TWAS
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Models
Genes
Traits
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Traits
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Impedance of leg (left)
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chr12:27,587,038-29,432,481
Best TWAS P=2.8e-12 · Best GWAS P=2.82e-07 conditioned to 2.66e-06
27.5M
28M
28.5M
29M
29.5M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Aorta
CCDC91
0.16
0.00
enet
37
0.02
0.041
-3.9
-7.0
2.8e-12
-0.06
0.11
0.59
TRUE
2
The Cancer Genome Atlas
Lung Adenocarcinoma
CCDC91
0.09
0.01
blup
170
0.02
0.001
-3.9
-5.3
9.6e-08
0.00
0.08
0.75
FALSE