Best TWAS P=3.04e-15 · Best GWAS P=1.3e-15 conditioned to 0.00142
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.92 | 6.9 | 7.1e-12 | -0.57 | 0.20 | 0.34 | FALSE |
2 | GTEx | Colon Transverse | TIMM17A | 0.17 | 0.07 | enet | 11 | 0.09 | 5.1e-05 | -4.40 | -5.3 | 9.5e-08 | 0.30 | 0.34 | 0.06 | FALSE |
3 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | -8.00 | 7.5 | 7.7e-14 | -0.99 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | -8.00 | 7.4 | 1.7e-13 | -0.98 | 0.01 | 0.99 | FALSE |
5 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -7.89 | 7.9 | 3.1e-15 | -0.97 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | 7.27 | 6.6 | 4.7e-11 | -0.56 | 0.04 | 0.17 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | -7.93 | 6.6 | 5.5e-11 | -0.86 | 0.01 | 0.96 | FALSE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | -7.91 | 7.3 | 3.9e-13 | -0.90 | 0.01 | 0.86 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 7.27 | 7.9 | 3.0e-15 | -0.74 | 0.22 | 0.78 | TRUE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | -7.79 | 6.4 | 1.9e-10 | -0.83 | 0.01 | 0.81 | FALSE |
11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LMOD1 | 0.08 | -0.01 | blup | 59 | 0.01 | 1.3e-01 | 0.41 | 5.6 | 2.7e-08 | -0.78 | 0.01 | 0.47 | FALSE |