Best TWAS P=8.5e-13 · Best GWAS P=1.75e-10 conditioned to 0.0574
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FBN2 | 0.22 | 0.24 | lasso | 11 | 0.28 | 1.6e-34 | -6.3 | -6.2 | 5.3e-10 | 0.96 | 0.00 | 1.00 | FALSE |
| 2 | METSIM | Adipose | FBN2 | 0.11 | 0.18 | bslmm | 564 | 0.18 | 1.3e-25 | -6.3 | -6.4 | 2.0e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | NTR | Blood | FBN2 | 0.03 | 0.02 | lasso | 7 | 0.01 | 5.3e-05 | -6.3 | -6.1 | 8.6e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | FBN2 | 0.08 | 0.08 | enet | 11 | 0.09 | 2.3e-11 | -6.3 | -6.1 | 7.9e-10 | 0.96 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FBN2 | 0.02 | 0.03 | lasso | 4 | 0.02 | 1.0e-05 | -6.0 | -5.8 | 5.1e-09 | 0.98 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FBN2 | 0.18 | 0.20 | lasso | 6 | 0.24 | 3.7e-27 | -6.3 | -6.6 | 5.4e-11 | 0.97 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FBN2 | 0.24 | 0.24 | lasso | 4 | 0.28 | 1.5e-13 | -6.3 | -5.6 | 1.6e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FBN2 | 0.11 | 0.12 | blup | 159 | 0.14 | 2.2e-16 | -4.7 | -7.2 | 8.5e-13 | 0.89 | 0.02 | 0.98 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FBN2 | 0.03 | 0.02 | lasso | 2 | 0.02 | 4.5e-03 | -5.9 | -5.9 | 4.0e-09 | 0.98 | 0.01 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FBN2 | 0.21 | 0.07 | blup | 159 | 0.10 | 4.2e-05 | -6.0 | -5.8 | 6.4e-09 | 0.89 | 0.01 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FBN2 | 0.19 | 0.20 | lasso | 3 | 0.17 | 3.7e-07 | -6.3 | -6.1 | 8.0e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBN2 | 0.04 | 0.02 | lasso | 4 | 0.01 | 1.7e-02 | -4.2 | -5.3 | 9.8e-08 | 0.02 | 0.19 | 0.25 | TRUE |
| 13 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | FBN2 | 0.20 | 0.12 | lasso | 4 | 0.10 | 9.4e-04 | -5.6 | -5.3 | 1.4e-07 | 0.72 | 0.02 | 0.81 | FALSE |
| 14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FBN2 | 0.09 | 0.04 | blup | 159 | 0.06 | 4.6e-05 | -6.3 | -5.4 | 7.3e-08 | 0.88 | 0.00 | 0.99 | FALSE |