TWAS
hub
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Usage
Models
Genes
Traits
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Traits
:
Leg fat percentage (right)
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chr3:14,947,539-16,385,395
Best TWAS P=5.36e-09 · Best GWAS P=5.44e-09 conditioned to 0.346
15M
15.2M
15.4M
15.6M
15.8M
16M
16.2M
16.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
BTD
0.07
0.09
lasso
3
0.07
1.2e-09
5.8
5.8
5.4e-09
0.95
0.00
1.00
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
BTD
0.04
0.02
lasso
3
0.02
6.5e-03
5.8
5.8
7.3e-09
0.97
0.00
0.89
FALSE
2
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
BTD
0.07
0.04
enet
9
0.04
1.6e-03
-4.7
5.3
1.2e-07
0.75
0.00
0.75
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
BTD
0.08
0.12
lasso
4
0.10
5.0e-10
4.5
5.1
3.1e-07
0.91
0.02
0.98
FALSE