[Hub]/) : Traits : Impedance of leg (left) : ← →

chr16:2,868,641-4,696,654

Best TWAS P=1.61e-10 · Best GWAS P=6.22e-17 conditioned to 5.33e-13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Frontal Cortex BA9 NLRC3 0.50 0.18 enet 30 0.33 1.6e-09 -3.4 5.7 1.4e-08 0.03 0.44 0.06 FALSE
2 GTEx Brain Hippocampus CLUAP1 0.37 0.10 lasso 5 0.09 4.9e-03 -4.5 -5.4 5.6e-08 0.02 0.17 0.06 FALSE
3 GTEx Heart Atrial Appendage NLRC3 0.27 0.07 lasso 3 0.08 2.2e-04 -3.7 5.2 2.3e-07 -0.07 0.29 0.08 FALSE
4 GTEx Pancreas CLUAP1 0.28 0.21 lasso 3 0.24 2.3e-10 -5.1 -5.2 1.8e-07 0.03 0.99 0.00 FALSE
5 ROSMAP Brain Pre-frontal Cortex RP11-462G12.1 0.11 0.07 enet 18 0.06 1.1e-08 8.2 6.4 1.6e-10 0.86 0.00 1.00 TRUE
6 The Cancer Genome Atlas Bladder Urothelial Carcinoma NLRC3 0.05 0.01 blup 39 0.02 9.8e-03 -5.1 5.5 3.2e-08 -0.09 0.01 0.72 FALSE
7 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma NLRC3 0.07 0.02 blup 39 0.01 7.4e-02 4.8 5.9 3.5e-09 -0.12 0.01 0.76 TRUE
8 The Cancer Genome Atlas Colon Adenocarcinoma NLRC3 0.14 0.04 blup 39 0.10 1.9e-06 -4.4 5.2 1.6e-07 -0.09 0.04 0.81 FALSE
9 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NLRC3 0.04 0.02 lasso 3 0.03 2.1e-04 3.3 5.2 2.4e-07 -0.15 0.01 0.90 FALSE
10 The Cancer Genome Atlas Brain Lower Grade Glioma NLRC3 0.32 0.28 enet 17 0.35 8.2e-41 -3.7 5.2 2.2e-07 -0.10 0.67 0.16 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma NLRC3 0.42 0.25 lasso 6 0.36 1.2e-38 -3.7 5.2 2.4e-07 -0.07 0.38 0.52 FALSE
12 The Cancer Genome Atlas Rectum Adenocarcinoma NLRC3 0.32 0.08 enet 10 0.23 3.3e-06 -3.7 5.5 4.3e-08 -0.14 0.01 0.74 FALSE