Best TWAS P=6.17e-14 · Best GWAS P=4.42e-12 conditioned to 0.00403
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UBXN6 | 0.10 | 0.00 | enet | 21 | 0.02 | 8.0e-03 | 6.6 | 5.2 | 2.2e-07 | -0.40 | 0.01 | 0.95 | FALSE |
2 | GTEx | Artery Aorta | UBXN6 | 0.13 | 0.02 | lasso | 5 | 0.03 | 5.7e-03 | 6.6 | 6.7 | 2.5e-11 | -0.32 | 0.01 | 0.98 | FALSE |
3 | GTEx | Artery Tibial | UBXN6 | 0.18 | 0.07 | lasso | 3 | 0.14 | 6.3e-11 | -4.5 | 6.0 | 1.5e-09 | -0.31 | 0.02 | 0.98 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | CTB-50L17.9 | 0.27 | 0.25 | lasso | 2 | 0.24 | 1.8e-07 | -5.2 | 5.5 | 3.1e-08 | -0.14 | 0.27 | 0.37 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | CHAF1A | 0.62 | 0.40 | lasso | 8 | 0.36 | 3.5e-10 | -5.2 | 5.2 | 2.4e-07 | -0.13 | 0.93 | 0.05 | FALSE |
6 | GTEx | Brain Cerebellum | CTB-50L17.9 | 0.53 | 0.41 | lasso | 2 | 0.50 | 3.6e-17 | -4.4 | 5.3 | 1.1e-07 | -0.17 | 0.87 | 0.13 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | CTB-50L17.9 | 0.27 | 0.21 | lasso | 3 | 0.19 | 7.9e-06 | -4.4 | 5.1 | 2.9e-07 | -0.16 | 0.17 | 0.68 | FALSE |
8 | GTEx | Brain Nucleus accumbens basal ganglia | CTB-50L17.9 | 0.45 | 0.25 | lasso | 8 | 0.23 | 8.6e-07 | -5.2 | 6.8 | 1.3e-11 | -0.23 | 0.06 | 0.90 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | UBXN6 | 0.09 | 0.10 | lasso | 1 | 0.08 | 1.5e-06 | 6.6 | 6.6 | 4.4e-11 | -0.38 | 0.00 | 0.99 | FALSE |
10 | GTEx | Heart Atrial Appendage | UBXN6 | 0.34 | 0.12 | lasso | 6 | 0.21 | 6.5e-10 | -5.2 | 6.4 | 2.0e-10 | -0.30 | 0.01 | 0.99 | FALSE |
11 | GTEx | Heart Left Ventricle | CHAF1A | 0.17 | 0.12 | lasso | 2 | 0.11 | 1.9e-06 | -5.2 | 5.2 | 1.8e-07 | -0.14 | 0.79 | 0.07 | FALSE |
12 | GTEx | Heart Left Ventricle | UBXN6 | 0.21 | 0.14 | lasso | 6 | 0.16 | 5.6e-09 | 6.6 | 6.8 | 1.3e-11 | -0.36 | 0.01 | 0.99 | FALSE |
13 | GTEx | Muscle Skeletal | UBXN6 | 0.19 | 0.14 | lasso | 5 | 0.18 | 4.1e-17 | 6.6 | 6.9 | 5.7e-12 | -0.32 | 0.00 | 1.00 | FALSE |
14 | GTEx | Prostate | MIR637 | 0.30 | -0.01 | lasso | 6 | -0.01 | 5.5e-01 | 6.6 | 5.3 | 1.2e-07 | -0.33 | 0.02 | 0.56 | FALSE |
15 | GTEx | Stomach | AC007292.4 | 0.27 | 0.09 | lasso | 5 | 0.04 | 4.0e-03 | 6.4 | -6.1 | 1.4e-09 | 0.44 | 0.02 | 0.86 | FALSE |
16 | GTEx | Whole Blood | UBXN6 | 0.06 | 0.03 | lasso | 4 | 0.01 | 4.1e-02 | 6.4 | 5.8 | 5.8e-09 | -0.42 | 0.01 | 0.97 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBXN6 | 0.03 | 0.03 | lasso | 3 | 0.03 | 2.3e-06 | 6.6 | 6.8 | 1.4e-11 | -0.41 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Glioblastoma Multiforme | SEMA6B | 0.24 | -0.01 | blup | 42 | 0.05 | 1.1e-02 | -4.8 | -5.3 | 1.1e-07 | 0.60 | 0.00 | 0.39 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBXN6 | 0.05 | 0.01 | blup | 57 | 0.04 | 6.6e-05 | -5.2 | 7.5 | 6.2e-14 | -0.62 | 0.06 | 0.83 | TRUE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBXN6 | 0.13 | 0.10 | lasso | 2 | 0.10 | 1.3e-10 | -5.2 | 5.7 | 1.3e-08 | -0.20 | 0.98 | 0.02 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | UBXN6 | 0.16 | 0.12 | lasso | 2 | 0.12 | 5.4e-12 | -5.2 | 5.6 | 2.1e-08 | -0.17 | 0.97 | 0.03 | FALSE |