Best TWAS P=1.37e-10 · Best GWAS P=2.08e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | DNAJB14 | 0.24 | 0.18 | lasso | 4 | 0.14 | 1.4e-05 | -5.6 | -5.4 | 8.2e-08 | 0.97 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Artery Aorta | DNAJB14 | 0.24 | 0.01 | lasso | 13 | 0.09 | 8.1e-06 | -3.4 | -5.6 | 1.8e-08 | 0.82 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Artery Tibial | DNAJB14 | 0.11 | 0.01 | enet | 15 | 0.05 | 1.2e-04 | -5.4 | -5.8 | 8.6e-09 | 0.75 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | DNAJB14 | 0.22 | 0.11 | lasso | 11 | 0.15 | 2.0e-11 | -3.4 | -5.3 | 1.2e-07 | 0.67 | 0.74 | 0.23 | FALSE |
| 5 | GTEx | Whole Blood | DAPP1 | 0.06 | 0.03 | enet | 15 | 0.01 | 1.8e-02 | 3.1 | 6.4 | 1.4e-10 | -0.27 | 0.18 | 0.43 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DNAJB14 | 0.03 | 0.01 | lasso | 4 | 0.01 | 1.8e-03 | -5.6 | -5.6 | 2.3e-08 | 0.93 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DAPP1 | 0.04 | 0.01 | enet | 14 | 0.02 | 1.3e-03 | -3.2 | 5.4 | 6.8e-08 | -0.51 | 0.02 | 0.32 | FALSE |