Best TWAS P=2.64e-11 · Best GWAS P=2.27e-10 conditioned to 0.019
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | PTK2 | 0.28 | 0.01 | lasso | 4 | 0.09 | 1.5e-03 | -5.58 | 6.6 | 3.3e-11 | -0.59 | 0.11 | 0.53 | FALSE |
| 2 | GTEx | Brain Cortex | PTK2 | 0.22 | 0.12 | lasso | 4 | 0.10 | 1.1e-03 | -5.45 | 5.3 | 1.4e-07 | -0.76 | 0.09 | 0.69 | FALSE |
| 3 | GTEx | Liver | CASC7 | 0.12 | 0.11 | enet | 8 | 0.01 | 1.4e-01 | -6.13 | -6.1 | 1.2e-09 | 1.00 | 0.06 | 0.77 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | PTK2 | 0.20 | -0.01 | enet | 34 | 0.01 | 7.2e-02 | 0.84 | -5.8 | 5.3e-09 | 0.45 | 0.11 | 0.39 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PTK2 | 0.05 | 0.07 | lasso | 4 | 0.07 | 5.4e-09 | -6.21 | 6.3 | 3.9e-10 | -0.98 | 0.04 | 0.96 | FALSE |
| 6 | YFS | Blood | PTK2 | 0.02 | 0.00 | blup | 538 | 0.01 | 8.6e-04 | -6.07 | 6.7 | 2.6e-11 | -0.70 | 0.05 | 0.56 | TRUE |