Best TWAS P=7.06e-11 · Best GWAS P=1.96e-09 conditioned to 0.418
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | 5.0 | 6.5 | 7.1e-11 | -0.79 | 0.07 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | -5.0 | 5.2 | 1.7e-07 | -0.07 | 0.00 | 0.68 | TRUE |
| 2 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | 4.6 | 6.2 | 5.6e-10 | -0.77 | 0.08 | 0.91 | FALSE |
| 5 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | -4.4 | -5.8 | 5.6e-09 | 0.47 | 0.04 | 0.50 | FALSE |
| 3 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | 5.6 | -5.6 | 2.6e-08 | 0.81 | 0.02 | 0.98 | FALSE |
| 1 | GTEx | Brain Putamen basal ganglia | CTB-33G10.6 | 0.21 | 0.02 | enet | 7 | -0.01 | 4.5e-01 | 5.5 | 5.3 | 1.5e-07 | -0.73 | 0.03 | 0.41 | FALSE |
| 6 | GTEx | Thyroid | FUZ | 0.08 | 0.00 | enet | 19 | 0.01 | 6.5e-02 | 5.3 | -5.1 | 2.9e-07 | 0.65 | 0.05 | 0.76 | FALSE |