Best TWAS P=1.53e-09 · Best GWAS P=2.32e-06 conditioned to 0.058
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | AC093668.2 | 0.25 | 0.21 | lasso | 5 | 0.18 | 1.5e-09 | 4.66 | 5.2 | 1.7e-07 | 0.96 | 0.00 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | RASA4 | 0.09 | 0.02 | lasso | 5 | 0.01 | 1.0e-01 | 4.35 | -5.3 | 1.4e-07 | -0.22 | 0.03 | 0.46 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RASA4DP | 0.27 | 0.10 | enet | 33 | 0.08 | 6.2e-05 | 4.57 | -5.7 | 9.2e-09 | -0.67 | 0.01 | 0.91 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RASA4DP | 0.33 | 0.01 | enet | 42 | 0.18 | 3.9e-11 | 4.37 | -6.0 | 1.5e-09 | -0.51 | 0.02 | 0.84 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | RASA4DP | 0.20 | 0.02 | enet | 30 | 0.03 | 2.2e-02 | 0.09 | -5.3 | 9.4e-08 | -0.43 | 0.01 | 0.18 | FALSE |
| 6 | GTEx | Nerve Tibial | RASA4DP | 0.29 | 0.04 | enet | 37 | 0.11 | 3.0e-08 | 4.23 | -6.0 | 2.2e-09 | -0.52 | 0.02 | 0.52 | FALSE |
| 7 | GTEx | Whole Blood | POLR2J | 0.05 | 0.05 | enet | 10 | 0.04 | 2.2e-04 | 4.66 | -5.2 | 1.6e-07 | -0.94 | 0.01 | 0.91 | FALSE |