[Hub]/) : Traits : Leg fat mass (right) :

chr20:42,816,319-44,279,989

Best TWAS P=2.37e-09 · Best GWAS P=5.41e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PABPC1L 0.17 0.16 lasso 1 0.15 8.0e-18 5.6 -5.6 2.1e-08 -0.99 0.01 0.99 FALSE
2 GTEx Adipose Subcutaneous YWHAB 0.13 0.17 lasso 2 0.15 2.8e-12 5.8 -5.8 6.2e-09 -1.00 0.00 1.00 FALSE
3 GTEx Adipose Visceral Omentum YWHAB 0.19 0.07 lasso 4 0.05 1.1e-03 5.6 -5.8 7.0e-09 -0.99 0.01 0.98 FALSE
4 GTEx Adrenal Gland YWHAB 0.23 0.15 lasso 3 0.10 1.4e-04 5.8 -5.7 1.0e-08 -1.00 0.01 0.99 FALSE
5 GTEx Artery Aorta YWHAB 0.29 0.17 lasso 5 0.15 1.3e-08 5.8 -6.0 2.4e-09 -0.99 0.01 0.99 TRUE
6 GTEx Artery Tibial YWHAB 0.17 0.15 lasso 3 0.16 3.5e-12 5.8 -5.8 6.2e-09 -1.00 0.00 1.00 FALSE
7 GTEx Brain Cerebellar Hemisphere YWHAB 0.42 0.22 lasso 4 0.18 2.3e-05 5.6 -5.7 1.5e-08 -0.99 0.01 0.98 FALSE
8 GTEx Brain Cerebellum YWHAB 0.43 0.19 lasso 7 0.16 1.7e-05 5.6 -5.9 2.8e-09 -0.97 0.01 0.98 FALSE
9 GTEx Brain Nucleus accumbens basal ganglia YWHAB 0.22 0.11 lasso 3 0.07 6.5e-03 5.6 -5.7 1.3e-08 -0.97 0.01 0.95 FALSE
10 GTEx Breast Mammary Tissue YWHAB 0.18 0.09 lasso 6 0.08 5.2e-05 5.8 -5.4 5.8e-08 -0.97 0.01 0.99 FALSE
11 GTEx Cells EBV-transformed lymphocytes YWHAB 0.27 0.12 enet 13 0.18 1.2e-06 5.2 -5.7 1.2e-08 -0.95 0.01 0.99 FALSE
12 GTEx Cells Transformed fibroblasts YWHAB 0.29 0.20 enet 21 0.26 1.5e-19 5.6 -5.9 3.4e-09 -0.84 0.01 0.99 FALSE
13 GTEx Colon Sigmoid YWHAB 0.27 0.14 lasso 4 0.10 1.7e-04 5.6 -5.2 2.1e-07 -0.94 0.01 0.98 FALSE
14 GTEx Esophagus Mucosa YWHAB 0.25 0.27 enet 7 0.27 4.2e-18 5.8 -5.7 1.1e-08 -0.99 0.01 0.99 FALSE
15 GTEx Esophagus Muscularis YWHAB 0.16 0.11 lasso 3 0.14 1.5e-08 4.7 -5.2 1.9e-07 -0.92 0.01 0.99 FALSE
16 GTEx Lung YWHAB 0.10 0.04 lasso 4 0.04 6.5e-04 5.8 -5.8 6.8e-09 -0.99 0.01 0.99 FALSE
17 GTEx Muscle Skeletal YWHAB 0.09 0.07 lasso 5 0.07 4.5e-07 5.6 -5.2 2.5e-07 -0.98 0.01 0.99 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic YWHAB 0.33 0.24 lasso 4 0.26 1.6e-14 5.6 -5.6 2.6e-08 -0.96 0.01 0.99 FALSE
19 GTEx Skin Sun Exposed Lower leg YWHAB 0.17 0.18 lasso 2 0.17 4.7e-14 5.8 -5.8 6.0e-09 -1.00 0.00 1.00 FALSE
20 GTEx Testis YWHAB 0.23 0.23 enet 14 0.23 1.8e-10 5.8 -5.5 5.0e-08 -0.97 0.00 1.00 FALSE
21 GTEx Thyroid YWHAB 0.22 0.18 lasso 2 0.17 5.3e-13 5.8 -5.8 5.6e-09 -1.00 0.00 1.00 FALSE
22 GTEx Whole Blood YWHAB 0.20 0.10 lasso 9 0.10 1.6e-09 5.8 -5.2 1.5e-07 -0.98 0.01 0.99 FALSE
23 NTR Blood YWHAB 0.16 0.19 lasso 5 0.19 2.2e-58 5.6 -5.6 2.1e-08 -0.99 0.01 0.99 FALSE
24 ROSMAP Brain Pre-frontal Cortex PABPC1L 0.24 0.21 lasso 3 0.21 8.1e-27 5.6 -5.3 9.8e-08 -0.98 0.01 0.99 FALSE
25 ROSMAP Brain Pre-frontal Cortex YWHAB 0.56 0.58 bslmm 418 0.59 7.7e-94 5.8 -5.8 7.2e-09 -1.00 0.00 1.00 FALSE
26 YFS Blood PABPC1L 0.17 0.13 enet 41 0.14 1.8e-43 4.7 5.1 2.8e-07 0.79 0.60 0.39 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma PABPC1L 0.02 0.02 lasso 4 0.02 2.2e-04 5.6 -5.6 2.2e-08 -0.99 0.01 0.99 FALSE
28 The Cancer Genome Atlas Colon Adenocarcinoma PABPC1L 0.08 0.01 enet 8 0.02 3.6e-02 5.6 -5.5 4.4e-08 -0.78 0.01 0.86 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma PABPC1L 0.20 0.21 lasso 3 0.21 5.5e-23 5.6 -5.6 2.1e-08 -0.99 0.01 0.99 FALSE
30 The Cancer Genome Atlas Brain Lower Grade Glioma YWHAB 0.06 0.07 enet 6 0.09 7.4e-11 4.7 -5.6 2.2e-08 -0.94 0.01 0.99 FALSE
31 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma YWHAB 0.07 0.06 lasso 2 0.06 1.3e-04 5.6 -6.0 2.7e-09 -0.99 0.01 0.97 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma PABPC1L 0.08 0.14 lasso 4 0.14 4.2e-14 5.6 -5.6 2.1e-08 -0.99 0.01 0.99 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma YWHAB 0.07 0.06 lasso 6 0.06 3.1e-07 5.6 -5.3 1.2e-07 -0.96 0.01 0.99 FALSE
34 The Cancer Genome Atlas Stomach Adenocarcinoma YWHAB 0.04 0.05 enet 10 0.03 2.3e-03 5.2 -5.2 1.7e-07 -0.88 0.01 0.92 FALSE
35 The Cancer Genome Atlas Thyroid Carcinoma YWHAB 0.12 0.13 lasso 5 0.12 4.3e-12 5.6 -5.6 1.8e-08 -0.99 0.01 0.99 FALSE