[Hub]/) : Traits : Impedance of leg (left) : ← →

chr5:55,509,554-56,917,974

Best TWAS P=1.63e-11 · Best GWAS P=4.71e-12 conditioned to 0.0357

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Breast Mammary Tissue (Female)	SETD9	0.21	0.12	lasso	11	0.16	1.4e-05	-6.6	6.7	1.6e-11	-0.87	0.07	0.87	TRUE
63	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C5orf35	0.23	0.08	blup	58	0.17	2.5e-05	-6.7	6.6	5.0e-11	-0.79	0.03	0.94	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	C5orf35	0.29	0.42	lasso	8	0.46	3.0e-107	-5.5	6.4	1.5e-10	-0.80	0.97	0.03	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C5orf35	0.24	0.35	lasso	11	0.37	1.9e-43	-5.5	6.4	1.7e-10	-0.81	0.97	0.03	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C5orf35	0.21	0.28	lasso	7	0.31	8.0e-27	-5.5	6.3	3.0e-10	-0.79	0.97	0.03	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	C5orf35	0.42	0.45	enet	17	0.50	3.2e-67	-5.5	6.3	3.7e-10	-0.82	0.97	0.03	FALSE
2	GTEx	Adipose Visceral Omentum	SETD9	0.16	0.20	lasso	8	0.16	6.8e-09	-5.5	6.2	4.0e-10	-0.81	0.57	0.43	FALSE
33	GTEx	Skin Sun Exposed Lower leg	SETD9	0.40	0.44	lasso	15	0.46	1.8e-42	-5.5	6.2	5.5e-10	-0.78	0.97	0.03	FALSE
35	GTEx	Stomach	SETD9	0.35	0.31	lasso	8	0.38	1.9e-19	-5.5	6.2	5.6e-10	-0.76	0.86	0.14	FALSE
59	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C5orf35	0.33	0.35	enet	22	0.36	4.9e-16	-5.5	6.2	5.7e-10	-0.78	0.72	0.28	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	SETD9	0.30	0.33	lasso	3	0.32	3.7e-09	-5.5	6.2	6.1e-10	-0.78	0.38	0.56	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP3K1	0.02	0.01	blup	83	0.01	9.1e-03	-3.5	-6.2	7.2e-10	0.86	0.03	0.71	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C5orf35	0.35	0.46	lasso	5	0.48	7.8e-62	-5.5	6.1	8.8e-10	-0.77	0.97	0.03	FALSE
21	GTEx	Esophagus Mucosa	SETD9	0.47	0.55	lasso	9	0.58	1.3e-47	-5.5	6.1	9.8e-10	-0.76	0.97	0.03	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C5orf35	0.27	0.30	lasso	6	0.36	1.4e-21	-5.5	6.1	1.0e-09	-0.77	0.91	0.09	FALSE
13	GTEx	Breast Mammary Tissue	SETD9	0.30	0.38	lasso	4	0.38	8.2e-21	-5.5	6.1	1.2e-09	-0.77	0.97	0.03	FALSE
19	GTEx	Colon Transverse	SETD9	0.47	0.42	lasso	10	0.43	4.0e-22	-5.5	6.0	1.4e-09	-0.76	0.97	0.03	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf35	0.46	0.61	lasso	14	0.63	1.5e-79	-5.5	6.1	1.4e-09	-0.75	0.97	0.03	FALSE
17	GTEx	Cells Transformed fibroblasts	SETD9	0.31	0.42	lasso	6	0.47	5.7e-39	-5.5	6.0	1.7e-09	-0.74	0.97	0.03	FALSE
38	GTEx	Uterus	SETD9	0.31	0.15	lasso	8	0.19	1.2e-04	-5.5	6.0	2.2e-09	-0.77	0.18	0.39	FALSE
1	GTEx	Adipose Subcutaneous	SETD9	0.15	0.14	lasso	10	0.16	3.0e-13	-5.1	6.0	2.3e-09	-0.75	0.93	0.07	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf35	0.28	0.39	lasso	5	0.40	2.1e-48	-5.5	5.9	3.7e-09	-0.74	0.97	0.03	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C5orf35	0.21	0.29	lasso	11	0.33	1.3e-38	-5.5	5.9	4.1e-09	-0.72	0.97	0.03	FALSE
24	GTEx	Heart Left Ventricle	SETD9	0.42	0.39	enet	12	0.39	5.8e-22	-5.5	5.8	4.8e-09	-0.70	0.97	0.03	FALSE
25	GTEx	Lung	SETD9	0.33	0.41	lasso	7	0.41	5.8e-34	-5.5	5.8	5.4e-09	-0.72	0.97	0.03	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	C5orf35	0.49	0.49	lasso	7	0.50	1.5e-17	-5.5	5.8	5.6e-09	-0.78	0.89	0.11	FALSE
12	GTEx	Brain Putamen basal ganglia	SETD9	0.23	0.15	lasso	3	0.14	2.9e-04	-5.0	5.8	5.8e-09	-0.67	0.08	0.63	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	C5orf35	0.45	0.50	lasso	6	0.52	1.8e-34	-5.5	5.8	5.8e-09	-0.73	0.97	0.03	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C5orf35	0.30	0.35	lasso	8	0.40	5.3e-21	-4.9	5.8	7.6e-09	-0.68	0.99	0.01	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	SETD9	0.51	0.56	lasso	9	0.58	1.9e-38	-5.5	5.8	8.9e-09	-0.74	0.97	0.03	FALSE
29	GTEx	Pancreas	SETD9	0.43	0.51	lasso	9	0.49	1.7e-23	-5.5	5.7	9.7e-09	-0.73	0.97	0.03	FALSE
37	GTEx	Thyroid	SETD9	0.38	0.41	lasso	4	0.42	9.7e-35	-5.5	5.7	1.0e-08	-0.70	0.97	0.03	FALSE
3	GTEx	Adrenal Gland	SETD9	0.39	0.29	lasso	8	0.35	1.6e-13	-5.5	5.7	1.1e-08	-0.67	0.82	0.18	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	C5orf35	0.44	0.58	lasso	9	0.60	1.4e-78	-5.5	5.7	1.1e-08	-0.73	0.97	0.03	FALSE
4	GTEx	Artery Aorta	SETD9	0.51	0.55	lasso	3	0.56	8.8e-37	-5.5	5.7	1.2e-08	-0.71	0.97	0.03	FALSE
67	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C5orf35	0.38	0.05	blup	58	0.06	7.0e-03	-3.2	5.7	1.4e-08	-0.75	0.03	0.75	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	SETD9	0.27	0.39	lasso	8	0.42	3.4e-59	-5.5	5.6	1.7e-08	-0.67	0.98	0.02	FALSE
5	GTEx	Artery Coronary	SETD9	0.46	0.40	lasso	7	0.50	4.3e-19	-5.5	5.6	1.9e-08	-0.66	0.99	0.01	FALSE
6	GTEx	Artery Tibial	SETD9	0.47	0.54	lasso	4	0.53	9.4e-49	-5.5	5.6	1.9e-08	-0.73	0.97	0.03	FALSE
8	GTEx	Brain Cerebellum	SETD9	0.44	0.25	enet	21	0.34	1.1e-10	-5.5	5.6	1.9e-08	-0.63	0.79	0.20	FALSE
22	GTEx	Esophagus Muscularis	SETD9	0.46	0.51	lasso	5	0.52	2.7e-36	-5.5	5.6	1.9e-08	-0.68	0.97	0.03	FALSE
23	GTEx	Heart Atrial Appendage	SETD9	0.29	0.36	lasso	3	0.35	2.1e-16	-5.5	5.6	2.0e-08	-0.71	0.97	0.03	FALSE
18	GTEx	Colon Sigmoid	SETD9	0.49	0.49	lasso	14	0.53	7.9e-22	-4.3	5.6	2.5e-08	-0.76	0.98	0.02	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	C5orf35	0.32	0.40	enet	19	0.44	4.8e-35	-5.5	5.6	2.6e-08	-0.72	0.98	0.02	FALSE
39	GTEx	Vagina	SETD9	0.44	0.52	lasso	3	0.49	4.8e-13	-5.5	5.5	2.8e-08	-0.70	0.74	0.25	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C5orf35	0.27	0.26	lasso	3	0.28	9.3e-19	-5.0	5.5	2.9e-08	-0.68	0.99	0.01	FALSE
14	GTEx	Breast Mammary Tissue (Male)	SETD9	0.42	0.37	lasso	4	0.33	1.9e-08	-5.5	5.5	3.0e-08	-0.69	0.80	0.11	FALSE
36	GTEx	Testis	SETD9	0.18	0.05	lasso	6	0.11	1.9e-05	-4.9	5.5	3.1e-08	-0.54	0.17	0.77	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	SETD9	0.35	0.47	lasso	3	0.45	7.0e-18	-5.5	5.5	3.2e-08	-0.71	0.97	0.03	FALSE
26	GTEx	Muscle Skeletal	SETD9	0.33	0.42	enet	32	0.44	1.3e-46	-5.5	5.5	3.8e-08	-0.67	0.97	0.03	FALSE
60	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C5orf35	0.50	0.49	lasso	10	0.56	4.1e-26	-5.5	5.5	4.5e-08	-0.67	0.98	0.02	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	C5orf35	0.23	0.24	blup	58	0.25	3.8e-15	-4.9	5.5	4.6e-08	-0.59	0.96	0.04	FALSE
30	GTEx	Pituitary	SETD9	0.38	0.29	lasso	13	0.28	1.3e-07	-5.5	5.4	5.2e-08	-0.71	0.61	0.08	FALSE
10	GTEx	Brain Hippocampus	SETD9	0.42	0.41	lasso	5	0.39	3.8e-10	-5.5	5.4	6.6e-08	-0.72	0.68	0.23	FALSE
40	GTEx	Whole Blood	SETD9	0.16	0.26	lasso	7	0.27	1.6e-24	-4.9	5.4	7.2e-08	-0.61	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C5orf35	0.31	0.23	lasso	8	0.29	8.9e-11	-5.5	5.4	7.2e-08	-0.70	0.63	0.36	FALSE
28	GTEx	Ovary	SETD9	0.35	0.29	enet	17	0.28	1.1e-07	-5.5	5.4	8.3e-08	-0.68	0.24	0.58	FALSE
9	GTEx	Brain Cortex	SETD9	0.43	0.36	lasso	6	0.27	4.5e-08	-5.5	5.3	9.6e-08	-0.72	0.66	0.30	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	SETD9	0.44	0.25	enet	27	0.37	4.0e-13	-5.1	5.3	1.1e-07	-0.64	0.99	0.01	FALSE
31	GTEx	Prostate	SETD9	0.36	0.26	lasso	6	0.23	1.7e-06	-5.0	5.3	1.2e-07	-0.70	0.69	0.14	FALSE
42	NTR	Blood	C5orf35	0.01	0.01	bslmm	497	0.00	2.1e-02	-4.3	5.3	1.2e-07	-0.67	0.32	0.42	FALSE
7	GTEx	Brain Caudate basal ganglia	SETD9	0.31	0.28	lasso	6	0.26	5.0e-08	-4.4	5.3	1.3e-07	-0.70	0.92	0.06	FALSE
41	METSIM	Adipose	SETD9	0.10	0.14	lasso	17	0.16	9.6e-23	-4.9	5.3	1.3e-07	-0.64	0.99	0.01	FALSE
27	GTEx	Nerve Tibial	SETD9	0.41	0.46	enet	24	0.47	3.3e-37	-5.5	5.3	1.4e-07	-0.67	0.97	0.03	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C5orf35	0.23	0.39	lasso	11	0.37	1.9e-18	-4.9	5.3	1.5e-07	-0.55	0.98	0.02	FALSE
34	GTEx	Spleen	SETD9	0.38	0.24	lasso	3	0.22	2.7e-06	-5.5	5.2	1.7e-07	-0.71	0.77	0.07	FALSE
48	The Cancer Genome Atlas	Esophageal Carcinoma	C5orf35	0.19	0.20	lasso	4	0.18	1.9e-06	-4.9	5.1	2.8e-07	-0.54	0.44	0.46	FALSE