 1.6
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.3 5.9 -2.4 2.2 -2.3
Whole body fat-free mass 2.7 15.6 16.0 -4.0 4.0 -3.9
Leg fat-free mass (right) 3.2 17.0 17.8 -4.1 4.2 -4.0
Arm fat percentage (left) 0.8 3.1 4.5 2.1 -0.5 2.1
Average weekly red wine intake 10.2 15.0 18.7 -3.9 3.4 -4.3
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.0 1.1 -1.7 1.0
Mood swings 0.7 1.2 1.4 1.0 -1.2 1.0
Loneliness, isolation 1.3 1.9 2.5 -1.6 1.4 -1.0
Long-standing illness, disability or infirmity 0.0 0.0 0.1 -0.0 0.1 0.4
Ever had bowel cancer screening 4.4 5.2 6.6 2.6 -2.1 2.1
Diabetes diagnosed by doctor 0.7 1.1 1.7 1.1 -0.8 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 0.4 -0.6 0.4
Friendships satisfaction 15.8 19.6 21.4 -4.5 4.1 -4.6
Qualifications: nursing, teaching 9.2 14.3 14.7 -3.8 3.8 -3.7
Commuting to job workplace: Walk 3.2 3.5 4.9 -1.8 1.5 -2.2
Eye problems/disorders: Cataract 0.2 0.2 0.3 -0.5 0.3 -0.6
Mouth/teeth dental problems: Mouth ulcers 13.9 22.2 25.2 -5.0 4.2 -4.8
Medication for cholesterol 2.8 4.2 6.2 -2.5 1.5 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.9 4.6 5.8 2.3 -1.7 2.4
Back pain experienced in last month 5.5 8.0 10.6 2.8 -3.3 2.4
Mineral and other dietary supplements 0.3 0.4 1.1 -1.0 -0.0 -0.5
Breast cancer (self-reported) 0.0 0.0 0.0 -0.1 0.1 -0.2
Asthma (self-reported) 1.8 3.5 4.8 2.2 -1.5 1.9
Osteoporosis (self-reported) 0.8 1.0 1.2 1.1 -1.0 1.0
Osteoarthritis (self-reported) 2.3 2.9 4.1 1.9 -1.0 2.0
Medication: Aspirin 0.6 0.8 1.5 1.2 -0.4 0.8
Medication: Gliclazide 0.3 0.3 0.5 -0.7 0.6 -0.3
Illnesses of father: None of the above (group 1) 0.5 0.7 1.0 -1.0 0.6 -0.9
Smoking status: Current 1.3 2.0 3.0 1.4 -1.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 1.8 -1.1 1.1 -1.4
Whole body water mass 2.7 15.3 15.4 -3.9 3.9 -3.9
Leg predicted mass (right) 3.3 17.8 18.6 -4.2 4.3 -4.1
Arm fat mass (left) 0.1 0.4 0.6 0.6 0.8 0.6
Number of self-reported non-cancer illnesses 2.6 4.6 4.9 2.1 -2.2 2.1
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.6 0.1 -0.4
Miserableness 0.2 0.3 0.6 -0.2 0.8 -0.3
Guilty feelings 0.6 0.9 1.6 -0.6 1.3 -0.9
Wears glasses or contact lenses 0.6 0.7 1.6 0.7 -0.3 1.3
Ever taken oral contraceptive pill 0.4 0.5 0.7 0.6 -0.6 0.8
Hearing aid user 0.1 0.1 0.2 0.2 -0.5 -0.0
Mother’s age at death 1.6 2.1 2.3 -1.5 1.3 -1.4
Financial situation satisfaction 14.7 18.2 20.7 -4.5 3.8 -4.4
Tinnitus: Yes, now most or all of the time 1.6 1.8 2.6 -1.2 1.2 -1.6
Commuting to job workplace: Public transport 0.7 0.9 1.5 -1.2 0.2 -1.0
Eye problems/disorders: Glaucoma 0.7 0.8 1.5 -1.2 -0.3 -0.9
Medication: Blood pressure 2.3 4.4 5.2 2.3 -1.9 2.1
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.1 0.9 -0.5 1.1
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.4 1.2 -0.4 0.8
High cholesterol (Self-reported) 2.6 4.6 5.2 2.0 -2.1 2.3
Medication: Bendroflumethiazide 3.5 5.3 5.9 2.4 -2.2 2.3
Medication: Paracetamol 5.3 8.2 9.9 2.9 -2.6 3.1
Medication: Lisinopril 0.2 0.2 0.4 0.4 0.6 0.3
Medication: Atorvastatin 1.5 1.8 2.8 1.2 -1.0 1.7
Illnesses of father: High blood pressure 0.6 0.7 1.2 1.1 -0.2 0.9
Alcohol drinker status: Never 0.1 0.1 0.2 0.4 -0.1 -0.3
Ever smoked 0.2 0.3 0.5 -0.1 -0.7 0.6
Basal metabolic rate 2.1 11.4 12.4 -3.3 3.5 -3.3
Leg fat percentage (left) 2.8 10.1 13.8 3.5 -2.0 3.7
Arm fat-free mass (left) 1.7 8.7 8.9 -3.0 2.9 -3.0
Number of operations (self-reported) 1.1 1.6 2.7 -1.0 1.6 -1.0
Average weekly beer plus cider intake 5.6 8.1 9.7 3.1 -2.3 3.1
Irritability 0.6 0.9 1.5 -0.8 1.2 -0.8
Risk taking 0.2 0.2 0.4 -0.5 0.1 -0.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 -0.3 1.1 -0.4
Fractured/broken bones in last 5 years 0.4 0.5 0.9 0.5 -0.6 1.0
Age started oral contraceptive pill 0.2 0.2 0.4 -0.4 0.6 -0.4
Diastolic blood pressure, automated reading 1.3 4.1 4.5 2.1 -2.1 1.9
Ever depressed for a whole week 0.0 0.0 0.1 -0.2 0.1 -0.1
Unable to work because of sickness or disability 6.3 8.2 10.8 2.7 -2.5 3.3
Commuting to job workplace: Cycle 5.2 6.2 7.7 -2.8 2.1 -2.5
Myopia 0.2 0.2 0.5 -0.7 0.3 -0.3
Vascular/heart problems diagnosed by doctor 2.4 6.5 9.4 -3.1 1.8 -2.6
Cholesterol lowering medication 5.1 7.5 9.6 2.9 -2.1 3.1
Medication: Omeprazole (e.g. Zanprol) 5.3 6.4 8.7 2.4 -2.1 2.9
Pain experienced in last month 2.2 3.6 5.6 -2.4 1.2 -2.0
Supplements: Calcium 6.6 7.3 7.9 -2.6 2.7 -2.8
Basal cell carcinoma (self-reported) 1.0 1.2 1.8 -1.3 0.3 -1.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 -0.4 -0.1 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.2 0.4 0.0 0.1
Heart disease (siblings) 0.8 1.0 1.3 0.8 -1.1 1.0
Alcohol drinker status: Previous 0.3 0.4 0.9 -0.5 0.9 -0.0
Pack years of smoking 1.6 2.3 3.8 1.0 -1.5 1.9
Impedance of whole body 3.0 15.3 16.6 4.1 -3.9 3.8
Leg fat mass (left) 0.4 1.6 2.6 1.4 -0.3 1.6
Arm predicted mass (left) 1.9 9.6 9.8 -3.1 3.0 -3.1