Best TWAS P=4.73e-42 · Best GWAS P=3.03e-154 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FTO | 0.11 | 0.00 | bslmm | 739 | 0.02 | 1.6e-03 | 1.6 | -11.5 | 1.0e-30 | 0.38 | 0.09 | 0.55 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | -4.8 | 6.1 | 1.1e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RBL2 | 0.34 | 0.28 | enet | 18 | 0.30 | 1.0e-24 | -4.8 | 5.9 | 3.2e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | RBL2 | 0.16 | 0.17 | enet | 11 | 0.20 | 2.1e-15 | -4.9 | 6.0 | 2.5e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | -4.6 | 6.4 | 1.3e-10 | 0.02 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | -4.8 | 5.5 | 3.6e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RBL2 | 0.36 | 0.36 | enet | 37 | 0.37 | 2.9e-26 | -4.8 | 5.8 | 7.1e-09 | 0.00 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Lung | RBL2 | 0.29 | 0.37 | enet | 16 | 0.35 | 9.1e-28 | -4.8 | 5.3 | 1.2e-07 | 0.03 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | -6.9 | 9.8 | 7.6e-23 | -0.10 | 0.28 | 0.23 | TRUE |
| 10 | GTEx | Nerve Tibial | RBL2 | 0.46 | 0.52 | enet | 19 | 0.53 | 1.6e-43 | -4.8 | 5.2 | 1.8e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | RBL2 | 0.35 | 0.33 | enet | 16 | 0.34 | 2.6e-19 | -4.8 | 5.4 | 5.4e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | RBL2 | 0.35 | 0.39 | enet | 25 | 0.37 | 2.9e-32 | -4.8 | 5.1 | 2.7e-07 | 0.03 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | -4.8 | 5.4 | 8.1e-08 | -0.06 | 1.00 | 0.00 | TRUE |
| 14 | GTEx | Testis | AKTIP | 0.19 | 0.00 | enet | 26 | 0.00 | 1.9e-01 | -4.6 | -13.6 | 4.7e-42 | 0.51 | 0.03 | 0.40 | TRUE |
| 15 | GTEx | Vagina | RBL2 | 0.41 | 0.37 | enet | 13 | 0.34 | 1.6e-08 | -4.5 | 5.2 | 2.5e-07 | 0.03 | 0.89 | 0.01 | FALSE |
| 16 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | -7.2 | -6.6 | 3.7e-11 | -0.01 | 1.00 | 0.00 | TRUE |
| 17 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | -7.2 | -5.3 | 1.1e-07 | 0.00 | 0.01 | 0.81 | TRUE |
| 18 | The Cancer Genome Atlas | Glioblastoma Multiforme | FTO | 0.27 | 0.16 | enet | 13 | 0.14 | 6.7e-05 | 2.0 | -8.8 | 2.0e-18 | 0.33 | 0.11 | 0.32 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | -4.6 | 5.7 | 1.6e-08 | 0.04 | 0.62 | 0.37 | FALSE |
| 20 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | -6.8 | 7.0 | 1.9e-12 | -0.03 | 0.01 | 0.80 | FALSE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | AKTIP | 0.18 | -0.01 | enet | 10 | 0.08 | 6.9e-04 | 2.2 | 5.3 | 1.3e-07 | -0.01 | 0.01 | 0.29 | TRUE |