Hub : Genes

LIME1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0440 0.0180 8.5e-03 0.003 0.007 0.008 0.008 0.005 1.3e-01 3.8e-02 3.5e-02 3.3e-02 7.1e-02
2 METSIM Adipose 0.0448 0.0216 1.2e-02 0.009 0.015 0.002 0.016 0.009 1.5e-02 2.4e-03 1.4e-01 1.7e-03 1.6e-02
3 YFS Blood 0.1180 0.0185 0.0e+00 0.188 0.168 0.187 0.185 0.186 3.6e-59 1.0e-52 5.3e-59 4.2e-58 1.5e-58
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0443 0.0234 2.7e-03 0.031 0.024 0.022 NA 0.025 1.8e-04 9.4e-04 1.3e-03 NA 7.2e-04
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.0800 0.0490 1.0e-03 0.074 0.034 0.061 NA 0.062 5.1e-05 4.6e-03 2.2e-04 NA 2.0e-04
6 TCGA Brain Lower Grade Glioma 0.0248 0.0156 4.3e-03 0.026 0.015 0.005 NA 0.015 5.4e-04 6.2e-03 8.8e-02 NA 7.4e-03
7 TCGA Prostate Adenocarcinoma 0.0425 0.0230 3.1e-05 0.046 0.048 0.042 NA 0.043 1.3e-05 9.0e-06 2.9e-05 NA 2.5e-05
8 TCGA Testicular Germ Cell Tumors 0.0990 0.0590 5.6e-03 0.019 0.040 0.000 NA 0.005 6.7e-02 1.5e-02 3.3e-01 NA 2.0e-01
9 TCGA Thyroid Carcinoma 0.0460 0.0220 2.2e-05 0.030 0.044 0.019 NA 0.027 6.3e-04 3.9e-05 4.8e-03 NA 1.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.5 0.8 1.9 -0.5 1.4 0.9 0.2 -0.6 0.9 1.0 0.9 0.9
Bipolar Disorder or Schizophrenia 2.0 4.9 6.8 -2.5 1.5 2.1 -0.6 -2.6 2.6 2.3 2.3 2.6
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 0.8 -0.1 -0.8 0.9 0.3 -0.8 -0.7 -0.6 0.0
Depression (Nagel 2018) 1.8 2.7 4.2 1.9 -0.1 -2.0 0.9 1.1 -2.0 -1.8 -2.0 -1.7
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.3 0.3 0.5 0.1 -0.5 0.1 0.0 -0.0 0.1 -0.0
Neuroticism (Nagel 2018) 0.6 1.4 8.0 1.4 0.7 0.9 2.8 1.0 -0.4 0.5 0.1 0.2
Schizophrenia (2018) 2.4 4.9 8.1 -2.8 0.5 2.0 -0.9 -2.8 2.7 2.2 2.2 2.5
Schizophrenia vs Biploar Disorder 0.5 0.6 2.0 -0.2 0.0 -1.2 -1.4 -0.4 -0.7 -0.9 -0.7 -0.2
Worry (Nagel 2018) 0.9 1.8 9.5 1.3 0.8 1.6 3.1 0.6 -0.1 1.1 0.6 0.2
Alzheimer’s Disease (in mother) 1.3 1.5 4.4 -2.1 0.6 0.3 -1.2 -1.9 1.4 0.5 0.5 1.0
Alzheimer’s Disease (in father) 0.2 0.3 0.9 0.3 -1.0 -0.7 -0.2 0.4 -0.2 -0.6 -0.5 -0.3
Alzheimer’s Disease (including proxy) 1.2 1.7 5.1 -2.2 0.0 0.3 -1.6 -1.5 1.8 0.6 0.6 1.3
Crohns Disease (2017) 13.0 28.6 55.1 2.1 -1.6 -7.4 -1.7 5.1 -6.3 -6.8 -6.6 -6.1
Irritable Bowel Disease (IBD) 17.4 41.5 77.4 3.3 -3.2 -8.8 -1.2 5.6 -7.8 -7.8 -7.7 -7.8
Ulcerative Colitis (UC) 10.8 20.2 34.6 3.2 -3.2 -5.9 -0.1 3.3 -5.5 -5.0 -5.2 -5.9
Major Depression (MDD) 0.5 0.6 5.5 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.7 1.3 2.7 -0.1 0.1 -1.6 -0.7 0.4 -1.6 -1.5 -1.3 -1.5
Verbal and Numeric Reasoning (VNR) 0.9 2.3 4.2 2.0 -0.2 -1.6 0.2 2.1 -1.8 -1.6 -1.4 -1.3
Breast Cancer 0.7 1.8 6.7 2.6 -0.8 0.1 2.1 1.7 -0.6 -0.1 -0.7 -1.0
Ovarian Cancer 1.3 1.8 3.6 0.7 -0.8 -1.6 -0.0 1.3 -1.6 -1.4 -1.6 -1.9
Prostate Cancer 16.9 23.8 47.2 3.7 -0.4 -4.7 -0.2 6.9 -5.0 -5.7 -6.1 -6.0
Age at First Birth 0.6 0.8 2.0 -1.2 0.6 1.0 -0.1 0.8 1.4 1.1 0.7 0.6
Bipolar Disorder (2011) 3.2 3.1 9.4 0.0 0.0 0.0 -1.7 0.0 2.2 2.0 2.6 3.1
Body Mass Index (BMI) (2010) 0.3 0.4 2.8 -0.5 1.7 0.3 0.1 0.0 0.3 0.1 -0.0 0.1
Coronary Artery Disease (CAD) 0.4 0.4 1.2 0.0 0.0 0.0 1.1 0.0 -0.2 0.9 1.1 0.8
Crohns Disease (2012) 14.7 23.7 43.2 2.6 -0.8 -6.6 -0.6 0.0 -6.4 -6.6 -6.6 -5.9
Mean Putamen Volume 0.4 0.4 2.4 -0.8 -1.6 -0.2 -0.6 -0.1 0.1 -0.0 -0.2 -0.5
Fasting Glucose 0.4 0.5 1.1 0.8 0.0 0.8 1.0 1.0 0.0 0.4 0.7 0.6
HbA1C 0.3 0.4 0.7 -0.7 0.7 0.6 -0.0 0.1 0.5 0.6 0.8 0.8
HDL Cholesterol 2.2 3.7 7.0 -0.3 1.3 2.7 1.2 -1.9 2.0 2.5 2.4 1.9
LDL Cholesterol 4.1 6.5 15.0 -1.0 3.9 2.8 0.4 -1.8 2.5 2.8 2.9 3.0
Lupus 0.2 0.3 1.8 1.3 0.0 0.4 1.0 -0.1 -0.1 -0.0 -0.1 0.1
Neuroticism (2016) 0.4 0.6 2.5 1.2 -0.5 1.0 1.6 -0.1 -0.2 0.3 0.4 -0.1
Primary Biliary Cirrhosis 1.3 1.9 3.9 1.7 -0.7 -2.0 0.1 0.1 -1.7 -1.7 -1.5 -1.4
Rheumatoid Arthritis 1.5 2.0 6.1 0.8 -1.5 -1.5 0.6 0.4 -2.5 -1.4 -1.3 -1.6
Schizophrenia (2014) 1.6 3.6 7.5 -2.7 1.0 1.4 -1.1 -2.3 2.1 1.7 1.9 2.1
Triglycerides 0.8 1.4 3.1 0.2 0.6 -1.8 -1.5 1.1 -1.2 -1.5 -1.1 -0.5
Type 2 Diabetes (T2D) (2012) 3.1 3.5 8.8 0.0 0.0 -3.0 -1.7 0.0 -2.1 -2.6 -2.2 -1.9
Ulcerative Colitis 11.7 17.0 28.3 2.8 -2.1 -5.3 0.2 4.7 -5.2 -4.6 -4.5 -4.6
Blood Eosinophil Count 0.8 5.8 17.7 -2.5 -0.7 -3.5 -4.2 -0.7 -1.3 -2.9 -2.2 -0.9
Blood Platelet Count 3.5 40.9 67.4 6.2 -3.3 -7.1 -0.5 7.0 -8.2 -7.8 -7.2 -6.2
Blood Red Count 2.6 25.1 48.9 3.7 -3.9 -5.9 0.1 5.1 -7.0 -5.8 -4.7 -5.6
Blood White Count 2.4 17.8 29.3 2.6 -3.2 -5.4 -1.9 3.1 -4.9 -5.3 -5.0 -4.8
Heel T-Score 1.3 10.6 22.7 3.9 1.4 4.5 4.8 -0.6 1.5 3.7 3.5 2.4
BMI 1.9 10.7 23.3 3.0 -0.6 -4.3 0.1 1.0 -4.8 -4.5 -3.8 -3.2
Height 1.2 23.1 40.7 1.2 -1.6 -5.9 -3.1 6.4 -3.6 -6.3 -6.1 -5.4
Waist Hip Ratio (WHR) 0.5 2.4 6.4 -1.2 -1.4 -2.1 -2.5 1.3 -1.1 -1.6 -1.1 -0.4
Systolic Blood Pressure 3.1 15.3 51.5 7.2 -1.4 -2.1 3.8 4.6 -5.3 -2.7 -1.8 -2.6
Smoking Status 4.0 9.6 17.3 2.0 -1.7 -4.0 -0.8 2.0 -4.2 -3.9 -3.6 -3.5
Allergy or Eczema 10.8 28.5 48.7 4.8 -2.8 -5.8 1.4 4.6 -7.0 -6.1 -6.3 -6.8
Cardiovascular Disease 2.4 8.0 21.9 4.4 -0.7 -2.7 1.4 2.8 -4.7 -2.8 -1.5 -1.6
Hypothyroidism (self reported) 1.2 2.8 7.2 2.0 1.0 2.0 2.7 -0.5 0.2 1.4 1.9 1.9
Respiratory disease 7.7 17.2 28.6 3.8 -1.8 -5.0 0.8 3.4 -5.4 -5.2 -5.1 -4.2
Type 2 Diabetes (T2D) (2018) 3.7 6.9 14.3 2.2 -1.3 -3.8 -1.2 2.3 -3.4 -3.5 -2.6 -2.0
Lung FEV1/FVC ratio 0.8 4.3 13.0 1.4 -1.0 -2.0 0.8 0.8 -2.6 -2.1 -2.5 -3.6
Lung FVC 15.1 76.8 156.2 -3.2 5.1 12.5 6.1 -7.2 9.9 12.0 10.0 8.3
Neuroticism 0.7 1.7 7.3 1.5 -0.1 0.3 2.7 1.6 -1.3 -0.3 -0.7 -0.9
Chronotype (morning person) 0.6 1.3 6.7 1.6 0.7 0.8 2.6 0.0 -0.8 0.7 0.6 -0.1
Hair Pigment 0.3 8.2 15.6 -0.8 -0.5 -3.9 -1.5 1.8 -3.2 -3.9 -3.7 -3.5
Tanning 0.0 0.6 2.7 1.0 0.2 0.9 1.6 -0.0 0.5 0.6 0.3 0.3
Hand grip strength (left) 0.1 0.4 1.7 1.3 0.3 0.3 1.0 0.7 -0.3 -0.0 0.1 -0.0
Number of treatments/medications taken 3.0 5.4 10.1 3.0 -2.1 -2.4 0.8 2.1 -3.2 -2.5 -1.9 -2.1
Average weekly spirits intake 1.3 1.6 4.6 0.4 -2.1 -1.6 -0.8 0.7 -1.0 -1.4 -1.3 -1.0
Sensitivity / hurt feelings 0.4 0.8 3.6 0.6 1.9 0.8 1.1 0.0 0.2 0.6 0.5 0.5
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.4 1.6 -0.1 -1.5 0.3 0.5 -1.2 -1.2 -1.3 -1.1
Hearing difficulty/problems: Yes 0.3 0.4 1.0 0.8 -0.7 -0.4 0.4 0.8 -0.3 -0.8 -1.0 -0.6
Relative age of first facial hair 1.0 2.1 6.8 2.4 0.5 -0.1 1.8 2.6 -1.0 -0.6 -1.0 -1.0
Other serious medical condition/disability diagnosed by doctor 3.4 4.4 10.2 3.2 -1.0 -1.7 1.0 1.7 -2.5 -2.2 -2.3 -2.1
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.3 0.2 -0.1 -0.2 0.7 1.1 -0.2 -0.4 -0.7 -0.7
Ever had hysterectomy (womb removed) 0.7 0.8 2.7 0.8 1.7 0.1 1.1 0.9 -0.4 -0.4 -1.0 -0.5
Systolic blood pressure, automated reading 4.9 14.3 33.6 5.8 -1.3 -2.7 3.1 4.1 -5.3 -3.6 -2.9 -3.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.4 0.9 0.1 -0.4 0.6 1.2 -0.7 -0.4 -0.3 -0.2
Angina 1.4 1.8 8.5 2.3 0.8 0.7 2.9 0.1 -0.8 0.7 0.6 0.5
Medication for hormone replacement therapy 1.4 1.5 4.8 1.8 -0.3 1.6 2.2 0.7 0.4 1.3 1.0 0.1
Vitamin and mineral supplements 0.2 0.3 1.1 -1.1 -0.4 -0.5 -0.7 -0.4 0.1 -0.3 -0.2 0.0
Supplements: Zinc 0.1 0.1 0.4 0.7 -0.2 0.5 0.0 0.4 0.2 0.4 0.3 0.2
Medication: Co-codamol 1.9 2.2 3.9 1.5 -1.1 -2.0 -0.4 1.1 -1.9 -1.8 -1.4 -1.5
Medication: Metformin 1.0 1.4 3.9 1.2 -0.5 -2.0 -1.6 0.1 -1.4 -1.5 -0.7 0.3
Diabetes (father) 2.2 2.7 4.5 0.6 -2.1 -2.1 -0.4 1.0 -2.1 -2.0 -1.9 -1.5
Diabetes (mother) 0.3 0.4 1.3 1.1 -0.5 -0.6 0.4 0.3 -0.9 -0.6 -0.7 -0.5
Severe depression (siblings) 2.5 2.8 6.3 -0.2 -0.6 -2.5 -0.8 0.7 -2.4 -2.2 -1.8 -1.7
Pack years adult smoking proportion 2.8 4.3 7.3 2.4 -1.2 -2.7 -0.4 1.3 -2.5 -2.4 -2.4 -2.3
Impedance of leg (right) 1.2 5.6 16.5 -2.9 -2.0 -2.7 -4.1 1.0 -0.8 -2.2 -2.0 -2.0
Leg fat-free mass (left) 0.7 3.9 8.4 2.9 0.6 -2.4 0.3 1.2 -2.3 -2.6 -2.2 -1.5
Trunk fat percentage 5.1 20.6 46.0 -0.6 -2.4 -6.8 -4.9 1.6 -4.3 -6.4 -5.4 -4.1
Hand grip strength (right) 0.2 0.6 2.7 1.6 0.0 0.1 1.1 0.7 -0.6 -0.2 -0.1 -0.4
Townsend deprivation index at recruitment 0.4 0.5 2.4 -0.5 -1.3 -0.5 -1.5 0.0 -0.2 -0.5 0.3 0.4
Current tobacco smoking 9.3 15.2 26.8 2.0 -2.5 -5.2 -1.7 2.9 -4.2 -4.9 -4.9 -4.7
Average weekly fortified wine intake 0.9 1.0 2.6 -1.1 0.7 0.8 -0.8 -0.2 1.2 0.9 1.2 1.6
Maternal smoking around birth 2.7 3.9 7.0 2.1 -0.7 -2.1 1.2 1.2 -2.7 -2.3 -2.5 -2.0
Fed-up feelings 0.3 0.6 1.5 0.9 -0.9 -1.1 0.5 -0.1 -1.2 -0.8 -0.6 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.9 5.2 8.2 2.9 -0.4 -2.5 1.1 2.0 -2.9 -2.3 -2.5 -2.5
Relative age voice broke 0.5 0.8 3.8 1.2 0.5 0.4 1.9 0.9 -0.7 0.3 0.1 0.0
Taking other prescription medications 2.6 4.1 7.5 2.4 -1.0 -2.4 0.7 1.4 -2.7 -2.6 -2.1 -1.7
Age when periods started (menarche) 0.2 0.5 1.5 -0.4 0.0 0.7 -0.8 0.9 1.2 0.6 0.4 0.1
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 8.6 1.9 2.9 0.5 2.3 1.5 -1.0 -0.0 -0.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 7.9 2.8 0.7 1.0 2.1 1.3 -0.4 0.4 0.2 0.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.9 -1.1 -1.7 0.3 -1.4 -1.4 0.7 0.4 0.9 0.9
Qualifications: CSEs or equivalent 1.4 1.8 3.7 1.1 1.0 -1.4 0.4 1.5 -1.9 -1.5 -1.5 -1.3
Serious illness, injury or assault to yourself 0.8 0.9 2.7 1.1 -1.6 -1.1 -0.9 0.5 -1.2 -0.9 -0.3 -0.4
High blood pressure 3.0 8.3 28.5 5.3 -1.0 -1.3 3.1 3.1 -4.3 -1.8 -0.7 -1.4
Hayfever, allergic rhinitis or eczema 8.5 18.5 32.8 4.0 -2.4 -4.3 1.3 4.0 -5.3 -4.7 -5.1 -5.7
Multivitamins +/- minerals 0.4 0.4 0.7 0.8 0.6 0.8 0.8 0.3 0.2 0.7 0.8 0.7
Stomach or abdominal pain in last month 0.2 0.2 1.3 0.2 -0.9 0.0 -0.1 -1.1 0.1 0.2 0.2 0.2
Supplements: Glucosamine 2.0 2.6 4.9 1.2 -0.6 -1.6 0.3 1.9 -1.6 -1.9 -2.2 -2.1
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.5 -1.4 0.6 1.1 -1.1 -1.9 1.6 1.3 1.4 1.2
Medication: Atenolol 1.0 1.3 4.5 2.1 -0.8 -0.7 1.1 -0.2 -1.7 -0.8 -0.5 -0.6
Medication: Levothyroxine sodium 1.6 2.7 6.4 2.2 2.0 1.7 2.5 0.6 0.0 1.3 1.6 1.3
Sitting height 0.3 2.0 7.0 0.1 2.6 1.4 0.1 -0.4 2.3 1.2 0.8 1.3
Chronic bronchitis/emphysema (father) 3.9 4.6 11.6 0.4 -2.2 -3.4 -1.5 0.3 -2.5 -2.7 -2.4 -1.8
High blood pressure (mother) 1.0 1.5 5.5 2.3 0.4 -0.7 1.0 1.1 -1.7 -0.8 -0.6 -0.9
Body mass index (BMI) 2.1 8.9 17.8 2.5 -0.7 -4.1 -0.6 0.9 -4.1 -4.2 -3.5 -2.9
Impedance of leg (left) 1.6 7.9 19.8 -2.9 -2.7 -3.3 -4.4 1.4 -1.2 -2.9 -2.6 -2.5
Leg predicted mass (left) 0.7 3.8 8.0 2.8 0.7 -2.4 0.3 1.2 -2.3 -2.5 -2.1 -1.4
Trunk fat mass 4.7 20.1 44.3 0.5 -2.2 -6.7 -4.1 2.0 -4.7 -6.5 -5.5 -4.2
Waist circumference 4.1 15.2 30.7 2.4 -1.6 -5.5 -1.5 2.2 -4.9 -5.5 -4.7 -3.6
Number of incorrect matches in round 2.3 3.8 9.1 -0.3 -0.9 2.8 0.7 -1.5 3.0 2.5 1.8 2.0
Past tobacco smoking 0.3 0.5 1.7 -0.6 1.1 0.1 -0.6 -0.3 1.3 0.2 -0.1 0.6
Alcohol usually taken with meals 0.4 0.6 1.7 0.5 1.0 1.1 1.3 0.3 0.5 0.6 0.3 -0.2
Nervous feelings 0.4 0.8 2.0 0.1 -0.2 1.4 1.4 0.0 0.4 1.3 1.0 0.8
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 5.6 1.6 -1.5 -2.4 0.1 1.8 -2.1 -2.3 -2.3 -2.0
Hearing difficulty/problems with background noise 0.8 1.3 3.5 1.3 -0.5 -0.5 1.5 1.9 -0.8 -0.5 -1.1 -1.2
Hair/balding pattern: Pattern 2 2.0 2.5 4.3 1.7 -0.7 -1.9 -0.3 1.3 -1.9 -2.1 -1.8 -1.7
Had menopause 3.7 4.6 12.3 1.1 -1.5 -1.9 0.7 3.5 -2.2 -2.2 -2.3 -2.5
Had other major operations 0.6 0.7 1.6 -0.5 0.1 -1.1 -0.9 -0.4 -1.1 -1.3 -0.8 -0.8
Forced vital capacity (FVC) 9.0 34.6 66.6 -2.7 4.6 8.2 2.6 -4.9 6.9 7.7 6.8 5.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 8.1 2.8 1.1 0.8 1.9 1.2 -0.6 0.2 0.3 0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.8 0.8 -0.8 -0.6 1.0 0.4 -1.3 -0.4 0.1 0.5
Qualifications: None of the above 0.1 0.2 1.3 -0.2 -1.1 -0.3 0.3 -0.1 0.1 -0.3 -0.4 -0.2
Financial difficulties in last 2 years 2.0 2.6 5.2 1.1 -0.1 -2.1 0.4 1.9 -2.3 -1.9 -1.7 -1.7
Mouth/teeth dental problems 0.8 1.3 2.5 -0.4 0.6 1.4 0.3 -1.3 1.6 1.5 1.2 1.1
Heart attack 1.7 2.2 4.4 1.3 1.2 1.7 2.1 -1.4 0.2 1.7 1.8 1.3
Allergy 11.2 25.7 38.8 -5.1 3.0 5.3 -1.4 -4.9 6.2 5.7 5.9 6.0
Pain all over the body in last month 7.5 8.0 15.7 1.0 -2.6 -4.0 -1.7 1.2 -3.1 -3.6 -3.4 -3.1
Diabetes (self-reported) 2.1 3.3 6.9 1.8 -0.4 -2.6 -0.8 1.9 -2.4 -2.4 -1.6 -1.1
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.9 0.7 -0.9 -2.0 -0.1 1.0 -2.0 -1.8 -1.8 -1.7
Medication: Ramipril 2.0 2.6 8.4 1.9 0.0 -2.1 0.6 0.9 -2.9 -1.7 -1.0 -1.3
Medication: Simvastatin 0.2 0.3 0.9 -0.6 0.7 -0.6 -0.9 0.1 -0.5 -0.6 0.2 0.5
Fluid intelligence score 0.3 0.6 2.0 1.4 -0.1 -0.5 0.1 1.1 -1.1 -0.7 -0.2 -0.6
Illnesses of siblings 0.3 0.5 1.5 -1.2 0.5 0.4 0.1 -0.8 0.9 0.8 0.3 -0.1
Neuroticism score 0.2 0.4 1.1 0.6 -0.8 -0.2 1.1 0.6 -1.0 -0.3 -0.4 -0.3
Weight 2.6 13.0 27.2 2.5 -0.8 -5.0 -1.4 2.1 -4.3 -5.2 -4.5 -3.5
Impedance of arm (right) 2.0 9.5 35.8 -5.9 -0.7 -0.6 -6.0 -1.3 2.9 0.5 0.7 1.7
Arm fat percentage (right) 3.0 11.9 28.5 -0.1 -1.3 -5.3 -3.8 0.6 -3.6 -5.0 -4.1 -2.8
Trunk fat-free mass 1.0 6.0 18.9 4.3 0.8 -1.7 2.0 2.5 -2.6 -2.4 -2.2 -1.9
Hip circumference 4.3 18.4 35.2 3.4 -1.6 -5.7 -0.6 2.4 -5.5 -5.9 -5.2 -4.5
Time employed in main current job 0.2 0.2 1.1 -0.2 -1.1 0.4 0.5 -0.1 0.3 0.2 0.1 0.1
Alcohol intake versus 10 years previously 1.4 2.1 5.6 0.3 -2.4 -1.3 0.2 1.9 -1.5 -1.3 -1.3 -1.6
Father’s age at death 0.6 0.7 4.1 -0.6 2.0 0.9 0.7 -0.2 0.6 0.7 0.3 0.1
Worrier / anxious feelings 1.1 2.0 4.5 1.0 -1.3 -0.9 0.9 2.1 -1.8 -1.2 -1.3 -1.7
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.8 8.3 1.2 -2.0 -2.9 -1.1 0.5 -2.6 -2.4 -1.9 -1.7
Falls in the last year 0.9 1.2 2.5 -0.5 -1.1 -1.6 -1.0 1.1 -1.3 -1.5 -0.9 -0.1
Hair/balding pattern: Pattern 3 0.7 1.1 4.4 1.3 -2.1 -0.3 1.3 0.2 -0.9 -0.0 -0.4 -0.9
Number of live births 1.0 1.4 3.5 -1.2 0.3 -1.9 -0.9 0.6 -1.4 -1.5 -1.2 -0.6
Forced expiratory volume in 1-second (FEV1) 6.5 21.8 44.1 -1.8 4.0 6.6 2.6 -3.9 5.4 6.2 5.2 4.0
Pulse rate 0.8 1.4 4.4 -0.8 -1.0 -1.3 -2.1 0.4 -0.6 -1.1 -0.9 -1.4
Happiness 0.3 0.3 1.6 0.8 -1.3 -0.2 0.3 -0.4 -0.7 -0.1 -0.0 -0.1
Noisy workplace 0.2 0.2 0.6 0.4 -0.3 -0.6 0.5 0.1 -0.8 -0.4 -0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.5 0.5 1.0 1.2 1.0 -0.1 0.4 1.1 1.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.8 -0.4 -1.3 -0.6 -1.2 0.4 -0.5 -0.4 -0.1 -0.4
Mouth/teeth dental problems: Dentures 3.5 5.9 8.7 1.5 -2.6 -2.8 0.4 1.5 -2.9 -2.8 -2.9 -2.9
Asthma 6.3 12.4 24.6 3.7 -1.5 -3.9 1.2 3.1 -5.0 -4.2 -3.9 -3.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.4 -0.3 0.3 -0.2 0.2 -0.6 -0.2 0.1 -0.3 -0.5
Medication: Cholesterol lowering 0.1 0.2 0.5 0.6 0.3 -0.1 -0.7 -0.1 -0.4 -0.3 0.2 0.5
Depression (self-reported) 1.1 1.3 2.7 0.5 0.5 0.9 -0.2 -1.3 1.5 1.3 1.3 1.7
Medication: Lansoprazole 0.7 0.8 2.5 0.6 -0.8 -1.6 -0.8 0.1 -1.2 -1.0 -0.5 -0.3
Prospective memory result 0.9 1.1 4.2 -2.1 0.7 0.2 -0.8 -0.6 1.6 0.9 0.2 0.8
Lung cancer (father) 2.1 2.5 4.8 2.1 -0.7 -0.8 1.2 1.5 -1.4 -1.4 -2.1 -2.2
Illnesses of mother 1.2 1.5 3.6 -0.9 -0.7 1.5 0.0 -0.9 1.9 1.6 1.4 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 5.7 18.2 37.9 -1.3 3.7 6.2 3.1 -3.2 4.7 5.7 4.7 3.7
Pulse wave Arterial Stiffness index 0.2 0.2 0.8 0.1 -0.3 -0.0 -0.8 0.9 -0.3 -0.5 -0.0 -0.3
Impedance of arm (left) 2.1 9.7 37.8 -6.1 -0.2 -0.3 -5.7 -1.6 3.1 0.7 0.9 1.6
Arm fat mass (right) 3.5 14.2 30.8 1.4 -1.5 -5.6 -2.6 1.4 -4.3 -5.5 -4.7 -3.5
Trunk predicted mass 1.1 6.0 18.8 4.3 0.9 -1.8 1.9 2.5 -2.6 -2.5 -2.2 -1.9
Standing height 0.5 4.8 9.5 0.6 -0.2 -2.8 -1.8 3.1 -1.0 -2.9 -2.8 -2.1
Length of working week for main job 0.2 0.2 0.7 0.6 -0.8 -0.2 0.2 -0.6 -0.1 0.0 -0.3 -0.3
Exposure to tobacco smoke at home 0.4 0.4 1.8 -0.4 -1.3 -0.4 -1.1 -0.4 -0.2 -0.4 -0.1 -0.0
Breastfed as a baby 0.2 0.3 0.4 -0.6 0.5 -0.4 -0.6 0.6 -0.2 -0.6 -0.5 -0.4
Tense / ‘highly strung’ 0.6 0.9 3.4 1.6 -0.9 -0.2 1.9 0.1 -0.9 -0.3 -0.7 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.2 11.3 3.4 0.6 -1.7 1.8 1.6 -3.0 -1.6 -1.4 -2.0
Hair/balding pattern: Pattern 4 0.2 0.5 1.1 0.7 -0.6 -0.1 0.7 0.8 -0.5 -0.7 -0.9 -1.1
Birth weight of first child 0.5 0.9 2.0 -1.4 -0.3 -1.1 -1.2 -0.7 -0.0 -0.7 -1.2 -0.8
Peak expiratory flow (PEF) 0.7 1.5 4.4 0.0 2.1 1.6 1.2 -1.2 0.8 1.4 1.0 0.3
Pulse wave reflection index 1.3 1.6 4.2 0.6 1.4 1.8 2.1 -0.2 0.6 1.2 1.3 1.1
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.3 0.2 -0.7 0.0 0.3 -1.1 -0.2 0.4 0.3 0.4
Loud music exposure frequency 0.4 0.5 1.4 -0.8 -1.2 -0.6 -0.7 -1.0 0.1 -0.2 -0.2 0.5
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 9.0 3.0 0.9 0.1 2.3 0.9 -1.5 -0.2 -0.4 -0.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 -0.3 0.3 0.6 -0.1 -0.2 0.3 0.4 0.4 0.3
Blood clot in the leg (DVT) 0.7 0.9 3.4 1.5 -0.1 -0.8 -0.1 1.8 -0.6 -0.8 -0.8 -0.3
Medication: Paracetamol 1.3 2.1 9.6 3.1 -0.5 0.4 2.6 0.3 -1.2 0.2 0.1 -0.7
Headache pain in last month 0.7 1.2 3.7 1.1 -1.9 -1.1 -0.4 0.6 -1.1 -1.0 -0.7 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 3.8 -1.9 0.1 0.3 -0.4 -0.8 1.4 0.6 -0.1 -0.1
Glaucoma (self-reported) 0.2 0.3 1.0 -0.3 -0.5 0.5 1.0 0.1 0.3 0.3 -0.5 -0.6
Gout (self-reported) 1.0 1.3 3.3 0.1 -0.5 1.1 0.4 -1.3 0.7 1.4 1.8 1.6
Hypothyroidism/myxoedema (self-reported) 1.2 2.2 7.7 2.0 1.1 1.5 2.8 -0.0 -0.2 1.1 1.5 1.3
Medication: Amlodipine 1.3 1.9 7.9 2.8 -0.5 0.4 2.1 1.5 -1.4 -0.2 0.2 -0.4
Medication: Ventolin 100micrograms inhaler 2.4 3.1 7.0 0.4 -0.4 -2.6 -0.3 1.5 -2.5 -2.4 -2.0 -1.6
Birth weight 0.7 1.6 9.0 -3.0 -0.1 0.0 -1.7 -0.5 1.3 0.3 0.1 0.2
Chronic bronchitis/emphysema (mother) 1.7 2.0 5.3 1.1 -1.7 -2.3 -0.3 0.4 -1.9 -1.8 -1.2 -0.4
High blood pressure (siblings) 0.1 0.2 0.5 0.5 -0.5 0.5 0.1 -0.0 -0.1 0.3 0.7 0.7
Forced vital capacity (FVC), Best measure 6.8 24.8 50.4 -1.8 3.9 7.1 3.1 -3.6 5.8 6.6 5.6 4.8
Body fat percentage 5.5 21.7 48.7 -0.2 -2.4 -7.0 -4.5 1.6 -4.9 -6.6 -5.6 -4.3
Leg fat percentage (right) 5.9 21.2 44.9 1.0 -2.6 -6.7 -3.2 1.7 -5.6 -6.5 -5.4 -4.7
Arm fat-free mass (right) 2.1 10.5 23.3 4.8 0.2 -2.8 2.3 2.8 -4.0 -3.6 -3.3 -3.2
Exposure to tobacco smoke outside home 0.6 0.8 2.1 -0.2 -1.0 -1.4 -1.1 -0.7 -1.5 -0.9 0.2 0.0
Comparative body size at age 10 0.4 1.0 4.1 -1.7 -0.2 -0.7 -2.0 -1.2 0.4 -0.3 -0.1 0.0
Number of full brothers 0.7 0.9 2.3 -0.4 -1.4 -1.5 -1.2 0.3 -0.9 -1.1 -0.6 -0.1
Worry too long after embarrassment 0.9 1.6 6.1 0.7 0.7 1.9 2.5 0.4 0.4 1.3 0.9 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 -0.5 -0.8 -0.5 -1.1 -1.1 0.2 0.0 0.2 0.4
Wheeze or whistling in the chest in last year 11.7 20.8 36.7 3.1 -3.2 -5.9 -0.8 3.0 -6.1 -5.9 -5.3 -4.8
Number of children fathered 0.1 0.1 0.4 0.4 -0.2 -0.1 0.3 -0.4 -0.7 -0.3 -0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 6.0 1.2 0.8 2.0 2.5 0.1 1.3 1.8 1.1 0.6
Age at first live birth 1.7 3.0 6.8 -0.9 0.3 2.6 0.2 -0.7 2.2 2.4 2.1 1.8
Pulse wave peak to peak time 0.1 0.1 0.5 -0.0 0.2 -0.1 0.7 -0.6 0.1 0.3 -0.2 0.2
Health satisfaction 0.4 0.5 1.5 0.0 -0.6 -1.2 -0.7 -0.6 -1.0 -0.8 -0.3 -0.4
Shortness of breath walking on level ground 0.7 0.8 2.0 0.2 -1.2 -1.4 -0.5 -1.1 -0.7 -1.0 -1.0 -0.4
Qualifications: College or University degree 3.5 11.1 21.4 -2.4 1.4 4.1 -0.3 -2.2 4.6 3.9 4.0 4.1
Eye problems/disorders: None of the above 0.6 0.7 1.3 -0.1 -0.6 -0.7 -0.2 -1.1 -1.0 -1.1 -0.9 -1.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.8 -0.2 -1.7 -0.8 -1.2 0.0 -0.5 -0.5 -0.4 0.1
Emphysema/chronic bronchitis 4.1 4.7 9.4 -0.3 -2.7 -3.1 -2.0 0.5 -1.4 -2.6 -2.6 -2.3
Medication for pain relief, constipation, heartburn 2.9 5.0 11.6 -2.7 1.4 2.3 -0.9 -0.9 3.4 2.4 2.2 2.6
Neck or shoulder pain in last month 0.1 0.2 0.5 -0.4 0.6 -0.4 0.0 -0.7 -0.6 -0.1 0.2 -0.3
Medication: Blood pressure 1.1 2.0 7.7 2.8 -0.3 -0.3 1.5 1.4 -2.2 -0.6 0.1 -0.6
Angina (self-reported) 1.4 1.8 8.7 2.4 0.7 0.6 3.0 0.3 -0.9 0.5 0.4 0.4
Migraine (self-reported) 1.5 1.9 4.8 1.5 -0.8 -1.0 1.3 0.7 -2.2 -1.2 -1.2 -1.8
Medication: Ibuprofen 0.4 0.5 1.6 -1.3 -0.2 -0.2 -1.0 -1.1 0.5 0.3 0.0 0.0
Medication: Allopurinol 1.0 1.3 3.3 0.4 -1.2 1.2 0.7 -1.1 0.5 1.4 1.8 1.3
Medication: Omeprazole 4.7 5.6 10.1 0.1 -2.0 -3.2 -2.3 1.3 -2.2 -3.2 -2.9 -2.5
Medication: Seretide 50 evohaler 0.9 1.0 2.1 0.4 -0.4 -1.2 0.5 0.8 -1.3 -1.5 -1.2 -1.2
Mean time to correctly identify matches 0.6 1.2 2.2 -0.4 -0.5 -1.4 -0.5 0.8 -1.3 -1.4 -1.3 -1.5
Heart disease (mother) 0.5 0.6 1.7 0.7 -0.4 -0.7 0.2 1.3 -1.1 -0.8 -0.7 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.2 3.8 7.1 2.3 1.1 -1.2 2.7 2.1 -2.3 -1.2 -1.8 -2.2
Whole body fat mass 5.0 21.0 44.7 1.2 -1.9 -6.7 -3.3 2.3 -5.3 -6.6 -5.6 -4.5
Leg fat mass (right) 4.4 16.9 35.6 1.8 -1.9 -6.0 -2.5 1.5 -5.1 -5.9 -4.9 -4.1
Arm predicted mass (right) 2.1 10.8 23.5 4.9 0.0 -3.0 2.2 2.8 -4.1 -3.6 -3.4 -3.3
Pulse rate, automated reading 3.0 9.8 17.7 -0.3 -2.0 -4.2 -2.8 2.6 -2.8 -3.8 -3.6 -4.0
Alcohol intake frequency. 1.0 2.4 6.2 -0.5 -2.5 -2.1 -1.8 0.3 -1.0 -1.7 -1.3 -1.3
Comparative height size at age 10 0.2 0.9 3.6 -1.0 -0.5 -1.1 -1.9 0.3 0.7 -1.0 -0.7 0.2
Number of full sisters 0.5 0.7 2.7 1.2 -1.6 -0.5 -0.4 0.4 -0.5 -0.6 -0.7 -0.4
Suffer from ‘nerves’ 0.1 0.2 0.7 -0.5 0.8 0.4 0.5 -0.4 0.1 0.6 0.2 -0.0
Overall health rating 1.8 3.9 10.4 1.2 -1.2 -3.2 -1.8 -0.3 -2.3 -2.7 -1.9 -1.4
Chest pain or discomfort 0.3 0.5 0.9 0.7 -0.5 -1.0 -0.2 -0.7 -1.0 -0.7 -0.4 0.6
Had major operations 0.4 0.4 0.7 0.8 -0.4 0.8 0.5 -0.6 0.8 0.8 0.5 0.3
Age at last live birth 0.6 0.9 2.2 -0.2 -0.2 1.5 0.1 -0.5 0.7 1.4 1.4 1.1
Family relationship satisfaction 0.6 0.8 4.2 0.5 -2.0 -0.9 -0.2 -0.7 -0.9 -0.5 -0.2 0.0
Leg pain on walking 0.3 0.3 0.9 0.7 -0.6 -0.9 0.2 -0.3 -0.8 -0.4 -0.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 3.6 4.3 8.2 1.5 -0.3 -2.3 0.2 2.7 -2.9 -2.5 -2.1 -2.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.5 -0.2 -0.6 -1.2 -0.8 0.1 -0.8 -1.1 -1.1 -1.2
Illness, injury, bereavement, stress in last 2 years 3.3 4.1 6.2 -1.6 2.3 2.4 0.7 -1.6 2.5 2.3 2.0 2.2
Medication: Aspirin 1.8 2.4 5.0 1.9 -1.2 -2.0 -0.8 0.3 -2.2 -1.9 -1.3 -1.2
Supplements: Vitamin C 0.4 0.5 2.3 0.7 1.5 0.2 -0.2 0.8 -0.2 -0.5 -0.6 -0.5
Knee pain experienced in last month 0.9 1.4 2.9 -0.1 -0.8 -1.7 -0.3 -0.2 -1.4 -1.5 -1.7 -1.3
Hypertension (Self-reported) 3.0 8.2 28.1 5.3 -1.2 -1.3 3.1 3.0 -4.3 -1.8 -0.7 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.3 0.1 1.5 -1.1 -0.7 0.0 -0.6 -1.1 -0.8 -0.1
Illnesses of father: Heart disease 0.8 1.1 2.5 0.2 1.2 1.3 0.1 0.0 1.1 1.1 1.4 1.6
Illnesses of siblings: Diabetes 3.1 3.8 5.9 1.6 -1.3 -2.1 -0.2 2.4 -2.4 -2.4 -2.2 -1.9
Smoking status: Previous 0.6 0.9 2.0 0.5 -0.6 1.2 1.4 -0.4 -0.4 1.0 1.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.1 1.4 1.0 -1.4 -0.2 0.9 -1.1 -1.2 -1.1 -1.0
Whole body fat-free mass 1.0 5.8 16.0 4.0 0.7 -2.1 1.5 2.2 -2.7 -2.7 -2.4 -2.0
Leg fat-free mass (right) 0.7 3.5 8.5 2.9 0.6 -2.1 0.5 1.3 -2.1 -2.4 -2.1 -1.4
Arm fat percentage (left) 2.8 11.4 27.8 -0.2 -1.1 -5.3 -3.6 0.5 -3.6 -4.9 -4.0 -2.8
Average weekly red wine intake 0.9 1.3 5.0 2.2 -1.8 -0.0 1.1 0.7 -0.8 -0.3 -0.4 -0.7
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.4 0.5 0.3 -0.1 0.6 0.1 -0.6 -0.2 -0.4 -0.3
Mood swings 1.1 2.0 4.1 0.1 -1.6 -2.0 -1.4 0.6 -1.3 -2.0 -1.6 -1.1
Loneliness, isolation 0.5 0.8 2.6 -0.0 -0.4 -1.6 -0.9 -0.1 -1.0 -1.2 -0.9 -0.2
Long-standing illness, disability or infirmity 4.3 6.6 13.3 2.5 -1.5 -3.6 -0.5 1.8 -3.5 -3.5 -2.5 -1.7
Ever had bowel cancer screening 0.7 0.8 2.9 0.2 0.6 -0.8 0.6 1.7 -0.7 -0.9 -0.9 -0.7
Diabetes diagnosed by doctor 2.5 4.1 9.2 1.9 -0.8 -3.0 -1.1 1.7 -2.8 -2.7 -1.7 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.9 -0.7 -1.7 -1.1 -1.7 0.0 -1.0 -0.8 -0.2 -0.2
Friendships satisfaction 0.4 0.5 1.7 0.2 -1.3 -0.4 -0.5 -1.2 -0.4 -0.4 -0.0 0.4
Qualifications: nursing, teaching 0.6 1.0 1.9 0.4 1.4 1.1 0.6 -0.9 0.9 1.2 1.1 0.9
Commuting to job workplace: Walk 0.3 0.3 0.9 0.7 -0.9 -0.1 0.2 0.8 -0.6 -0.1 0.2 -0.0
Eye problems/disorders: Cataract 1.3 1.5 3.8 -0.8 0.3 0.9 -0.6 -0.9 1.4 1.4 1.8 1.9
Mouth/teeth dental problems: Mouth ulcers 2.7 4.3 7.8 -0.6 2.7 2.8 0.9 -1.0 1.9 2.6 2.7 2.0
Medication for cholesterol 4.5 6.8 19.6 -4.4 1.3 1.6 -2.8 -2.8 3.6 1.8 1.2 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.4 0.3 -0.3 -0.1 0.1 0.6 -0.4 -0.2 -0.4 -0.6
Back pain experienced in last month 0.2 0.4 1.0 -0.0 -0.7 -0.7 -1.0 -0.8 0.3 -0.4 -0.5 0.2
Mineral and other dietary supplements 0.4 0.5 0.9 -0.6 -0.6 0.8 0.1 -1.0 0.5 0.8 1.0 0.5
Breast cancer (self-reported) 1.0 1.2 2.6 -1.6 0.3 1.1 -0.5 -1.1 0.9 1.2 1.6 1.1
Asthma (self-reported) 5.6 11.2 22.5 3.4 -1.4 -3.8 1.0 2.9 -4.7 -4.1 -3.8 -3.2
Osteoporosis (self-reported) 0.3 0.4 1.5 -1.2 -0.5 0.6 0.2 -0.0 0.8 0.6 0.3 0.5
Osteoarthritis (self-reported) 0.5 0.6 1.7 -0.0 -0.6 -0.8 0.4 0.7 -0.9 -0.8 -0.9 -1.3
Medication: Aspirin 1.6 2.0 4.0 1.7 -1.4 -1.8 -0.8 0.2 -2.0 -1.8 -1.1 -1.2
Medication: Gliclazide 1.3 1.5 2.7 0.7 -1.7 -1.6 -1.3 0.3 -1.6 -1.5 -0.8 -0.8
Illnesses of father: None of the above (group 1) 0.6 0.7 2.0 -1.4 1.2 0.7 -0.3 -0.8 1.0 0.7 0.4 0.0
Smoking status: Current 8.2 13.1 22.4 1.9 -2.1 -4.7 -1.6 2.9 -3.8 -4.6 -4.6 -4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.8 20.7 45.1 -1.7 1.7 6.7 3.6 -3.2 4.8 6.4 5.7 4.2
Whole body water mass 1.0 5.9 16.8 4.1 0.6 -2.1 1.6 2.1 -2.8 -2.7 -2.4 -2.0
Leg predicted mass (right) 0.7 3.8 9.3 3.0 0.5 -2.2 0.6 1.4 -2.3 -2.5 -2.1 -1.5
Arm fat mass (left) 3.1 12.6 28.3 1.4 -1.0 -5.3 -2.4 1.2 -4.3 -5.2 -4.4 -3.3
Number of self-reported non-cancer illnesses 6.7 11.6 21.0 4.0 0.2 -3.7 1.6 3.4 -4.6 -3.8 -3.6 -3.4
Average weekly champagne plus white wine intake 0.2 0.2 1.2 -0.3 -0.0 0.5 1.1 0.4 0.5 0.4 0.0 -0.3
Miserableness 1.2 2.1 4.0 1.1 -1.7 -2.0 -0.8 0.6 -1.5 -1.7 -1.6 -1.5
Guilty feelings 1.1 1.7 3.7 -1.2 0.1 1.7 0.5 -0.2 1.4 1.5 1.5 1.9
Wears glasses or contact lenses 0.4 0.4 1.0 -0.6 -0.1 0.6 -0.1 0.9 0.6 0.6 0.8 1.0
Ever taken oral contraceptive pill 0.9 1.0 2.1 0.2 0.1 -1.4 -0.4 -0.1 -1.5 -1.3 -1.1 -1.4
Hearing aid user 1.5 1.7 3.6 0.2 -1.8 -1.6 -0.6 -0.4 -1.4 -1.9 -1.5 -1.2
Mother’s age at death 0.3 0.3 1.4 -0.6 1.2 0.2 -0.3 -0.4 0.8 0.1 -0.4 0.0
Financial situation satisfaction 1.4 1.7 3.3 -0.6 0.1 1.4 -0.2 -1.8 1.5 1.5 1.6 1.8
Tinnitus: Yes, now most or all of the time 1.8 2.1 9.7 2.2 0.7 1.1 3.1 1.5 -0.2 0.7 0.3 -0.1
Commuting to job workplace: Public transport 0.1 0.2 0.6 0.8 -0.3 -0.2 0.3 -0.6 -0.3 -0.3 -0.1 0.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.5 -0.1 -0.7 0.1 0.5 0.1 0.0 0.1 -0.4 -0.4
Medication: Blood pressure 5.7 10.9 28.8 5.4 -1.4 -2.2 3.2 3.7 -4.6 -2.7 -1.9 -2.5
Pain type(s) experienced in last month: Hip pain 0.8 1.1 3.3 -1.0 -0.2 -1.8 -1.3 0.2 -1.1 -1.2 -0.6 -0.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.3 0.5 -0.3 -1.0 -0.7 1.1 -0.8 -1.1 -0.9 -0.6
High cholesterol (Self-reported) 0.5 0.9 4.3 -0.9 0.8 -0.6 -2.1 -0.8 0.1 -0.4 0.3 1.1
Medication: Bendroflumethiazide 1.3 2.0 4.5 2.1 -0.5 -1.4 0.3 2.1 -2.0 -1.4 -0.9 -0.7
Medication: Paracetamol 0.3 0.5 1.9 1.4 -0.5 0.4 1.0 -0.6 -0.3 0.5 0.6 -0.0
Medication: Lisinopril 0.6 0.8 2.8 1.5 -0.4 0.0 1.0 1.7 -1.0 -0.1 0.2 -0.3
Medication: Atorvastatin 0.4 0.5 2.1 1.3 -1.4 -0.2 -0.3 -0.1 -0.4 0.1 0.2 0.1
Illnesses of father: High blood pressure 0.2 0.3 0.9 0.6 -0.9 -0.1 -0.2 0.6 -1.0 -0.3 0.1 0.1
Alcohol drinker status: Never 0.4 0.5 1.2 -0.7 -0.8 -0.8 -1.1 -0.6 0.3 -0.5 -0.8 -0.6
Ever smoked 0.1 0.1 0.4 -0.3 -0.0 0.1 0.3 -0.4 -0.6 0.1 0.3 -0.2
Basal metabolic rate 1.4 7.5 13.7 3.7 0.3 -3.1 0.6 2.2 -3.3 -3.5 -3.1 -2.5
Leg fat percentage (left) 7.0 25.2 52.1 1.0 -3.1 -7.2 -3.4 2.0 -6.1 -7.1 -5.9 -5.1
Arm fat-free mass (left) 2.4 12.1 22.1 4.7 -0.3 -3.5 1.5 3.0 -4.2 -4.2 -3.9 -3.5
Number of operations (self-reported) 0.8 1.2 3.6 1.9 1.1 -0.9 0.7 0.7 -1.6 -1.1 -0.7 -0.6
Average weekly beer plus cider intake 1.2 1.8 4.6 -0.7 -0.7 -2.2 -1.4 0.5 -1.2 -1.6 -1.6 -1.3
Irritability 1.4 2.3 5.1 1.1 -2.3 -1.3 0.4 1.5 -1.8 -1.7 -1.6 -1.5
Risk taking 0.5 0.7 4.4 -0.7 -0.3 -0.3 -2.1 -0.6 0.5 0.2 0.7 0.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.1 0.0 -0.8 1.4 0.6 -0.8 1.3 1.3 1.3 1.4
Fractured/broken bones in last 5 years 0.4 0.5 1.3 -0.6 -1.1 0.0 -0.7 -0.6 0.9 0.3 0.6 1.1
Age started oral contraceptive pill 0.4 0.5 2.2 0.5 -0.4 1.1 1.5 0.8 0.3 0.4 -0.1 -0.1
Diastolic blood pressure, automated reading 6.9 21.5 40.2 6.1 -1.5 -4.2 2.3 4.8 -6.3 -4.8 -4.2 -5.2
Ever depressed for a whole week 1.0 1.3 5.2 2.1 -0.6 0.7 2.3 -0.0 -0.7 0.5 0.5 0.3
Unable to work because of sickness or disability 0.9 1.2 3.0 0.8 -1.6 -1.7 -1.1 -1.1 -0.4 -0.7 -0.9 -0.1
Commuting to job workplace: Cycle 2.5 3.1 6.5 -1.1 0.7 2.1 0.2 -1.7 1.6 2.1 2.5 2.3
Myopia 2.3 3.3 8.6 -2.9 1.5 0.8 -2.4 -1.3 2.4 1.2 1.2 1.6
Vascular/heart problems diagnosed by doctor 2.9 7.9 25.0 -5.0 1.2 1.5 -3.0 -3.0 4.3 1.8 0.7 1.5
Cholesterol lowering medication 0.2 0.4 1.1 0.4 -0.0 -1.0 -0.6 0.2 -0.9 -0.8 -0.3 -0.2
Medication: Omeprazole (e.g. Zanprol) 7.4 9.1 17.4 0.5 -1.8 -4.1 -2.4 1.7 -3.2 -4.2 -3.8 -3.3
Pain experienced in last month 3.5 5.9 13.1 -0.5 2.0 3.6 1.6 -0.0 2.9 3.3 2.8 2.5
Supplements: Calcium 0.7 0.8 3.3 0.6 1.8 0.7 0.9 0.9 0.4 0.6 0.4 0.5
Basal cell carcinoma (self-reported) 0.5 0.6 1.7 -0.6 0.6 -0.8 -1.3 1.2 -0.0 -0.6 -0.5 -0.2
Heart attack/myocardial infarction (self-reported) 1.5 2.0 4.0 1.2 1.0 1.6 2.0 -1.4 0.2 1.6 1.7 1.2
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 3.4 1.2 -0.1 -1.0 -0.5 1.8 -0.6 -1.0 -0.9 -0.4
Heart disease (siblings) 0.5 0.6 2.1 1.4 -0.8 0.2 0.9 0.9 -0.1 -0.2 -0.5 -0.6
Alcohol drinker status: Previous 1.4 1.6 3.3 0.4 -1.0 -1.8 -0.5 0.3 -1.6 -1.6 -1.5 -1.3
Pack years of smoking 2.8 4.1 6.6 2.2 -1.1 -2.6 -0.4 1.4 -2.2 -2.4 -2.4 -2.4
Impedance of whole body 1.5 7.9 33.2 -5.3 -1.5 -1.8 -5.8 -0.2 1.3 -1.0 -0.8 -0.3
Leg fat mass (left) 4.7 18.5 39.0 1.7 -2.2 -6.2 -2.7 1.6 -5.3 -6.1 -5.2 -4.2
Arm predicted mass (left) 2.2 11.2 19.7 4.4 -0.2 -3.5 1.3 3.0 -4.1 -4.1 -3.7 -3.3