Hub : Genes

MAP3K1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.3166 0.0959 2.9e-03 0.050 NA 0.101 NA 0.134 6.9e-03 NA 1.8e-04 NA 1.6e-05
2 GTEx Brain Putamen basal ganglia 0.4760 0.1180 1.8e-03 -0.012 NA 0.007 NA -0.011 8.9e-01 NA 2.1e-01 NA 7.0e-01
3 GTEx Cells Transformed fibroblasts 0.1700 0.0550 3.5e-03 0.138 NA 0.106 NA 0.127 1.7e-10 NA 2.5e-08 NA 8.9e-10
4 YFS Blood 0.0532 0.0132 1.5e-08 0.039 0.032 0.041 0.041 0.047 1.2e-12 8.8e-11 2.0e-13 1.6e-13 5.5e-15
5 TCGA Lung Adenocarcinoma 0.0185 0.0118 9.1e-03 0.012 0.013 0.010 NA 0.013 1.3e-02 9.1e-03 2.0e-02 NA 1.1e-02
6 TCGA Thyroid Carcinoma 0.0400 0.0230 1.5e-03 0.027 0.027 0.029 NA 0.032 1.1e-03 1.1e-03 7.3e-04 NA 4.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.7 1.1 2.0 -1.2 0.6 -1.4 0.5 1.2 1.0
Bipolar Disorder or Schizophrenia 0.9 2.2 7.0 -2.0 -0.3 -2.6 1.4 0.0 -0.4
Depressed Affect (Nagel 2018) 1.2 2.5 8.9 -0.9 3.0 -1.8 1.2 0.2 0.7
Depression (Nagel 2018) 0.2 0.3 1.3 -0.0 0.3 -0.3 1.1 0.2 0.2
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.9 1.0 -2.2 0.4 -1.2 2.1 1.5
Neuroticism (Nagel 2018) 0.4 0.9 2.2 -0.3 1.0 -1.5 1.5 -0.3 -0.0
Schizophrenia (2018) 1.0 2.1 5.1 -1.6 -0.8 -2.3 1.2 -1.0 -1.3
Schizophrenia vs Biploar Disorder 1.9 2.5 7.7 0.3 -1.0 -0.2 -0.2 -2.8 -2.5
Worry (Nagel 2018) 0.4 0.8 1.6 0.7 -0.2 -1.3 0.8 -1.1 -1.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.7 -0.7 -0.2 0.4 0.5 0.0
Alzheimer’s Disease (in father) 1.3 1.4 3.3 1.3 0.6 0.4 0.9 -1.8 -1.5
Alzheimer’s Disease (including proxy) 0.6 0.8 1.2 1.0 -0.6 -0.8 1.0 -1.0 -1.1
Crohns Disease (2017) 0.6 1.3 3.4 0.8 -0.8 -0.1 1.9 1.4 1.0
Irritable Bowel Disease (IBD) 1.1 2.5 6.9 -0.8 -1.8 0.1 2.6 1.8 1.1
Ulcerative Colitis (UC) 0.9 1.8 4.6 -2.1 -1.5 0.4 1.7 0.8 0.3
Major Depression (MDD) 1.0 1.2 3.3 -1.8 1.7 0.4 0.6 -0.4 -0.6
Reaction Time 0.5 0.9 2.1 0.9 -0.7 1.2 1.5 -0.3 -0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.9 1.5 -2.0 1.2 -0.9 1.1 0.6
Breast Cancer 26.5 63.7 201.6 -0.8 -0.4 -0.4 -0.5 -14.2 -13.4
Ovarian Cancer 0.9 1.2 4.8 -0.3 0.6 -1.0 2.2 0.8 0.5
Prostate Cancer 0.2 0.3 1.5 -1.2 0.1 -0.5 0.5 0.0 0.0
Age at First Birth 0.8 1.2 2.1 -0.6 -1.2 0.5 -1.2 -1.2 -1.4
Bipolar Disorder (2011) 1.1 1.1 3.1 0.3 -0.8 -1.8 1.3 0.9 0.2
Body Mass Index (BMI) (2010) 0.7 1.0 2.4 -0.7 1.1 0.0 0.0 1.6 1.4
Coronary Artery Disease (CAD) 3.5 4.2 12.5 0.4 0.9 -0.2 -0.4 3.5 3.4
Crohns Disease (2012) 0.4 0.6 2.0 -0.7 -1.4 -0.2 0.5 0.9 0.0
Mean Putamen Volume 0.6 0.7 1.2 0.6 -1.0 0.8 -0.2 -1.1 -1.0
Fasting Glucose 0.4 0.5 1.2 -1.1 -0.4 0.4 0.7 0.4 0.8
HbA1C 0.9 1.0 2.4 0.7 0.4 -1.5 1.2 1.0 0.7
HDL Cholesterol 0.8 1.3 3.0 0.9 0.5 0.3 -1.7 -1.7 -0.9
LDL Cholesterol 0.3 0.4 1.7 0.2 0.4 0.7 1.3 0.2 0.3
Lupus 0.3 0.5 1.3 -0.2 0.6 -0.1 0.9 1.1 0.6
Neuroticism (2016) 1.5 2.2 4.0 -1.8 1.2 -2.0 1.4 -1.3 -0.9
Primary Biliary Cirrhosis 0.2 0.4 1.0 -1.0 -0.1 -0.5 -0.4 0.8 0.2
Rheumatoid Arthritis 1.2 1.7 4.2 0.3 -0.1 0.9 1.6 -1.6 -2.1
Schizophrenia (2014) 0.7 1.6 3.5 -0.9 -0.4 -1.9 1.5 -0.8 -1.4
Triglycerides 1.1 1.8 5.0 -0.0 -1.4 -0.8 0.3 2.2 1.8
Type 2 Diabetes (T2D) (2012) 3.0 3.4 8.7 -3.0 -0.9 -1.1 -1.1 1.8 2.3
Ulcerative Colitis 1.2 1.7 6.8 -0.9 -2.6 0.5 0.4 -0.4 -1.4
Blood Eosinophil Count 0.3 2.1 4.2 -0.9 2.0 -1.2 -0.8 -2.0 -1.2
Blood Platelet Count 0.2 2.0 4.5 2.1 -1.4 1.1 -0.5 -1.3 -1.6
Blood Red Count 0.5 4.5 10.9 -0.2 -2.6 0.3 -0.6 -3.0 -3.3
Blood White Count 0.3 1.9 9.1 0.0 -3.0 0.5 -0.7 -0.8 -1.1
Heel T-Score 0.3 2.6 8.2 -1.3 1.3 -1.7 -2.9 -0.8 -0.7
BMI 0.6 3.4 8.5 1.5 0.3 1.3 -1.2 2.9 2.5
Height 1.2 22.5 74.3 -0.8 3.3 -0.1 -0.5 -8.6 -7.0
Waist Hip Ratio (WHR) 1.4 6.1 23.2 -0.8 1.5 -1.9 -4.8 2.1 1.6
Systolic Blood Pressure 0.9 4.4 14.6 -3.0 -3.8 -1.0 0.5 0.9 0.8
Smoking Status 0.5 1.3 2.4 -1.2 1.5 0.9 -0.1 0.9 1.4
Allergy or Eczema 0.1 0.2 0.6 -0.2 -0.8 -0.2 0.7 0.2 0.0
Cardiovascular Disease 0.5 1.7 7.0 -1.3 -2.6 -1.1 -0.0 0.4 -0.2
Hypothyroidism (self reported) 0.2 0.5 1.5 0.7 1.2 -1.0 0.1 -0.1 0.5
Respiratory disease 0.4 0.8 1.9 -1.4 1.3 -0.7 -0.5 -0.2 0.5
Type 2 Diabetes (T2D) (2018) 2.8 5.2 10.3 -3.1 -0.9 -2.2 1.0 3.2 2.2
Lung FEV1/FVC ratio 0.8 3.9 10.6 -0.1 -3.2 -1.0 -0.4 -2.7 -2.0
Lung FVC 1.8 9.0 17.8 1.1 3.3 -0.6 -2.5 -4.2 -4.2
Neuroticism 0.9 2.1 7.2 -0.9 2.7 -1.7 1.2 0.1 0.6
Chronotype (morning person) 0.6 1.4 6.9 0.9 -0.1 2.6 0.8 0.1 0.0
Hair Pigment 0.3 8.5 15.8 -1.5 -2.7 0.5 3.9 -4.0 -3.2
Tanning 0.1 0.9 2.8 -1.7 1.1 0.7 -0.4 -0.7 -0.7
Hand grip strength (left) 0.9 2.3 4.7 -1.5 0.6 -1.7 0.4 -2.2 -1.9
Number of treatments/medications taken 0.2 0.4 1.9 -0.5 0.5 -0.2 1.4 0.0 0.4
Average weekly spirits intake 2.0 2.4 6.9 -1.4 1.2 -1.8 -2.6 -0.8 -0.3
Sensitivity / hurt feelings 0.3 0.4 1.6 1.2 0.7 -0.0 0.5 -0.6 -0.1
Frequency of depressed mood in last 2 weeks 1.6 2.2 7.4 0.5 0.2 -0.8 2.7 1.4 1.7
Hearing difficulty/problems: Yes 1.4 2.2 6.4 -2.5 1.3 -2.1 0.2 0.3 0.4
Relative age of first facial hair 1.0 2.0 4.7 0.8 -2.2 1.6 -0.9 1.1 1.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.1 -0.3 0.2 -1.4 -0.5 1.0 1.4
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 -1.0 -0.4 -0.4 0.3 0.8 1.3
Ever had hysterectomy (womb removed) 1.1 1.3 6.0 0.7 0.9 -0.4 -2.4 -0.6 -0.2
Systolic blood pressure, automated reading 0.5 1.3 5.4 -1.1 -2.3 -1.0 -0.5 -0.1 -0.3
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.1 -1.0 -0.9 -0.8 0.9 0.8 0.8
Angina 1.3 1.7 3.2 0.4 1.0 -1.4 -1.0 1.8 1.8
Medication for hormone replacement therapy 1.5 1.6 4.1 -0.4 0.5 -1.4 0.6 1.7 2.0
Vitamin and mineral supplements 0.4 0.6 2.8 -1.7 -0.1 0.0 0.3 -0.6 -0.5
Supplements: Zinc 4.3 4.7 14.8 -0.1 -0.7 0.7 -1.3 3.9 3.3
Medication: Co-codamol 0.1 0.2 0.6 -0.1 0.4 0.8 -0.0 -0.4 -0.2
Medication: Metformin 3.4 4.8 15.2 -3.9 -1.7 -1.3 0.8 2.5 1.5
Diabetes (father) 0.8 1.0 4.6 2.1 0.6 0.7 -0.9 -0.2 0.1
Diabetes (mother) 4.0 5.1 10.4 0.2 -3.0 0.4 1.6 3.2 3.0
Severe depression (siblings) 0.8 0.9 2.1 -0.0 1.0 -0.9 -1.5 -0.9 -0.8
Pack years adult smoking proportion 0.9 1.3 6.1 -0.3 0.5 -1.2 2.5 0.0 0.2
Impedance of leg (right) 2.2 10.6 38.4 0.6 0.8 -0.7 1.1 -6.2 -4.7
Leg fat-free mass (left) 0.2 0.9 3.3 -0.2 1.8 -0.1 -0.9 0.9 0.7
Trunk fat percentage 0.9 3.7 7.3 1.7 2.6 0.8 -0.3 -2.7 -2.0
Hand grip strength (right) 0.5 1.3 2.9 -1.1 0.4 -0.9 0.4 -1.7 -1.6
Townsend deprivation index at recruitment 1.4 2.0 3.2 -1.7 -1.1 0.0 1.8 1.4 1.6
Current tobacco smoking 1.2 1.9 5.4 -0.3 1.8 -0.4 0.3 1.6 2.3
Average weekly fortified wine intake 0.3 0.3 0.6 -0.4 -0.7 0.8 0.7 0.2 0.1
Maternal smoking around birth 0.8 1.1 2.8 -1.4 0.5 -1.7 0.4 -0.9 -0.8
Fed-up feelings 1.3 2.4 6.8 -0.7 2.1 -1.0 2.6 0.5 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 2.9 -0.8 0.2 -1.7 0.2 0.4 0.8
Relative age voice broke 0.6 0.9 2.6 1.0 0.9 1.6 -0.9 -0.4 -0.2
Taking other prescription medications 0.2 0.3 0.8 0.4 0.9 -0.5 -0.8 0.1 0.3
Age when periods started (menarche) 0.8 1.9 4.2 0.8 -1.1 0.2 2.0 1.5 1.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.9 0.2 -0.5 -0.5 1.0 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 4.2 -1.9 2.1 -1.0 -0.6 -1.3 -0.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.3 -0.5 -0.1 0.5 -0.3 0.6 0.1
Qualifications: CSEs or equivalent 2.0 2.6 8.7 -0.3 -1.4 -1.7 2.9 1.0 1.2
Serious illness, injury or assault to yourself 1.4 1.7 3.1 0.9 0.5 0.4 1.8 1.8 1.7
High blood pressure 0.5 1.4 6.2 -0.3 -2.5 -1.1 0.8 -0.4 -0.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 0.5 -0.4 0.1 0.5 1.1 1.2
Multivitamins +/- minerals 0.5 0.6 1.3 0.8 -0.7 -1.1 0.0 -0.8 -0.7
Stomach or abdominal pain in last month 0.9 1.1 2.6 -0.3 0.1 -1.6 1.5 0.9 1.0
Supplements: Glucosamine 0.4 0.5 1.4 -0.2 1.2 0.8 -0.8 -0.6 0.3
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.1 0.4 -1.2 0.4 0.4 1.4 1.4
Medication: Atenolol 0.5 0.6 1.3 0.6 -0.7 -1.2 -0.9 -0.8 -0.2
Medication: Levothyroxine sodium 0.6 1.0 2.9 -0.1 0.6 -1.0 -0.9 -1.7 -0.9
Sitting height 1.3 9.3 30.7 -0.5 1.4 -0.6 -1.4 -5.5 -4.5
Chronic bronchitis/emphysema (father) 1.4 1.6 5.8 2.4 -0.8 1.8 0.0 -0.3 0.4
High blood pressure (mother) 4.0 5.6 12.1 -3.5 0.9 -2.1 1.2 -2.6 -2.8
Body mass index (BMI) 0.5 2.3 4.0 1.7 1.5 1.3 -0.6 2.0 1.7
Impedance of leg (left) 2.1 10.1 37.9 0.4 0.7 -0.3 0.8 -6.2 -4.6
Leg predicted mass (left) 0.2 0.9 3.6 -0.1 1.9 -0.2 -0.9 0.7 0.5
Trunk fat mass 0.7 2.9 7.2 1.3 2.7 0.8 -0.5 -2.2 -1.6
Waist circumference 0.4 1.5 5.3 0.8 2.3 0.2 -1.1 1.2 0.7
Number of incorrect matches in round 0.7 1.2 4.1 -2.0 -0.4 -1.0 -0.7 0.3 1.0
Past tobacco smoking 1.2 2.1 3.8 -0.7 0.3 -1.2 1.7 -2.0 -2.0
Alcohol usually taken with meals 0.7 1.2 3.8 -0.8 0.7 -0.0 -0.6 -1.3 -1.9
Nervous feelings 0.5 0.9 2.1 0.0 -0.2 -1.1 1.5 -1.4 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.1 -0.8 0.8 -1.8 0.9 -0.3 -0.3
Hearing difficulty/problems with background noise 2.1 3.3 9.1 -3.0 2.0 -1.7 0.4 1.0 1.7
Hair/balding pattern: Pattern 2 0.7 0.9 2.1 -0.8 1.4 0.7 -0.7 0.9 1.1
Had menopause 0.7 0.9 2.8 -0.4 1.0 -0.6 -1.7 -0.6 -0.9
Had other major operations 0.6 0.8 1.8 -0.9 0.7 -0.2 -0.4 1.4 1.1
Forced vital capacity (FVC) 2.9 11.1 30.4 -0.7 2.8 -0.3 -1.9 -5.5 -4.9
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 8.9 -3.0 1.9 -1.9 -0.5 -0.6 -0.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.3 1.5 -0.2 1.1 0.1 -0.3 1.0
Qualifications: None of the above 0.1 0.2 0.6 -0.8 0.4 -0.1 0.8 -0.0 0.1
Financial difficulties in last 2 years 0.4 0.6 2.0 -0.6 0.9 -0.4 1.4 -0.2 -0.3
Mouth/teeth dental problems 0.5 0.8 1.3 -1.1 -1.0 -0.6 -1.1 -0.7 -0.6
Heart attack 0.4 0.6 1.7 0.3 -0.5 0.5 -0.3 1.3 1.1
Allergy 0.5 1.1 2.4 -1.2 0.5 -0.0 -0.4 -1.5 -1.5
Pain all over the body in last month 0.3 0.3 0.9 -0.2 0.1 0.7 -0.5 -0.9 -0.0
Diabetes (self-reported) 4.3 6.7 12.8 -3.5 -0.5 -3.6 0.4 3.2 2.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.1 -1.3 -0.0 -0.0 -0.1 1.8 1.1
Medication: Ramipril 1.7 2.2 5.5 1.1 -1.1 0.5 0.4 2.4 2.2
Medication: Simvastatin 1.2 1.7 4.1 -2.0 -0.2 -2.0 0.8 1.0 0.6
Fluid intelligence score 0.5 1.0 5.0 -0.6 -2.2 -0.3 -0.0 0.6 0.3
Illnesses of siblings 0.6 0.8 2.1 -0.1 1.4 -0.3 -0.1 -1.4 -0.9
Neuroticism score 0.9 1.8 4.3 -0.8 1.9 -2.1 0.7 0.6 1.3
Weight 0.4 1.8 6.3 1.2 2.5 0.7 -1.2 -0.9 -0.6
Impedance of arm (right) 1.1 5.1 17.7 0.4 -0.2 -0.7 0.2 -4.2 -3.5
Arm fat percentage (right) 0.2 0.9 3.0 1.7 1.2 1.0 -0.5 0.2 0.2
Trunk fat-free mass 0.2 1.1 2.9 -0.3 1.7 0.1 -1.7 0.6 0.6
Hip circumference 0.3 1.1 3.0 1.0 1.7 0.8 1.5 -0.4 -0.2
Time employed in main current job 1.1 1.3 3.7 1.0 1.1 -0.0 0.1 -1.9 -1.4
Alcohol intake versus 10 years previously 1.7 2.6 7.6 -1.1 0.0 -1.8 2.8 1.5 1.2
Father’s age at death 0.5 0.7 1.6 -0.7 -0.5 -0.3 -1.2 1.3 0.6
Worrier / anxious feelings 0.4 0.8 2.4 1.2 0.3 -1.5 0.6 -0.6 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.5 7.4 0.1 2.7 -2.0 2.7 0.5 1.4
Falls in the last year 0.4 0.6 1.7 0.2 1.3 -0.4 -0.7 0.7 0.7
Hair/balding pattern: Pattern 3 0.5 0.8 3.7 0.5 -1.9 0.0 0.4 -0.4 -0.6
Number of live births 1.3 1.8 9.2 -0.8 0.3 -0.9 3.0 -0.1 -0.0
Forced expiratory volume in 1-second (FEV1) 3.1 10.4 31.4 -0.4 1.7 -0.6 -2.1 -5.6 -4.8
Pulse rate 0.5 0.9 2.3 0.2 -1.3 1.5 -0.1 -0.7 -0.8
Happiness 1.6 2.0 4.0 0.2 -1.3 -1.8 0.9 1.5 2.0
Noisy workplace 0.2 0.2 0.9 0.9 -0.1 -0.2 -0.4 -0.4 0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.8 -1.7 -1.1 0.5 -0.5 -0.0 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.7 -0.0 -0.7 0.8 0.7 -0.1 -0.2
Mouth/teeth dental problems: Dentures 0.2 0.3 1.4 -0.4 -0.4 0.4 1.2 -0.2 -0.2
Asthma 0.2 0.5 1.3 -0.6 0.6 0.2 -1.1 0.6 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 -1.0 -0.4 -0.2 0.5 0.2 0.5
Medication: Cholesterol lowering 1.3 2.0 4.1 -1.3 -0.0 -1.7 0.5 2.0 1.7
Depression (self-reported) 0.6 0.7 2.2 -1.5 0.8 0.2 0.7 0.7 0.2
Medication: Lansoprazole 0.6 0.7 2.4 0.1 0.2 1.6 -1.1 -0.3 -0.5
Prospective memory result 0.7 0.9 2.7 -0.9 0.6 -1.2 -1.6 -0.2 -0.1
Lung cancer (father) 0.9 1.1 2.4 0.7 1.0 0.1 -1.4 0.8 1.6
Illnesses of mother 1.5 1.9 7.8 2.8 0.1 1.6 -0.9 0.0 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.3 7.4 18.1 -0.9 1.9 -1.9 -2.2 -4.3 -3.6
Pulse wave Arterial Stiffness index 2.1 2.5 7.2 -2.7 1.6 0.2 -2.2 -0.3 -0.1
Impedance of arm (left) 1.8 8.4 27.7 0.6 -0.2 -0.9 0.4 -5.3 -4.6
Arm fat mass (right) 0.3 1.1 3.8 1.2 1.9 0.7 -1.0 0.1 0.2
Trunk predicted mass 0.2 1.1 3.0 -0.3 1.7 0.1 -1.7 0.7 0.7
Standing height 1.3 12.5 38.4 -0.9 2.4 -1.2 -1.7 -6.2 -5.0
Length of working week for main job 2.5 2.7 8.4 0.9 2.9 1.7 -1.3 -1.2 -1.1
Exposure to tobacco smoke at home 0.3 0.3 1.1 -0.1 1.1 -0.4 -0.3 0.5 0.7
Breastfed as a baby 1.1 1.3 3.2 -1.8 -0.2 -1.0 -1.3 1.0 1.1
Tense / ‘highly strung’ 0.1 0.2 0.3 0.4 0.5 -0.5 0.2 -0.5 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 4.0 -0.2 0.6 0.1 2.0 1.4 1.8
Hair/balding pattern: Pattern 4 0.5 1.2 3.0 1.7 0.7 -0.8 0.4 -1.7 -0.6
Birth weight of first child 0.8 1.4 3.7 -0.5 1.9 -1.5 -1.0 -1.2 -0.4
Peak expiratory flow (PEF) 1.4 3.2 9.4 -0.4 0.3 -0.3 -1.2 -3.1 -2.9
Pulse wave reflection index 0.4 0.5 0.8 -0.9 0.7 -0.1 -0.9 0.4 0.9
Ever highly irritable/argumentative for 2 days 1.3 1.5 4.6 -0.5 0.4 -2.1 1.7 -1.0 -0.3
Loud music exposure frequency 0.4 0.4 0.9 -0.2 -1.0 -0.8 0.9 -0.3 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.1 -0.5 0.3 0.3 1.0 -0.6 -0.6
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 3.9 1.7 -0.1 2.0 -0.1 1.4 1.2
Blood clot in the leg (DVT) 1.0 1.3 3.0 1.1 -1.7 1.3 -0.1 0.8 1.0
Medication: Paracetamol 1.2 2.0 9.5 0.4 0.7 0.3 3.1 -1.3 -0.4
Headache pain in last month 0.5 0.9 2.3 -0.2 1.5 -1.5 0.7 0.4 0.6
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.6 1.7 0.6 1.9 -1.0 -0.8 -0.5
Glaucoma (self-reported) 0.2 0.2 0.4 -0.1 -0.3 -0.3 0.7 -0.5 -0.6
Gout (self-reported) 1.1 1.5 3.9 -1.4 0.7 -0.2 0.3 2.0 1.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.1 1.2 0.7 -1.8 0.0 -0.9 0.1
Medication: Amlodipine 0.3 0.4 1.0 -0.6 -0.4 -0.5 1.0 0.7 0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.1 -0.1 -0.5 -1.0 0.5 -0.0 0.3
Birth weight 0.2 0.5 1.6 -1.3 -0.5 -0.3 -0.2 -0.7 -0.7
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.8 1.0 0.6 0.1 -0.3 0.5 1.3
High blood pressure (siblings) 0.1 0.2 0.4 -0.6 -0.7 -0.3 -0.1 0.3 -0.2
Forced vital capacity (FVC), Best measure 2.2 8.1 17.2 -0.6 3.0 -1.7 -2.4 -4.1 -3.7
Body fat percentage 0.7 2.8 5.4 2.0 2.3 1.1 -0.1 -2.0 -1.6
Leg fat percentage (right) 0.5 1.7 3.6 1.8 1.9 0.8 0.4 -1.4 -1.0
Arm fat-free mass (right) 0.2 1.2 5.8 0.1 2.4 0.3 -1.1 0.1 0.3
Exposure to tobacco smoke outside home 1.3 1.8 6.8 -0.4 1.7 -2.6 -0.2 -0.6 -0.5
Comparative body size at age 10 0.6 1.8 4.6 2.1 0.3 1.2 -1.6 1.2 0.8
Number of full brothers 0.6 0.7 2.7 -0.2 0.9 0.8 1.6 -0.0 0.1
Worry too long after embarrassment 0.1 0.2 0.7 -0.4 0.1 -0.3 0.5 0.8 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.2 -0.4 0.1 -0.4 1.2 2.3 1.6
Wheeze or whistling in the chest in last year 0.4 0.8 1.5 0.9 1.1 1.2 0.6 0.7 0.4
Number of children fathered 0.4 0.5 1.0 0.5 -0.8 -0.6 -1.0 -0.3 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.9 -0.5 0.8 -0.7 -1.0 0.7 0.8
Age at first live birth 0.4 0.7 2.1 0.2 0.1 0.0 -0.6 -1.5 -1.4
Pulse wave peak to peak time 1.9 2.2 6.3 2.5 -1.3 -0.2 2.2 -0.1 -0.2
Health satisfaction 0.2 0.2 1.1 0.5 -0.1 0.0 1.0 -0.1 0.3
Shortness of breath walking on level ground 0.6 0.7 2.0 0.9 0.2 1.1 1.4 -0.2 0.1
Qualifications: College or University degree 0.8 2.6 6.8 0.4 -2.2 1.5 -2.6 1.2 -0.1
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.3 -0.3 -0.0 -0.4 0.1 -0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.4 1.2 -0.2 1.0 0.7 -0.0 -0.5
Emphysema/chronic bronchitis 0.6 0.7 1.7 0.0 0.5 -0.9 1.0 0.7 1.3
Medication for pain relief, constipation, heartburn 0.6 1.1 2.2 -0.3 -0.6 0.0 -1.5 -1.2 -1.5
Neck or shoulder pain in last month 0.9 1.2 2.6 0.1 1.6 -1.6 1.3 -0.7 0.5
Medication: Blood pressure 0.7 1.2 2.0 -0.8 -0.7 -0.5 1.3 1.4 1.4
Angina (self-reported) 1.1 1.4 2.3 0.6 1.0 -1.4 -0.9 1.5 1.5
Migraine (self-reported) 0.9 1.2 3.4 0.0 -1.2 0.6 0.7 1.1 1.8
Medication: Ibuprofen 0.6 0.7 2.3 -1.5 -0.1 -0.9 1.0 -0.1 0.1
Medication: Allopurinol 1.1 1.5 4.0 -1.1 0.7 0.5 0.1 2.0 1.7
Medication: Omeprazole 0.9 1.1 2.1 1.3 0.8 0.8 -0.1 1.2 1.5
Medication: Seretide 50 evohaler 1.4 1.6 3.4 -0.6 1.7 -1.9 -1.3 -1.0 -0.7
Mean time to correctly identify matches 0.3 0.6 2.4 0.7 -0.3 1.5 -0.1 0.7 0.3
Heart disease (mother) 0.7 0.9 2.2 -0.5 -1.1 -0.3 -0.3 1.2 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 8.6 1.7 -2.9 1.0 0.6 -0.8 -0.8
Whole body fat mass 0.6 2.3 7.0 1.5 2.6 0.8 -0.5 -1.5 -1.1
Leg fat mass (right) 0.3 1.3 4.7 1.3 2.2 0.8 -0.1 -0.5 -0.3
Arm predicted mass (right) 0.2 1.2 5.8 0.1 2.4 0.3 -1.1 -0.2 0.1
Pulse rate, automated reading 0.2 0.6 1.2 -0.8 0.8 -0.2 0.2 -1.1 -0.9
Alcohol intake frequency. 0.5 1.2 6.0 -0.1 0.8 -0.0 2.4 0.5 0.6
Comparative height size at age 10 1.4 7.8 24.4 -1.1 0.9 -1.0 -0.7 -4.9 -4.3
Number of full sisters 0.7 0.9 2.5 -0.6 0.4 -0.3 -0.4 1.6 1.5
Suffer from ‘nerves’ 0.6 0.9 2.2 0.2 0.0 -1.5 -0.6 1.0 1.4
Overall health rating 1.1 2.3 3.8 -2.0 1.1 -1.0 1.9 1.3 1.7
Chest pain or discomfort 1.1 1.5 7.4 0.3 2.7 0.2 -0.8 0.6 0.8
Had major operations 1.0 1.2 5.4 -0.7 2.3 -0.3 -0.7 0.8 0.5
Age at last live birth 0.2 0.3 0.9 -0.5 -1.0 -0.2 0.3 -0.4 0.0
Family relationship satisfaction 0.2 0.3 0.8 -0.1 -0.3 -0.4 -0.9 0.5 0.5
Leg pain on walking 0.1 0.2 0.5 0.7 0.4 0.3 0.2 -0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.1 1.8 1.7 0.4 0.8 -1.3 -0.7
Commuting to job workplace: Car/motor vehicle 1.5 1.7 7.8 1.1 2.8 -0.3 -0.9 0.2 0.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.6 1.6 -1.4 1.6 -1.9 -0.4 -0.6
Medication: Aspirin 0.3 0.4 1.3 -0.7 0.2 -1.1 0.1 0.4 -0.3
Supplements: Vitamin C 2.2 2.6 6.4 -0.3 1.2 -0.4 -1.2 2.5 2.4
Knee pain experienced in last month 2.1 3.3 6.0 -0.9 2.4 -1.1 1.1 2.1 2.4
Hypertension (Self-reported) 0.3 0.8 4.1 -0.2 -2.0 -0.7 0.2 -0.2 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.9 0.8 1.0 1.2 -0.5 0.6 1.4
Illnesses of father: Heart disease 0.2 0.3 1.1 -0.3 0.1 -0.1 1.1 0.4 -0.3
Illnesses of siblings: Diabetes 1.3 1.6 5.3 0.9 -2.3 0.3 0.6 1.0 1.4
Smoking status: Previous 0.9 1.3 2.4 0.1 -0.5 1.6 -1.3 1.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.8 -0.9 0.7 0.5 0.0 -0.7 -0.1
Whole body fat-free mass 0.2 1.1 3.5 -0.2 1.9 0.1 -1.3 0.8 0.7
Leg fat-free mass (right) 0.2 1.0 2.7 -0.3 1.6 0.1 -1.0 1.1 0.8
Arm fat percentage (left) 0.3 1.0 3.3 1.8 1.3 0.8 -0.2 -0.4 -0.5
Average weekly red wine intake 0.7 1.0 2.5 0.4 -1.2 1.6 -1.0 -0.2 -0.9
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.6 -0.3 -0.1 0.6 0.3 1.6 1.5
Mood swings 1.2 2.2 8.3 0.5 2.9 -1.8 0.3 -0.2 1.1
Loneliness, isolation 0.8 1.1 2.0 -0.4 1.2 -1.0 0.4 1.2 1.4
Long-standing illness, disability or infirmity 0.7 1.1 2.7 -0.7 0.6 -1.6 1.1 1.1 0.9
Ever had bowel cancer screening 0.2 0.3 0.9 -0.1 -0.6 0.9 -0.1 -0.1 -0.6
Diabetes diagnosed by doctor 3.1 5.1 9.8 -2.9 -1.2 -2.5 0.8 3.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.4 -0.4 -0.2 -0.4 1.5 1.0 1.3
Friendships satisfaction 1.8 2.2 6.4 -1.6 -0.9 -2.5 -0.0 1.4 1.3
Qualifications: nursing, teaching 1.5 2.4 8.4 -1.1 -1.9 -0.2 -2.9 -0.5 -0.7
Commuting to job workplace: Walk 0.5 0.6 1.4 -0.9 -0.7 -0.1 0.1 -1.2 -0.8
Eye problems/disorders: Cataract 0.2 0.2 0.5 -0.7 -0.3 0.4 -0.7 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 4.0 1.8 1.2 -0.2 0.8 2.0 1.2
Medication for cholesterol 0.5 0.8 2.4 1.0 0.8 1.6 0.2 0.6 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 5.0 0.8 -1.0 -0.4 -0.4 1.3 2.2
Back pain experienced in last month 0.5 0.8 3.7 0.2 0.7 -1.9 0.2 -0.5 0.4
Mineral and other dietary supplements 0.9 1.2 2.3 -1.5 -0.4 0.1 0.9 -1.3 -1.5
Breast cancer (self-reported) 4.5 5.4 17.2 0.9 1.4 -0.2 -0.6 4.1 3.4
Asthma (self-reported) 0.4 0.7 2.9 -0.8 0.5 0.3 -1.7 0.5 0.5
Osteoporosis (self-reported) 1.6 2.0 5.5 0.3 0.2 1.6 -0.3 2.3 2.0
Osteoarthritis (self-reported) 0.5 0.6 2.0 -0.5 0.8 -0.4 -0.1 0.8 1.4
Medication: Aspirin 0.5 0.7 2.1 -1.1 0.2 -1.5 0.6 0.1 -0.7
Medication: Gliclazide 1.9 2.1 8.2 -2.9 -1.7 -0.9 -0.1 0.8 0.6
Illnesses of father: None of the above (group 1) 0.5 0.7 1.7 -1.2 0.0 -0.1 -1.3 0.4 0.8
Smoking status: Current 1.0 1.7 4.8 -0.3 1.7 -0.7 -0.0 1.3 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 6.9 -0.7 0.5 0.9 -0.0 -2.6 -2.3
Whole body water mass 0.2 1.2 3.8 -0.2 2.0 0.1 -1.4 0.8 0.8
Leg predicted mass (right) 0.2 1.0 2.8 -0.4 1.7 0.1 -1.1 1.1 0.8
Arm fat mass (left) 0.3 1.2 4.2 1.3 2.0 0.5 -0.8 -0.3 -0.2
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 -1.0 -0.1 0.4 -0.7 0.5 1.0
Average weekly champagne plus white wine intake 0.3 0.4 1.2 0.6 -1.1 0.1 -0.6 0.3 0.0
Miserableness 2.9 5.1 14.7 -1.4 3.8 -2.7 1.8 0.8 1.7
Guilty feelings 1.0 1.6 4.7 -1.1 -0.1 -0.5 -0.6 1.7 2.2
Wears glasses or contact lenses 1.5 1.7 3.8 0.5 1.4 0.2 -1.9 1.5 1.5
Ever taken oral contraceptive pill 0.2 0.2 0.7 0.7 0.1 -0.8 0.0 0.1 -0.1
Hearing aid user 0.7 0.7 2.2 0.6 0.3 -1.3 -0.1 -1.5 -0.1
Mother’s age at death 2.7 3.4 7.9 0.3 1.4 -1.6 -1.1 -2.6 -2.8
Financial situation satisfaction 0.9 1.1 2.6 -1.1 -0.4 -0.9 0.8 1.2 1.6
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.6 -0.0 1.2 -1.2 1.4 -1.9 -1.0
Commuting to job workplace: Public transport 1.4 1.6 4.4 -0.7 -2.1 0.5 0.4 -0.9 -1.9
Eye problems/disorders: Glaucoma 0.8 1.0 2.1 -0.2 1.0 -0.7 0.3 -1.5 -1.4
Medication: Blood pressure 0.6 1.1 4.3 0.1 -2.1 -0.4 -0.8 -0.8 -0.8
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.5 -1.4 -0.2 -2.1 0.6 0.7 1.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.1 1.8 0.3 -0.4 -0.2 0.9 0.8
High cholesterol (Self-reported) 0.9 1.6 6.5 -1.6 -0.2 -2.5 0.7 0.6 0.2
Medication: Bendroflumethiazide 0.3 0.4 1.2 -0.6 -0.2 -0.8 -0.5 -1.1 0.1
Medication: Paracetamol 1.3 2.0 8.7 -0.1 1.5 -0.0 2.9 -1.1 0.1
Medication: Lisinopril 0.3 0.4 0.7 -0.8 -0.6 0.6 -0.7 -0.8 -0.2
Medication: Atorvastatin 0.6 0.7 2.9 0.5 -0.4 -0.2 0.2 1.7 1.1
Illnesses of father: High blood pressure 1.4 1.8 4.2 1.5 -1.1 0.7 -0.1 -1.6 -2.1
Alcohol drinker status: Never 0.3 0.3 1.1 1.0 -0.3 -0.2 -0.8 0.3 0.4
Ever smoked 0.5 0.9 1.8 0.5 -0.5 0.1 -1.2 1.3 1.3
Basal metabolic rate 0.2 0.9 4.0 0.0 2.0 0.2 -1.2 0.3 0.3
Leg fat percentage (left) 0.5 1.8 3.0 1.7 1.7 1.2 -0.2 -1.4 -0.9
Arm fat-free mass (left) 0.3 1.5 6.7 0.0 2.6 0.3 -1.4 0.2 0.5
Number of operations (self-reported) 0.1 0.2 0.9 -0.9 -0.4 0.3 -0.0 0.1 0.2
Average weekly beer plus cider intake 0.7 1.0 3.1 -0.5 0.3 -0.6 1.0 1.8 1.0
Irritability 0.2 0.4 1.0 -1.0 0.8 -0.4 -0.7 -0.2 0.0
Risk taking 0.5 0.7 1.7 -1.0 1.3 -0.6 -0.2 0.6 0.8
Ever had prostate specific antigen (PSA) test 2.9 3.4 7.8 0.5 -0.4 1.7 -1.4 -2.7 -2.8
Fractured/broken bones in last 5 years 0.9 1.1 2.2 -1.0 1.5 0.3 -1.0 -1.1 -1.1
Age started oral contraceptive pill 1.8 2.3 8.8 0.2 0.9 -1.8 -3.0 -0.6 -0.7
Diastolic blood pressure, automated reading 0.6 1.9 4.6 -1.5 -0.6 -0.7 -0.8 -2.1 -1.7
Ever depressed for a whole week 0.6 0.7 2.3 0.2 0.7 0.3 0.4 1.2 1.5
Unable to work because of sickness or disability 0.8 1.0 1.7 -0.6 1.0 1.3 0.8 -1.0 -1.1
Commuting to job workplace: Cycle 0.3 0.4 0.6 -0.7 -0.7 -0.8 0.5 0.5 0.5
Myopia 0.5 0.8 2.1 -0.8 -1.4 0.6 -1.1 -0.3 -0.2
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.6 0.7 1.6 1.6 -0.3 -0.4 -0.2
Cholesterol lowering medication 1.2 1.7 7.7 -1.3 0.1 -2.8 0.5 -0.4 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 1.1 0.7 0.5 -0.2 0.5 1.0
Pain experienced in last month 1.6 2.6 6.2 0.7 -2.5 2.0 -0.9 -1.1 -1.7
Supplements: Calcium 0.7 0.8 1.5 1.1 -0.8 0.7 -0.3 1.2 0.9
Basal cell carcinoma (self-reported) 0.4 0.4 1.6 -1.2 -0.6 -0.5 0.3 -0.4 0.1
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.7 0.0 -0.4 0.2 0.0 1.3 1.0
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.2 1.0 -2.0 1.4 0.2 0.7 0.8
Heart disease (siblings) 1.7 2.0 4.7 -0.1 2.2 -0.5 0.4 2.1 1.6
Alcohol drinker status: Previous 1.0 1.1 2.8 -0.6 0.7 0.7 0.3 -1.6 -1.7
Pack years of smoking 0.7 1.0 4.0 -0.3 0.3 -1.4 2.0 0.0 0.2
Impedance of whole body 2.2 11.3 40.3 0.5 0.6 -0.8 0.7 -6.3 -5.1
Leg fat mass (left) 0.4 1.6 5.4 1.4 2.3 1.1 -0.5 -0.7 -0.4
Arm predicted mass (left) 0.2 1.2 5.1 -0.2 2.3 0.2 -1.1 0.3 0.6