Best TWAS P=3.08e-12 · Best GWAS P=1.28e-12 conditioned to 0.0273
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RIF1 | 0.11 | 0.07 | lasso | 4 | 0.07 | 8.0e-09 | 6.01 | -6.2 | 5.6e-10 | -0.77 | 0.32 | 0.68 | FALSE |
2 | GTEx | Adipose Subcutaneous | RIF1 | 0.26 | 0.20 | lasso | 2 | 0.28 | 6.8e-23 | -5.08 | -6.3 | 3.3e-10 | -0.64 | 0.99 | 0.01 | FALSE |
3 | GTEx | Adrenal Gland | RIF1 | 0.14 | 0.04 | lasso | 2 | 0.05 | 6.4e-03 | 6.01 | -6.3 | 2.1e-10 | -0.75 | 0.11 | 0.38 | FALSE |
4 | GTEx | Artery Aorta | RIF1 | 0.22 | 0.14 | lasso | 3 | 0.17 | 1.5e-09 | 6.01 | -6.5 | 1.0e-10 | -0.74 | 0.56 | 0.44 | FALSE |
5 | GTEx | Artery Coronary | RIF1 | 0.28 | 0.09 | lasso | 6 | 0.09 | 6.8e-04 | 6.01 | -6.5 | 6.5e-11 | -0.74 | 0.07 | 0.87 | FALSE |
6 | GTEx | Artery Tibial | RIF1 | 0.20 | 0.17 | lasso | 3 | 0.23 | 2.8e-18 | -5.06 | -6.3 | 2.4e-10 | -0.67 | 0.91 | 0.08 | FALSE |
7 | GTEx | Brain Putamen basal ganglia | RIF1 | 0.21 | 0.02 | enet | 10 | 0.03 | 7.4e-02 | -0.43 | -5.1 | 2.9e-07 | -0.56 | 0.06 | 0.37 | FALSE |
8 | GTEx | Breast Mammary Tissue | RIF1 | 0.19 | 0.10 | lasso | 6 | 0.13 | 4.4e-07 | -5.04 | -6.0 | 1.5e-09 | -0.64 | 0.29 | 0.71 | FALSE |
9 | GTEx | Breast Mammary Tissue (Male) | RIF1 | 0.42 | 0.18 | lasso | 9 | 0.26 | 7.5e-07 | -5.04 | -6.1 | 8.3e-10 | -0.61 | 0.12 | 0.72 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | RIF1 | 0.11 | 0.07 | enet | 12 | 0.08 | 1.2e-06 | 6.01 | -6.0 | 1.7e-09 | -0.83 | 0.01 | 0.98 | FALSE |
11 | GTEx | Colon Sigmoid | RIF1 | 0.25 | 0.14 | lasso | 8 | 0.10 | 1.9e-04 | 6.01 | -6.1 | 1.3e-09 | -0.79 | 0.12 | 0.75 | FALSE |
12 | GTEx | Colon Transverse | RIF1 | 0.20 | 0.04 | lasso | 7 | 0.06 | 7.5e-04 | 7.10 | -7.0 | 3.1e-12 | -0.85 | 0.01 | 0.98 | TRUE |
13 | GTEx | Esophagus Gastroesophageal Junction | RIF1 | 0.15 | 0.13 | lasso | 5 | 0.16 | 1.8e-06 | 6.01 | -6.3 | 3.7e-10 | -0.69 | 0.24 | 0.51 | FALSE |
14 | GTEx | Esophagus Muscularis | RIF1 | 0.32 | 0.25 | lasso | 5 | 0.30 | 1.3e-18 | -5.04 | -5.6 | 2.2e-08 | -0.61 | 0.99 | 0.01 | FALSE |
15 | GTEx | Lung | RIF1 | 0.15 | 0.12 | lasso | 2 | 0.17 | 4.0e-13 | 6.01 | -6.4 | 1.3e-10 | -0.70 | 0.50 | 0.50 | FALSE |
16 | GTEx | Nerve Tibial | RIF1 | 0.35 | 0.21 | lasso | 5 | 0.30 | 5.7e-22 | 6.01 | -6.5 | 6.2e-11 | -0.70 | 0.60 | 0.40 | FALSE |
17 | GTEx | Pancreas | RIF1 | 0.16 | 0.11 | lasso | 3 | 0.08 | 2.7e-04 | 6.01 | -5.8 | 6.8e-09 | -0.80 | 0.04 | 0.91 | FALSE |
18 | GTEx | Pituitary | RIF1 | 0.20 | -0.01 | lasso | 4 | -0.01 | 7.5e-01 | -5.08 | -5.7 | 1.0e-08 | -0.57 | 0.06 | 0.38 | FALSE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | RIF1 | 0.37 | 0.34 | enet | 26 | 0.39 | 5.5e-23 | -5.08 | -6.5 | 9.8e-11 | -0.66 | 0.98 | 0.02 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | RIF1 | 0.34 | 0.28 | enet | 11 | 0.38 | 3.4e-33 | -5.08 | -6.3 | 3.1e-10 | -0.65 | 0.98 | 0.02 | FALSE |
21 | GTEx | Spleen | RIF1 | 0.39 | 0.25 | lasso | 3 | 0.20 | 9.1e-06 | 6.01 | -6.1 | 1.3e-09 | -0.76 | 0.11 | 0.64 | FALSE |
22 | METSIM | Adipose | RIF1 | 0.04 | 0.04 | lasso | 7 | 0.03 | 2.2e-05 | 6.01 | -7.0 | 3.7e-12 | -0.94 | 0.01 | 0.99 | FALSE |
23 | The Cancer Genome Atlas | Thyroid Carcinoma | NEB | 0.12 | 0.05 | blup | 101 | 0.08 | 1.9e-08 | -4.64 | 5.3 | 1.4e-07 | 0.46 | 0.94 | 0.06 | FALSE |