TWAS hub - MAP3K1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.3166	0.0959	2.9e-03	0.050	NA	0.101	NA	0.134	6.9e-03	NA	1.8e-04	NA	1.6e-05
2	GTEx	Brain Putamen basal ganglia	0.4760	0.1180	1.8e-03	-0.012	NA	0.007	NA	-0.011	8.9e-01	NA	2.1e-01	NA	7.0e-01
3	GTEx	Cells Transformed fibroblasts	0.1700	0.0550	3.5e-03	0.138	NA	0.106	NA	0.127	1.7e-10	NA	2.5e-08	NA	8.9e-10
4	YFS	Blood	0.0532	0.0132	1.5e-08	0.039	0.032	0.041	0.041	0.047	1.2e-12	8.8e-11	2.0e-13	1.6e-13	5.5e-15
5	TCGA	Lung Adenocarcinoma	0.0185	0.0118	9.1e-03	0.012	0.013	0.010	NA	0.013	1.3e-02	9.1e-03	2.0e-02	NA	1.1e-02
6	TCGA	Thyroid Carcinoma	0.0400	0.0230	1.5e-03	0.027	0.027	0.029	NA	0.032	1.1e-03	1.1e-03	7.3e-04	NA	4.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Breast Cancer	26.5	63.7	201.6	-0.8	-0.4	-0.4	-0.5	-14.2	-13.4
Breast cancer (self-reported)	4.5	5.4	17.2	0.9	1.4	-0.2	-0.6	4.1	3.4
Supplements: Zinc	4.3	4.7	14.8	-0.1	-0.7	0.7	-1.3	3.9	3.3
Diabetes (self-reported)	4.3	6.7	12.8	-3.5	-0.5	-3.6	0.4	3.2	2.1
Diabetes (mother)	4.0	5.1	10.4	0.2	-3.0	0.4	1.6	3.2	3.0
High blood pressure (mother)	4.0	5.6	12.1	-3.5	0.9	-2.1	1.2	-2.6	-2.8
Coronary Artery Disease (CAD)	3.5	4.2	12.5	0.4	0.9	-0.2	-0.4	3.5	3.4
Medication: Metformin	3.4	4.8	15.2	-3.9	-1.7	-1.3	0.8	2.5	1.5
Forced expiratory volume in 1-second (FEV1)	3.1	10.4	31.4	-0.4	1.7	-0.6	-2.1	-5.6	-4.8
Diabetes diagnosed by doctor	3.1	5.1	9.8	-2.9	-1.2	-2.5	0.8	3.1	1.9
Type 2 Diabetes (T2D) (2012)	3.0	3.4	8.7	-3.0	-0.9	-1.1	-1.1	1.8	2.3
Forced vital capacity (FVC)	2.9	11.1	30.4	-0.7	2.8	-0.3	-1.9	-5.5	-4.9
Miserableness	2.9	5.1	14.7	-1.4	3.8	-2.7	1.8	0.8	1.7
Ever had prostate specific antigen (PSA) test	2.9	3.4	7.8	0.5	-0.4	1.7	-1.4	-2.7	-2.8
Type 2 Diabetes (T2D) (2018)	2.8	5.2	10.3	-3.1	-0.9	-2.2	1.0	3.2	2.2
Mother’s age at death	2.7	3.4	7.9	0.3	1.4	-1.6	-1.1	-2.6	-2.8
Length of working week for main job	2.5	2.7	8.4	0.9	2.9	1.7	-1.3	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.4	18.1	-0.9	1.9	-1.9	-2.2	-4.3	-3.6
Impedance of leg (right)	2.2	10.6	38.4	0.6	0.8	-0.7	1.1	-6.2	-4.7
Forced vital capacity (FVC), Best measure	2.2	8.1	17.2	-0.6	3.0	-1.7	-2.4	-4.1	-3.7
Supplements: Vitamin C	2.2	2.6	6.4	-0.3	1.2	-0.4	-1.2	2.5	2.4
Impedance of whole body	2.2	11.3	40.3	0.5	0.6	-0.8	0.7	-6.3	-5.1
Impedance of leg (left)	2.1	10.1	37.9	0.4	0.7	-0.3	0.8	-6.2	-4.6
Hearing difficulty/problems with background noise	2.1	3.3	9.1	-3.0	2.0	-1.7	0.4	1.0	1.7
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	7.4	0.1	2.7	-2.0	2.7	0.5	1.4
Pulse wave Arterial Stiffness index	2.1	2.5	7.2	-2.7	1.6	0.2	-2.2	-0.3	-0.1
Knee pain experienced in last month	2.1	3.3	6.0	-0.9	2.4	-1.1	1.1	2.1	2.4
Average weekly spirits intake	2.0	2.4	6.9	-1.4	1.2	-1.8	-2.6	-0.8	-0.3
Qualifications: CSEs or equivalent	2.0	2.6	8.7	-0.3	-1.4	-1.7	2.9	1.0	1.2
Schizophrenia vs Biploar Disorder	1.9	2.5	7.7	0.3	-1.0	-0.2	-0.2	-2.8	-2.5
Pulse wave peak to peak time	1.9	2.2	6.3	2.5	-1.3	-0.2	2.2	-0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	8.6	1.7	-2.9	1.0	0.6	-0.8	-0.8
Medication: Gliclazide	1.9	2.1	8.2	-2.9	-1.7	-0.9	-0.1	0.8	0.6
Lung FVC	1.8	9.0	17.8	1.1	3.3	-0.6	-2.5	-4.2	-4.2
Impedance of arm (left)	1.8	8.4	27.7	0.6	-0.2	-0.9	0.4	-5.3	-4.6
Friendships satisfaction	1.8	2.2	6.4	-1.6	-0.9	-2.5	-0.0	1.4	1.3
Age started oral contraceptive pill	1.8	2.3	8.8	0.2	0.9	-1.8	-3.0	-0.6	-0.7
Medication: Ramipril	1.7	2.2	5.5	1.1	-1.1	0.5	0.4	2.4	2.2
Alcohol intake versus 10 years previously	1.7	2.6	7.6	-1.1	0.0	-1.8	2.8	1.5	1.2
Heart disease (siblings)	1.7	2.0	4.7	-0.1	2.2	-0.5	0.4	2.1	1.6
Frequency of depressed mood in last 2 weeks	1.6	2.2	7.4	0.5	0.2	-0.8	2.7	1.4	1.7
Happiness	1.6	2.0	4.0	0.2	-1.3	-1.8	0.9	1.5	2.0
Osteoporosis (self-reported)	1.6	2.0	5.5	0.3	0.2	1.6	-0.3	2.3	2.0
Pain experienced in last month	1.6	2.6	6.2	0.7	-2.5	2.0	-0.9	-1.1	-1.7
Neuroticism (2016)	1.5	2.2	4.0	-1.8	1.2	-2.0	1.4	-1.3	-0.9
Medication for hormone replacement therapy	1.5	1.6	4.1	-0.4	0.5	-1.4	0.6	1.7	2.0
Illnesses of mother	1.5	1.9	7.8	2.8	0.1	1.6	-0.9	0.0	0.3
Commuting to job workplace: Car/motor vehicle	1.5	1.7	7.8	1.1	2.8	-0.3	-0.9	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.6	1.6	-1.4	1.6	-1.9	-0.4	-0.6
Qualifications: nursing, teaching	1.5	2.4	8.4	-1.1	-1.9	-0.2	-2.9	-0.5	-0.7
Wears glasses or contact lenses	1.5	1.7	3.8	0.5	1.4	0.2	-1.9	1.5	1.5
Waist Hip Ratio (WHR)	1.4	6.1	23.2	-0.8	1.5	-1.9	-4.8	2.1	1.6
Hearing difficulty/problems: Yes	1.4	2.2	6.4	-2.5	1.3	-2.1	0.2	0.3	0.4
Townsend deprivation index at recruitment	1.4	2.0	3.2	-1.7	-1.1	0.0	1.8	1.4	1.6
Serious illness, injury or assault to yourself	1.4	1.7	3.1	0.9	0.5	0.4	1.8	1.8	1.7
Chronic bronchitis/emphysema (father)	1.4	1.6	5.8	2.4	-0.8	1.8	0.0	-0.3	0.4
Peak expiratory flow (PEF)	1.4	3.2	9.4	-0.4	0.3	-0.3	-1.2	-3.1	-2.9
Medication: Seretide 50 evohaler	1.4	1.6	3.4	-0.6	1.7	-1.9	-1.3	-1.0	-0.7
Comparative height size at age 10	1.4	7.8	24.4	-1.1	0.9	-1.0	-0.7	-4.9	-4.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.6	-0.0	1.2	-1.2	1.4	-1.9	-1.0
Commuting to job workplace: Public transport	1.4	1.6	4.4	-0.7	-2.1	0.5	0.4	-0.9	-1.9
Illnesses of father: High blood pressure	1.4	1.8	4.2	1.5	-1.1	0.7	-0.1	-1.6	-2.1
Alzheimer’s Disease (in father)	1.3	1.4	3.3	1.3	0.6	0.4	0.9	-1.8	-1.5
Angina	1.3	1.7	3.2	0.4	1.0	-1.4	-1.0	1.8	1.8
Fed-up feelings	1.3	2.4	6.8	-0.7	2.1	-1.0	2.6	0.5	1.2
Sitting height	1.3	9.3	30.7	-0.5	1.4	-0.6	-1.4	-5.5	-4.5
Number of live births	1.3	1.8	9.2	-0.8	0.3	-0.9	3.0	-0.1	-0.0
Medication: Cholesterol lowering	1.3	2.0	4.1	-1.3	-0.0	-1.7	0.5	2.0	1.7
Standing height	1.3	12.5	38.4	-0.9	2.4	-1.2	-1.7	-6.2	-5.0
Ever highly irritable/argumentative for 2 days	1.3	1.5	4.6	-0.5	0.4	-2.1	1.7	-1.0	-0.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.9	1.7	-0.1	2.0	-0.1	1.4	1.2
Exposure to tobacco smoke outside home	1.3	1.8	6.8	-0.4	1.7	-2.6	-0.2	-0.6	-0.5
Illnesses of siblings: Diabetes	1.3	1.6	5.3	0.9	-2.3	0.3	0.6	1.0	1.4
Medication: Paracetamol	1.3	2.0	8.7	-0.1	1.5	-0.0	2.9	-1.1	0.1
Depressed Affect (Nagel 2018)	1.2	2.5	8.9	-0.9	3.0	-1.8	1.2	0.2	0.7
Rheumatoid Arthritis	1.2	1.7	4.2	0.3	-0.1	0.9	1.6	-1.6	-2.1
Ulcerative Colitis	1.2	1.7	6.8	-0.9	-2.6	0.5	0.4	-0.4	-1.4
Height	1.2	22.5	74.3	-0.8	3.3	-0.1	-0.5	-8.6	-7.0
Current tobacco smoking	1.2	1.9	5.4	-0.3	1.8	-0.4	0.3	1.6	2.3
Past tobacco smoking	1.2	2.1	3.8	-0.7	0.3	-1.2	1.7	-2.0	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	8.9	-3.0	1.9	-1.9	-0.5	-0.6	-0.1
Medication: Simvastatin	1.2	1.7	4.1	-2.0	-0.2	-2.0	0.8	1.0	0.6
Medication: Paracetamol	1.2	2.0	9.5	0.4	0.7	0.3	3.1	-1.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	5.2	-0.4	0.1	-0.4	1.2	2.3	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.1	1.8	1.7	0.4	0.8	-1.3	-0.7
Mood swings	1.2	2.2	8.3	0.5	2.9	-1.8	0.3	-0.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	5.0	0.8	-1.0	-0.4	-0.4	1.3	2.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.5	-1.4	-0.2	-2.1	0.6	0.7	1.3
Cholesterol lowering medication	1.2	1.7	7.7	-1.3	0.1	-2.8	0.5	-0.4	-0.7
Irritable Bowel Disease (IBD)	1.1	2.5	6.9	-0.8	-1.8	0.1	2.6	1.8	1.1
Bipolar Disorder (2011)	1.1	1.1	3.1	0.3	-0.8	-1.8	1.3	0.9	0.2
Triglycerides	1.1	1.8	5.0	-0.0	-1.4	-0.8	0.3	2.2	1.8
Ever had hysterectomy (womb removed)	1.1	1.3	6.0	0.7	0.9	-0.4	-2.4	-0.6	-0.2
Impedance of arm (right)	1.1	5.1	17.7	0.4	-0.2	-0.7	0.2	-4.2	-3.5
Time employed in main current job	1.1	1.3	3.7	1.0	1.1	-0.0	0.1	-1.9	-1.4
Breastfed as a baby	1.1	1.3	3.2	-1.8	-0.2	-1.0	-1.3	1.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	4.0	-0.2	0.6	0.1	2.0	1.4	1.8
Gout (self-reported)	1.1	1.5	3.9	-1.4	0.7	-0.2	0.3	2.0	1.5
Angina (self-reported)	1.1	1.4	2.3	0.6	1.0	-1.4	-0.9	1.5	1.5
Medication: Allopurinol	1.1	1.5	4.0	-1.1	0.7	0.5	0.1	2.0	1.7
Overall health rating	1.1	2.3	3.8	-2.0	1.1	-1.0	1.9	1.3	1.7
Chest pain or discomfort	1.1	1.5	7.4	0.3	2.7	0.2	-0.8	0.6	0.8
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.0	1.8	1.2	-0.2	0.8	2.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	6.9	-0.7	0.5	0.9	-0.0	-2.6	-2.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.2	1.0	-2.0	1.4	0.2	0.7	0.8
Schizophrenia (2018)	1.0	2.1	5.1	-1.6	-0.8	-2.3	1.2	-1.0	-1.3
Major Depression (MDD)	1.0	1.2	3.3	-1.8	1.7	0.4	0.6	-0.4	-0.6
Relative age of first facial hair	1.0	2.0	4.7	0.8	-2.2	1.6	-0.9	1.1	1.4
Blood clot in the leg (DVT)	1.0	1.3	3.0	1.1	-1.7	1.3	-0.1	0.8	1.0
Had major operations	1.0	1.2	5.4	-0.7	2.3	-0.3	-0.7	0.8	0.5
Smoking status: Current	1.0	1.7	4.8	-0.3	1.7	-0.7	-0.0	1.3	2.2
Guilty feelings	1.0	1.6	4.7	-1.1	-0.1	-0.5	-0.6	1.7	2.2
Alcohol drinker status: Previous	1.0	1.1	2.8	-0.6	0.7	0.7	0.3	-1.6	-1.7
Bipolar Disorder or Schizophrenia	0.9	2.2	7.0	-2.0	-0.3	-2.6	1.4	0.0	-0.4
Ulcerative Colitis (UC)	0.9	1.8	4.6	-2.1	-1.5	0.4	1.7	0.8	0.3
Ovarian Cancer	0.9	1.2	4.8	-0.3	0.6	-1.0	2.2	0.8	0.5
HbA1C	0.9	1.0	2.4	0.7	0.4	-1.5	1.2	1.0	0.7
Systolic Blood Pressure	0.9	4.4	14.6	-3.0	-3.8	-1.0	0.5	0.9	0.8
Neuroticism	0.9	2.1	7.2	-0.9	2.7	-1.7	1.2	0.1	0.6
Hand grip strength (left)	0.9	2.3	4.7	-1.5	0.6	-1.7	0.4	-2.2	-1.9
Pack years adult smoking proportion	0.9	1.3	6.1	-0.3	0.5	-1.2	2.5	0.0	0.2
Trunk fat percentage	0.9	3.7	7.3	1.7	2.6	0.8	-0.3	-2.7	-2.0
Stomach or abdominal pain in last month	0.9	1.1	2.6	-0.3	0.1	-1.6	1.5	0.9	1.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.1	0.4	-1.2	0.4	0.4	1.4	1.4
Neuroticism score	0.9	1.8	4.3	-0.8	1.9	-2.1	0.7	0.6	1.3
Lung cancer (father)	0.9	1.1	2.4	0.7	1.0	0.1	-1.4	0.8	1.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.6	1.7	0.6	1.9	-1.0	-0.8	-0.5
Neck or shoulder pain in last month	0.9	1.2	2.6	0.1	1.6	-1.6	1.3	-0.7	0.5
Migraine (self-reported)	0.9	1.2	3.4	0.0	-1.2	0.6	0.7	1.1	1.8
Medication: Omeprazole	0.9	1.1	2.1	1.3	0.8	0.8	-0.1	1.2	1.5
Smoking status: Previous	0.9	1.3	2.4	0.1	-0.5	1.6	-1.3	1.5	1.1
Mineral and other dietary supplements	0.9	1.2	2.3	-1.5	-0.4	0.1	0.9	-1.3	-1.5
Financial situation satisfaction	0.9	1.1	2.6	-1.1	-0.4	-0.9	0.8	1.2	1.6
High cholesterol (Self-reported)	0.9	1.6	6.5	-1.6	-0.2	-2.5	0.7	0.6	0.2
Fractured/broken bones in last 5 years	0.9	1.1	2.2	-1.0	1.5	0.3	-1.0	-1.1	-1.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.9	1.0	-2.2	0.4	-1.2	2.1	1.5
Age at First Birth	0.8	1.2	2.1	-0.6	-1.2	0.5	-1.2	-1.2	-1.4
HDL Cholesterol	0.8	1.3	3.0	0.9	0.5	0.3	-1.7	-1.7	-0.9
Lung FEV1/FVC ratio	0.8	3.9	10.6	-0.1	-3.2	-1.0	-0.4	-2.7	-2.0
Diabetes (father)	0.8	1.0	4.6	2.1	0.6	0.7	-0.9	-0.2	0.1
Severe depression (siblings)	0.8	0.9	2.1	-0.0	1.0	-0.9	-1.5	-0.9	-0.8
Maternal smoking around birth	0.8	1.1	2.8	-1.4	0.5	-1.7	0.4	-0.9	-0.8
Age when periods started (menarche)	0.8	1.9	4.2	0.8	-1.1	0.2	2.0	1.5	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.2	-1.9	2.1	-1.0	-0.6	-1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.1	-1.3	-0.0	-0.0	-0.1	1.8	1.1
Birth weight of first child	0.8	1.4	3.7	-0.5	1.9	-1.5	-1.0	-1.2	-0.4
Qualifications: College or University degree	0.8	2.6	6.8	0.4	-2.2	1.5	-2.6	1.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	0.8	1.0	1.2	-0.5	0.6	1.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.6	-0.3	-0.1	0.6	0.3	1.6	1.5
Loneliness, isolation	0.8	1.1	2.0	-0.4	1.2	-1.0	0.4	1.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.4	-0.4	-0.2	-0.4	1.5	1.0	1.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.1	-0.2	1.0	-0.7	0.3	-1.5	-1.4
Unable to work because of sickness or disability	0.8	1.0	1.7	-0.6	1.0	1.3	0.8	-1.0	-1.1
Bipolar Disorder (2018)	0.7	1.1	2.0	-1.2	0.6	-1.4	0.5	1.2	1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.9	1.5	-2.0	1.2	-0.9	1.1	0.6
Body Mass Index (BMI) (2010)	0.7	1.0	2.4	-0.7	1.1	0.0	0.0	1.6	1.4
Schizophrenia (2014)	0.7	1.6	3.5	-0.9	-0.4	-1.9	1.5	-0.8	-1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	-0.3	0.2	-1.4	-0.5	1.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.1	-1.0	-0.9	-0.8	0.9	0.8	0.8
Trunk fat mass	0.7	2.9	7.2	1.3	2.7	0.8	-0.5	-2.2	-1.6
Number of incorrect matches in round	0.7	1.2	4.1	-2.0	-0.4	-1.0	-0.7	0.3	1.0
Alcohol usually taken with meals	0.7	1.2	3.8	-0.8	0.7	-0.0	-0.6	-1.3	-1.9
Hair/balding pattern: Pattern 2	0.7	0.9	2.1	-0.8	1.4	0.7	-0.7	0.9	1.1
Had menopause	0.7	0.9	2.8	-0.4	1.0	-0.6	-1.7	-0.6	-0.9
Prospective memory result	0.7	0.9	2.7	-0.9	0.6	-1.2	-1.6	-0.2	-0.1
Body fat percentage	0.7	2.8	5.4	2.0	2.3	1.1	-0.1	-2.0	-1.6
Medication: Blood pressure	0.7	1.2	2.0	-0.8	-0.7	-0.5	1.3	1.4	1.4
Heart disease (mother)	0.7	0.9	2.2	-0.5	-1.1	-0.3	-0.3	1.2	1.5
Number of full sisters	0.7	0.9	2.5	-0.6	0.4	-0.3	-0.4	1.6	1.5
Average weekly red wine intake	0.7	1.0	2.5	0.4	-1.2	1.6	-1.0	-0.2	-0.9
Long-standing illness, disability or infirmity	0.7	1.1	2.7	-0.7	0.6	-1.6	1.1	1.1	0.9
Hearing aid user	0.7	0.7	2.2	0.6	0.3	-1.3	-0.1	-1.5	-0.1
Average weekly beer plus cider intake	0.7	1.0	3.1	-0.5	0.3	-0.6	1.0	1.8	1.0
Supplements: Calcium	0.7	0.8	1.5	1.1	-0.8	0.7	-0.3	1.2	0.9
Pack years of smoking	0.7	1.0	4.0	-0.3	0.3	-1.4	2.0	0.0	0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	1.2	1.0	-0.6	-0.8	1.0	-1.0	-1.1
Crohns Disease (2017)	0.6	1.3	3.4	0.8	-0.8	-0.1	1.9	1.4	1.0
Mean Putamen Volume	0.6	0.7	1.2	0.6	-1.0	0.8	-0.2	-1.1	-1.0
BMI	0.6	3.4	8.5	1.5	0.3	1.3	-1.2	2.9	2.5
Chronotype (morning person)	0.6	1.4	6.9	0.9	-0.1	2.6	0.8	0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.9	-0.8	0.2	-1.7	0.2	0.4	0.8
Relative age voice broke	0.6	0.9	2.6	1.0	0.9	1.6	-0.9	-0.4	-0.2
Medication: Levothyroxine sodium	0.6	1.0	2.9	-0.1	0.6	-1.0	-0.9	-1.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.1	-0.8	0.8	-1.8	0.9	-0.3	-0.3
Had other major operations	0.6	0.8	1.8	-0.9	0.7	-0.2	-0.4	1.4	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	1.5	-0.2	1.1	0.1	-0.3	1.0
Illnesses of siblings	0.6	0.8	2.1	-0.1	1.4	-0.3	-0.1	-1.4	-0.9
Depression (self-reported)	0.6	0.7	2.2	-1.5	0.8	0.2	0.7	0.7	0.2
Medication: Lansoprazole	0.6	0.7	2.4	0.1	0.2	1.6	-1.1	-0.3	-0.5
Comparative body size at age 10	0.6	1.8	4.6	2.1	0.3	1.2	-1.6	1.2	0.8
Number of full brothers	0.6	0.7	2.7	-0.2	0.9	0.8	1.6	-0.0	0.1
Shortness of breath walking on level ground	0.6	0.7	2.0	0.9	0.2	1.1	1.4	-0.2	0.1
Emphysema/chronic bronchitis	0.6	0.7	1.7	0.0	0.5	-0.9	1.0	0.7	1.3
Medication for pain relief, constipation, heartburn	0.6	1.1	2.2	-0.3	-0.6	0.0	-1.5	-1.2	-1.5
Medication: Ibuprofen	0.6	0.7	2.3	-1.5	-0.1	-0.9	1.0	-0.1	0.1
Whole body fat mass	0.6	2.3	7.0	1.5	2.6	0.8	-0.5	-1.5	-1.1
Suffer from ‘nerves’	0.6	0.9	2.2	0.2	0.0	-1.5	-0.6	1.0	1.4
Medication: Blood pressure	0.6	1.1	4.3	0.1	-2.1	-0.4	-0.8	-0.8	-0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.1	1.8	0.3	-0.4	-0.2	0.9	0.8
Medication: Atorvastatin	0.6	0.7	2.9	0.5	-0.4	-0.2	0.2	1.7	1.1
Diastolic blood pressure, automated reading	0.6	1.9	4.6	-1.5	-0.6	-0.7	-0.8	-2.1	-1.7
Ever depressed for a whole week	0.6	0.7	2.3	0.2	0.7	0.3	0.4	1.2	1.5
Reaction Time	0.5	0.9	2.1	0.9	-0.7	1.2	1.5	-0.3	-0.7
Blood Red Count	0.5	4.5	10.9	-0.2	-2.6	0.3	-0.6	-3.0	-3.3
Smoking Status	0.5	1.3	2.4	-1.2	1.5	0.9	-0.1	0.9	1.4
Cardiovascular Disease	0.5	1.7	7.0	-1.3	-2.6	-1.1	-0.0	0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	-1.0	-0.4	-0.4	0.3	0.8	1.3
Systolic blood pressure, automated reading	0.5	1.3	5.4	-1.1	-2.3	-1.0	-0.5	-0.1	-0.3
Hand grip strength (right)	0.5	1.3	2.9	-1.1	0.4	-0.9	0.4	-1.7	-1.6
High blood pressure	0.5	1.4	6.2	-0.3	-2.5	-1.1	0.8	-0.4	-0.6
Multivitamins +/- minerals	0.5	0.6	1.3	0.8	-0.7	-1.1	0.0	-0.8	-0.7
Medication: Atenolol	0.5	0.6	1.3	0.6	-0.7	-1.2	-0.9	-0.8	-0.2
Body mass index (BMI)	0.5	2.3	4.0	1.7	1.5	1.3	-0.6	2.0	1.7
Nervous feelings	0.5	0.9	2.1	0.0	-0.2	-1.1	1.5	-1.4	-0.6
Mouth/teeth dental problems	0.5	0.8	1.3	-1.1	-1.0	-0.6	-1.1	-0.7	-0.6
Allergy	0.5	1.1	2.4	-1.2	0.5	-0.0	-0.4	-1.5	-1.5
Fluid intelligence score	0.5	1.0	5.0	-0.6	-2.2	-0.3	-0.0	0.6	0.3
Father’s age at death	0.5	0.7	1.6	-0.7	-0.5	-0.3	-1.2	1.3	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	3.7	0.5	-1.9	0.0	0.4	-0.4	-0.6
Pulse rate	0.5	0.9	2.3	0.2	-1.3	1.5	-0.1	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.5	1.2	3.0	1.7	0.7	-0.8	0.4	-1.7	-0.6
Headache pain in last month	0.5	0.9	2.3	-0.2	1.5	-1.5	0.7	0.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.1	1.2	0.7	-1.8	0.0	-0.9	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	1.0	0.6	0.1	-0.3	0.5	1.3
Leg fat percentage (right)	0.5	1.7	3.6	1.8	1.9	0.8	0.4	-1.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-0.5	0.8	-0.7	-1.0	0.7	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.4	1.2	-0.2	1.0	0.7	-0.0	-0.5
Alcohol intake frequency.	0.5	1.2	6.0	-0.1	0.8	-0.0	2.4	0.5	0.6
Commuting to job workplace: Walk	0.5	0.6	1.4	-0.9	-0.7	-0.1	0.1	-1.2	-0.8
Medication for cholesterol	0.5	0.8	2.4	1.0	0.8	1.6	0.2	0.6	0.2
Back pain experienced in last month	0.5	0.8	3.7	0.2	0.7	-1.9	0.2	-0.5	0.4
Osteoarthritis (self-reported)	0.5	0.6	2.0	-0.5	0.8	-0.4	-0.1	0.8	1.4
Medication: Aspirin	0.5	0.7	2.1	-1.1	0.2	-1.5	0.6	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	-1.2	0.0	-0.1	-1.3	0.4	0.8
Ever smoked	0.5	0.9	1.8	0.5	-0.5	0.1	-1.2	1.3	1.3
Leg fat percentage (left)	0.5	1.8	3.0	1.7	1.7	1.2	-0.2	-1.4	-0.9
Risk taking	0.5	0.7	1.7	-1.0	1.3	-0.6	-0.2	0.6	0.8
Myopia	0.5	0.8	2.1	-0.8	-1.4	0.6	-1.1	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	1.1	0.7	0.5	-0.2	0.5	1.0
Neuroticism (Nagel 2018)	0.4	0.9	2.2	-0.3	1.0	-1.5	1.5	-0.3	-0.0
Worry (Nagel 2018)	0.4	0.8	1.6	0.7	-0.2	-1.3	0.8	-1.1	-1.0
Crohns Disease (2012)	0.4	0.6	2.0	-0.7	-1.4	-0.2	0.5	0.9	0.0
Fasting Glucose	0.4	0.5	1.2	-1.1	-0.4	0.4	0.7	0.4	0.8
Respiratory disease	0.4	0.8	1.9	-1.4	1.3	-0.7	-0.5	-0.2	0.5
Vitamin and mineral supplements	0.4	0.6	2.8	-1.7	-0.1	0.0	0.3	-0.6	-0.5
Supplements: Glucosamine	0.4	0.5	1.4	-0.2	1.2	0.8	-0.8	-0.6	0.3
Waist circumference	0.4	1.5	5.3	0.8	2.3	0.2	-1.1	1.2	0.7
Financial difficulties in last 2 years	0.4	0.6	2.0	-0.6	0.9	-0.4	1.4	-0.2	-0.3
Heart attack	0.4	0.6	1.7	0.3	-0.5	0.5	-0.3	1.3	1.1
Weight	0.4	1.8	6.3	1.2	2.5	0.7	-1.2	-0.9	-0.6
Worrier / anxious feelings	0.4	0.8	2.4	1.2	0.3	-1.5	0.6	-0.6	-0.3
Falls in the last year	0.4	0.6	1.7	0.2	1.3	-0.4	-0.7	0.7	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.8	-1.7	-1.1	0.5	-0.5	-0.0	-0.8
Pulse wave reflection index	0.4	0.5	0.8	-0.9	0.7	-0.1	-0.9	0.4	0.9
Loud music exposure frequency	0.4	0.4	0.9	-0.2	-1.0	-0.8	0.9	-0.3	0.3
Wheeze or whistling in the chest in last year	0.4	0.8	1.5	0.9	1.1	1.2	0.6	0.7	0.4
Number of children fathered	0.4	0.5	1.0	0.5	-0.8	-0.6	-1.0	-0.3	-0.6
Age at first live birth	0.4	0.7	2.1	0.2	0.1	0.0	-0.6	-1.5	-1.4
Asthma (self-reported)	0.4	0.7	2.9	-0.8	0.5	0.3	-1.7	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.6	0.7	1.6	1.6	-0.3	-0.4	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	1.6	-1.2	-0.6	-0.5	0.3	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	0.0	-0.4	0.2	0.0	1.3	1.0
Leg fat mass (left)	0.4	1.6	5.4	1.4	2.3	1.1	-0.5	-0.7	-0.4
LDL Cholesterol	0.3	0.4	1.7	0.2	0.4	0.7	1.3	0.2	0.3
Lupus	0.3	0.5	1.3	-0.2	0.6	-0.1	0.9	1.1	0.6
Blood Eosinophil Count	0.3	2.1	4.2	-0.9	2.0	-1.2	-0.8	-2.0	-1.2
Blood White Count	0.3	1.9	9.1	0.0	-3.0	0.5	-0.7	-0.8	-1.1
Heel T-Score	0.3	2.6	8.2	-1.3	1.3	-1.7	-2.9	-0.8	-0.7
Hair Pigment	0.3	8.5	15.8	-1.5	-2.7	0.5	3.9	-4.0	-3.2
Sensitivity / hurt feelings	0.3	0.4	1.6	1.2	0.7	-0.0	0.5	-0.6	-0.1
Average weekly fortified wine intake	0.3	0.3	0.6	-0.4	-0.7	0.8	0.7	0.2	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	0.5	-0.4	0.1	0.5	1.1	1.2
Pain all over the body in last month	0.3	0.3	0.9	-0.2	0.1	0.7	-0.5	-0.9	-0.0
Hip circumference	0.3	1.1	3.0	1.0	1.7	0.8	1.5	-0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.0	-0.7	0.8	0.7	-0.1	-0.2
Arm fat mass (right)	0.3	1.1	3.8	1.2	1.9	0.7	-1.0	0.1	0.2
Exposure to tobacco smoke at home	0.3	0.3	1.1	-0.1	1.1	-0.4	-0.3	0.5	0.7
Medication: Amlodipine	0.3	0.4	1.0	-0.6	-0.4	-0.5	1.0	0.7	0.1
Mean time to correctly identify matches	0.3	0.6	2.4	0.7	-0.3	1.5	-0.1	0.7	0.3
Leg fat mass (right)	0.3	1.3	4.7	1.3	2.2	0.8	-0.1	-0.5	-0.3
Medication: Aspirin	0.3	0.4	1.3	-0.7	0.2	-1.1	0.1	0.4	-0.3
Hypertension (Self-reported)	0.3	0.8	4.1	-0.2	-2.0	-0.7	0.2	-0.2	-0.3
Arm fat percentage (left)	0.3	1.0	3.3	1.8	1.3	0.8	-0.2	-0.4	-0.5
Arm fat mass (left)	0.3	1.2	4.2	1.3	2.0	0.5	-0.8	-0.3	-0.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	-0.1	0.4	-0.7	0.5	1.0
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.6	-1.1	0.1	-0.6	0.3	0.0
Medication: Bendroflumethiazide	0.3	0.4	1.2	-0.6	-0.2	-0.8	-0.5	-1.1	0.1
Medication: Lisinopril	0.3	0.4	0.7	-0.8	-0.6	0.6	-0.7	-0.8	-0.2
Alcohol drinker status: Never	0.3	0.3	1.1	1.0	-0.3	-0.2	-0.8	0.3	0.4
Arm fat-free mass (left)	0.3	1.5	6.7	0.0	2.6	0.3	-1.4	0.2	0.5
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.7	-0.7	-0.8	0.5	0.5	0.5
Depression (Nagel 2018)	0.2	0.3	1.3	-0.0	0.3	-0.3	1.1	0.2	0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	-0.7	-0.2	0.4	0.5	0.0
Prostate Cancer	0.2	0.3	1.5	-1.2	0.1	-0.5	0.5	0.0	0.0
Primary Biliary Cirrhosis	0.2	0.4	1.0	-1.0	-0.1	-0.5	-0.4	0.8	0.2
Blood Platelet Count	0.2	2.0	4.5	2.1	-1.4	1.1	-0.5	-1.3	-1.6
Hypothyroidism (self reported)	0.2	0.5	1.5	0.7	1.2	-1.0	0.1	-0.1	0.5
Number of treatments/medications taken	0.2	0.4	1.9	-0.5	0.5	-0.2	1.4	0.0	0.4
Leg fat-free mass (left)	0.2	0.9	3.3	-0.2	1.8	-0.1	-0.9	0.9	0.7
Taking other prescription medications	0.2	0.3	0.8	0.4	0.9	-0.5	-0.8	0.1	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	0.2	-0.5	-0.5	1.0	-0.1	0.2
Leg predicted mass (left)	0.2	0.9	3.6	-0.1	1.9	-0.2	-0.9	0.7	0.5
Arm fat percentage (right)	0.2	0.9	3.0	1.7	1.2	1.0	-0.5	0.2	0.2
Trunk fat-free mass	0.2	1.1	2.9	-0.3	1.7	0.1	-1.7	0.6	0.6
Noisy workplace	0.2	0.2	0.9	0.9	-0.1	-0.2	-0.4	-0.4	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	-0.4	-0.4	0.4	1.2	-0.2	-0.2
Asthma	0.2	0.5	1.3	-0.6	0.6	0.2	-1.1	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-1.0	-0.4	-0.2	0.5	0.2	0.5
Trunk predicted mass	0.2	1.1	3.0	-0.3	1.7	0.1	-1.7	0.7	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	-0.5	0.3	0.3	1.0	-0.6	-0.6
Glaucoma (self-reported)	0.2	0.2	0.4	-0.1	-0.3	-0.3	0.7	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	-0.1	-0.5	-1.0	0.5	-0.0	0.3
Birth weight	0.2	0.5	1.6	-1.3	-0.5	-0.3	-0.2	-0.7	-0.7
Arm fat-free mass (right)	0.2	1.2	5.8	0.1	2.4	0.3	-1.1	0.1	0.3
Health satisfaction	0.2	0.2	1.1	0.5	-0.1	0.0	1.0	-0.1	0.3
Arm predicted mass (right)	0.2	1.2	5.8	0.1	2.4	0.3	-1.1	-0.2	0.1
Pulse rate, automated reading	0.2	0.6	1.2	-0.8	0.8	-0.2	0.2	-1.1	-0.9
Age at last live birth	0.2	0.3	0.9	-0.5	-1.0	-0.2	0.3	-0.4	0.0
Family relationship satisfaction	0.2	0.3	0.8	-0.1	-0.3	-0.4	-0.9	0.5	0.5
Illnesses of father: Heart disease	0.2	0.3	1.1	-0.3	0.1	-0.1	1.1	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.8	-0.9	0.7	0.5	0.0	-0.7	-0.1
Whole body fat-free mass	0.2	1.1	3.5	-0.2	1.9	0.1	-1.3	0.8	0.7
Leg fat-free mass (right)	0.2	1.0	2.7	-0.3	1.6	0.1	-1.0	1.1	0.8
Ever had bowel cancer screening	0.2	0.3	0.9	-0.1	-0.6	0.9	-0.1	-0.1	-0.6
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	-0.3	0.4	-0.7	-0.3	-0.1
Whole body water mass	0.2	1.2	3.8	-0.2	2.0	0.1	-1.4	0.8	0.8
Leg predicted mass (right)	0.2	1.0	2.8	-0.4	1.7	0.1	-1.1	1.1	0.8
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.7	0.1	-0.8	0.0	0.1	-0.1
Basal metabolic rate	0.2	0.9	4.0	0.0	2.0	0.2	-1.2	0.3	0.3
Irritability	0.2	0.4	1.0	-1.0	0.8	-0.4	-0.7	-0.2	0.0
Arm predicted mass (left)	0.2	1.2	5.1	-0.2	2.3	0.2	-1.1	0.3	0.6
Allergy or Eczema	0.1	0.2	0.6	-0.2	-0.8	-0.2	0.7	0.2	0.0
Tanning	0.1	0.9	2.8	-1.7	1.1	0.7	-0.4	-0.7	-0.7
Medication: Co-codamol	0.1	0.2	0.6	-0.1	0.4	0.8	-0.0	-0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	-0.5	-0.1	0.5	-0.3	0.6	0.1
Qualifications: None of the above	0.1	0.2	0.6	-0.8	0.4	-0.1	0.8	-0.0	0.1
Tense / ‘highly strung’	0.1	0.2	0.3	0.4	0.5	-0.5	0.2	-0.5	0.3
High blood pressure (siblings)	0.1	0.2	0.4	-0.6	-0.7	-0.3	-0.1	0.3	-0.2
Worry too long after embarrassment	0.1	0.2	0.7	-0.4	0.1	-0.3	0.5	0.8	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.3	-0.3	-0.0	-0.4	0.1	-0.1
Leg pain on walking	0.1	0.2	0.5	0.7	0.4	0.3	0.2	-0.4	0.3
Number of operations (self-reported)	0.1	0.2	0.9	-0.9	-0.4	0.3	-0.0	0.1	0.2

Hub : Genes

MAP3K1

Models

Trait associations