TWAS
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Usage
Models
Genes
Traits
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Traits
:
Impedance of leg (left)
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chr16:870,950-2,522,715
Best TWAS P=1.42e-08 · Best GWAS P=6.91e-09 conditioned to 0.015
0.8M
1M
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
IFT140
0.11
0.02
bslmm
498
0.07
5.9e-09
1.3
5.7
1.4e-08
-0.73
0.18
0.81
TRUE
3
YFS
Blood
CRAMP1L
0.02
0.01
lasso
5
0.01
1.6e-04
-4.3
-5.4
5.4e-08
0.77
0.41
0.56
FALSE
4
YFS
Blood
FAHD1
0.04
0.04
lasso
6
0.04
1.3e-13
4.8
5.3
1.1e-07
-0.27
0.51
0.48
FALSE
5
The Cancer Genome Atlas
Esophageal Carcinoma
CRAMP1L
0.11
0.08
blup
60
0.07
2.2e-03
-4.3
-5.2
1.6e-07
0.87
0.02
0.84
FALSE
1
GTEx
Breast Mammary Tissue (Female)
HAGH
0.13
0.00
enet
11
0.01
2.0e-01
4.6
5.2
2.2e-07
-0.35
0.10
0.20
FALSE