Best TWAS P=6.86e-10 · Best GWAS P=3.2e-09 conditioned to 0.00425
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | -5.4 | 6.0 | 1.6e-09 | -0.53 | 0.09 | 0.90 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | -5.8 | 5.9 | 4.0e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | -5.9 | 5.8 | 8.1e-09 | -0.89 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Ovary | PTPN13 | 0.18 | -0.01 | enet | 29 | 0.07 | 8.4e-03 | -5.9 | 6.2 | 6.9e-10 | -0.58 | 0.03 | 0.71 | TRUE |
| 5 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | -5.9 | -5.8 | 5.1e-09 | 0.99 | 0.01 | 0.99 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | -5.4 | 5.2 | 1.6e-07 | -0.53 | 0.09 | 0.91 | FALSE |