TWAS hub - CCR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1350	0.0480	1.0e-04	0.067	NA	0.063	NA	0.067	9.9e-06	NA	1.9e-05	NA	8.9e-06
2	GTEx	Whole Blood	0.1250	0.0400	7.8e-06	0.101	NA	0.066	NA	0.095	1.3e-09	NA	9.6e-07	NA	4.8e-09
3	NTR	Blood	0.1695	0.0281	0.0e+00	0.119	0.167	0.190	0.189	0.181	2.4e-36	1.6e-51	3.7e-59	1.4e-58	5.0e-56
4	YFS	Blood	0.4855	0.0403	0.0e+00	0.300	0.346	0.374	0.380	0.357	6.9e-100	1.1e-118	1.3e-130	2.0e-133	2.3e-123
5	TCGA	Colon Adenocarcinoma	0.0830	0.0600	7.8e-03	0.010	0.021	0.021	NA	0.015	8.0e-02	2.1e-02	2.2e-02	NA	4.1e-02
6	TCGA	Brain Lower Grade Glioma	0.0448	0.0245	2.4e-03	0.001	0.014	0.026	NA	0.011	2.3e-01	7.9e-03	5.4e-04	NA	1.7e-02
7	TCGA	Lung Squamous Cell Carcinoma	0.0316	0.0186	2.7e-03	0.024	0.021	0.015	NA	0.017	8.2e-04	1.5e-03	6.6e-03	NA	4.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Mouth/teeth dental problems: Mouth ulcers	57.0	90.6	148.8	-8.9	-10.6	-8.7	-8.2	-12.0	-2.5	-12.2
Mouth/teeth dental problems	11.4	17.5	29.3	3.7	4.9	4.0	4.1	4.7	1.0	5.4
Osteoporosis (self-reported)	8.6	10.6	22.1	3.7	2.3	3.2	1.9	4.3	1.3	4.7
Ulcerative Colitis (UC)	4.4	8.3	18.3	-2.2	-3.1	-4.3	-1.7	-3.6	-0.2	-3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	4.3	5.6	9.9	-1.2	-3.1	-2.8	-2.7	-2.1	-0.9	-2.7
Medication: Aspirin	4.2	5.4	10.0	-2.9	-0.9	-2.8	-1.3	-3.2	-0.6	-3.0
HbA1C	4.1	4.5	7.8	-0.2	-1.4	-2.8	-2.6	-1.9	-2.0	-2.7
Heel T-Score	4.1	32.6	77.1	-2.4	-6.9	-8.8	-6.2	-3.8	-3.6	-5.6
Medication: Aspirin	3.9	5.2	10.6	-3.1	-0.4	-2.4	-1.2	-3.2	0.0	-2.9
Average weekly spirits intake	3.7	4.5	6.8	1.8	2.6	2.3	2.3	2.1	0.1	2.6
Rheumatoid Arthritis	3.6	4.9	12.7	1.7	0.9	2.8	1.7	3.6	1.3	2.3
Medication: Cholesterol lowering	3.6	5.7	13.3	-2.5	-1.7	-2.0	-0.9	-3.6	-1.5	-3.2
Lung cancer (father)	3.6	4.2	10.5	-3.2	-0.2	-0.0	-0.2	-3.2	0.4	-3.0
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	12.1	3.5	-0.6	0.6	0.4	3.3	-1.1	2.1
Supplements: Calcium	3.2	3.6	9.7	3.1	0.4	0.9	0.5	2.7	0.5	2.6
Impedance of leg (right)	3.1	14.8	33.5	0.6	5.8	4.9	4.8	1.6	2.6	3.7
Medication: Omeprazole (e.g. Zanprol)	3.1	3.7	6.6	0.9	2.2	2.4	0.8	2.6	1.0	2.5
Body Mass Index (BMI) (2010)	3.0	4.1	7.2	-1.9	-1.5	-2.5	-1.8	-2.7	-0.7	-2.5
Impedance of leg (left)	3.0	14.4	29.7	1.1	5.5	4.8	4.8	1.8	2.4	3.8
Pulse rate	3.0	5.1	7.6	-0.8	-2.8	-2.7	-2.7	-0.9	-2.6	-2.3
Eye problems/disorders: Glaucoma	3.0	3.6	8.3	-0.8	-2.0	-2.9	-2.0	-1.8	-1.0	-2.0
Glaucoma (self-reported)	2.9	3.4	9.0	0.1	-2.4	-3.0	-2.2	-0.6	-1.2	-1.6
Illnesses of siblings: Diabetes	2.9	3.6	8.5	0.3	-2.9	-2.8	-2.1	0.0	-1.7	-1.3
Mineral and other dietary supplements	2.9	3.9	8.2	-2.5	-0.6	-2.1	-1.3	-2.9	-0.9	-2.4
Pulse rate, automated reading	2.8	8.9	12.8	-2.0	-3.4	-3.4	-3.1	-2.6	-2.4	-3.6
Loneliness, isolation	2.8	3.9	9.6	0.8	-2.2	-3.1	-2.9	0.8	-1.6	-0.6
Number of full sisters	2.6	3.2	8.8	-2.7	0.9	-0.1	0.2	-3.0	2.0	-1.1
Alcohol intake versus 10 years previously	2.5	3.7	7.9	-0.2	-2.4	-2.6	-2.8	-0.2	-1.8	-1.4
Medication: Omeprazole	2.5	3.0	6.1	1.4	1.5	2.0	0.2	2.5	0.7	2.5
High cholesterol (Self-reported)	2.5	4.4	8.4	-2.2	-2.1	-1.9	-1.3	-2.7	-0.6	-2.9
Sensitivity / hurt feelings	2.4	4.0	7.2	-0.6	-2.5	-2.7	-2.0	-0.8	-2.3	-2.2
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	7.0	1.7	1.6	2.1	0.6	2.6	1.4	2.5
Average weekly champagne plus white wine intake	2.2	3.1	4.3	1.9	1.4	1.7	2.0	2.1	0.8	2.0
Medication: Metformin	2.1	2.9	7.0	-0.1	-2.2	-2.6	-1.5	-1.0	-1.8	-1.4
High blood pressure (mother)	2.1	3.0	4.8	-0.4	-2.1	-2.0	-2.2	-0.6	-2.0	-1.7
Guilty feelings	2.1	3.2	6.6	0.6	-2.5	-2.3	-2.6	0.4	-1.6	-0.9
Vascular/heart problems diagnosed by doctor	2.1	5.8	11.4	1.7	2.4	3.4	2.0	2.8	1.3	2.8
Impedance of whole body	2.1	10.6	18.6	1.7	4.3	4.3	3.4	2.3	2.1	3.7
LDL Cholesterol	2.0	3.2	7.5	-1.9	-1.1	-1.3	-1.2	-2.7	-1.1	-2.4
Ulcerative Colitis	2.0	2.9	9.8	-0.2	-2.2	-3.1	-0.9	-1.2	-0.9	-1.5
Medication: Lansoprazole	2.0	2.3	5.4	0.2	2.3	1.4	1.9	0.3	1.5	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	5.3	1.0	1.7	1.4	0.7	1.9	1.3	2.3
Medication for cholesterol	2.0	3.0	9.5	0.1	2.2	3.1	1.8	0.9	1.2	1.1
Hearing aid user	2.0	2.3	4.3	-0.8	-1.9	-1.7	-2.1	-0.9	-0.8	-1.7
Medication: Atorvastatin	2.0	2.4	8.1	-2.3	0.2	-0.7	0.8	-2.9	0.7	-1.5
Ever depressed for a whole week	2.0	2.5	7.7	2.8	-0.9	-0.1	-0.4	2.3	-1.4	1.2
Alzheimer’s Disease (in mother)	1.9	2.3	4.1	2.0	-1.6	-0.3	-1.4	1.9	-1.8	0.7
Irritable Bowel Disease (IBD)	1.9	4.5	7.8	-2.2	-1.9	-2.8	-1.1	-2.5	1.4	-2.3
High blood pressure	1.9	5.4	9.6	-1.5	-2.5	-3.1	-2.0	-2.4	-1.5	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	3.4	1.6	1.6	0.7	1.6	1.3	1.6	1.9
Commuting to job workplace: Public transport	1.9	2.2	9.1	-0.5	0.8	1.6	1.6	-0.1	3.0	0.6
Medication: Lisinopril	1.9	2.4	6.4	-1.6	-0.6	-1.6	-0.2	-2.5	-0.3	-2.1
Lupus	1.8	2.8	6.4	1.8	0.4	1.1	1.6	2.5	0.8	2.3
Supplements: Glucosamine	1.8	2.4	6.0	2.5	-0.3	1.3	0.6	2.4	-0.2	1.6
Shortness of breath walking on level ground	1.8	2.1	4.4	1.3	-1.6	-2.1	-1.3	1.0	-1.8	0.0
Medication: Ibuprofen	1.8	2.1	5.4	2.3	-0.9	-0.6	-0.4	1.9	-1.7	1.1
Cardiovascular Disease	1.7	5.6	10.7	-0.6	-3.2	-3.3	-1.3	-2.1	-2.3	-2.5
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.3	2.3	-0.7	0.7	-0.2	2.2	1.0	1.8
Had other major operations	1.7	2.1	5.8	0.6	1.3	1.5	2.4	1.0	1.4	1.4
High blood pressure (siblings)	1.7	2.5	8.9	-2.3	0.6	-0.3	0.3	-3.0	0.6	-1.6
Pack years adult smoking proportion	1.6	2.4	5.7	-0.4	-1.9	-2.4	-1.4	-1.0	-1.1	-1.8
Townsend deprivation index at recruitment	1.6	2.2	5.3	0.7	-1.7	-2.3	-2.2	-0.0	-1.1	-0.7
Noisy workplace	1.6	2.0	5.1	2.0	0.3	0.1	0.3	2.2	0.5	2.1
Headache pain in last month	1.6	2.7	4.0	-1.6	-1.5	-2.0	-1.5	-2.0	-0.3	-1.8
Illnesses of father: None of the above (group 1)	1.6	2.0	6.4	-0.3	1.7	2.5	1.1	0.2	1.8	0.6
Triglycerides	1.5	2.4	7.5	-2.0	-0.1	-0.9	0.3	-2.7	-0.8	-1.9
Maternal smoking around birth	1.5	2.1	4.7	-2.2	1.8	1.2	1.5	-1.0	1.4	-0.6
Happiness	1.5	1.8	4.5	2.1	-0.4	-0.5	-1.2	1.9	-0.2	1.6
Impedance of arm (left)	1.5	7.1	13.0	2.0	2.9	3.6	2.0	2.4	1.9	3.3
Health satisfaction	1.5	1.9	3.0	1.7	-1.4	-1.7	-1.2	1.1	-1.4	0.9
Heart disease (mother)	1.5	1.8	2.8	-1.6	-0.4	-1.7	-1.4	-1.6	0.5	-1.6
Heart attack/myocardial infarction (self-reported)	1.5	2.0	7.6	-0.2	-0.9	-2.8	-1.2	-1.2	-1.3	-0.9
Pack years of smoking	1.5	2.2	4.8	-0.6	-1.7	-2.2	-1.3	-1.1	-0.9	-1.9
Alzheimer’s Disease (including proxy)	1.4	2.0	3.3	1.4	-1.8	-0.7	-1.7	1.7	-1.6	0.2
BMI	1.4	8.1	16.7	-1.1	-3.3	-4.1	-2.3	-1.8	-3.2	-3.0
Taking other prescription medications	1.4	2.2	4.7	2.2	-1.4	-1.9	-1.0	1.4	-1.1	0.9
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.3	-0.6	1.7	1.1	1.0	-0.3	2.1	0.8
Heart attack	1.4	1.8	7.2	0.0	-0.9	-2.7	-1.2	-0.9	-1.3	-0.6
Hypertension (Self-reported)	1.4	4.0	7.9	-1.1	-2.4	-2.8	-1.7	-2.0	-1.2	-2.3
Diabetes diagnosed by doctor	1.4	2.3	4.9	-0.3	-1.9	-2.2	-1.9	-0.7	-1.5	-1.2
Qualifications: nursing, teaching	1.4	2.2	4.5	-1.0	-1.6	-0.9	-2.1	-1.6	-1.4	-1.5
Basal cell carcinoma (self-reported)	1.4	1.6	4.1	-0.7	1.5	1.9	0.6	0.3	2.0	0.8
Blood Eosinophil Count	1.3	10.4	30.9	-5.6	-0.1	0.3	1.5	-4.3	-1.3	-4.4
Pain all over the body in last month	1.3	1.4	4.8	2.2	-0.2	-0.5	-0.3	1.5	-0.6	1.5
Medication: Simvastatin	1.3	1.9	3.4	-1.1	-1.8	-1.4	-1.1	-1.4	-0.6	-1.8
Impedance of arm (right)	1.3	5.9	11.8	1.6	2.7	3.4	2.0	2.0	1.5	3.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.7	1.2	-1.2	-1.4	-1.3	0.8	-1.9	0.2
Loud music exposure frequency	1.3	1.4	3.1	1.7	0.7	0.0	0.9	1.8	-0.3	1.6
Illnesses of father: Heart disease	1.3	1.9	6.4	-0.1	-1.2	-2.5	-1.2	-1.0	-1.5	-0.7
Long-standing illness, disability or infirmity	1.3	1.9	4.1	2.0	-1.6	-1.5	-0.9	1.6	-1.1	0.5
Ever had bowel cancer screening	1.3	1.5	3.9	1.6	-0.1	0.7	1.3	2.0	-0.3	1.3
Back pain experienced in last month	1.3	1.9	4.1	1.4	1.1	1.1	0.5	2.0	1.2	1.8
Medication: Bendroflumethiazide	1.3	1.9	5.4	-0.1	-1.4	-2.3	-0.6	-0.8	-2.0	-1.0
Irritability	1.3	2.2	5.6	-0.1	-1.8	-2.4	-2.1	-0.4	-0.8	-1.1
Bipolar Disorder (2011)	1.2	1.2	3.3	-1.8	0.4	0.4	-0.1	-1.4	0.2	-1.5
Type 2 Diabetes (T2D) (2012)	1.2	1.3	2.9	1.3	-1.5	-1.7	-0.2	0.5	-1.6	0.1
Hypothyroidism (self reported)	1.2	2.8	8.1	1.9	-2.8	-2.4	-1.2	1.0	-0.3	0.2
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.9	0.3	-1.5	-2.2	-0.9	-0.6	-0.9	-0.4
Average weekly fortified wine intake	1.2	1.4	2.7	-1.2	1.2	1.5	1.6	-0.9	-0.3	-1.1
Body mass index (BMI)	1.2	4.9	10.8	-0.9	-2.8	-3.3	-2.3	-1.5	-1.8	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.6	-1.5	-1.1	-2.4	-1.7	-1.9	0.4	-1.6
Illnesses of siblings	1.2	1.7	5.8	1.6	-0.0	1.1	-0.2	2.4	-0.7	1.3
Birth weight of first child	1.2	2.1	5.6	-0.3	1.7	2.4	1.4	-0.1	2.0	0.9
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.0	-0.5	1.5	1.8	1.6	-0.1	2.0	1.2
Number of children fathered	1.2	1.4	3.3	-0.0	1.8	1.7	0.7	0.5	1.0	1.3
Angina (self-reported)	1.2	1.6	4.8	-0.4	-0.5	-2.2	-0.6	-2.2	-0.0	-1.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.3	-1.6	-0.2	-1.2	-0.9	-1.8	1.3	-0.6
Mood swings	1.2	2.1	4.5	-0.6	-1.3	-2.1	-1.6	-0.7	-1.9	-1.4
Medication: Gliclazide	1.2	1.3	3.8	-0.6	-1.4	-2.0	-0.8	-0.8	-0.4	-1.3
Illnesses of father: High blood pressure	1.2	1.5	3.5	-1.0	-1.2	-1.9	-1.7	-1.2	-0.0	-0.7
Supplements: Zinc	1.1	1.2	2.4	0.3	1.2	1.5	1.5	1.1	0.4	1.0
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	7.1	1.3	-2.7	-2.0	-1.3	0.6	-0.7	-0.3
Medication: Amlodipine	1.1	1.5	7.1	0.6	-0.9	-2.7	-1.4	-0.4	-0.1	-0.2
Comparative body size at age 10	1.1	3.2	8.0	-0.7	-2.1	-2.8	-1.7	-1.3	-0.8	-2.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.1	1.7	-0.2	1.2	0.3	1.8	-0.1	1.4
Miserableness	1.1	1.9	3.7	-1.7	-0.1	-1.5	-1.6	-1.9	0.0	-1.3
Cholesterol lowering medication	1.1	1.7	3.1	-1.4	-1.4	-1.8	-1.2	-1.3	0.2	-1.4
Age at First Birth	1.0	1.5	4.1	0.8	0.7	2.0	1.6	1.1	-0.0	1.3
Blood Red Count	1.0	9.5	22.6	-3.7	-1.3	-3.2	-2.1	-4.8	0.4	-3.6
Falls in the last year	1.0	1.3	3.5	1.9	0.2	0.2	0.5	1.6	-0.1	1.6
Depression (self-reported)	1.0	1.2	4.4	-0.3	-2.1	-0.5	-0.6	-1.1	-0.6	-1.3
Worry too long after embarrassment	1.0	1.6	5.3	0.4	-1.7	-2.3	-1.7	-0.1	-0.2	-0.5
Age at first live birth	1.0	1.7	4.4	-0.3	1.3	2.1	1.8	-0.1	1.5	0.5
Eye problems/disorders: None of the above	1.0	1.2	3.1	-1.2	1.3	1.8	0.5	0.4	1.2	0.3
Medication: Paracetamol	1.0	1.5	4.0	1.0	0.8	1.0	0.2	2.0	1.2	1.5
Alcohol drinker status: Never	1.0	1.2	2.5	-1.6	-0.2	-1.2	-0.7	-1.4	0.9	-1.1
Age started oral contraceptive pill	1.0	1.3	2.8	0.8	0.9	1.5	0.7	1.1	1.7	1.0
Coronary Artery Disease (CAD)	0.9	1.1	3.2	-0.2	-0.9	-1.8	-0.1	-0.7	-1.6	-0.6
Angina	0.9	1.2	4.1	0.0	-0.5	-2.0	-0.8	-1.8	-0.0	-0.7
Arm fat mass (right)	0.9	3.8	8.0	-0.5	-2.8	-2.6	-2.2	-1.1	-1.7	-1.6
Pulse wave reflection index	0.9	1.2	2.4	1.1	1.0	0.9	1.5	0.7	0.8	1.3
Leg fat-free mass (right)	0.9	4.7	17.5	0.1	-4.2	-2.2	-2.3	-0.6	-1.6	-1.6
Arm fat mass (left)	0.9	3.5	7.7	-0.3	-2.8	-2.5	-2.1	-0.9	-1.8	-1.5
Number of operations (self-reported)	0.9	1.3	3.3	-1.8	0.4	0.8	-0.4	-1.1	1.7	-0.6
Vitamin and mineral supplements	0.8	1.1	3.4	-1.2	0.3	-1.8	-1.1	-1.1	0.2	-0.4
Leg fat-free mass (left)	0.8	4.4	15.8	-0.0	-4.0	-2.2	-2.2	-0.6	-1.6	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.2	0.8	-1.1	-1.8	-1.4	0.5	0.2	0.1
Age when periods started (menarche)	0.8	2.0	5.5	-0.0	1.6	2.4	1.6	0.9	1.3	1.1
Leg predicted mass (left)	0.8	4.1	14.7	-0.0	-3.8	-2.1	-2.2	-0.5	-1.4	-1.5
Diabetes (self-reported)	0.8	1.3	2.5	0.2	-1.6	-1.5	-1.3	-0.2	-1.5	-0.7
Neuroticism score	0.8	1.6	3.8	0.2	-1.6	-2.0	-1.7	0.0	-1.0	-1.1
Hair/balding pattern: Pattern 4	0.8	1.9	3.6	-0.6	-1.2	-1.8	-1.9	-0.4	-1.4	-1.5
Medication: Paracetamol	0.8	1.3	3.3	0.1	1.2	1.0	0.0	1.3	1.8	1.3
Exposure to tobacco smoke outside home	0.8	1.1	2.3	-1.2	-0.5	-1.1	-0.8	-1.5	0.5	-1.3
Medication: Blood pressure	0.8	1.3	3.1	-0.9	-0.7	-1.8	0.0	-1.6	-0.6	-1.4
Migraine (self-reported)	0.8	1.0	2.8	-1.4	1.7	0.7	0.8	-0.7	0.8	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.1	-1.3	0.5	-1.0	-0.6	-1.4	0.4	-1.0
Leg predicted mass (right)	0.8	4.5	16.9	0.1	-4.1	-2.2	-2.2	-0.5	-1.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.8	1.1	3.3	1.4	-0.8	-0.6	-0.6	1.8	-0.5	0.8
Unable to work because of sickness or disability	0.8	1.1	2.7	1.6	-0.5	-0.4	-0.0	1.3	-1.6	0.6
Commuting to job workplace: Cycle	0.8	1.0	2.5	0.9	-1.1	-1.1	-0.8	0.6	-1.6	-0.3
Severe depression (siblings)	0.7	0.8	1.8	-0.9	1.4	1.0	0.7	-0.4	1.1	0.5
Fed-up feelings	0.7	1.2	4.4	0.4	-0.6	-2.1	-1.2	0.5	-1.3	-0.0
Relative age voice broke	0.7	1.0	2.5	1.6	-0.2	0.5	-0.5	1.5	0.1	1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	1.4	-0.2	-0.5	-0.6	1.3	-0.3	1.1
Medication: Levothyroxine sodium	0.7	1.2	3.1	1.7	-1.8	-1.0	-0.4	1.1	-0.5	0.5
Sitting height	0.7	5.2	15.5	-1.1	-3.9	-1.9	-2.4	-1.2	-1.3	-2.7
Waist circumference	0.7	2.6	6.9	-0.4	-2.2	-2.6	-1.6	-0.9	-1.5	-1.1
Hearing difficulty/problems with background noise	0.7	1.2	2.7	1.1	-1.0	-1.2	-1.6	1.0	-1.1	0.0
Qualifications: None of the above	0.7	1.4	3.0	0.8	-1.4	-1.1	-1.7	0.7	-1.5	-0.6
Arm fat percentage (right)	0.7	2.8	5.5	-0.5	-2.2	-2.4	-2.1	-1.0	-1.5	-1.3
Time employed in main current job	0.7	0.8	2.7	0.3	1.0	1.7	0.9	0.9	-0.1	0.6
Illnesses of mother	0.7	0.9	2.1	0.1	0.8	1.4	1.3	-0.2	1.1	0.7
Exposure to tobacco smoke at home	0.7	0.8	1.4	0.9	-0.5	-1.0	-1.2	0.9	-1.1	0.4
Breastfed as a baby	0.7	0.9	1.2	-0.9	-1.0	-0.9	-1.1	-0.8	-0.9	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	1.5	0.1	-1.4	-0.1	0.7	-0.1	1.0
Birth weight	0.7	1.5	4.0	1.6	-0.3	1.5	0.3	2.0	-0.8	1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	-1.6	-0.2	-0.8	-0.1	-1.2	0.2	-1.1
Age at last live birth	0.7	1.0	2.4	-0.6	0.8	1.6	1.2	-0.7	1.1	-0.3
Leg pain on walking	0.7	0.8	2.0	1.4	-0.5	-0.7	-0.0	1.3	0.5	1.1
Arm fat percentage (left)	0.7	2.6	5.2	-0.3	-2.1	-2.3	-2.1	-0.8	-1.4	-1.2
Average weekly red wine intake	0.7	1.0	1.8	-1.2	-0.1	0.6	0.7	-1.3	1.4	-1.0
Whole body water mass	0.7	3.9	13.0	-0.6	-3.6	-2.1	-1.9	-1.0	-1.3	-1.9
Ever taken oral contraceptive pill	0.7	0.7	1.3	1.1	0.1	0.2	0.3	1.2	1.1	1.1
Medication: Blood pressure	0.7	1.3	4.6	-0.6	-0.9	-2.1	-1.5	-0.9	0.1	-0.5
Alcohol drinker status: Previous	0.7	0.8	2.0	1.1	0.9	0.0	0.3	1.1	-0.2	1.4
Reaction Time	0.6	1.2	3.1	-1.0	-0.1	-1.0	-1.3	-1.7	0.8	-1.0
Breast Cancer	0.6	1.3	3.6	1.9	-0.3	0.4	-0.3	1.4	0.6	1.7
HDL Cholesterol	0.6	1.0	3.1	0.8	-1.8	-0.9	-1.4	0.9	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.8	-0.6	-1.0	-1.7	-1.3	-0.6	-1.0	-1.0
Lung FEV1/FVC ratio	0.6	3.3	9.4	1.9	0.7	1.7	1.0	3.1	0.5	2.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	-0.6	-1.1	-0.9	-0.7	-0.7	-0.8	-1.2
Medication: Co-codamol	0.6	0.7	1.5	1.2	-0.5	-0.4	-0.7	1.0	0.8	0.9
Multivitamins +/- minerals	0.6	0.7	2.6	-0.3	0.4	1.3	0.7	-0.2	1.6	-0.1
Weight	0.6	2.8	8.1	-0.4	-2.9	-2.1	-1.8	-0.7	-1.2	-1.2
Number of full brothers	0.6	0.7	1.8	-1.3	-0.1	-0.2	-0.0	-1.3	-0.2	-1.1
Medication: Seretide 50 evohaler	0.6	0.6	3.8	0.6	-0.1	0.5	-0.2	0.3	-2.0	0.2
Supplements: Vitamin C	0.6	0.7	2.3	0.1	0.5	1.3	1.5	-0.1	-0.8	0.3
Whole body fat-free mass	0.6	3.3	11.6	-0.4	-3.4	-1.8	-1.8	-0.8	-1.2	-1.6
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.5	-0.9	-1.3	-1.1	-0.3	-0.7	-0.6
Financial situation satisfaction	0.6	0.8	2.1	1.1	0.0	-1.0	-0.5	1.5	-0.4	0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.6	-0.4	-0.0	-1.0	-1.6	0.6	-1.0	-0.4
Basal metabolic rate	0.6	3.3	11.3	-0.4	-3.4	-1.9	-1.8	-0.8	-1.2	-1.6
Arm fat-free mass (left)	0.6	3.2	8.7	-0.8	-3.0	-2.2	-1.4	-1.2	-1.2	-1.8
Myopia	0.6	0.9	2.9	0.9	-1.1	-0.3	-1.0	1.7	0.1	0.5
Crohns Disease (2017)	0.5	1.2	6.7	-1.2	0.3	0.2	0.2	-0.3	2.6	-0.2
Crohns Disease (2012)	0.5	0.9	3.9	0.3	0.3	0.7	-0.2	0.9	2.0	0.7
Neuroticism (2016)	0.5	0.7	1.5	1.1	0.5	0.2	0.6	1.1	0.7	1.2
Blood White Count	0.5	3.3	10.4	-1.3	-0.8	-3.2	-0.6	-1.9	-1.7	-2.0
Chronotype (morning person)	0.5	1.1	4.2	1.0	-0.9	-2.0	-0.6	1.0	0.0	0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.8	-1.0	-1.1	-0.3	0.4	-1.2	-0.2
Diabetes (father)	0.5	0.6	1.7	1.0	-1.3	-0.8	-0.1	0.6	0.1	0.3
Diabetes (mother)	0.5	0.6	1.9	1.4	-0.3	-0.8	-0.1	0.9	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.5	-0.9	-0.4	-1.6	-1.0	-1.0	1.5	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	2.1	-0.3	-0.3	-1.4	-1.0	-0.6	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	-1.3	-0.0	-0.5	-0.7	-0.9	0.2	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	0.2	-0.4	-1.3	-0.7	-0.5	-1.2	-0.6
Alcohol usually taken with meals	0.5	0.8	2.1	1.5	-0.4	1.3	0.5	1.0	0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	0.8	-1.0	-1.6	-0.9	0.2	-0.7	0.0
Father’s age at death	0.5	0.7	1.6	-0.4	-1.1	-0.8	-1.3	0.6	0.8	-0.3
Prospective memory result	0.5	0.6	1.9	0.7	-0.2	0.3	0.1	1.1	-1.4	0.6
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	1.2	-0.9	-1.8	-0.4	-0.0	-0.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	1.1	-0.8	-0.1	-0.5	1.2	-0.7	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.5	1.0	-0.3	0.3	-0.1	0.7	1.2	1.0
Medication: Allopurinol	0.5	0.7	1.9	0.2	-1.4	-1.1	-0.8	0.3	-1.0	-0.5
Arm predicted mass (right)	0.5	2.4	6.9	-0.8	-2.6	-1.6	-1.2	-1.1	-1.0	-1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.4	-0.1	1.0	0.6	0.9	-0.4	-1.2	-0.1
Friendships satisfaction	0.5	0.6	1.2	1.0	-0.7	-0.7	-1.1	0.8	-0.5	0.6
Smoking status: Current	0.5	0.7	2.5	0.6	-1.1	-1.6	-0.5	0.5	-0.7	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.9	-0.3	-1.1	-1.4	-0.8	-1.2	-0.5	-0.9
Wears glasses or contact lenses	0.5	0.6	1.5	-1.2	0.9	0.5	0.4	-0.3	1.2	-0.1
Arm predicted mass (left)	0.5	2.8	7.0	-1.2	-2.6	-1.9	-1.1	-1.4	-1.0	-1.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.2	-0.8	-0.2	-1.5	-0.5	-1.1	-0.6	-0.8
Depression (Nagel 2018)	0.4	0.5	1.4	0.2	-1.0	-1.2	-1.0	-0.1	-0.0	-0.6
Allergy or Eczema	0.4	1.1	2.9	-1.7	0.1	-0.6	-0.1	-1.5	1.2	-1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.5	-1.0	-0.7	-1.3	0.5	-0.4	-0.3
Hand grip strength (right)	0.4	1.1	2.3	1.1	1.2	0.8	0.9	1.1	0.3	1.5
Current tobacco smoking	0.4	0.7	3.3	0.2	-0.9	-1.8	-0.5	-0.1	-0.7	-0.3
Medication: Atenolol	0.4	0.5	1.7	0.5	0.5	-0.1	1.3	0.7	0.4	0.8
Trunk fat-free mass	0.4	2.3	8.0	-0.6	-2.8	-1.4	-1.4	-0.8	-1.0	-1.4
Hip circumference	0.4	1.9	4.9	-0.1	-2.2	-1.5	-1.7	-0.5	-1.5	-0.9
Trunk predicted mass	0.4	2.4	8.2	-0.6	-2.9	-1.5	-1.5	-0.8	-1.0	-1.5
Length of working week for main job	0.4	0.4	1.4	0.7	0.4	-0.4	0.7	-0.1	1.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.1	-1.0	-0.8	-0.4	-0.1	-1.3	-0.8
Peak expiratory flow (PEF)	0.4	0.9	3.5	-1.2	0.3	0.6	0.6	-0.4	1.9	-0.5
Gout (self-reported)	0.4	0.5	2.3	0.2	-0.7	-0.8	-0.1	0.2	-1.5	-0.5
Arm fat-free mass (right)	0.4	2.1	6.7	-0.7	-2.6	-1.6	-1.0	-1.1	-0.9	-1.5
Alcohol intake frequency.	0.4	1.0	3.0	-0.8	0.1	-1.7	-1.5	-0.7	0.6	-0.1
Overall health rating	0.4	0.8	3.2	-0.6	-0.0	-1.8	-0.4	-1.2	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.5	1.4	-0.1	0.8	0.3	1.1	0.1	1.6
Commuting to job workplace: Walk	0.4	0.5	1.4	0.7	-0.7	-0.5	-0.4	1.2	0.3	0.6
Breast cancer (self-reported)	0.4	0.5	1.2	1.1	0.3	-0.3	-0.4	0.9	-0.5	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.4	-0.3	-0.0	0.7	-0.4	-0.2	1.6	-0.2
Diastolic blood pressure, automated reading	0.4	1.1	3.3	0.2	-1.8	-1.0	-1.8	-0.1	-0.5	-0.4
Pain experienced in last month	0.4	0.7	1.3	-0.9	-0.6	0.6	-0.2	-1.0	-0.9	-1.1
Heart disease (siblings)	0.4	0.5	1.1	0.5	1.1	-0.3	0.8	-0.2	0.8	0.9
Bipolar Disorder (2018)	0.3	0.4	1.5	-0.8	0.5	-0.1	0.4	-1.2	0.2	-0.7
Neuroticism (Nagel 2018)	0.3	0.8	2.1	-0.6	-0.5	-1.5	-0.9	-1.0	0.2	-0.9
Worry (Nagel 2018)	0.3	0.6	1.6	-0.2	1.1	0.9	0.7	-0.1	1.2	0.1
Ovarian Cancer	0.3	0.3	0.8	0.6	0.2	-0.1	-0.2	0.8	0.7	0.9
Fasting Glucose	0.3	0.4	1.9	-0.3	1.4	0.8	0.1	-0.1	-0.0	0.1
Medication for hormone replacement therapy	0.3	0.3	0.7	0.6	-0.9	-0.7	0.0	0.2	-0.7	-0.1
Trunk fat mass	0.3	1.5	3.8	-0.1	-2.0	-1.6	-1.3	-0.3	-1.4	-0.7
Financial difficulties in last 2 years	0.3	0.5	1.3	-0.9	-0.1	-1.1	-0.3	-0.5	0.1	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.8	-0.6	0.4	0.2	0.9	-0.4	0.6
Tense / ‘highly strung’	0.3	0.5	1.0	-1.0	-0.4	-0.5	-0.6	-0.8	0.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-1.1	-0.2	0.3	-0.6	-0.3	-0.3	-0.8
Mean time to correctly identify matches	0.3	0.7	1.2	-0.9	0.5	-0.3	-0.9	-1.1	1.0	-0.6
Whole body fat mass	0.3	1.3	3.0	-0.3	-1.7	-1.6	-1.2	-0.5	-1.2	-0.8
Comparative height size at age 10	0.3	1.8	4.6	1.6	0.1	0.8	1.3	1.5	0.8	2.1
Had major operations	0.3	0.4	0.9	-0.2	0.1	0.9	-0.9	0.1	0.8	0.2
Family relationship satisfaction	0.3	0.3	0.7	0.8	-0.4	-0.7	-0.6	0.6	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	0.6	-0.1	0.7	0.6	1.0	0.5	0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.1	1.0	-0.6	0.1	-0.6	0.5	-0.7	0.2
Leg fat mass (left)	0.3	1.0	2.0	-0.4	-1.4	-1.4	-0.6	-0.7	-1.3	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.2	-1.3	-0.3	-0.4	0.0	-1.5	0.3	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.7	-0.6	0.2	-0.2	0.7	-0.8	0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.1	-0.5	0.2	-0.8	0.4	-0.3	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.5	-0.4	-0.3	-0.5	-0.7	1.0	-0.4
Height	0.2	4.1	13.5	0.8	0.4	3.7	1.4	1.5	2.2	2.3
Smoking Status	0.2	0.5	1.6	0.0	-0.6	-0.0	-0.5	-0.3	-1.3	-1.1
Relative age of first facial hair	0.2	0.4	0.9	0.9	-0.9	0.4	-0.8	0.4	-0.3	0.5
Systolic blood pressure, automated reading	0.2	0.7	2.3	-0.1	-0.9	-1.2	-1.5	-0.1	-0.3	-0.4
Trunk fat percentage	0.2	0.6	1.4	0.0	-1.2	-1.1	-0.9	-0.1	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-0.8	-0.5	-0.7	-0.5	-1.2	-0.1	-0.8
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.3	0.6	0.2	0.8	0.3	0.5	0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.2	0.3	0.3	0.6	-0.6	0.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.8	0.8	0.1	0.1	-0.4	0.4	0.1
Medication: Ramipril	0.2	0.3	0.9	0.1	0.3	-0.9	-0.9	-0.1	0.1	0.3
Fluid intelligence score	0.2	0.4	0.9	-0.7	0.3	0.9	1.0	-0.5	0.3	-0.4
Worrier / anxious feelings	0.2	0.5	1.9	-0.6	0.5	0.2	0.7	-0.2	1.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.4	-0.5	-0.6	-0.8	-0.0	0.6	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	1.2	0.3	0.7	-0.1	-0.1	0.6	0.1	1.1
Number of live births	0.2	0.3	0.5	-0.7	0.6	0.7	0.6	-0.5	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.6	-0.0	0.6	0.9	1.3	0.2	0.8	0.5
Standing height	0.2	2.0	5.0	1.3	-0.6	2.2	0.8	1.5	0.9	1.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.4	-0.3	-0.8	-0.5	-0.3	-0.2	0.0
Pulse wave peak to peak time	0.2	0.2	0.5	-0.7	0.5	-0.3	-0.3	-0.7	0.5	-0.4
Qualifications: College or University degree	0.2	0.5	1.1	-0.2	-0.8	-0.9	-1.0	-0.6	0.5	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	0.3	0.4	0.4	0.5	-0.1	1.0	0.4
Leg fat mass (right)	0.2	0.8	1.5	-0.7	-1.1	-1.2	-0.4	-0.9	-1.1	-0.8
Suffer from ‘nerves’	0.2	0.2	0.7	-0.1	-0.5	0.5	-0.8	0.1	0.4	-0.5
Chest pain or discomfort	0.2	0.3	0.7	-0.6	-0.6	-0.4	-0.2	-0.2	-0.8	-0.5
Smoking status: Previous	0.2	0.3	0.6	-0.7	0.3	0.8	-0.3	-0.4	-0.2	-0.8
Osteoarthritis (self-reported)	0.2	0.3	1.5	-0.0	-0.2	-1.2	-0.4	-0.2	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.4	0.6	0.8	0.7	0.7	0.9	0.6
Leg fat percentage (left)	0.2	0.6	1.4	-0.7	-0.2	-1.2	-0.2	-0.8	-1.0	-0.5
Risk taking	0.2	0.3	0.7	0.6	-0.9	-0.9	-0.4	0.3	-0.6	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.5	0.2	-0.5	-0.3	0.1	0.3	-1.2	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.6	-0.3	0.6	0.4	-0.6	-0.1	-0.5
Schizophrenia (2018)	0.1	0.2	0.7	-0.2	-0.8	0.8	0.3	0.3	-0.2	-0.1
Major Depression (MDD)	0.1	0.1	0.7	0.2	0.0	-0.1	0.8	0.2	-0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	-0.2	0.7	0.4	1.0	-0.2	0.4	0.3
Prostate Cancer	0.1	0.1	0.4	0.2	0.0	0.4	0.0	-0.1	0.7	0.1
Mean Putamen Volume	0.1	0.1	0.3	0.3	-0.2	0.5	0.6	0.4	-0.1	0.0
Schizophrenia (2014)	0.1	0.1	0.8	0.2	-0.9	0.3	0.0	-0.2	-0.2	0.1
Waist Hip Ratio (WHR)	0.1	0.6	1.6	-0.3	1.0	-1.3	0.8	-0.8	-0.3	0.5
Systolic Blood Pressure	0.1	0.5	1.8	-0.5	-0.5	-1.4	-0.4	-0.6	-0.5	-0.4
Respiratory disease	0.1	0.3	1.1	0.0	-0.5	-0.6	0.1	-0.7	1.0	0.3
Neuroticism	0.1	0.3	0.8	-0.4	-0.4	-0.9	-0.3	-0.3	0.3	-0.6
Hair Pigment	0.1	3.0	6.1	-2.5	0.7	2.0	0.3	-2.4	1.6	-1.4
Number of treatments/medications taken	0.1	0.1	0.3	0.4	-0.0	-0.3	0.5	0.2	0.2	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.0	0.4	0.6	0.5	-0.1	-0.5	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.6	-0.2	0.5	0.2	0.3	-0.3	0.8	0.2
Number of incorrect matches in round	0.1	0.2	0.5	-0.1	-0.7	0.5	-0.5	0.1	-0.3	-0.3
Past tobacco smoking	0.1	0.1	0.3	0.3	-0.1	-0.5	-0.0	0.2	0.2	0.5
Nervous feelings	0.1	0.2	0.5	0.7	-0.1	0.7	-0.1	0.3	0.1	-0.1
Had menopause	0.1	0.2	0.5	0.0	0.3	0.7	0.2	0.4	0.6	0.2
Allergy	0.1	0.2	0.7	-0.0	0.8	0.4	0.4	0.4	0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	0.5	0.2	0.6	0.6	0.8	0.9	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	0.2	-1.0	0.3	-1.0	0.2	-0.3	0.1
Asthma	0.1	0.1	0.6	-0.3	-0.4	-0.3	-0.0	-0.7	0.3	0.0
Blood clot in the leg (DVT)	0.1	0.2	0.8	0.2	-0.5	-0.1	0.4	0.3	-0.9	-0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	1.7	-0.2	0.5	0.9	1.3	-0.2	0.7	0.1
Body fat percentage	0.1	0.6	1.4	-0.3	-0.9	-1.2	-0.8	-0.4	-0.9	-0.4
Leg fat percentage (right)	0.1	0.4	1.1	-1.1	0.4	-0.7	0.2	-1.0	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	0.1	-0.9	0.2	0.3	-0.4	-0.5	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.6	0.1	-0.0	-0.4	-0.4	-0.2	0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.2	-0.1	0.0	0.2	-0.3	0.6	-0.1
Knee pain experienced in last month	0.1	0.2	0.7	0.0	-0.3	-0.8	0.2	0.6	-0.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.3	-0.4	-0.1	0.5	-0.3	-0.2	-0.4
Mother’s age at death	0.1	0.1	0.8	-0.2	0.9	0.1	-0.1	-0.4	0.1	-0.2
Ever smoked	0.1	0.1	0.5	0.2	-0.5	-0.3	-0.2	0.2	-0.7	-0.4
Average weekly beer plus cider intake	0.1	0.2	0.7	-0.3	0.3	0.1	-0.5	0.3	0.9	0.2
Blood Platelet Count	0.0	0.5	1.3	-1.0	0.1	-0.2	0.8	-1.1	0.1	-0.7
Lung FVC	0.0	0.1	0.3	0.4	-0.1	-0.4	-0.3	0.6	0.4	0.0
Tanning	0.0	0.1	0.6	0.3	-0.2	0.1	-0.7	0.3	-0.2	-0.2
Hand grip strength (left)	0.0	0.1	0.4	0.3	0.6	-0.0	0.2	0.3	-0.0	0.3
Forced vital capacity (FVC)	0.0	0.2	0.4	0.2	-0.2	0.4	0.6	0.5	0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	-0.1	-0.2	0.0	-0.3	-0.4	-0.0
Mouth/teeth dental problems: Dentures	0.0	0.0	0.2	0.1	-0.1	-0.2	-0.1	0.1	0.4	0.2
Asthma (self-reported)	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.1	-0.5	0.3	0.2

Hub : Genes

CCR1

Models

Trait associations