Best TWAS P=9.3e-15 · Best GWAS P=1.99e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EP300 | 0.05 | 0.00 | bslmm | 289 | 0.02 | 0.00319 | -4.3 | 5.6 | 2.7e-08 | 0.16 | 0.44 | 0.06 | TRUE |
2 | GTEx | Brain Frontal Cortex BA9 | SLC25A17 | 0.11 | -0.01 | lasso | 5 | 0.00 | 0.34900 | 4.3 | 5.5 | 3.4e-08 | 0.35 | 0.08 | 0.15 | TRUE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 0.00266 | 5.7 | 6.8 | 9.1e-12 | 0.85 | 0.02 | 0.82 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | MKL1 | 0.05 | 0.03 | blup | 105 | 0.04 | 0.00386 | 5.1 | 6.2 | 4.2e-10 | 0.38 | 0.05 | 0.17 | TRUE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 0.00016 | 7.9 | 7.4 | 1.4e-13 | 0.90 | 0.00 | 0.94 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADSL | 0.07 | 0.02 | blup | 33 | 0.05 | 0.00052 | 2.8 | 5.5 | 3.4e-08 | 0.68 | 0.07 | 0.50 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 0.00894 | 7.7 | 7.2 | 7.4e-13 | 0.84 | 0.01 | 0.59 | TRUE |
8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 0.00665 | 7.9 | 7.7 | 9.3e-15 | 0.97 | 0.00 | 0.82 | TRUE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 0.07710 | 7.8 | 7.5 | 5.2e-14 | 0.92 | 0.00 | 0.76 | TRUE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ADSL | 0.04 | 0.00 | blup | 33 | 0.03 | 0.00260 | 3.0 | 5.5 | 2.9e-08 | 0.68 | 0.02 | 0.72 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MKL1 | 0.05 | 0.01 | blup | 95 | 0.02 | 0.02200 | -6.5 | 6.6 | 3.2e-11 | 0.47 | 0.03 | 0.79 | FALSE |