TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Impedance of leg (left)
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chr13:95,632,770-97,735,785
Best TWAS P=2.55e-11 · Best GWAS P=6.77e-13 conditioned to 0.00477
96M
96.5M
97M
97.5M
0
2
4
6
8
10
12
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Colon Transverse
DNAJC3
0.10
0.06
lasso
7
0.05
1.8e-03
-5.3
6.7
2.5e-11
-0.86
0.02
0.93
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
HS6ST3
0.06
0.03
blup
307
0.03
7.4e-05
4.2
-5.3
1.0e-07
0.72
0.05
0.85
FALSE
3
METSIM
Adipose
UGGT2
0.12
0.14
lasso
15
0.13
3.9e-19
4.9
5.3
1.4e-07
-0.69
1.00
0.00
FALSE
1
GTEx
Colon Sigmoid
UGGT2
0.23
0.09
lasso
8
0.09
3.6e-04
4.3
5.1
2.7e-07
-0.61
0.41
0.15
FALSE