Best TWAS P=6.68e-10 · Best GWAS P=8.64e-11 conditioned to 0.0191
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RNF212 | 0.14 | 0.11 | lasso | 6 | 0.11 | 2.3e-13 | 5.9 | -5.9 | 4.1e-09 | -0.92 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | RNF212 | 0.15 | 0.03 | lasso | 3 | 0.01 | 1.5e-01 | 6.0 | -6.2 | 6.7e-10 | -0.85 | 0.03 | 0.74 | TRUE |
| 3 | GTEx | Esophagus Muscularis | RP11-20I20.4 | 0.19 | 0.09 | lasso | 3 | 0.10 | 1.9e-06 | -3.9 | 6.0 | 2.0e-09 | 0.79 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Lung | RP11-20I20.4 | 0.07 | 0.00 | lasso | 3 | 0.01 | 6.0e-02 | 3.9 | 5.5 | 4.9e-08 | 0.56 | 0.10 | 0.29 | FALSE |
| 5 | GTEx | Pancreas | CRIPAK | 0.34 | 0.13 | lasso | 6 | 0.27 | 1.0e-11 | 4.8 | 5.1 | 2.7e-07 | 0.46 | 0.80 | 0.06 | FALSE |
| 6 | METSIM | Adipose | SPON2 | 0.06 | 0.06 | lasso | 8 | 0.05 | 2.2e-08 | 5.9 | 6.1 | 7.8e-10 | 0.92 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RNF212 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | 5.9 | -5.9 | 4.4e-09 | -0.96 | 0.00 | 1.00 | FALSE |