Best TWAS P=7.3e-25 · Best GWAS P=6.46e-23 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | -9.9 | -10.3 | 7.3e-25 | 0.96 | 0.02 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | -9.8 | -10.1 | 6.8e-24 | 0.97 | 0.01 | 0.99 | FALSE |
| 1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | -7.8 | -7.6 | 2.8e-14 | 0.67 | 0.95 | 0.05 | FALSE |
| 2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | 5.2 | 6.6 | 4.6e-11 | -0.48 | 0.06 | 0.10 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | -9.0 | -6.3 | 3.1e-10 | 0.84 | 0.04 | 0.84 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CADM2 | 0.05 | 0.00 | blup | 339 | 0.02 | 3.2e-03 | -3.8 | -5.3 | 1.3e-07 | 0.66 | 0.03 | 0.65 | FALSE |