TWAS
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Traits
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Traits
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Impedance of leg (right)
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chr4:90,107,063-91,568,912
Best TWAS P=1.35e-07 · Best GWAS P=2.14e-08 conditioned to 0.000333
90.2M
90.4M
90.6M
90.8M
91M
91.2M
91.4M
91.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
MMRN1
0.28
0.22
bslmm
395
0.22
1.1e-27
4.8
5.3
1.4e-07
0.46
0.24
0.75
TRUE
2
The Cancer Genome Atlas
Testicular Germ Cell Tumors
MMRN1
0.24
0.12
lasso
2
0.11
8.2e-05
5.3
5.1
2.9e-07
0.43
0.01
0.91
FALSE