TWAS
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Genes
Traits
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Traits
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Impedance of leg (left)
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chr3:84,317,575-86,808,226
Best TWAS P=1.36e-11 · Best GWAS P=1.69e-13 conditioned to 2.96e-05
84.5M
85M
85.5M
86M
86.5M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
CADM2
0.05
0.03
lasso
3
0.04
5.0e-05
-6.6
-6.8
1.4e-11
0.59
0.30
0.68
TRUE
1
METSIM
Adipose
CADM2
0.05
0.06
lasso
10
0.06
1.3e-09
-6.2
-6.6
4.9e-11
0.76
0.82
0.18
FALSE
2
The Cancer Genome Atlas
Lung Adenocarcinoma
CADM2
0.08
0.04
lasso
4
0.05
2.1e-06
-6.6
-6.5
6.8e-11
0.50
0.54
0.45
FALSE