TWAS
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Models
Genes
Traits
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Traits
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Impedance of arm (right)
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chr20:61,667,526-62,912,463
Best TWAS P=2.21e-09 · Best GWAS P=1.23e-09 conditioned to 0.000356
61.6M
61.8M
62M
62.2M
62.4M
62.6M
62.8M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LIME1
0.04
0.03
lasso
3
0.02
7.2e-04
-5.8
-6.0
2.2e-09
0.50
0.00
0.96
TRUE
1
CommonMind
Brain Pre-frontal Cortex
LIME1
0.04
0.00
bslmm
439
0.01
3.3e-02
3.5
-5.9
2.9e-09
0.43
0.03
0.90
FALSE
3
YFS
Blood
SLC2A4RG
0.03
0.02
lasso
11
0.02
4.2e-08
-5.8
-5.3
1.2e-07
0.49
0.01
0.99
FALSE
2
GTEx
Skin Sun Exposed Lower leg
SLC2A4RG
0.12
0.01
enet
15
0.03
7.2e-04
-4.2
-5.2
2.1e-07
0.31
0.09
0.35
FALSE