Hub : Genes

CASC7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2070	0.0610	1.2e-05	0.119	NA	0.094	NA	0.087	3.4e-09	NA	1.6e-07	NA	4.6e-07
2	GTEx	Liver	0.1210	0.0530	3.3e-03	0.110	NA	0.013	NA	0.005	5.5e-04	NA	1.3e-01	NA	2.3e-01
3	GTEx	Testis	0.2750	0.0830	7.0e-03	0.150	NA	0.128	NA	0.129	3.5e-07	NA	2.7e-06	NA	2.4e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.0543	0.0256	2.2e-03	0.044	0.011	0.041	0.016	0.008	2.3e-06	0.011	4.9e-06	0.0031	2.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	2.3	-0.5	0.9	-1.4	1.5
Bipolar Disorder or Schizophrenia	0.8	1.9	4.1	2.0	-0.4	-1.8	0.4
Depressed Affect (Nagel 2018)	4.8	10.0	14.7	3.6	-3.8	-1.0	-3.4
Depression (Nagel 2018)	2.9	4.4	8.3	2.9	-1.8	-0.1	-2.5
Intelligence (Savage-Jansen 2018)	1.9	5.7	12.4	-1.8	3.5	0.4	2.6
Neuroticism (Nagel 2018)	3.9	9.2	14.8	3.1	-3.4	-0.8	-3.9
Schizophrenia (2018)	1.5	3.1	9.0	3.0	-1.2	-1.2	-0.7
Schizophrenia vs Biploar Disorder	1.9	2.5	6.9	1.0	-2.6	-0.5	-1.3
Worry (Nagel 2018)	1.6	3.5	6.9	2.6	-1.5	-1.5	-1.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	-1.2	-0.9	-0.5	0.8
Alzheimer’s Disease (in father)	0.5	0.6	0.9	0.1	-0.8	0.9	-0.8
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	-1.0	-0.9	0.3	0.5
Crohns Disease (2017)	0.4	1.0	2.3	1.1	-0.4	-0.5	-1.5
Irritable Bowel Disease (IBD)	1.7	4.0	6.8	2.6	-1.8	-1.1	-2.2
Ulcerative Colitis (UC)	2.7	5.1	8.1	2.8	-2.5	-1.2	-2.2
Major Depression (MDD)	0.7	0.8	2.0	0.5	-0.0	-1.4	1.0
Reaction Time	2.9	5.6	17.7	4.2	-1.9	-0.8	-0.6
Verbal and Numeric Reasoning (VNR)	1.7	4.1	8.0	-1.4	2.5	0.0	2.8
Breast Cancer	1.4	3.5	7.2	-0.7	1.7	-2.7	1.8
Ovarian Cancer	0.6	0.8	1.5	0.3	-1.2	0.5	-1.0
Prostate Cancer	0.8	1.1	2.4	0.3	-0.5	1.3	-1.5
Age at First Birth	1.0	1.4	3.5	-1.0	0.7	1.9	0.9
Bipolar Disorder (2011)	0.2	0.2	0.7	0.9	-0.2	0.0	0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	-1.2	0.8	0.1	1.1
Coronary Artery Disease (CAD)	0.3	0.4	1.3	-0.3	-0.4	-1.1	-0.3
Crohns Disease (2012)	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.7
Mean Putamen Volume	1.2	1.3	3.2	1.8	-1.2	-0.3	-0.8
Fasting Glucose	0.1	0.1	0.3	-0.6	0.2	-0.3	0.4
HbA1C	0.1	0.1	0.3	0.6	-0.2	-0.3	-0.3
HDL Cholesterol	0.9	1.4	2.7	-1.6	0.4	1.1	-1.3
LDL Cholesterol	0.7	1.1	2.0	1.3	-1.4	-0.4	-0.8
Lupus	0.4	0.7	1.1	0.9	-0.8	-1.0	0.4
Neuroticism (2016)	1.5	2.2	3.5	1.9	-1.5	0.3	-1.7
Primary Biliary Cirrhosis	0.5	0.7	1.7	0.9	-0.4	1.3	-0.5
Rheumatoid Arthritis	1.4	1.9	5.1	2.3	-1.4	-0.5	-0.5
Schizophrenia (2014)	1.0	2.2	6.9	2.6	-0.9	-1.0	-0.3
Triglycerides	0.4	0.7	1.4	0.8	-1.2	0.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	-0.9	-1.4	0.2	-1.1
Ulcerative Colitis	0.6	0.9	2.5	-0.6	-0.8	0.3	-1.6
Blood Eosinophil Count	0.4	2.9	7.0	1.9	0.6	-2.6	0.7
Blood Platelet Count	1.2	14.4	39.4	6.3	-3.9	0.4	-1.7
Blood Red Count	0.6	5.8	11.6	2.5	-3.4	-0.7	-2.2
Blood White Count	0.4	2.9	5.1	2.1	-2.3	0.4	-1.4
Heel T-Score	0.2	1.4	3.8	-0.9	1.0	1.9	-0.1
BMI	0.3	1.5	2.2	1.2	1.5	-1.1	1.1
Height	0.4	8.2	29.9	-5.5	-0.7	-1.4	-0.5
Waist Hip Ratio (WHR)	2.2	10.1	24.3	2.9	-4.9	-1.9	-2.1
Systolic Blood Pressure	1.7	8.7	27.2	1.9	5.2	-0.0	2.0
Smoking Status	2.4	5.7	16.6	0.8	-4.1	-0.2	-2.3
Allergy or Eczema	2.2	5.8	14.5	-2.2	2.0	-0.2	3.8
Cardiovascular Disease	1.1	3.6	8.6	0.8	2.9	-0.8	2.1
Hypothyroidism (self reported)	3.4	7.8	13.2	-2.2	3.6	-0.9	3.5
Respiratory disease	0.2	0.4	0.8	-0.4	0.9	-0.7	-0.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.3	1.0	1.5	-0.0	1.4
Lung FEV1/FVC ratio	1.9	9.6	24.3	-0.6	4.9	-0.6	3.7
Lung FVC	1.2	6.1	11.9	-0.4	-3.4	0.8	-3.4
Neuroticism	3.4	8.3	11.5	3.2	-3.4	-0.1	-3.4
Chronotype (morning person)	1.0	2.2	4.6	0.6	-2.1	-1.8	-0.7
Hair Pigment	0.1	3.7	7.7	-1.4	2.2	-0.4	2.8
Tanning	0.0	0.5	2.0	-0.0	-0.2	-1.4	-0.2
Hand grip strength (left)	0.2	0.5	1.6	-1.3	0.5	0.1	0.3
Number of treatments/medications taken	0.3	0.5	1.6	1.2	0.7	-0.1	0.2
Average weekly spirits intake	0.6	0.7	1.1	0.9	-1.1	-0.7	-0.6
Sensitivity / hurt feelings	4.8	8.3	14.5	0.4	-3.8	2.0	-3.8
Frequency of depressed mood in last 2 weeks	4.5	6.3	8.5	2.9	-2.9	0.2	-2.9
Hearing difficulty/problems: Yes	6.2	9.5	17.1	1.8	-4.0	1.2	-4.1
Relative age of first facial hair	0.2	0.4	0.7	-0.8	0.2	-0.8	-0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	-1.4	0.5	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	5.8	7.3	16.3	0.5	-1.8	4.0	-3.1
Ever had hysterectomy (womb removed)	1.4	1.6	2.1	1.2	-1.3	1.1	-1.4
Systolic blood pressure, automated reading	1.0	3.0	8.9	1.6	3.0	-0.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.5	-0.5	1.2	-0.3	1.0
Angina	0.4	0.5	1.2	1.1	0.5	-0.7	-0.1
Medication for hormone replacement therapy	1.8	2.0	3.8	-1.8	-0.3	1.9	-0.8
Vitamin and mineral supplements	0.1	0.2	0.4	-0.0	0.6	0.2	0.5
Supplements: Zinc	0.4	0.4	0.8	-0.1	0.8	0.9	-0.5
Medication: Co-codamol	2.0	2.4	5.1	1.6	-2.3	-1.2	-0.5
Medication: Metformin	0.5	0.7	1.0	1.0	-0.2	-1.0	1.0
Diabetes (father)	2.1	2.6	6.4	-1.7	0.9	2.5	0.4
Diabetes (mother)	0.9	1.1	3.0	0.6	0.3	1.7	1.0
Severe depression (siblings)	0.4	0.4	1.3	-1.1	0.5	0.0	0.4
Pack years adult smoking proportion	0.9	1.4	2.7	0.2	1.6	0.5	-1.6
Impedance of leg (right)	2.1	10.0	35.7	2.0	-6.0	0.2	0.1
Leg fat-free mass (left)	0.6	3.2	5.0	-2.2	2.1	-1.8	0.5
Trunk fat percentage	0.9	3.5	11.1	0.4	-3.3	-0.9	-1.4
Hand grip strength (right)	0.0	0.1	0.2	-0.4	0.2	-0.2	0.1
Townsend deprivation index at recruitment	1.3	1.9	6.4	0.6	-0.7	-0.6	-2.5
Current tobacco smoking	2.0	3.3	5.7	2.0	-1.9	0.1	-2.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.1	0.3	0.5	-0.1
Maternal smoking around birth	1.1	1.7	2.9	0.4	-1.5	-1.7	-1.1
Fed-up feelings	2.3	4.1	6.9	2.6	-2.5	-0.4	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.3	2.1	-0.7	0.8	-1.5
Relative age voice broke	0.4	0.6	1.3	-1.1	0.7	0.4	0.6
Taking other prescription medications	0.3	0.4	0.9	0.9	0.8	0.1	-0.3
Age when periods started (menarche)	0.6	1.4	2.4	-1.6	1.3	1.0	0.6
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	2.6	1.1	-1.4	-0.0	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	5.3	-1.7	2.3	-0.5	2.0
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.4	1.4	-1.1	0.3	-2.1
Qualifications: CSEs or equivalent	0.6	0.8	1.4	1.2	-0.8	-0.6	0.9
Serious illness, injury or assault to yourself	1.4	1.7	3.0	-0.4	1.5	-1.7	1.1
High blood pressure	2.7	7.5	20.4	0.7	4.5	-1.5	2.6
Hayfever, allergic rhinitis or eczema	2.0	4.4	12.9	-1.5	1.6	0.0	3.6
Multivitamins +/- minerals	0.3	0.4	1.3	-0.2	-1.1	-0.6	0.0
Stomach or abdominal pain in last month	1.2	1.5	2.6	1.4	-0.6	-1.6	1.1
Supplements: Glucosamine	3.3	4.3	7.7	1.7	-2.8	1.2	-2.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.9	0.8	0.4	-1.4	1.3
Medication: Atenolol	1.2	1.4	3.1	-0.1	1.8	0.2	1.6
Medication: Levothyroxine sodium	2.2	3.6	9.1	-1.3	3.0	-0.8	1.8
Sitting height	1.3	8.9	25.4	-5.0	2.0	-1.6	1.8
Chronic bronchitis/emphysema (father)	3.3	3.9	7.4	2.2	-2.7	1.1	-1.5
High blood pressure (mother)	1.0	1.4	3.2	0.4	1.8	-1.2	0.8
Body mass index (BMI)	0.1	0.4	0.6	0.7	-0.3	-0.7	-0.8
Impedance of leg (left)	2.2	10.6	37.0	2.1	-6.1	0.4	-1.1
Leg predicted mass (left)	0.6	3.2	5.2	-2.3	2.1	-1.7	0.5
Trunk fat mass	0.5	2.0	5.2	-0.5	-2.3	-1.2	-1.0
Waist circumference	0.4	1.5	2.4	0.9	-1.6	-1.3	-1.0
Number of incorrect matches in round	0.2	0.3	0.9	1.0	-0.5	0.1	-0.2
Past tobacco smoking	2.0	3.7	12.6	0.1	3.5	-0.0	1.5
Alcohol usually taken with meals	0.3	0.5	1.0	0.4	-0.1	1.0	-0.8
Nervous feelings	0.9	1.6	4.1	0.9	-1.2	-0.2	-2.0
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	7.4	2.7	-2.0	0.3	-2.3
Hearing difficulty/problems with background noise	4.8	7.7	15.1	1.1	-3.9	0.3	-3.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.3	0.9	-0.9	1.5	-0.4
Had menopause	2.8	3.5	6.1	1.4	-1.7	2.5	-1.7
Had other major operations	0.8	1.0	2.3	0.9	-1.5	0.0	-1.0
Forced vital capacity (FVC)	0.6	2.4	4.4	-1.3	-2.1	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	3.0	-1.6	1.7	0.2	0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	1.0	-1.3	-0.8	-0.5
Qualifications: None of the above	3.6	7.6	11.3	2.9	-3.2	-0.4	-3.4
Financial difficulties in last 2 years	0.9	1.2	3.5	1.9	-1.1	0.4	-0.2
Mouth/teeth dental problems	0.8	1.2	3.1	-0.7	1.8	-0.8	0.9
Heart attack	3.1	4.0	11.1	-1.1	3.3	-0.5	1.9
Allergy	1.4	3.1	7.4	0.7	-2.1	-0.3	-2.7
Pain all over the body in last month	0.3	0.4	0.9	-0.2	-0.9	-0.7	-0.3
Diabetes (self-reported)	0.8	1.3	2.6	-0.0	1.6	-1.0	1.3
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.8	-1.4	1.8	0.8	2.6
Medication: Ramipril	0.8	1.0	3.2	0.2	1.8	-0.9	-0.0
Medication: Simvastatin	0.4	0.6	1.4	0.0	0.8	-0.6	1.2
Fluid intelligence score	1.3	2.7	7.1	0.1	1.9	-0.3	2.7
Illnesses of siblings	0.5	0.7	1.9	-1.4	-0.2	-0.9	-0.1
Neuroticism score	3.8	8.0	13.5	3.0	-3.1	0.3	-3.7
Weight	0.2	1.0	2.3	-1.1	-0.5	-1.5	-0.4
Impedance of arm (right)	0.9	4.1	13.5	1.4	-3.7	0.4	-1.0
Arm fat percentage (right)	0.4	1.4	3.3	1.1	-1.8	-0.8	-0.9
Trunk fat-free mass	0.7	3.9	9.1	-3.0	2.1	-1.2	0.8
Hip circumference	0.1	0.6	2.0	-1.4	0.2	-0.7	-0.1
Time employed in main current job	0.3	0.3	1.1	-0.0	-0.4	-0.2	1.0
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.2	-0.2	-0.0	0.1
Father’s age at death	1.3	1.7	5.0	-2.2	-0.3	-0.2	1.3
Worrier / anxious feelings	1.6	3.0	7.3	2.7	-1.8	-0.6	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.7	7.6	2.3	-2.8	0.3	-2.5
Falls in the last year	5.7	7.7	21.1	1.4	-4.6	-0.4	-2.8
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	-1.3	1.2	1.0	0.8
Number of live births	1.2	1.7	3.7	1.9	-1.0	-0.0	-1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.6	-0.7	-0.9	-1.9	-0.1
Pulse rate	1.2	2.0	7.0	2.6	-0.5	-0.2	0.7
Happiness	1.3	1.5	2.3	0.8	-1.5	-1.5	1.0
Noisy workplace	0.5	0.6	1.6	0.6	-0.6	0.0	-1.2
Qualifications: A levels/AS levels or equivalent	2.2	5.0	10.9	-1.2	2.0	-1.8	3.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	0.1	-0.8	-0.7	-0.1
Mouth/teeth dental problems: Dentures	1.2	2.1	5.0	0.4	-1.2	1.3	-2.2
Asthma	0.4	0.8	2.1	-0.7	1.5	-0.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	1.2	-0.5	-0.3	-1.2
Medication: Cholesterol lowering	1.8	2.8	7.2	-0.3	2.7	-0.2	2.0
Depression (self-reported)	2.2	2.6	6.1	2.5	-1.8	0.6	-0.9
Medication: Lansoprazole	1.0	1.2	2.4	1.5	-1.1	-1.0	-0.3
Prospective memory result	2.0	2.5	5.6	0.7	-1.8	2.4	-0.7
Lung cancer (father)	0.1	0.2	0.5	0.3	-0.7	-0.2	0.0
Illnesses of mother	0.9	1.1	2.6	0.3	-1.6	1.0	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.8	-1.0	-1.1	-2.2	0.8
Pulse wave Arterial Stiffness index	3.4	3.9	10.9	0.6	-1.8	-1.1	-3.3
Impedance of arm (left)	0.7	3.0	10.4	1.0	-3.2	0.1	-0.9
Arm fat mass (right)	0.2	0.7	1.4	0.2	-1.2	-0.7	-0.9
Trunk predicted mass	0.7	3.9	8.6	-2.9	2.1	-1.3	0.9
Standing height	0.6	6.0	18.7	-4.3	-0.4	-2.1	1.0
Length of working week for main job	0.9	1.0	2.7	-0.9	-1.6	0.6	-0.3
Exposure to tobacco smoke at home	1.9	2.1	2.9	1.7	1.7	-0.1	1.7
Breastfed as a baby	0.2	0.3	0.7	-0.6	0.9	0.1	0.2
Tense / ‘highly strung’	0.7	1.1	2.6	1.1	-0.7	-1.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.4	0.5	-1.0	1.2	-1.5
Hair/balding pattern: Pattern 4	0.6	1.4	2.5	-1.2	1.6	-1.1	-0.7
Birth weight of first child	2.3	4.1	9.1	-0.2	-3.0	0.2	-2.7
Peak expiratory flow (PEF)	1.5	3.4	6.4	-0.8	1.4	-2.2	2.5
Pulse wave reflection index	1.4	1.7	2.5	-0.8	-1.1	-1.6	-1.6
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.1	1.1	-1.2	-0.3	-1.8
Loud music exposure frequency	2.8	3.1	10.3	0.1	-1.4	-0.4	-3.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-1.2	0.7	-0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.6	1.2	-1.3	-0.9	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.4	0.5	0.4	-1.2	-0.2
Medication: Paracetamol	4.0	6.6	9.3	3.0	-3.0	-0.1	-2.8
Headache pain in last month	1.0	1.7	4.3	1.1	-1.1	-2.1	0.4
Medication for cholesterol, blood pressure or diabetes	3.7	6.1	15.9	1.2	-4.0	-0.1	-2.7
Glaucoma (self-reported)	2.6	3.1	6.2	-0.2	0.7	2.4	-2.5
Gout (self-reported)	0.7	1.0	2.5	0.5	0.3	-1.6	1.1
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	11.3	-1.8	3.4	-0.9	3.0
Medication: Amlodipine	0.3	0.5	1.1	1.1	0.7	0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	0.2	1.3	-0.5	0.7
Birth weight	0.9	1.9	4.3	-0.2	-2.1	0.2	-1.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	-0.9	-0.6	1.2	-0.9
High blood pressure (siblings)	0.4	0.6	1.5	0.4	1.2	0.7	0.6
Forced vital capacity (FVC), Best measure	0.7	2.4	4.4	-1.6	-2.1	-1.6	0.1
Body fat percentage	0.9	3.5	11.0	0.9	-3.3	-0.9	-1.2
Leg fat percentage (right)	1.4	5.1	14.7	2.1	-3.8	-0.8	-0.9
Arm fat-free mass (right)	0.5	2.4	6.5	-2.5	1.4	-1.1	0.3
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.7	-0.3	0.1	-0.7
Comparative body size at age 10	0.2	0.7	1.9	0.8	0.2	-1.4	-0.4
Number of full brothers	0.2	0.2	0.5	-0.7	-0.3	-0.2	-0.5
Worry too long after embarrassment	1.3	2.2	6.3	0.4	-1.0	1.1	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	1.0	-0.6	0.4	-0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	1.0	1.0	0.5	-0.3
Number of children fathered	0.8	0.9	2.5	-0.6	-1.6	0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.4	-1.5	1.0	0.1	0.1
Age at first live birth	1.1	2.0	3.3	-1.8	1.8	-1.1	0.4
Pulse wave peak to peak time	3.3	3.9	11.3	-0.7	1.7	0.8	3.4
Health satisfaction	1.0	1.3	2.6	1.6	-0.8	-1.1	-0.9
Shortness of breath walking on level ground	1.0	1.2	2.9	1.7	-1.1	-1.0	-0.2
Qualifications: College or University degree	3.4	10.6	16.6	-4.0	4.1	0.7	3.1
Eye problems/disorders: None of the above	1.1	1.2	2.6	-0.4	-0.5	-1.4	1.6
Mouth/teeth dental problems: Loose teeth	2.0	2.3	5.7	0.6	-2.4	0.1	-1.8
Emphysema/chronic bronchitis	0.8	0.9	1.4	0.7	1.0	1.2	-0.7
Medication for pain relief, constipation, heartburn	1.0	1.7	4.2	-2.1	1.3	0.4	0.8
Neck or shoulder pain in last month	1.7	2.4	4.3	2.1	-1.5	0.5	-1.7
Medication: Blood pressure	3.1	5.5	14.4	-1.1	3.8	-0.3	2.5
Angina (self-reported)	0.4	0.5	0.8	0.7	0.9	-0.9	0.1
Migraine (self-reported)	0.9	1.2	2.1	1.4	-0.7	-1.5	0.1
Medication: Ibuprofen	0.9	1.0	1.7	1.3	-0.9	-0.3	-1.2
Medication: Allopurinol	0.2	0.3	1.0	0.1	0.1	-1.0	0.3
Medication: Omeprazole	1.2	1.5	3.3	-0.2	1.8	-0.6	1.5
Medication: Seretide 50 evohaler	1.9	2.2	5.4	-1.8	2.3	-0.1	0.4
Mean time to correctly identify matches	2.9	5.5	13.9	3.7	-2.0	0.1	-2.1
Heart disease (mother)	0.7	0.8	2.5	-0.4	1.6	0.6	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.1	0.4	0.5	1.8	-1.1
Whole body fat mass	0.4	1.8	4.8	-0.1	-2.2	-1.2	-1.0
Leg fat mass (right)	0.5	2.0	5.4	0.7	-2.3	-1.4	-0.7
Arm predicted mass (right)	0.5	2.5	6.0	-2.5	1.4	-1.3	0.6
Pulse rate, automated reading	0.7	2.2	5.0	1.7	0.3	-1.0	2.2
Alcohol intake frequency.	1.5	3.4	10.6	3.3	-1.1	-1.4	-0.1
Comparative height size at age 10	0.5	2.8	5.4	-1.2	-2.3	-1.8	-1.0
Number of full sisters	0.2	0.2	0.4	0.1	0.6	0.2	0.6
Suffer from ‘nerves’	2.2	3.4	6.4	2.1	-1.6	-0.0	-2.5
Overall health rating	4.3	9.2	25.3	5.0	-2.7	-0.9	-1.9
Chest pain or discomfort	0.7	1.0	2.5	-0.0	0.3	1.6	-1.1
Had major operations	0.4	0.5	1.5	-0.1	0.1	1.2	-0.7
Age at last live birth	1.5	2.2	2.3	-1.5	1.5	-1.5	1.5
Family relationship satisfaction	1.3	1.6	5.8	0.7	-0.4	-2.4	0.2
Leg pain on walking	1.2	1.5	3.0	0.9	-1.3	-0.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	3.1	1.8	0.5	-0.3	-1.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.3	0.8	-0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.3	0.7	1.0	-0.4
Medication: Aspirin	1.5	2.0	2.7	-1.4	1.5	-1.1	1.6
Supplements: Vitamin C	0.4	0.5	1.3	0.2	0.8	-0.3	-1.1
Knee pain experienced in last month	2.0	3.1	7.1	1.0	-2.7	0.7	-1.9
Hypertension (Self-reported)	2.2	6.0	18.0	0.6	4.2	-1.2	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.8	0.4	1.3	-0.8	0.6
Illnesses of father: Heart disease	0.9	1.3	3.2	0.4	1.2	1.8	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.5	1.2	-0.3	0.9	-0.2
Smoking status: Previous	0.9	1.4	5.0	-0.2	-2.2	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	9.6	-1.5	1.5	-3.1	2.4
Whole body fat-free mass	0.6	3.2	7.0	-2.6	2.0	-1.3	0.5
Leg fat-free mass (right)	0.7	4.0	7.0	-2.5	2.6	-1.6	0.2
Arm fat percentage (left)	0.3	1.4	2.5	1.1	-1.6	-1.1	-0.8
Average weekly red wine intake	0.4	0.5	1.6	-0.1	0.7	1.3	-0.0
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.6	1.9	0.1	-1.7	-0.2
Mood swings	7.0	12.6	19.7	3.3	-3.9	2.2	-4.4
Loneliness, isolation	1.5	2.1	3.7	1.9	-1.6	-1.4	-0.4
Long-standing illness, disability or infirmity	0.8	1.3	3.0	1.7	-0.5	-0.8	-1.1
Ever had bowel cancer screening	0.2	0.3	0.7	-0.6	-0.3	-0.2	0.8
Diabetes diagnosed by doctor	1.5	2.5	5.1	0.2	1.2	-1.8	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	-0.4	0.3	-1.0	-0.8
Friendships satisfaction	3.5	4.4	11.0	-1.0	1.3	-3.3	1.9
Qualifications: nursing, teaching	2.9	4.5	11.5	-1.5	1.8	-0.9	3.4
Commuting to job workplace: Walk	3.1	3.3	8.6	0.4	-1.4	2.9	-1.5
Eye problems/disorders: Cataract	1.0	1.2	2.5	0.4	0.4	1.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.2	-0.6	0.5	1.5	-0.1
Medication for cholesterol	0.2	0.2	0.3	-0.5	-0.5	0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	-1.2	0.2	-0.4	0.4
Back pain experienced in last month	4.1	5.9	9.6	2.3	-3.1	0.4	-2.9
Mineral and other dietary supplements	1.2	1.6	3.5	-1.9	1.2	-0.3	1.2
Breast cancer (self-reported)	2.0	2.3	4.8	-0.2	-1.7	2.2	-1.4
Asthma (self-reported)	0.5	1.1	2.3	-1.1	1.5	-0.4	0.8
Osteoporosis (self-reported)	0.3	0.4	1.1	-1.1	0.7	0.3	-0.1
Osteoarthritis (self-reported)	4.4	5.7	8.2	2.2	-2.9	2.2	-2.2
Medication: Aspirin	1.2	1.5	2.3	-1.0	1.3	-1.1	1.5
Medication: Gliclazide	0.6	0.6	1.6	0.9	-0.3	-1.3	0.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	-1.0	-0.2	-1.4	1.1
Smoking status: Current	2.1	3.3	5.7	1.6	-2.2	-0.0	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.3	1.2	-0.8	-1.1	-0.9
Whole body water mass	0.6	3.6	7.7	-2.8	2.1	-1.3	0.6
Leg predicted mass (right)	0.7	3.9	6.9	-2.4	2.6	-1.7	0.2
Arm fat mass (left)	0.2	0.7	1.3	0.1	-1.1	-1.2	-0.6
Number of self-reported non-cancer illnesses	1.1	1.9	5.0	0.9	1.3	2.2	-0.5
Average weekly champagne plus white wine intake	1.7	2.4	5.8	-0.8	1.1	-1.3	2.4
Miserableness	3.7	6.4	9.9	2.8	-2.8	-0.2	-3.1
Guilty feelings	5.2	7.8	14.4	2.7	-2.5	1.7	-3.8
Wears glasses or contact lenses	0.9	1.1	2.1	0.8	-0.4	-1.1	-1.5
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.0	0.5	0.2	-0.2
Hearing aid user	3.1	3.5	6.7	-0.7	-2.0	2.6	-1.7
Mother’s age at death	0.7	0.8	2.8	-1.7	-0.4	0.5	-0.4
Financial situation satisfaction	1.8	2.2	4.0	2.0	-1.8	-1.1	-0.2
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.4	2.1	-2.1	0.3	-1.6
Commuting to job workplace: Public transport	1.1	1.3	4.0	-0.4	-0.9	2.0	-0.0
Eye problems/disorders: Glaucoma	1.5	1.8	3.9	0.1	-0.1	1.8	-2.0
Medication: Blood pressure	1.2	2.3	4.3	2.1	2.0	-0.8	-0.1
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.1	0.5	-2.0	0.8	-1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	1.0	-1.3	-0.3	-1.0
High cholesterol (Self-reported)	0.5	0.8	2.3	1.5	-0.9	-0.1	-0.4
Medication: Bendroflumethiazide	0.9	1.4	2.7	0.3	1.6	0.0	1.6
Medication: Paracetamol	3.1	4.8	7.9	2.5	-2.8	-0.0	-2.3
Medication: Lisinopril	1.4	1.8	2.9	-0.9	1.7	-0.8	1.7
Medication: Atorvastatin	0.7	0.9	1.5	1.2	-0.7	-1.1	-0.6
Illnesses of father: High blood pressure	0.7	0.9	1.8	0.4	1.2	-0.1	1.4
Alcohol drinker status: Never	0.6	0.8	1.2	1.1	-1.0	-0.7	0.5
Ever smoked	1.8	3.1	9.6	-0.2	-3.1	0.5	-1.6
Basal metabolic rate	0.5	2.5	5.7	-2.4	1.4	-1.4	0.4
Leg fat percentage (left)	1.3	4.9	13.1	1.9	-3.6	-0.8	-1.5
Arm fat-free mass (left)	0.3	1.5	4.3	-2.1	0.8	-0.9	0.4
Number of operations (self-reported)	1.9	2.8	7.7	-0.6	-1.3	2.8	-1.1
Average weekly beer plus cider intake	0.1	0.2	0.5	0.1	0.7	0.4	0.2
Irritability	1.6	2.7	7.8	0.5	-1.6	0.5	-2.8
Risk taking	0.2	0.3	1.1	-0.5	0.1	-0.1	1.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.2	-0.3	0.5	0.6
Fractured/broken bones in last 5 years	0.9	1.1	2.5	0.9	-0.5	-1.6	-0.9
Age started oral contraceptive pill	0.1	0.1	0.2	-0.3	0.4	0.4	0.5
Diastolic blood pressure, automated reading	0.8	2.4	8.2	1.0	2.9	-0.0	0.6
Ever depressed for a whole week	1.0	1.3	2.6	0.8	-1.6	0.1	-1.4
Unable to work because of sickness or disability	2.3	3.0	8.6	2.9	-1.5	-0.3	-1.0
Commuting to job workplace: Cycle	0.7	0.8	2.3	0.4	-0.9	-1.5	0.1
Myopia	2.1	3.0	5.1	-1.3	2.3	1.4	1.8
Vascular/heart problems diagnosed by doctor	2.7	7.4	19.9	-0.6	-4.5	1.2	-2.8
Cholesterol lowering medication	0.8	1.1	3.5	0.9	-1.9	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	2.7	-0.1	1.6	-0.8	1.3
Pain experienced in last month	2.9	4.8	8.5	-2.9	2.6	0.4	2.0
Supplements: Calcium	0.7	0.7	1.5	1.2	0.4	1.0	-0.6
Basal cell carcinoma (self-reported)	1.3	1.5	2.8	-1.2	1.1	1.7	0.7
Heart attack/myocardial infarction (self-reported)	3.0	3.9	8.9	-1.2	3.0	-0.9	2.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.7	-0.0	-1.0	-0.4
Heart disease (siblings)	0.7	0.8	3.1	0.1	0.2	1.8	-0.4
Alcohol drinker status: Previous	2.2	2.5	6.1	1.6	-2.5	-0.8	-1.0
Pack years of smoking	0.9	1.3	3.0	-0.1	1.7	0.5	-1.3
Impedance of whole body	1.3	6.9	24.3	1.5	-4.9	0.3	-0.9
Leg fat mass (left)	0.5	1.9	4.6	0.6	-2.2	-1.3	-1.0
Arm predicted mass (left)	0.4	1.9	5.7	-2.4	0.9	-1.0	0.3