[Hub]/) : Traits : Impedance of leg (left) :

chr5:55,509,554-56,917,974

Best TWAS P=1.63e-11 · Best GWAS P=4.71e-12 conditioned to 0.0357

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SETD9 0.15 0.14 lasso 10 0.16 3.0e-13 -5.1 6.0 2.3e-09 -0.75 0.93 0.07 FALSE
2 GTEx Adipose Visceral Omentum SETD9 0.16 0.20 lasso 8 0.16 6.8e-09 -5.5 6.2 4.0e-10 -0.81 0.57 0.43 FALSE
3 GTEx Adrenal Gland SETD9 0.39 0.29 lasso 8 0.35 1.6e-13 -5.5 5.7 1.1e-08 -0.67 0.82 0.18 FALSE
4 GTEx Artery Aorta SETD9 0.51 0.55 lasso 3 0.56 8.8e-37 -5.5 5.7 1.2e-08 -0.71 0.97 0.03 FALSE
5 GTEx Artery Coronary SETD9 0.46 0.40 lasso 7 0.50 4.3e-19 -5.5 5.6 1.9e-08 -0.66 0.99 0.01 FALSE
6 GTEx Artery Tibial SETD9 0.47 0.54 lasso 4 0.53 9.4e-49 -5.5 5.6 1.9e-08 -0.73 0.97 0.03 FALSE
7 GTEx Brain Caudate basal ganglia SETD9 0.31 0.28 lasso 6 0.26 5.0e-08 -4.4 5.3 1.3e-07 -0.70 0.92 0.06 FALSE
8 GTEx Brain Cerebellum SETD9 0.44 0.25 enet 21 0.34 1.1e-10 -5.5 5.6 1.9e-08 -0.63 0.79 0.20 FALSE
9 GTEx Brain Cortex SETD9 0.43 0.36 lasso 6 0.27 4.5e-08 -5.5 5.3 9.6e-08 -0.72 0.66 0.30 FALSE
10 GTEx Brain Hippocampus SETD9 0.42 0.41 lasso 5 0.39 3.8e-10 -5.5 5.4 6.6e-08 -0.72 0.68 0.23 FALSE
11 GTEx Brain Nucleus accumbens basal ganglia SETD9 0.30 0.33 lasso 3 0.32 3.7e-09 -5.5 6.2 6.1e-10 -0.78 0.38 0.56 FALSE
12 GTEx Brain Putamen basal ganglia SETD9 0.23 0.15 lasso 3 0.14 2.9e-04 -5.0 5.8 5.8e-09 -0.67 0.08 0.63 FALSE
13 GTEx Breast Mammary Tissue SETD9 0.30 0.38 lasso 4 0.38 8.2e-21 -5.5 6.1 1.2e-09 -0.77 0.97 0.03 FALSE
14 GTEx Breast Mammary Tissue (Male) SETD9 0.42 0.37 lasso 4 0.33 1.9e-08 -5.5 5.5 3.0e-08 -0.69 0.80 0.11 FALSE
15 GTEx Breast Mammary Tissue (Female) SETD9 0.21 0.12 lasso 11 0.16 1.4e-05 -6.6 6.7 1.6e-11 -0.87 0.07 0.87 TRUE
16 GTEx Cells EBV-transformed lymphocytes SETD9 0.44 0.25 enet 27 0.37 4.0e-13 -5.1 5.3 1.1e-07 -0.64 0.99 0.01 FALSE
17 GTEx Cells Transformed fibroblasts SETD9 0.31 0.42 lasso 6 0.47 5.7e-39 -5.5 6.0 1.7e-09 -0.74 0.97 0.03 FALSE
18 GTEx Colon Sigmoid SETD9 0.49 0.49 lasso 14 0.53 7.9e-22 -4.3 5.6 2.5e-08 -0.76 0.98 0.02 FALSE
19 GTEx Colon Transverse SETD9 0.47 0.42 lasso 10 0.43 4.0e-22 -5.5 6.0 1.4e-09 -0.76 0.97 0.03 FALSE
20 GTEx Esophagus Gastroesophageal Junction SETD9 0.35 0.47 lasso 3 0.45 7.0e-18 -5.5 5.5 3.2e-08 -0.71 0.97 0.03 FALSE
21 GTEx Esophagus Mucosa SETD9 0.47 0.55 lasso 9 0.58 1.3e-47 -5.5 6.1 9.8e-10 -0.76 0.97 0.03 FALSE
22 GTEx Esophagus Muscularis SETD9 0.46 0.51 lasso 5 0.52 2.7e-36 -5.5 5.6 1.9e-08 -0.68 0.97 0.03 FALSE
23 GTEx Heart Atrial Appendage SETD9 0.29 0.36 lasso 3 0.35 2.1e-16 -5.5 5.6 2.0e-08 -0.71 0.97 0.03 FALSE
24 GTEx Heart Left Ventricle SETD9 0.42 0.39 enet 12 0.39 5.8e-22 -5.5 5.8 4.8e-09 -0.70 0.97 0.03 FALSE
25 GTEx Lung SETD9 0.33 0.41 lasso 7 0.41 5.8e-34 -5.5 5.8 5.4e-09 -0.72 0.97 0.03 FALSE
26 GTEx Muscle Skeletal SETD9 0.33 0.42 enet 32 0.44 1.3e-46 -5.5 5.5 3.8e-08 -0.67 0.97 0.03 FALSE
27 GTEx Nerve Tibial SETD9 0.41 0.46 enet 24 0.47 3.3e-37 -5.5 5.3 1.4e-07 -0.67 0.97 0.03 FALSE
28 GTEx Ovary SETD9 0.35 0.29 enet 17 0.28 1.1e-07 -5.5 5.4 8.3e-08 -0.68 0.24 0.58 FALSE
29 GTEx Pancreas SETD9 0.43 0.51 lasso 9 0.49 1.7e-23 -5.5 5.7 9.7e-09 -0.73 0.97 0.03 FALSE
30 GTEx Pituitary SETD9 0.38 0.29 lasso 13 0.28 1.3e-07 -5.5 5.4 5.2e-08 -0.71 0.61 0.08 FALSE
31 GTEx Prostate SETD9 0.36 0.26 lasso 6 0.23 1.7e-06 -5.0 5.3 1.2e-07 -0.70 0.69 0.14 FALSE
32 GTEx Skin Not Sun Exposed Suprapubic SETD9 0.51 0.56 lasso 9 0.58 1.9e-38 -5.5 5.8 8.9e-09 -0.74 0.97 0.03 FALSE
33 GTEx Skin Sun Exposed Lower leg SETD9 0.40 0.44 lasso 15 0.46 1.8e-42 -5.5 6.2 5.5e-10 -0.78 0.97 0.03 FALSE
34 GTEx Spleen SETD9 0.38 0.24 lasso 3 0.22 2.7e-06 -5.5 5.2 1.7e-07 -0.71 0.77 0.07 FALSE
35 GTEx Stomach SETD9 0.35 0.31 lasso 8 0.38 1.9e-19 -5.5 6.2 5.6e-10 -0.76 0.86 0.14 FALSE
36 GTEx Testis SETD9 0.18 0.05 lasso 6 0.11 1.9e-05 -4.9 5.5 3.1e-08 -0.54 0.17 0.77 FALSE
37 GTEx Thyroid SETD9 0.38 0.41 lasso 4 0.42 9.7e-35 -5.5 5.7 1.0e-08 -0.70 0.97 0.03 FALSE
38 GTEx Uterus SETD9 0.31 0.15 lasso 8 0.19 1.2e-04 -5.5 6.0 2.2e-09 -0.77 0.18 0.39 FALSE
39 GTEx Vagina SETD9 0.44 0.52 lasso 3 0.49 4.8e-13 -5.5 5.5 2.8e-08 -0.70 0.74 0.25 FALSE
40 GTEx Whole Blood SETD9 0.16 0.26 lasso 7 0.27 1.6e-24 -4.9 5.4 7.2e-08 -0.61 1.00 0.00 FALSE
41 METSIM Adipose SETD9 0.10 0.14 lasso 17 0.16 9.6e-23 -4.9 5.3 1.3e-07 -0.64 0.99 0.01 FALSE
42 NTR Blood C5orf35 0.01 0.01 bslmm 497 0.00 2.1e-02 -4.3 5.3 1.2e-07 -0.67 0.32 0.42 FALSE
43 ROSMAP Brain Pre-frontal Cortex SETD9 0.27 0.39 lasso 8 0.42 3.4e-59 -5.5 5.6 1.7e-08 -0.67 0.98 0.02 FALSE
44 The Cancer Genome Atlas Bladder Urothelial Carcinoma C5orf35 0.21 0.28 lasso 7 0.31 8.0e-27 -5.5 6.3 3.0e-10 -0.79 0.97 0.03 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma C5orf35 0.29 0.42 lasso 8 0.46 3.0e-107 -5.5 6.4 1.5e-10 -0.80 0.97 0.03 FALSE
46 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C5orf35 0.30 0.35 lasso 8 0.40 5.3e-21 -4.9 5.8 7.6e-09 -0.68 0.99 0.01 FALSE
47 The Cancer Genome Atlas Colon Adenocarcinoma C5orf35 0.45 0.50 lasso 6 0.52 1.8e-34 -5.5 5.8 5.8e-09 -0.73 0.97 0.03 FALSE
48 The Cancer Genome Atlas Esophageal Carcinoma C5orf35 0.19 0.20 lasso 4 0.18 1.9e-06 -4.9 5.1 2.8e-07 -0.54 0.44 0.46 FALSE
49 The Cancer Genome Atlas Glioblastoma Multiforme C5orf35 0.49 0.49 lasso 7 0.50 1.5e-17 -5.5 5.8 5.6e-09 -0.78 0.89 0.11 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C5orf35 0.24 0.35 lasso 11 0.37 1.9e-43 -5.5 6.4 1.7e-10 -0.81 0.97 0.03 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C5orf35 0.35 0.46 lasso 5 0.48 7.8e-62 -5.5 6.1 8.8e-10 -0.77 0.97 0.03 FALSE
52 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C5orf35 0.27 0.30 lasso 6 0.36 1.4e-21 -5.5 6.1 1.0e-09 -0.77 0.91 0.09 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma C5orf35 0.28 0.39 lasso 5 0.40 2.1e-48 -5.5 5.9 3.7e-09 -0.74 0.97 0.03 FALSE
54 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C5orf35 0.23 0.39 lasso 11 0.37 1.9e-18 -4.9 5.3 1.5e-07 -0.55 0.98 0.02 FALSE
55 The Cancer Genome Atlas Lung Adenocarcinoma C5orf35 0.42 0.45 enet 17 0.50 3.2e-67 -5.5 6.3 3.7e-10 -0.82 0.97 0.03 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma MAP3K1 0.02 0.01 blup 83 0.01 9.1e-03 -3.5 -6.2 7.2e-10 0.86 0.03 0.71 FALSE
57 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C5orf35 0.21 0.29 lasso 11 0.33 1.3e-38 -5.5 5.9 4.1e-09 -0.72 0.97 0.03 FALSE
58 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C5orf35 0.27 0.26 lasso 3 0.28 9.3e-19 -5.0 5.5 2.9e-08 -0.68 0.99 0.01 FALSE
59 The Cancer Genome Atlas Pancreatic Adenocarcinoma C5orf35 0.33 0.35 enet 22 0.36 4.9e-16 -5.5 6.2 5.7e-10 -0.78 0.72 0.28 FALSE
60 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C5orf35 0.50 0.49 lasso 10 0.56 4.1e-26 -5.5 5.5 4.5e-08 -0.67 0.98 0.02 FALSE
61 The Cancer Genome Atlas Prostate Adenocarcinoma C5orf35 0.44 0.58 lasso 9 0.60 1.4e-78 -5.5 5.7 1.1e-08 -0.73 0.97 0.03 FALSE
62 The Cancer Genome Atlas Soft Tissue Sarcoma C5orf35 0.23 0.24 blup 58 0.25 3.8e-15 -4.9 5.5 4.6e-08 -0.59 0.96 0.04 FALSE
63 The Cancer Genome Atlas Skin Cutaneous Melanoma C5orf35 0.23 0.08 blup 58 0.17 2.5e-05 -6.7 6.6 5.0e-11 -0.79 0.03 0.94 FALSE
64 The Cancer Genome Atlas Stomach Adenocarcinoma C5orf35 0.32 0.40 enet 19 0.44 4.8e-35 -5.5 5.6 2.6e-08 -0.72 0.98 0.02 FALSE
65 The Cancer Genome Atlas Testicular Germ Cell Tumors C5orf35 0.31 0.23 lasso 8 0.29 8.9e-11 -5.5 5.4 7.2e-08 -0.70 0.63 0.36 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma C5orf35 0.46 0.61 lasso 14 0.63 1.5e-79 -5.5 6.1 1.4e-09 -0.75 0.97 0.03 FALSE
67 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma C5orf35 0.38 0.05 blup 58 0.06 7.0e-03 -3.2 5.7 1.4e-08 -0.75 0.03 0.75 FALSE