[Hub]/) : Traits : Impedance of leg (left) :

chr16:49,403,920-50,831,256

Best TWAS P=1.11e-08 · Best GWAS P=1.5e-07 conditioned to 0.723

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous HEATR3 0.17 0.19 lasso 8 0.20 2.3e-16 5.2 -5.1 2.7e-07 -0.99 0.01 0.99 FALSE
2 GTEx Adrenal Gland HEATR3 0.33 0.30 lasso 9 0.31 1.3e-11 5.3 -5.4 6.7e-08 -0.98 0.01 0.99 FALSE
3 GTEx Artery Aorta HEATR3 0.41 0.41 enet 62 0.42 5.4e-25 5.3 -5.7 1.1e-08 -0.89 0.01 0.99 TRUE
4 GTEx Artery Aorta RP11-429P3.3 0.15 0.15 lasso 4 0.14 5.6e-08 5.3 -5.3 1.1e-07 -0.99 0.01 0.99 FALSE
5 GTEx Artery Coronary HEATR3 0.30 0.25 lasso 5 0.25 6.0e-09 5.3 -5.3 1.2e-07 -0.99 0.01 0.99 FALSE
6 GTEx Artery Tibial HEATR3 0.27 0.31 enet 17 0.32 2.1e-25 5.2 -5.2 1.8e-07 -0.99 0.01 0.99 FALSE
7 GTEx Brain Caudate basal ganglia HEATR3 0.36 0.14 lasso 12 0.20 2.6e-06 5.2 -5.5 4.0e-08 -0.94 0.01 0.98 FALSE
8 GTEx Brain Cerebellum HEATR3 0.70 0.66 lasso 7 0.69 1.4e-27 5.3 -5.3 1.2e-07 -0.98 0.01 0.99 FALSE
9 GTEx Brain Cerebellum RP11-429P3.3 0.40 0.22 enet 11 0.26 1.9e-08 5.3 -5.2 2.2e-07 -0.90 0.01 0.98 FALSE
10 GTEx Brain Cortex HEATR3 0.51 0.46 lasso 11 0.47 8.5e-15 5.3 -5.6 1.8e-08 -0.98 0.01 0.99 FALSE
11 GTEx Brain Frontal Cortex BA9 HEATR3 0.30 0.20 lasso 10 0.16 5.6e-05 5.2 -5.5 3.6e-08 -0.98 0.01 0.96 FALSE
12 GTEx Brain Hippocampus HEATR3 0.27 0.23 enet 9 0.19 3.9e-05 5.3 -5.1 2.9e-07 -1.00 0.01 0.96 FALSE
13 GTEx Brain Hypothalamus HEATR3 0.26 0.01 lasso 6 0.01 1.9e-01 5.3 -5.3 1.1e-07 -0.99 0.02 0.80 FALSE
14 GTEx Brain Putamen basal ganglia HEATR3 0.27 0.16 lasso 6 0.15 2.3e-04 5.3 -5.2 1.6e-07 -0.96 0.02 0.87 FALSE
15 GTEx Cells Transformed fibroblasts HEATR3 0.22 0.18 lasso 15 0.20 1.4e-14 4.9 -5.2 1.8e-07 -0.93 0.02 0.98 FALSE
16 GTEx Colon Sigmoid HEATR3 0.27 0.32 lasso 5 0.28 1.6e-10 5.2 -5.1 2.9e-07 -0.99 0.01 0.99 FALSE
17 GTEx Colon Transverse HEATR3 0.36 0.36 lasso 7 0.36 9.1e-18 5.2 -5.2 2.0e-07 -1.00 0.01 0.99 FALSE
18 GTEx Esophagus Muscularis HEATR3 0.40 0.38 lasso 8 0.39 6.1e-25 5.2 -5.3 1.4e-07 -0.99 0.01 0.99 FALSE
19 GTEx Heart Atrial Appendage HEATR3 0.30 0.30 lasso 8 0.27 1.1e-12 5.3 -5.2 1.8e-07 -1.00 0.01 0.99 FALSE
20 GTEx Lung HEATR3 0.34 0.40 enet 19 0.41 6.4e-34 5.3 -5.4 6.1e-08 -0.98 0.01 0.99 FALSE
21 GTEx Ovary HEATR3 0.30 0.14 lasso 11 0.16 1.2e-04 5.2 -5.3 1.4e-07 -0.97 0.02 0.92 FALSE
22 GTEx Ovary RP11-429P3.3 0.27 0.11 enet 15 0.15 1.9e-04 4.7 -5.5 2.8e-08 -0.80 0.02 0.91 FALSE
23 GTEx Pituitary HEATR3 0.55 0.36 lasso 7 0.48 1.3e-13 5.3 -5.3 1.4e-07 -0.93 0.01 0.98 FALSE
24 GTEx Spleen HEATR3 0.43 0.13 lasso 9 0.13 2.7e-04 5.2 -5.3 1.2e-07 -0.96 0.01 0.98 FALSE
25 GTEx Stomach HEATR3 0.36 0.27 enet 14 0.28 1.6e-13 4.9 -5.3 1.3e-07 -0.97 0.01 0.98 FALSE
26 GTEx Testis HEATR3 0.47 0.37 enet 33 0.38 4.5e-18 5.2 -5.3 1.3e-07 -0.94 0.01 0.99 FALSE
27 GTEx Testis RP11-429P3.3 0.21 0.03 lasso 5 0.03 1.6e-02 5.2 -5.1 3.1e-07 -0.99 0.02 0.87 FALSE
28 The Cancer Genome Atlas Glioblastoma Multiforme HEATR3 0.13 0.07 blup 39 0.10 5.1e-04 4.8 -5.5 3.2e-08 -0.93 0.01 0.89 FALSE
29 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HEATR3 0.14 0.04 blup 39 0.08 3.2e-04 4.9 -5.3 1.2e-07 -0.83 0.01 0.76 FALSE