TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Impedance of leg (left)
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chr3:45,262,393-46,944,274
Best TWAS P=6.99e-09 · Best GWAS P=1.39e-08 conditioned to 0.00228
45.2M
45.4M
45.6M
45.8M
46M
46.2M
46.4M
46.6M
46.8M
47M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Gastroesophageal Junction
FYCO1
0.15
0.13
lasso
5
0.13
2.8e-05
5.2
5.8
7.0e-09
0.54
0.03
0.92
TRUE
4
GTEx
Whole Blood
CCR1
0.12
0.10
lasso
4
0.09
4.8e-09
5.0
5.5
5.2e-08
0.85
0.03
0.97
FALSE
5
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
FYCO1
0.08
0.03
enet
12
0.04
8.1e-04
5.2
5.3
1.3e-07
0.48
0.01
0.94
FALSE
3
GTEx
Nerve Tibial
FYCO1
0.26
0.24
enet
25
0.27
2.8e-19
5.2
5.2
2.0e-07
0.50
0.03
0.97
FALSE
2
GTEx
Esophagus Muscularis
FYCO1
0.17
0.06
lasso
8
0.08
1.7e-05
4.0
5.2
2.3e-07
0.63
0.08
0.90
FALSE