TWAS
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Usage
Models
Genes
Traits
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Traits
:
Impedance of leg (left)
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chr2:42,753,863-44,157,441
Best TWAS P=6.83e-11 · Best GWAS P=3.05e-14 conditioned to 4.24e-05
42.8M
43M
43.2M
43.4M
43.6M
43.8M
44M
44.2M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Thyroid
AC010883.5
0.11
0.09
lasso
2
0.08
1.5e-06
6.6
6.5
6.8e-11
0.75
0.83
0.15
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
ZFP36L2
0.03
0.01
blup
38
0.01
1.1e-02
2.8
-6.3
3.4e-10
-0.86
0.01
0.83
FALSE
1
GTEx
Nerve Tibial
ZFP36L2
0.06
0.00
lasso
8
0.01
3.5e-02
5.9
-5.1
3.1e-07
-0.54
0.20
0.28
FALSE