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chr20:42,816,319-44,279,989

Best TWAS P=2.37e-09 · Best GWAS P=5.41e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PABPC1L	0.17	0.16	lasso	1	0.15	8.0e-18	5.6	-5.6	2.1e-08	-0.99	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	YWHAB	0.13	0.17	lasso	2	0.15	2.8e-12	5.8	-5.8	6.2e-09	-1.00	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	YWHAB	0.19	0.07	lasso	4	0.05	1.1e-03	5.6	-5.8	7.0e-09	-0.99	0.01	0.98	FALSE
4	GTEx	Adrenal Gland	YWHAB	0.23	0.15	lasso	3	0.10	1.4e-04	5.8	-5.7	1.0e-08	-1.00	0.01	0.99	FALSE
5	GTEx	Artery Aorta	YWHAB	0.29	0.17	lasso	5	0.15	1.3e-08	5.8	-6.0	2.4e-09	-0.99	0.01	0.99	TRUE
6	GTEx	Artery Tibial	YWHAB	0.17	0.15	lasso	3	0.16	3.5e-12	5.8	-5.8	6.2e-09	-1.00	0.00	1.00	FALSE
7	GTEx	Brain Cerebellar Hemisphere	YWHAB	0.42	0.22	lasso	4	0.18	2.3e-05	5.6	-5.7	1.5e-08	-0.99	0.01	0.98	FALSE
8	GTEx	Brain Cerebellum	YWHAB	0.43	0.19	lasso	7	0.16	1.7e-05	5.6	-5.9	2.8e-09	-0.97	0.01	0.98	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	YWHAB	0.22	0.11	lasso	3	0.07	6.5e-03	5.6	-5.7	1.3e-08	-0.97	0.01	0.95	FALSE
10	GTEx	Breast Mammary Tissue	YWHAB	0.18	0.09	lasso	6	0.08	5.2e-05	5.8	-5.4	5.8e-08	-0.97	0.01	0.99	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	YWHAB	0.27	0.12	enet	13	0.18	1.2e-06	5.2	-5.7	1.2e-08	-0.95	0.01	0.99	FALSE
12	GTEx	Cells Transformed fibroblasts	YWHAB	0.29	0.20	enet	21	0.26	1.5e-19	5.6	-5.9	3.4e-09	-0.84	0.01	0.99	FALSE
13	GTEx	Colon Sigmoid	YWHAB	0.27	0.14	lasso	4	0.10	1.7e-04	5.6	-5.2	2.1e-07	-0.94	0.01	0.98	FALSE
14	GTEx	Esophagus Mucosa	YWHAB	0.25	0.27	enet	7	0.27	4.2e-18	5.8	-5.7	1.1e-08	-0.99	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	YWHAB	0.16	0.11	lasso	3	0.14	1.5e-08	4.7	-5.2	1.9e-07	-0.92	0.01	0.99	FALSE
16	GTEx	Lung	YWHAB	0.10	0.04	lasso	4	0.04	6.5e-04	5.8	-5.8	6.8e-09	-0.99	0.01	0.99	FALSE
17	GTEx	Muscle Skeletal	YWHAB	0.09	0.07	lasso	5	0.07	4.5e-07	5.6	-5.2	2.5e-07	-0.98	0.01	0.99	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	YWHAB	0.33	0.24	lasso	4	0.26	1.6e-14	5.6	-5.6	2.6e-08	-0.96	0.01	0.99	FALSE
19	GTEx	Skin Sun Exposed Lower leg	YWHAB	0.17	0.18	lasso	2	0.17	4.7e-14	5.8	-5.8	6.0e-09	-1.00	0.00	1.00	FALSE
20	GTEx	Testis	YWHAB	0.23	0.23	enet	14	0.23	1.8e-10	5.8	-5.5	5.0e-08	-0.97	0.00	1.00	FALSE
21	GTEx	Thyroid	YWHAB	0.22	0.18	lasso	2	0.17	5.3e-13	5.8	-5.8	5.6e-09	-1.00	0.00	1.00	FALSE
22	GTEx	Whole Blood	YWHAB	0.20	0.10	lasso	9	0.10	1.6e-09	5.8	-5.2	1.5e-07	-0.98	0.01	0.99	FALSE
23	NTR	Blood	YWHAB	0.16	0.19	lasso	5	0.19	2.2e-58	5.6	-5.6	2.1e-08	-0.99	0.01	0.99	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	PABPC1L	0.24	0.21	lasso	3	0.21	8.1e-27	5.6	-5.3	9.8e-08	-0.98	0.01	0.99	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	YWHAB	0.56	0.58	bslmm	418	0.59	7.7e-94	5.8	-5.8	7.2e-09	-1.00	0.00	1.00	FALSE
26	YFS	Blood	PABPC1L	0.17	0.13	enet	41	0.14	1.8e-43	4.7	5.1	2.8e-07	0.79	0.60	0.39	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC1L	0.02	0.02	lasso	4	0.02	2.2e-04	5.6	-5.6	2.2e-08	-0.99	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	PABPC1L	0.08	0.01	enet	8	0.02	3.6e-02	5.6	-5.5	4.4e-08	-0.78	0.01	0.86	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	PABPC1L	0.20	0.21	lasso	3	0.21	5.5e-23	5.6	-5.6	2.1e-08	-0.99	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	YWHAB	0.06	0.07	enet	6	0.09	7.4e-11	4.7	-5.6	2.2e-08	-0.94	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	YWHAB	0.07	0.06	lasso	2	0.06	1.3e-04	5.6	-6.0	2.7e-09	-0.99	0.01	0.97	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	PABPC1L	0.08	0.14	lasso	4	0.14	4.2e-14	5.6	-5.6	2.1e-08	-0.99	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	YWHAB	0.07	0.06	lasso	6	0.06	3.1e-07	5.6	-5.3	1.2e-07	-0.96	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Stomach Adenocarcinoma	YWHAB	0.04	0.05	enet	10	0.03	2.3e-03	5.2	-5.2	1.7e-07	-0.88	0.01	0.92	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	YWHAB	0.12	0.13	lasso	5	0.12	4.3e-12	5.6	-5.6	1.8e-08	-0.99	0.01	0.99	FALSE