Best TWAS P=2.23e-11 · Best GWAS P=3.17e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PLK1S1 | 0.08 | 0.01 | lasso | 3 | 0.04 | 1.1e-05 | -5.5 | -5.6 | 2.8e-08 | 0.80 | 0.03 | 0.97 | FALSE |
2 | GTEx | Artery Tibial | PLK1S1 | 0.07 | 0.08 | enet | 10 | 0.08 | 4.0e-07 | -6.5 | -6.7 | 2.2e-11 | 0.97 | 0.03 | 0.97 | TRUE |
3 | GTEx | Esophagus Mucosa | PLK1S1 | 0.11 | 0.11 | lasso | 5 | 0.09 | 7.8e-07 | -5.8 | -5.7 | 1.1e-08 | 0.88 | 0.07 | 0.93 | FALSE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | PLK1S1 | 0.21 | 0.09 | lasso | 6 | 0.12 | 5.3e-07 | -6.5 | -5.8 | 5.5e-09 | 0.96 | 0.07 | 0.93 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | PLK1S1 | 0.15 | 0.13 | enet | 10 | 0.15 | 3.9e-12 | -6.0 | -5.6 | 2.8e-08 | 0.87 | 0.67 | 0.33 | FALSE |
6 | GTEx | Testis | PLK1S1 | 0.64 | 0.34 | enet | 33 | 0.39 | 1.0e-18 | -6.0 | -6.3 | 3.0e-10 | 0.81 | 0.69 | 0.31 | FALSE |
7 | GTEx | Whole Blood | PLK1S1 | 0.08 | 0.04 | enet | 9 | 0.02 | 4.0e-03 | -6.0 | -6.5 | 8.3e-11 | 0.92 | 0.05 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLK1S1 | 0.05 | 0.07 | enet | 9 | 0.07 | 5.5e-15 | -5.7 | -6.0 | 2.7e-09 | 0.93 | 0.12 | 0.88 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLK1S1 | 0.04 | 0.03 | blup | 64 | 0.04 | 4.0e-05 | -6.0 | -6.5 | 7.8e-11 | 0.93 | 0.07 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLK1S1 | 0.09 | 0.02 | blup | 64 | 0.05 | 3.1e-03 | -5.5 | -6.6 | 4.2e-11 | 0.80 | 0.02 | 0.61 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLK1S1 | 0.19 | 0.12 | enet | 14 | 0.13 | 4.3e-13 | -5.9 | -5.8 | 5.0e-09 | 0.82 | 0.65 | 0.35 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | PLK1S1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | -5.9 | -6.0 | 2.4e-09 | 0.90 | 0.11 | 0.70 | FALSE |