TWAS hub - DAPP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0820	0.0340	6.3e-04	0.035	NA	0.050	NA	0.045	0.00065	NA	5.7e-05	NA	1.4e-04
2	GTEx	Whole Blood	0.0550	0.0220	2.3e-03	0.029	NA	0.014	NA	0.012	0.00098	NA	1.8e-02	NA	2.6e-02
3	NTR	Blood	0.0312	0.0119	6.8e-05	0.005	0.012	0.015	0.012	0.009	0.00650	8.5e-05	6.4e-06	4.7e-05	3.7e-04
4	YFS	Blood	0.0371	0.0113	5.5e-08	0.013	0.021	0.023	NA	0.024	0.00004	1.5e-07	2.8e-08	NA	1.9e-08
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0588	0.0315	1.8e-03	0.013	0.029	0.020	NA	0.014	0.01200	2.9e-04	2.4e-03	NA	9.8e-03
6	TCGA	Brain Lower Grade Glioma	0.0433	0.0231	3.2e-03	0.009	0.017	0.022	NA	0.011	0.03100	3.9e-03	1.3e-03	NA	1.8e-02
7	TCGA	Prostate Adenocarcinoma	0.0963	0.0499	3.7e-03	0.042	0.029	0.037	NA	0.034	0.00003	5.1e-04	8.1e-05	NA	1.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hypothyroidism (self reported)	4.0	9.1	17.2	2.9	4.0	4.2	3.4	2.0	2.6	-0.2
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	13.5	2.2	3.7	3.3	3.2	2.1	2.2	-0.7
Average weekly spirits intake	3.4	4.3	16.7	-1.7	-4.1	-0.3	-1.4	-2.3	-1.7	-0.6
Bipolar Disorder (2011)	3.2	3.1	5.1	1.2	2.1	1.7	2.2	1.8	2.2	0.5
Impedance of leg (left)	3.2	15.5	41.2	3.4	6.4	0.1	2.8	3.7	5.4	2.4
Medication: Levothyroxine sodium	3.1	5.2	9.0	2.2	2.7	2.7	3.0	1.8	2.2	0.2
Medication: Gliclazide	2.9	3.2	9.0	-1.7	-1.0	-1.3	-2.7	0.5	-3.0	0.6
Impedance of leg (right)	2.8	13.3	34.8	2.8	5.9	-0.4	2.3	3.5	5.0	2.7
Lupus	2.7	4.1	17.0	-0.3	-0.7	0.5	2.2	-2.3	-0.8	-4.1
Bilateral oophorectomy (both ovaries removed)	2.6	2.9	6.7	2.4	0.5	2.6	1.7	1.2	1.2	1.3
Exposure to tobacco smoke outside home	2.4	3.2	5.0	1.6	1.6	2.2	1.6	2.2	2.2	0.6
Pain all over the body in last month	2.3	2.4	4.1	2.0	1.7	1.9	2.0	-0.1	1.6	-0.6
Ever had bowel cancer screening	2.1	2.5	8.6	1.3	0.6	2.9	1.1	1.0	2.0	0.6
Current tobacco smoking	2.0	3.3	9.1	-1.2	-1.9	-1.7	-0.8	-3.0	-1.9	-1.4
Medication: Lansoprazole	2.0	2.2	6.2	-2.5	-2.0	-0.9	-1.8	-0.9	-0.8	-0.2
Smoking status: Current	2.0	3.2	8.8	-0.9	-2.3	-1.7	-0.9	-3.0	-1.7	-1.1
Ever had prostate specific antigen (PSA) test	2.0	2.4	5.5	-2.3	-0.9	-0.9	-2.1	-1.0	-1.9	-0.4
Alzheimer’s Disease (in father)	1.9	2.1	4.7	-1.4	-1.8	-1.6	-1.1	-0.7	-2.2	0.4
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.8	1.5	0.8	2.2	2.1	0.6	1.6	-1.3
Hand grip strength (right)	1.8	4.8	17.4	2.5	1.8	4.2	1.2	2.1	1.0	0.6
Medication: Allopurinol	1.8	2.4	5.0	-2.2	-1.9	0.7	-2.0	-1.8	-0.4	-0.4
Guilty feelings	1.8	2.7	10.9	-0.7	-3.3	-1.0	-0.5	-1.4	-1.9	-0.6
Blood Platelet Count	1.7	19.6	28.0	4.6	4.7	5.0	5.3	4.7	4.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.9	1.6	-0.5	1.3	1.9	-1.7	0.2	-2.2
Medication for cholesterol	1.7	2.6	5.1	-1.5	-1.2	-2.1	-2.3	-1.4	-1.6	-0.4
Mineral and other dietary supplements	1.7	2.3	7.0	-0.8	-0.8	-1.0	-0.6	-2.6	-1.5	-2.1
Supplements: Fish oil (including cod liver oil)	1.7	2.2	6.6	1.0	1.3	0.8	0.0	2.6	0.9	2.1
Primary Biliary Cirrhosis	1.6	2.3	6.1	1.4	0.7	0.8	2.1	-0.3	-1.5	-2.5
Respiratory disease	1.6	3.5	8.0	1.8	1.0	1.7	2.8	1.7	2.3	0.7
Severe depression (siblings)	1.6	1.7	3.3	-0.6	-0.1	0.8	1.8	-1.6	1.7	-1.5
Qualifications: CSEs or equivalent	1.6	2.1	3.6	-1.0	-1.8	-1.9	-1.0	-1.1	-1.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	5.0	0.5	-0.1	-2.2	0.1	-2.1	-0.0	-1.9
Bipolar Disorder (2018)	1.5	2.3	4.7	1.8	1.7	1.1	1.7	2.2	0.4	1.0
Mean Putamen Volume	1.5	1.7	2.8	-1.4	0.2	-1.4	-0.5	-1.7	-1.6	-1.6
Leg fat-free mass (left)	1.5	7.9	15.5	-1.8	-3.4	-0.0	-2.1	-3.7	-3.9	-2.7
Leg predicted mass (left)	1.5	8.0	15.5	-1.8	-3.4	-0.0	-2.1	-3.8	-3.9	-2.7
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	4.7	-1.8	-2.2	-0.2	-1.8	-1.6	0.1	-0.2
Exposure to tobacco smoke at home	1.5	1.7	3.6	1.9	1.3	0.2	1.8	-0.4	1.6	-0.8
Leg fat-free mass (right)	1.5	8.2	16.0	-1.8	-3.3	0.3	-2.0	-3.8	-4.0	-3.0
Commuting to job workplace: Public transport	1.5	1.8	4.5	0.7	1.3	0.4	-0.8	1.9	2.1	1.3
Medication: Bendroflumethiazide	1.5	2.3	4.7	2.0	1.7	0.8	1.0	1.5	2.2	1.0
Fractured/broken bones in last 5 years	1.5	1.9	4.5	1.5	1.0	1.0	2.1	-1.1	0.9	-1.7
Crohns Disease (2017)	1.4	3.0	5.8	-0.6	-1.3	-2.0	-0.2	-2.4	-2.3	-1.9
Birth weight	1.4	3.0	5.6	2.4	1.9	2.1	1.1	1.2	2.0	0.5
Health satisfaction	1.4	1.9	7.2	-0.2	-1.5	0.2	0.7	-2.7	-1.0	-1.4
Knee pain experienced in last month	1.4	2.1	4.1	-1.8	-2.0	-1.8	-1.1	-1.1	-1.3	-0.3
Leg predicted mass (right)	1.4	7.7	14.8	-1.7	-3.2	0.4	-1.9	-3.7	-3.9	-2.9
Medication: Blood pressure	1.4	2.6	7.8	1.2	1.4	2.0	2.8	0.2	1.4	-1.1
Impedance of whole body	1.4	7.2	20.9	1.3	4.6	0.1	1.4	1.8	4.4	1.8
Bipolar Disorder or Schizophrenia	1.3	3.1	6.6	2.5	2.6	1.1	1.6	2.3	-0.1	0.1
Medication: Cholesterol lowering	1.3	2.0	8.0	-0.5	-2.8	-0.1	1.0	-0.4	-1.7	-1.3
Migraine (self-reported)	1.3	1.7	6.0	-0.6	-2.0	-0.7	-0.1	-2.5	-0.9	-0.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	6.0	-0.8	-0.8	-0.9	-0.9	-1.2	-2.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.6	-1.4	-1.6	1.0	-0.9	-0.5	-1.6	-1.4
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.9	-0.0	0.9	2.0	1.0	1.7	1.1	1.1
Commuting to job workplace: Cycle	1.3	1.6	5.2	0.3	0.9	0.2	-0.2	0.9	2.3	2.1
Depression (Nagel 2018)	1.2	1.7	4.0	2.0	-0.1	2.0	1.8	-0.6	0.4	-0.8
Lung FEV1/FVC ratio	1.2	5.9	9.6	-2.3	-1.9	-2.5	-2.2	-2.0	-2.8	-3.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.9	0.6	0.7	1.5	1.6	1.0	1.7	1.1
Angina	1.2	1.6	4.1	1.2	0.2	0.3	2.0	-1.2	0.4	-2.0
Relative age voice broke	1.2	1.8	4.5	-1.0	-2.1	-1.5	-1.7	-0.2	-0.6	1.1
Stomach or abdominal pain in last month	1.2	1.5	3.3	-1.2	-1.8	1.3	-0.8	-0.4	-1.1	1.3
Medication: Atenolol	1.2	1.5	3.7	0.3	-0.3	1.9	1.7	1.2	0.8	1.3
Gout (self-reported)	1.2	1.7	3.4	-1.9	-1.2	1.2	-1.6	-1.3	-0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	1.5	1.6	0.4	1.6	1.2	1.5	-0.1
Wheeze or whistling in the chest in last year	1.2	2.1	5.9	1.3	0.3	2.4	2.3	-0.1	1.2	-0.6
Shortness of breath walking on level ground	1.2	1.4	5.6	0.3	0.3	0.2	2.4	-0.9	-0.6	-1.8
Neck or shoulder pain in last month	1.2	1.7	6.2	0.8	-0.3	1.4	-0.5	1.6	-0.0	2.5
Comparative height size at age 10	1.2	6.8	15.3	-2.8	-2.0	-1.0	-2.1	-3.9	-2.9	-2.6
Asthma (self-reported)	1.2	2.4	5.5	1.0	0.8	2.3	2.0	1.3	1.9	0.8
Average weekly champagne plus white wine intake	1.2	1.7	4.1	-1.1	-1.1	-1.4	-2.0	0.1	-1.0	1.6
Ever taken oral contraceptive pill	1.2	1.4	4.0	-2.0	-1.5	-1.3	-0.8	-0.8	-0.4	-0.7
Ever smoked	1.2	2.1	3.9	-1.9	-1.3	-1.6	-0.3	-2.0	-1.4	-1.0
Irritability	1.2	2.1	3.7	1.5	1.5	1.3	1.6	1.9	0.7	1.3
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.7	-0.5	-1.6	-1.6	0.0	-1.3	-1.1	-0.4
Ever had hysterectomy (womb removed)	1.1	1.3	3.5	-1.0	-1.1	1.0	-0.4	0.1	1.5	1.9
Fed-up feelings	1.1	2.0	6.8	1.4	0.9	2.6	1.5	0.5	1.3	-0.3
Taking other prescription medications	1.1	1.7	4.5	0.7	1.0	1.5	2.1	0.3	1.5	-1.1
Asthma	1.1	2.2	5.6	0.8	0.8	2.4	1.9	1.1	1.8	0.7
Pulse wave reflection index	1.1	1.4	3.2	-1.8	-0.8	-1.4	-1.2	-0.3	-1.5	0.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.1	1.2	1.8	1.5	1.7	0.5	0.6	0.3
Angina (self-reported)	1.1	1.4	3.6	0.9	-0.0	0.2	1.8	-1.4	0.2	-1.9
Alcohol intake frequency.	1.1	2.5	8.5	-2.5	-0.7	2.9	-1.5	-0.0	-0.7	0.0
Medication: Aspirin	1.1	1.4	4.1	1.3	0.5	2.0	1.3	1.3	0.2	-0.7
Whole body fat-free mass	1.1	6.1	14.4	-1.0	-2.5	0.1	-1.4	-3.1	-3.8	-3.0
Long-standing illness, disability or infirmity	1.1	1.7	5.0	0.8	0.5	1.0	2.2	0.4	2.1	0.2
Illnesses of father: None of the above (group 1)	1.1	1.4	4.5	1.4	1.3	0.9	0.0	2.1	0.6	0.3
Whole body water mass	1.1	6.0	13.8	-1.0	-2.6	0.2	-1.5	-3.1	-3.7	-3.0
Number of self-reported non-cancer illnesses	1.1	1.9	5.0	0.7	-0.1	2.2	2.0	0.1	0.7	-1.7
Basal metabolic rate	1.1	5.9	13.4	-0.9	-2.5	-0.0	-1.4	-3.2	-3.7	-2.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.1	1.1	-0.9	1.3	1.2	-1.4	1.1	-1.0
Medication: Metformin	1.0	1.5	6.7	-0.6	-0.5	0.1	-0.9	0.9	-2.6	-1.3
Chronic bronchitis/emphysema (father)	1.0	1.2	4.1	0.2	-0.6	-1.0	-0.0	-2.0	-0.9	-1.5
Past tobacco smoking	1.0	1.8	4.7	1.3	1.5	1.4	0.5	2.2	1.0	0.5
Medication: Ramipril	1.0	1.3	4.4	-1.3	-0.3	-0.4	-1.4	-0.7	-2.1	-0.5
Number of live births	1.0	1.5	4.5	0.1	-1.1	-2.1	0.6	-1.5	-0.1	-1.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	5.1	1.5	2.3	1.0	0.4	0.4	1.3	0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.1	-1.2	-1.5	-0.8	-0.6	-0.7	-1.8	0.0
Average weekly beer plus cider intake	1.0	1.4	4.3	2.1	1.0	0.7	2.0	-0.3	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	-0.9	-1.1	-1.4	-0.6	-1.0	-1.2	-1.5
Smoking Status	0.9	2.3	5.9	-1.1	-1.7	-1.4	-0.8	-2.4	-1.5	-0.7
Maternal smoking around birth	0.9	1.3	3.4	-1.8	-0.7	-1.3	-1.3	-0.8	-1.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.5	1.0	0.0	1.1	0.6	1.5	0.7	1.6
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	10.0	-0.8	-1.1	-0.0	-1.7	-2.1	-1.0	-3.2
Medication: Blood pressure	0.9	1.6	3.4	-1.8	-1.5	-0.7	-1.7	-1.0	-1.0	-0.4
Osteoporosis (self-reported)	0.9	1.1	3.7	-0.8	-1.9	0.9	-0.4	-1.2	-0.5	0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.3	-0.4	0.2	-0.9	0.5	-1.6	-0.4	-2.1
HbA1C	0.8	0.9	3.1	-0.8	1.0	1.0	-0.2	0.5	-0.3	1.8
Schizophrenia (2014)	0.8	1.7	3.6	1.8	1.9	1.0	1.7	1.0	-0.0	-0.5
Ulcerative Colitis	0.8	1.2	3.2	0.6	1.1	-1.8	0.5	1.8	0.4	0.6
Number of treatments/medications taken	0.8	1.4	4.1	1.3	0.1	2.0	1.4	0.7	1.1	-0.4
Diabetes (mother)	0.8	1.0	2.4	-0.4	-0.6	-1.4	-0.7	-1.5	-1.3	0.2
Alcohol usually taken with meals	0.8	1.3	4.6	-2.1	-0.8	-1.0	-1.1	0.7	-1.0	-0.0
Heart attack	0.8	1.0	2.9	0.3	-0.6	1.7	1.2	-0.5	-0.7	-1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.1	0.3	1.4	1.0	0.8	-0.6	-1.4	-1.0
Weight	0.8	4.1	9.2	-0.5	-2.0	-0.2	-0.9	-2.8	-3.0	-2.6
Trunk fat-free mass	0.8	4.7	12.2	-0.7	-1.9	0.2	-1.2	-2.6	-3.5	-2.9
Prospective memory result	0.8	1.0	3.3	0.4	-0.6	-0.1	1.8	-0.6	0.7	-1.5
Pulse wave Arterial Stiffness index	0.8	0.9	3.8	-0.0	0.3	1.1	2.0	-0.7	0.2	-0.9
Trunk predicted mass	0.8	4.6	12.2	-0.7	-1.9	0.1	-1.2	-2.6	-3.5	-2.8
Tense / ‘highly strung’	0.8	1.3	3.7	-1.2	-1.9	0.3	-1.2	-0.3	-1.4	0.7
Comparative body size at age 10	0.8	2.3	6.7	-1.1	-2.6	-1.0	-1.8	-1.6	-1.2	-0.5
Medication: Ibuprofen	0.8	1.0	2.7	-1.2	-1.6	0.6	-1.0	-1.0	0.8	-0.1
Age at last live birth	0.8	1.1	3.8	-1.0	0.0	-1.9	-0.7	-0.9	-1.1	-0.8
Qualifications: nursing, teaching	0.8	1.3	3.6	0.1	-1.4	0.2	-1.6	0.5	-0.9	1.9
Breast cancer (self-reported)	0.8	1.0	2.6	0.9	-0.1	1.3	0.7	1.1	-0.6	1.6
Arm fat mass (left)	0.8	3.2	6.7	-0.3	-2.4	-0.4	-0.6	-2.4	-2.6	-1.9
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.2	0.2	0.4	0.4	1.4	0.7	1.3	1.5
Basal cell carcinoma (self-reported)	0.8	1.0	3.5	0.4	1.4	1.9	0.7	-0.0	0.5	-0.7
Systolic Blood Pressure	0.7	3.5	8.0	1.5	2.8	1.3	1.1	2.4	2.2	-0.9
Medication for hormone replacement therapy	0.7	0.7	1.9	0.8	0.8	0.3	1.1	1.4	0.6	0.7
Medication: Co-codamol	0.7	0.8	1.4	-0.7	-1.2	0.3	-0.8	-0.7	-1.1	1.0
Body mass index (BMI)	0.7	2.8	8.0	0.0	-2.6	-0.6	-0.5	-1.4	-2.8	-1.5
Pulse rate	0.7	1.2	3.6	1.9	0.4	0.4	1.7	-0.0	0.7	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	0.3	0.3	1.5	0.7	-0.0	1.6	-0.5
Lung cancer (father)	0.7	0.8	2.6	0.5	0.3	-1.6	1.2	-0.8	0.2	-0.8
Length of working week for main job	0.7	0.7	1.9	0.3	0.6	1.0	0.5	1.4	0.6	1.1
High blood pressure (siblings)	0.7	1.0	3.3	0.0	-1.8	1.1	1.1	-0.9	-0.4	0.1
Number of children fathered	0.7	0.8	2.0	-0.8	-1.3	-0.2	-0.6	0.2	-1.0	-1.4
Pulse wave peak to peak time	0.7	0.8	4.1	0.0	-0.0	-1.0	-2.0	0.6	-0.3	0.7
Pulse rate, automated reading	0.7	2.4	8.9	3.0	1.7	0.8	2.1	0.0	0.1	-0.2
Family relationship satisfaction	0.7	0.9	2.5	-1.4	-0.3	-0.6	-1.6	-0.2	-1.0	0.6
Supplements: Vitamin C	0.7	0.8	2.2	0.6	0.2	-1.5	-1.1	1.0	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.7	-0.5	0.8	-1.3	-1.6	-1.6	-0.9	-0.9
Medication: Aspirin	0.7	0.9	3.6	0.8	-0.0	1.9	0.8	1.0	0.2	-0.5
Arm fat-free mass (left)	0.7	3.3	9.7	0.2	-1.5	0.1	-0.5	-2.1	-3.1	-2.5
Risk taking	0.7	1.0	3.3	-1.8	-0.5	-1.0	-0.8	0.1	-1.4	0.1
Age started oral contraceptive pill	0.7	0.8	1.6	-0.2	-0.1	1.1	0.7	1.3	1.2	0.9
Ever depressed for a whole week	0.7	0.8	1.9	-1.4	0.5	-1.0	-0.7	1.0	0.5	0.8
Unable to work because of sickness or disability	0.7	0.8	3.5	0.1	-0.2	0.0	-0.5	-1.9	0.1	-1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.6	0.4	-0.3	1.9	1.2	-0.1	-0.5	-1.0
Arm predicted mass (left)	0.7	3.4	8.5	0.0	-1.6	0.1	-0.4	-2.3	-2.9	-2.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.2	0.6	1.6	2.0	0.4	-1.0	2.1	-0.8
Schizophrenia (2018)	0.6	1.3	3.7	1.7	1.9	0.7	0.7	1.2	-0.4	-0.6
Irritable Bowel Disease (IBD)	0.6	1.5	6.4	-0.7	-0.3	-2.5	0.3	-0.8	-1.1	-1.2
Body Mass Index (BMI) (2010)	0.6	0.8	4.0	1.0	-0.0	-2.0	0.5	-0.1	-0.5	0.4
Coronary Artery Disease (CAD)	0.6	0.7	3.0	0.1	0.5	-1.7	-0.4	-1.2	-0.3	-0.2
LDL Cholesterol	0.6	1.0	2.3	-0.2	-0.1	-0.5	1.5	-1.1	0.7	-1.5
Systolic blood pressure, automated reading	0.6	1.8	5.2	1.0	1.8	0.1	0.3	2.3	1.7	-0.3
Supplements: Zinc	0.6	0.6	2.1	-1.4	-0.3	-0.7	-0.9	-0.6	-0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	-1.4	-1.2	-0.2	-0.4	-0.7	-0.4	0.2
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.6	0.6	1.1	0.5	1.0	0.5	1.4
Nervous feelings	0.6	1.2	4.7	-1.0	0.1	-2.2	-0.9	-0.6	-1.2	0.4
Depression (self-reported)	0.6	0.8	2.0	-0.5	-0.7	-0.7	-1.4	-1.3	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.9	-0.9	-1.0	-0.4	-1.9	-1.5	-0.9	-2.2
Arm fat mass (right)	0.6	2.7	5.5	-0.3	-2.4	-0.3	-0.5	-2.3	-2.2	-1.7
Hair/balding pattern: Pattern 4	0.6	1.4	2.8	-1.2	-0.6	-1.2	-1.6	-0.7	-1.7	-0.7
Peak expiratory flow (PEF)	0.6	1.4	4.6	-0.4	-0.8	0.2	-0.5	-1.9	-0.8	-2.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	0.3	1.3	0.4	0.2	1.3	0.9	0.8
Blood clot in the leg (DVT)	0.6	0.8	3.3	-0.1	-0.6	0.1	0.8	-0.4	-1.1	-1.8
Arm fat-free mass (right)	0.6	3.1	7.9	0.6	-1.5	0.2	-0.3	-2.0	-2.8	-2.7
Emphysema/chronic bronchitis	0.6	0.7	1.5	-0.4	-0.4	-1.2	-0.6	1.0	-0.9	1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	3.2	-0.0	1.8	-1.8	-0.1	0.6	-0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.4	-0.1	-0.3	-0.2	1.4	0.3	-0.7	-1.6
Arm predicted mass (right)	0.6	3.2	8.4	0.1	-1.4	0.2	-0.5	-2.0	-2.9	-2.7
Illnesses of father: Heart disease	0.6	0.9	3.5	0.4	-0.5	0.2	1.9	-0.1	1.5	-0.1
Loneliness, isolation	0.6	0.8	2.8	0.1	-0.3	1.0	0.5	-1.0	-0.5	-1.7
Wears glasses or contact lenses	0.6	0.7	1.6	0.1	0.6	0.9	1.0	-0.9	1.3	-0.6
Medication: Lisinopril	0.6	0.8	2.3	0.2	0.5	1.5	1.1	1.3	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.2	0.0	-0.4	0.4	1.1	-0.5	-0.6	-1.8
Depressed Affect (Nagel 2018)	0.5	1.0	5.8	0.5	-0.1	2.4	0.9	0.4	0.4	-0.3
Ulcerative Colitis (UC)	0.5	0.9	5.3	-0.5	0.5	-2.3	0.7	0.6	0.1	-0.1
Fasting Glucose	0.5	0.6	1.6	0.0	0.6	0.3	-1.3	0.2	-1.2	0.8
HDL Cholesterol	0.5	0.8	1.6	0.7	1.3	0.6	-0.4	0.9	1.0	1.1
Blood Eosinophil Count	0.5	3.7	7.1	-2.0	-0.2	-2.7	-1.8	-2.6	-2.1	-0.4
BMI	0.5	3.0	9.9	0.1	-2.3	-0.8	-0.3	-1.0	-3.1	-2.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.0	0.0	-0.8	-0.1	0.4	-0.3	-1.1	-1.4
Average weekly fortified wine intake	0.5	0.6	1.5	0.3	0.4	0.8	-0.5	1.1	1.2	0.5
Age when periods started (menarche)	0.5	1.1	3.6	0.7	1.9	0.8	0.7	1.5	0.6	0.4
Supplements: Glucosamine	0.5	0.7	2.9	-0.3	1.0	-0.2	-0.3	1.7	0.1	0.7
High blood pressure (mother)	0.5	0.7	1.6	-1.2	-1.0	0.1	-0.7	-0.5	-1.2	-0.7
Waist circumference	0.5	1.8	3.3	1.2	-1.2	-0.5	0.9	-1.7	-1.5	-1.8
Had menopause	0.5	0.7	2.6	-0.6	-1.6	-0.8	0.3	-0.8	-0.6	0.2
Had other major operations	0.5	0.6	2.5	-0.1	-0.4	1.1	-0.3	0.2	-0.6	1.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.9	-1.4	0.4	1.0	-0.4	0.7	0.9	0.2
Diabetes (self-reported)	0.5	0.8	2.8	0.5	-0.8	-0.3	0.3	0.3	-1.7	-1.2
Fluid intelligence score	0.5	1.1	4.1	-1.2	0.6	-0.4	-2.0	0.6	-0.3	1.2
Impedance of arm (right)	0.5	2.3	8.2	-0.8	2.2	-0.2	-0.4	0.3	2.9	1.5
Arm fat percentage (right)	0.5	1.8	5.4	-0.4	-2.3	-0.3	-0.5	-1.7	-1.8	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	2.1	-1.4	0.6	0.7	-0.8	-0.6	-1.1	0.0
Impedance of arm (left)	0.5	2.3	8.2	-0.5	2.3	0.2	-0.4	0.1	2.9	1.5
Worry too long after embarrassment	0.5	0.8	1.8	0.5	0.0	0.0	1.2	-1.3	1.3	-0.7
Age at first live birth	0.5	0.9	4.7	0.7	2.2	-0.6	-0.4	-0.2	-0.5	-0.7
Eye problems/disorders: None of the above	0.5	0.5	1.3	0.0	0.8	1.0	0.7	0.5	1.1	0.2
Whole body fat mass	0.5	2.2	4.3	-0.1	-1.8	-0.5	-0.4	-2.0	-2.1	-2.0
Overall health rating	0.5	1.0	2.2	0.1	-0.9	1.0	1.2	-0.7	-1.0	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	0.3	-0.8	0.7	0.2	-1.3	-0.3	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.7	-0.6	-0.5	-1.1	1.2	-0.1	0.8
Diabetes diagnosed by doctor	0.5	0.7	2.9	0.3	-0.8	0.1	0.2	1.1	-1.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	1.2	-0.6	-0.2	0.9	-0.3	0.6	0.5
Financial situation satisfaction	0.5	0.6	1.8	-0.8	1.3	-0.2	0.3	-0.4	-0.2	-1.3
Illnesses of father: High blood pressure	0.5	0.7	2.4	-0.6	-1.5	-0.1	-0.9	-0.3	-0.3	1.1
Myopia	0.5	0.7	1.4	-0.3	0.5	1.0	0.2	-0.6	-1.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-0.9	-0.7	-0.4	-0.9	0.5	-1.1	0.5
Supplements: Calcium	0.5	0.5	2.1	-0.2	-0.4	1.4	0.3	-0.6	0.5	0.8
Schizophrenia vs Biploar Disorder	0.4	0.6	1.7	0.3	1.3	0.4	0.3	1.2	0.2	0.5
Alzheimer’s Disease (in mother)	0.4	0.5	2.8	0.2	0.4	-0.2	0.3	0.1	0.6	-1.7
Reaction Time	0.4	0.8	1.8	0.9	0.3	-1.3	0.3	-1.0	1.0	0.9
Blood White Count	0.4	3.1	6.6	2.5	1.5	1.9	2.6	0.3	1.4	-1.0
Lung FVC	0.4	2.0	7.4	-0.4	-2.7	1.4	-0.1	-0.6	0.5	-2.0
Chronotype (morning person)	0.4	0.9	2.2	-0.4	1.0	0.7	-0.5	1.5	1.4	0.7
Hearing difficulty/problems: Yes	0.4	0.5	1.5	0.3	0.8	-0.1	1.1	-1.2	-0.1	-0.5
Relative age of first facial hair	0.4	0.7	2.2	-1.5	-1.0	0.8	-0.6	0.2	-0.5	0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.5	-1.0	-0.0	-0.9	1.2	-0.1	0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.2	-1.1	0.8	0.1	0.3	1.5	0.4	1.1
Multivitamins +/- minerals	0.4	0.5	1.5	0.5	0.2	0.9	0.7	-1.2	0.8	-0.3
Trunk fat mass	0.4	1.8	3.8	-0.2	-1.3	-0.4	-0.5	-2.0	-1.8	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	0.2	-0.3	1.6	-0.1	0.1	0.7	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.2	-0.4	0.9	-0.6	0.4	1.8	0.7	0.8
Medication: Simvastatin	0.4	0.6	3.4	-0.7	-1.8	-0.2	-0.1	0.2	-0.5	0.5
Illnesses of siblings	0.4	0.5	1.5	0.2	1.2	-0.1	-0.3	1.0	0.2	-1.1
Father’s age at death	0.4	0.6	1.9	-0.7	-0.4	1.4	-0.8	-0.4	-0.7	0.7
Noisy workplace	0.4	0.4	1.1	0.7	0.8	1.1	0.7	-0.0	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	0.8	-0.5	1.4	1.1	0.7	1.1	0.7
Mouth/teeth dental problems: Dentures	0.4	0.6	2.6	-1.6	0.1	0.0	0.2	0.7	-0.9	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.0	-1.2	-0.4	-1.2	-0.6	-0.8	0.5
Qualifications: College or University degree	0.4	1.4	5.7	0.4	1.3	0.5	0.0	0.7	2.4	1.1
Medication: Omeprazole	0.4	0.4	0.9	-0.6	-0.9	-0.7	-0.9	0.3	-0.7	-0.2
Heart disease (mother)	0.4	0.5	1.6	-0.1	-0.4	0.9	-0.2	0.5	0.6	1.3
Leg fat mass (right)	0.4	1.5	4.6	0.6	-1.4	-0.8	-0.0	-1.2	-2.1	-1.4
Leg pain on walking	0.4	0.5	1.3	0.4	-0.1	1.0	0.8	-0.6	-0.1	-1.2
Arm fat percentage (left)	0.4	1.8	5.1	-0.2	-2.2	-0.2	-0.5	-1.7	-1.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	0.9	-0.2	-0.6	0.6	-0.1	-0.8	1.2
Back pain experienced in last month	0.4	0.6	2.0	-0.3	-1.3	1.4	-0.3	0.3	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.4	-0.3	-1.2	0.7	-0.3	0.0	0.1	-1.9
Mother’s age at death	0.4	0.5	1.3	-0.3	-0.3	0.5	-0.7	-0.7	-0.8	-1.1
High cholesterol (Self-reported)	0.4	0.6	3.8	0.1	-1.9	0.5	0.0	0.2	-0.0	0.6
Alcohol drinker status: Never	0.4	0.4	2.8	-0.2	0.2	1.7	-0.1	0.3	-0.1	-0.4
Diastolic blood pressure, automated reading	0.4	1.1	2.7	1.4	1.6	-0.6	0.8	-0.1	0.4	-1.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	-0.3	-0.3	-1.4	-1.3	-0.5	-0.2	1.6
Cholesterol lowering medication	0.4	0.5	1.9	0.1	-0.8	0.3	0.5	0.4	0.9	1.4
Leg fat mass (left)	0.4	1.5	4.0	0.7	-1.3	-0.6	0.1	-1.2	-2.0	-1.5
Worry (Nagel 2018)	0.3	0.6	1.7	-1.2	-0.2	0.2	-0.2	1.1	-0.2	1.3
Major Depression (MDD)	0.3	0.4	1.3	0.3	-0.2	-0.6	1.0	1.1	0.3	0.5
Prostate Cancer	0.3	0.4	1.4	0.4	-0.0	-1.2	0.3	0.4	0.6	1.0
Crohns Disease (2012)	0.3	0.6	1.1	-0.6	-0.0	-0.8	0.8	-0.9	-1.0	-0.6
Triglycerides	0.3	0.6	2.4	-0.4	-1.5	0.2	0.0	0.0	-1.1	0.3
Blood Red Count	0.3	2.6	6.8	-0.0	-2.6	-1.6	-0.4	-2.5	-1.5	-0.7
Height	0.3	6.3	15.8	-1.6	1.0	0.9	-2.9	-4.0	-2.4	-3.2
Waist Hip Ratio (WHR)	0.3	1.2	5.3	1.6	0.4	-0.4	2.3	-0.3	0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	0.8	-0.6	-0.8	0.9	1.0	-1.0	-0.0
Hand grip strength (left)	0.3	0.7	1.6	0.8	0.7	1.2	-0.6	1.3	-0.9	-0.1
Diabetes (father)	0.3	0.3	1.0	0.0	-0.9	-0.1	1.0	-0.6	0.4	-0.1
High blood pressure	0.3	0.8	2.3	0.3	0.9	1.5	0.8	1.0	0.7	-0.7
Sitting height	0.3	2.0	5.6	-0.2	2.1	1.2	-0.7	-2.4	0.8	-1.3
Forced vital capacity (FVC)	0.3	1.3	5.3	0.0	-0.5	0.9	-1.0	-1.1	-0.5	-2.3
Qualifications: None of the above	0.3	0.7	1.9	-0.6	-1.1	-1.0	-0.2	-0.0	-1.4	-0.7
Mouth/teeth dental problems	0.3	0.4	1.3	0.5	-0.3	-0.7	-1.1	-0.5	0.6	-0.3
Allergy	0.3	0.7	2.3	0.7	-1.1	-0.9	-1.5	0.1	-0.0	0.2
Hip circumference	0.3	1.1	3.4	0.2	-0.8	-0.3	-0.4	-1.0	-1.6	-1.8
Worrier / anxious feelings	0.3	0.5	2.8	-0.9	-1.7	-0.0	-0.4	-0.0	0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.6	0.2	1.2	1.1	0.1	0.1	-0.6
Happiness	0.3	0.3	1.3	-0.1	-0.4	-0.4	0.6	-0.3	-0.5	-1.1
Illnesses of mother	0.3	0.4	0.6	0.6	0.7	0.6	0.4	0.8	0.6	0.3
Standing height	0.3	3.1	10.2	-0.9	1.2	0.5	-1.1	-3.2	-1.0	-2.6
Birth weight of first child	0.3	0.6	1.7	1.2	1.3	0.8	-0.0	0.4	-0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.6	0.7	0.8	0.0	0.9	0.8	0.7
Medication: Paracetamol	0.3	0.5	2.1	0.1	-1.4	0.0	-0.8	-0.6	-0.1	0.3
Headache pain in last month	0.3	0.5	1.4	0.0	-1.0	0.6	-0.5	-0.7	0.3	1.2
Glaucoma (self-reported)	0.3	0.4	0.9	-0.7	-0.9	-0.1	-0.3	-0.7	-0.1	-0.9
Medication: Amlodipine	0.3	0.4	1.9	0.1	-1.4	-0.2	-0.2	0.4	-0.5	0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	-0.3	-0.7	0.5	-1.2	-1.0	-0.5	-1.9
Number of full brothers	0.3	0.4	1.5	1.2	-0.0	-0.1	0.6	-0.7	0.6	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.4	-0.8	0.3	-0.6	-0.7	-0.9	-0.4
Smoking status: Previous	0.3	0.4	1.4	-0.8	-0.2	-1.2	-0.3	-0.5	-0.6	-0.0
Average weekly red wine intake	0.3	0.4	1.1	0.2	-0.8	-0.4	0.3	-0.0	-0.9	-1.0
Hearing aid user	0.3	0.4	1.2	1.1	-0.6	-0.0	0.5	0.2	-0.8	0.4
Number of operations (self-reported)	0.3	0.4	1.0	0.3	-0.8	0.7	0.7	-0.5	-0.4	1.0
Pain experienced in last month	0.3	0.5	2.0	-0.0	1.4	-0.9	-0.5	0.2	-0.1	-0.5
Alcohol drinker status: Previous	0.3	0.3	1.1	-0.5	0.1	1.1	0.4	0.8	-0.0	-0.4
Neuroticism (Nagel 2018)	0.2	0.5	2.1	-0.4	-0.4	1.5	0.2	0.8	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	0.1	1.2	0.9	-0.3	-0.9	0.6	-0.2
Breast Cancer	0.2	0.6	2.7	-0.6	0.3	0.2	0.1	0.9	1.6	0.2
Ovarian Cancer	0.2	0.2	0.8	-0.1	0.2	-0.3	-0.0	0.2	-0.8	-0.9
Age at First Birth	0.2	0.2	1.1	0.2	0.4	-0.2	-0.1	0.1	0.6	-1.1
Rheumatoid Arthritis	0.2	0.3	1.5	-0.4	0.1	0.1	-0.4	-0.0	-1.2	-0.0
Heel T-Score	0.2	1.2	4.8	-1.7	-0.3	-2.2	-0.8	-0.3	-0.0	0.2
Tanning	0.2	2.1	6.0	1.0	2.4	0.0	1.6	2.1	0.7	0.4
Vitamin and mineral supplements	0.2	0.3	1.4	0.3	0.0	0.2	0.4	1.2	-0.7	-0.1
Pack years adult smoking proportion	0.2	0.4	1.3	1.1	0.5	0.1	0.8	0.3	-0.2	-0.2
Trunk fat percentage	0.2	0.6	1.8	0.0	-0.6	-0.4	-0.2	-1.3	-0.7	-1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.4	-1.2	0.8	-0.4	0.4	-0.6	-0.4	-0.0
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.5	0.2	0.5	0.8	-0.7	0.4	0.4
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	0.3	-0.2	-0.3	1.1	0.1	0.6	-0.2
Financial difficulties in last 2 years	0.2	0.3	1.0	-0.7	1.0	-0.4	-0.3	-0.1	0.3	-0.7
Time employed in main current job	0.2	0.2	0.5	0.6	0.3	0.7	0.4	-0.2	-0.5	-0.6
Falls in the last year	0.2	0.2	0.4	-0.6	-0.5	0.4	-0.1	-0.5	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.7	0.8	-0.1	-0.2	0.6	-0.0	-0.4
Breastfed as a baby	0.2	0.3	1.0	-0.2	1.0	0.6	0.2	0.7	-0.3	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.1	-0.5	0.2	-0.6	-0.2	-0.6	0.5
Medication: Seretide 50 evohaler	0.2	0.2	1.0	-0.1	0.5	0.1	-0.4	0.1	0.3	1.0
Mean time to correctly identify matches	0.2	0.4	1.4	0.4	0.1	-1.1	0.3	-1.2	0.3	0.1
Number of full sisters	0.2	0.3	1.5	0.3	-0.4	-0.1	0.2	-1.2	0.1	-0.1
Suffer from ‘nerves’	0.2	0.4	0.8	-0.2	0.6	-0.7	-0.2	0.5	0.9	0.8
Chest pain or discomfort	0.2	0.3	0.9	0.4	-0.6	0.6	1.0	0.5	-0.1	0.2
Had major operations	0.2	0.2	0.6	0.5	-0.8	-0.2	0.0	-0.7	0.1	0.3
Hypertension (Self-reported)	0.2	0.6	1.8	0.1	0.6	1.4	0.8	0.7	0.5	-0.9
Mood swings	0.2	0.3	1.6	-0.3	-0.6	1.3	0.3	-0.0	-0.1	-0.5
Friendships satisfaction	0.2	0.3	1.1	-0.4	-0.5	0.5	-1.1	-0.4	0.2	0.1
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.9	-0.1	-0.8	0.4	0.3	-0.0	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	-0.3	-0.8	-0.5	-0.9	-0.8	-0.2	-0.2
Miserableness	0.2	0.4	2.1	0.2	-0.1	1.4	0.0	-0.2	0.8	0.1
Medication: Atorvastatin	0.2	0.3	1.3	0.0	-1.1	-0.0	-0.2	0.7	-0.3	0.2
Leg fat percentage (left)	0.2	0.6	2.1	1.4	-0.2	-0.7	1.1	0.3	-0.2	-0.4
Pack years of smoking	0.2	0.3	0.9	1.0	0.3	0.3	0.9	0.4	-0.2	-0.2
Neuroticism (2016)	0.1	0.2	0.5	-0.3	0.2	0.7	-0.7	-0.2	0.2	0.5
Allergy or Eczema	0.1	0.4	1.4	-0.3	1.2	-0.4	0.2	0.4	-0.5	0.8
Cardiovascular Disease	0.1	0.3	0.7	0.4	-0.1	0.4	0.4	0.3	-0.8	-0.9
Neuroticism	0.1	0.3	1.3	-0.6	-0.3	1.1	0.7	0.4	0.3	-0.2
Hair Pigment	0.1	3.7	7.6	-2.8	-1.1	-2.6	-1.7	-2.0	-1.8	-0.6
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.8	-0.4	0.1	0.1	-0.5	-0.0	-0.9
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.0	-0.4	-0.0	-0.3
Number of incorrect matches in round	0.1	0.2	0.8	0.2	0.4	0.6	0.3	-0.1	0.9	-0.4
Neuroticism score	0.1	0.2	0.8	-0.2	-0.5	0.9	0.5	0.2	0.5	-0.2
Loud music exposure frequency	0.1	0.1	0.5	-0.1	-0.3	-0.7	-0.5	-0.2	0.3	0.2
Body fat percentage	0.1	0.6	1.1	0.2	-0.9	-0.5	0.0	-0.9	-1.0	-1.1
Leg fat percentage (right)	0.1	0.5	1.4	1.2	-0.2	-0.9	0.9	0.3	-0.3	0.0
Commuting to job workplace: Walk	0.1	0.1	0.3	0.6	-0.2	-0.1	0.1	0.4	0.2	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.6	0.0	0.2	-0.0	0.2	0.4	-0.5	-0.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.2	0.1	0.0	-0.4	-0.6	0.5	-0.4
Medication: Paracetamol	0.1	0.2	0.5	0.6	-0.7	0.1	-0.5	-0.1	0.1	0.5
Heart disease (siblings)	0.1	0.1	0.6	-0.5	-0.2	0.3	0.0	0.8	-0.0	-0.0

Hub : Genes

DAPP1

Models

Trait associations