Best TWAS P=5.6e-12 · Best GWAS P=1.88e-11 conditioned to 0.00218
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | FBLN1 | 0.09 | 0.04 | lasso | 9 | 0.06 | 2.4e-05 | 6.7 | -6.0 | 1.8e-09 | -0.95 | 0.00 | 0.98 | FALSE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SMC1B | 0.10 | 0.04 | lasso | 5 | 0.05 | 1.1e-06 | 3.1 | -5.4 | 6.5e-08 | -0.38 | 0.81 | 0.05 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RIBC2 | 0.03 | 0.01 | blup | 59 | 0.03 | 1.8e-04 | -4.9 | -6.9 | 5.6e-12 | -0.63 | 0.04 | 0.93 | TRUE |
| 4 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RIBC2 | 0.11 | 0.02 | blup | 58 | 0.09 | 2.0e-04 | -4.7 | -6.8 | 1.4e-11 | -0.70 | 0.06 | 0.56 | FALSE |