TWAS hub - PABPC1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1670	0.0360	2.3e-12	0.155	0.116	0.144	0.144	0.150	2.1e-18	5.4e-14	3.6e-17	3.5e-17	8.0e-18
2	GTEx	Adrenal Gland	0.3229	0.1065	2.8e-03	0.075	NA	0.042	NA	0.068	1.2e-03	NA	1.2e-02	NA	1.9e-03
3	GTEx	Artery Aorta	0.1400	0.0630	5.0e-03	0.103	NA	0.090	NA	0.091	2.7e-06	NA	1.1e-05	NA	1.1e-05
4	GTEx	Artery Tibial	0.1450	0.0502	6.1e-04	-0.002	NA	0.002	NA	-0.003	4.6e-01	NA	2.3e-01	NA	6.6e-01
5	GTEx	Brain Hippocampus	0.2692	0.0980	3.8e-03	0.028	NA	0.022	NA	0.036	7.3e-02	NA	1.0e-01	NA	5.1e-02
6	GTEx	Cells Transformed fibroblasts	0.1150	0.0410	6.9e-04	0.034	NA	0.077	NA	0.069	1.3e-03	NA	2.0e-06	NA	6.5e-06
7	METSIM	Adipose	0.1091	0.0366	2.0e-03	0.029	0.025	0.021	0.043	0.015	3.4e-05	9.1e-05	3.1e-04	3.8e-07	2.2e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.2428	0.0423	0.0e+00	0.209	0.179	0.209	0.210	0.213	2.4e-26	2.2e-22	2.7e-26	1.7e-26	8.0e-27
9	YFS	Blood	0.1732	0.0270	0.0e+00	0.131	0.127	0.140	0.134	0.136	1.8e-40	2.6e-39	1.8e-43	1.1e-41	2.7e-42
10	TCGA	Breast Invasive Carcinoma	0.0165	0.0084	1.9e-03	0.022	0.009	0.015	NA	0.016	2.0e-05	4.6e-03	3.3e-04	NA	2.2e-04
11	TCGA	Colon Adenocarcinoma	0.0760	0.0490	8.7e-03	0.005	0.006	0.017	NA	0.005	1.5e-01	1.4e-01	3.6e-02	NA	1.5e-01
12	TCGA	Brain Lower Grade Glioma	0.1957	0.0584	0.0e+00	0.209	0.202	0.197	NA	0.206	2.6e-23	1.8e-22	7.1e-22	NA	5.5e-23
13	TCGA	Prostate Adenocarcinoma	0.0802	0.0278	3.6e-10	0.140	0.110	0.132	NA	0.136	1.7e-14	1.6e-11	1.2e-13	NA	4.2e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Worry too long after embarrassment	8.5	14.2	21.1	-4.5	-3.8	3.5	-2.6	-1.2	3.6	0.2	-4.5	4.6	-4.5	-3.7	-4.5	-4.5
Weight	6.8	33.5	50.5	-7.1	-6.7	4.8	3.8	-0.2	5.9	0.4	-6.7	5.9	-7.1	-6.0	-7.1	-7.1
Trunk fat mass	6.7	28.6	41.9	-6.5	-5.7	4.1	3.8	-0.2	5.7	0.5	-6.2	5.8	-6.5	-6.0	-6.5	-6.5
Whole body fat mass	6.5	27.1	39.8	-6.3	-5.6	4.0	3.7	-0.2	5.5	0.1	-6.0	5.6	-6.3	-5.9	-6.3	-6.3
Hip circumference	6.2	26.9	40.8	-6.4	-6.1	4.2	2.3	-0.3	5.4	-0.3	-6.0	5.2	-6.4	-5.9	-6.4	-6.4
Basal metabolic rate	6.2	34.1	53.7	-7.3	-7.1	5.3	3.1	0.2	6.1	0.7	-6.8	5.5	-7.3	-5.3	-7.3	-7.3
Arm fat mass (left)	5.9	24.3	35.8	-6.0	-5.4	3.5	2.9	-0.4	5.3	-0.5	-5.7	5.1	-6.0	-5.9	-6.0	-6.0
Leg predicted mass (left)	5.8	30.6	48.4	-6.9	-6.6	5.1	3.0	0.2	5.7	0.8	-6.5	5.1	-6.9	-5.0	-7.0	-7.0
Arm fat-free mass (right)	5.7	29.0	46.0	-6.8	-6.8	4.7	3.0	-0.5	5.7	1.0	-6.3	5.0	-6.8	-4.3	-6.8	-6.8
Leg fat mass (left)	5.7	22.1	31.8	-5.6	-5.1	3.7	3.5	-0.5	4.8	-0.1	-5.3	5.2	-5.6	-5.5	-5.6	-5.6
Arm predicted mass (left)	5.7	28.8	45.7	-6.7	-6.5	4.8	2.9	-0.0	5.7	0.3	-6.3	5.0	-6.7	-4.7	-6.8	-6.8
Leg fat-free mass (left)	5.6	29.9	47.5	-6.9	-6.5	5.0	2.9	0.1	5.6	0.9	-6.4	5.1	-6.9	-4.8	-6.9	-6.9
Leg fat mass (right)	5.6	21.8	31.4	-5.6	-5.0	3.7	3.2	-0.6	4.8	-0.2	-5.3	5.1	-5.6	-5.5	-5.6	-5.6
Whole body fat-free mass	5.6	31.9	51.0	-7.1	-7.0	5.1	2.8	0.2	5.8	0.7	-6.6	5.2	-7.1	-4.9	-7.1	-7.1
Whole body water mass	5.6	32.2	51.1	-7.1	-7.0	5.2	2.6	0.1	6.0	0.8	-6.7	5.3	-7.1	-4.8	-7.2	-7.2
Arm fat mass (right)	5.5	22.8	32.8	-5.7	-5.2	3.7	3.1	-0.4	5.3	-0.2	-5.4	5.1	-5.7	-5.7	-5.7	-5.7
Trunk predicted mass	5.5	31.2	49.6	-7.0	-7.0	5.2	2.5	0.5	5.8	0.8	-6.6	5.1	-7.0	-4.7	-7.0	-7.0
Arm predicted mass (right)	5.4	27.8	44.8	-6.6	-6.7	4.5	2.7	-0.4	5.5	0.8	-6.2	4.9	-6.6	-4.3	-6.7	-6.7
Trunk fat-free mass	5.3	30.4	48.7	-6.9	-7.0	5.1	2.4	0.6	5.7	0.7	-6.5	5.0	-6.9	-4.7	-7.0	-7.0
Arm fat-free mass (left)	5.3	27.1	42.9	-6.5	-6.3	4.5	2.6	-0.5	5.5	0.5	-6.1	4.9	-6.5	-4.7	-6.5	-6.5
Leg fat-free mass (right)	5.2	27.5	44.1	-6.6	-6.3	4.8	2.9	0.2	5.4	0.9	-6.2	4.9	-6.6	-4.4	-6.6	-6.6
Leg predicted mass (right)	5.2	28.0	44.8	-6.7	-6.4	4.8	2.9	0.1	5.4	0.9	-6.2	4.9	-6.7	-4.5	-6.7	-6.7
Chronotype (morning person)	4.9	11.3	20.9	4.5	4.0	-2.6	-0.6	-1.0	-1.5	-0.2	4.1	-3.0	4.6	3.3	4.6	4.6
Arm fat percentage (left)	4.3	17.0	31.8	-4.9	-4.2	2.6	2.7	-0.5	4.4	-0.6	-4.6	4.5	-4.8	-5.6	-4.9	-4.9
Waist circumference	4.2	15.5	25.2	-4.8	-5.0	2.4	2.9	-0.8	3.7	-0.9	-4.5	3.6	-4.7	-4.7	-4.8	-4.8
Trunk fat percentage	4.1	16.5	25.3	-4.8	-3.9	2.8	3.4	-0.5	4.3	0.4	-4.6	4.6	-4.8	-5.0	-4.8	-4.8
Number of incorrect matches in round	4.0	6.7	10.7	3.0	3.3	-2.0	1.1	0.5	-2.9	-0.2	2.8	-2.9	3.0	2.9	3.0	3.0
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.1	9.4	-2.7	-1.9	1.9	0.9	1.0	2.6	-0.0	-2.5	2.3	-2.7	-3.1	-2.7	-2.7
Body fat percentage	4.0	15.9	27.4	-4.6	-3.8	2.7	3.3	-0.5	4.3	-0.0	-4.5	4.6	-4.6	-5.2	-4.6	-4.6
Risk taking	4.0	5.8	10.0	3.1	3.0	-1.3	1.7	-0.2	-1.4	1.7	3.2	-1.4	3.1	2.5	3.1	3.1
Worrier / anxious feelings	3.9	7.4	12.6	-3.5	-2.3	2.4	-0.5	-0.2	2.9	-0.5	-3.4	2.9	-3.6	-2.4	-3.5	-3.5
BMI	3.7	21.4	33.5	-5.6	-4.9	3.7	1.6	0.4	5.5	-0.7	-5.3	4.9	-5.5	-5.8	-5.6	-5.6
Arm fat percentage (right)	3.7	14.4	29.1	-4.5	-3.6	2.5	2.4	-0.4	4.1	-0.7	-4.3	4.2	-4.4	-5.4	-4.5	-4.5
Height	3.6	69.6	127.7	-10.6	-11.3	7.5	5.3	1.2	6.5	1.4	-9.9	6.9	-10.6	-7.2	-10.6	-10.6
Miserableness	3.6	6.2	11.1	-2.9	-2.0	3.0	-0.3	0.5	2.6	0.6	-3.0	3.3	-2.9	-2.5	-2.9	-2.9
Ever used hormone-replacement therapy (HRT)	3.5	4.5	8.3	-2.3	-2.1	2.5	1.9	1.4	1.9	0.3	-2.1	2.1	-2.3	-2.9	-2.3	-2.3
Medication: Co-codamol	3.5	4.0	7.3	2.4	2.7	-1.6	-0.4	0.2	-2.1	0.6	2.2	-2.2	2.4	2.1	2.4	2.4
Age when periods started (menarche)	3.4	8.3	14.8	-3.8	-2.3	2.6	0.2	1.1	1.7	0.2	-3.9	3.7	-3.8	-2.1	-3.8	-3.8
Body mass index (BMI)	3.3	14.1	23.9	-4.4	-3.9	2.6	2.3	-1.0	4.2	-0.8	-4.2	4.1	-4.4	-4.9	-4.4	-4.4
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.6	10.8	2.1	2.5	-3.3	-0.1	-1.1	-1.4	-0.9	1.8	-2.1	2.1	0.8	2.1	2.1
Leg fat percentage (left)	3.3	11.8	22.8	-3.9	-3.5	2.1	3.2	-0.7	3.4	-0.6	-3.8	4.0	-3.9	-4.8	-3.9	-3.9
Hand grip strength (right)	3.2	8.8	17.3	-3.8	-4.2	2.5	0.2	0.6	3.3	-0.0	-3.6	2.4	-3.8	-1.7	-3.8	-3.8
Leg fat percentage (right)	3.2	11.7	23.1	-3.9	-3.5	2.3	2.7	-0.6	3.5	-0.9	-3.8	3.9	-3.9	-4.8	-3.9	-3.9
Medication for hormone replacement therapy	3.1	3.5	10.1	-2.1	-1.8	0.8	2.2	0.5	1.5	-0.6	-2.0	1.3	-2.1	-3.2	-2.1	-2.1
Hypothyroidism (self reported)	3.0	6.8	11.2	3.1	2.6	-1.9	-1.7	1.6	-2.9	0.7	3.3	-2.1	3.2	3.0	3.1	3.1
Hand grip strength (left)	3.0	7.9	13.0	-3.6	-3.3	2.3	0.1	0.4	3.1	-0.5	-3.6	2.7	-3.6	-1.9	-3.6	-3.6
Tense / ‘highly strung’	3.0	4.9	13.0	2.7	2.7	-2.0	-1.3	0.0	-1.2	-0.5	2.4	-1.0	2.7	3.6	2.7	2.7
Schizophrenia (2018)	2.9	6.0	12.5	2.9	3.2	-1.3	-1.3	0.5	-2.5	0.8	2.6	-1.8	2.9	3.5	3.0	3.0
Standing height	2.9	29.2	49.6	-6.7	-7.0	5.3	3.7	1.9	4.7	2.7	-6.4	4.8	-6.7	-3.3	-6.7	-6.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	8.0	2.5	1.8	-2.1	-1.5	0.4	-2.4	-0.1	2.2	-2.3	2.5	2.8	2.5	2.5
Medication: Ibuprofen	2.8	3.3	6.9	-2.1	-1.4	1.7	0.9	0.8	2.2	-0.0	-1.9	1.8	-2.1	-2.6	-2.1	-2.1
Alzheimer’s Disease (in father)	2.7	3.0	4.1	2.0	1.8	-2.0	-1.9	0.4	-1.7	-1.4	2.0	-1.7	1.9	1.0	1.9	1.9
Alcohol intake versus 10 years previously	2.7	4.0	11.6	2.3	3.4	-1.6	-1.0	-0.7	-2.3	-1.3	2.1	-1.4	2.2	1.7	2.2	2.2
Fed-up feelings	2.6	4.7	7.6	-2.7	-1.9	2.3	-1.6	0.3	1.8	-0.4	-2.8	2.5	-2.7	-1.7	-2.7	-2.7
Supplements: Glucosamine	2.6	3.4	5.1	-1.8	-1.7	2.3	1.3	1.8	2.1	1.6	-1.6	2.2	-1.8	-1.8	-1.8	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	8.4	-2.9	-2.9	1.9	0.3	0.3	2.3	1.2	-2.8	2.2	-2.9	-2.1	-2.9	-2.9
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	5.2	2.0	2.0	-2.1	-0.2	-1.0	-2.0	-0.6	2.3	-2.0	2.1	1.4	2.1	2.1
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	7.0	-1.9	-0.6	0.8	-0.4	-1.2	2.5	0.6	-2.0	2.7	-1.9	-2.2	-1.9	-1.9
Supplements: Vitamin C	2.4	2.8	6.1	1.6	1.5	-2.2	-2.5	0.7	-1.7	-0.6	1.4	-1.7	1.6	2.1	1.6	1.6
Medication: Atorvastatin	2.4	2.9	4.8	1.8	2.2	-2.0	0.6	0.0	-1.9	-1.6	1.7	-1.4	1.8	2.2	1.8	1.8
Medication: Lisinopril	2.3	3.0	5.5	2.0	1.5	-2.3	-1.5	-1.3	-1.5	-0.3	2.0	-1.5	2.0	1.7	2.0	2.0
Ovarian Cancer	2.2	3.0	7.0	-1.8	-1.6	2.6	2.0	1.1	0.6	2.5	-1.5	1.2	-1.8	-0.5	-1.8	-1.8
Crohns Disease (2012)	2.2	3.5	6.0	-2.2	-2.4	2.0	2.4	0.5	2.0	0.4	-2.0	1.3	-2.1	-1.6	-2.1	-2.1
Guilty feelings	2.2	3.3	8.7	-1.9	-0.8	2.1	-2.9	-1.0	1.4	0.5	-2.2	2.3	-1.9	-1.0	-1.9	-1.9
Father’s age at death	2.1	2.8	6.3	1.9	1.0	-1.5	0.6	-0.8	-1.9	0.6	1.8	-2.2	1.9	2.5	1.9	1.9
Qualifications: College or University degree	2.1	6.5	10.7	3.2	2.0	-2.9	-1.2	0.2	-1.6	-1.2	2.8	-2.8	3.2	3.3	3.2	3.2
Alzheimer’s Disease (including proxy)	2.0	2.8	6.2	1.6	1.6	-2.5	-2.4	-1.0	-1.2	-1.5	1.7	-1.3	1.8	1.0	1.8	1.8
Schizophrenia (2014)	2.0	4.4	9.7	2.5	2.7	-1.2	0.3	1.1	-1.8	1.1	2.2	-1.6	2.6	3.1	2.6	2.6
Medication: Levothyroxine sodium	2.0	3.3	6.6	2.1	1.4	-1.6	0.6	0.4	-2.6	1.0	2.3	-1.6	2.1	2.3	2.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.5	4.5	1.9	1.1	-1.6	-1.2	-0.2	-1.6	-0.2	1.9	-2.1	1.9	1.8	1.8	1.8
Health satisfaction	2.0	2.6	7.2	1.5	1.7	-2.7	-0.1	-2.0	-2.2	-0.7	1.3	-1.5	1.4	1.4	1.5	1.5
Illnesses of siblings: Diabetes	2.0	2.5	5.3	2.0	1.0	-1.1	2.3	0.9	-1.2	0.0	1.9	-1.3	2.0	1.3	2.0	2.0
Depressed Affect (Nagel 2018)	1.9	3.9	7.0	-2.1	-1.6	2.3	-0.6	1.2	2.4	0.6	-2.2	2.6	-2.0	-2.7	-2.0	-2.0
Neuroticism (Nagel 2018)	1.9	4.4	8.5	-2.1	-1.6	2.3	-1.9	2.0	2.5	0.4	-2.4	2.9	-2.0	-2.1	-2.0	-2.0
Reaction Time	1.9	3.6	5.6	2.4	1.7	-1.1	-1.2	2.2	-1.8	0.0	2.0	-2.0	2.3	1.6	2.3	2.3
Bipolar Disorder or Schizophrenia	1.7	4.2	8.6	2.5	2.6	-0.7	-1.0	1.7	-1.3	1.4	2.1	-0.7	2.6	2.9	2.6	2.6
Qualifications: CSEs or equivalent	1.7	2.3	5.0	-1.8	-0.8	1.7	0.8	0.9	1.6	1.0	-1.4	0.8	-1.8	-2.2	-1.8	-1.8
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.0	-1.9	-1.1	1.1	0.2	0.9	0.3	-1.1	-2.0	1.8	-1.9	-0.1	-1.9	-1.9
Comparative height size at age 10	1.7	9.5	15.3	-3.8	-3.9	3.1	1.8	1.8	2.4	1.4	-3.7	2.5	-3.8	-2.6	-3.8	-3.8
Age at First Birth	1.6	2.3	4.2	2.0	1.4	-0.6	0.4	1.5	-0.3	1.0	2.0	-1.0	2.0	1.6	2.0	2.0
Sensitivity / hurt feelings	1.6	2.7	3.8	-1.8	-1.4	1.8	-1.4	-0.1	1.6	0.8	-1.9	2.0	-1.9	-1.9	-1.9	-1.9
High blood pressure (mother)	1.6	2.2	3.4	1.6	1.7	-1.2	-0.9	-1.1	-1.8	-0.8	1.8	-1.2	1.7	1.8	1.6	1.6
Peak expiratory flow (PEF)	1.6	3.6	5.7	-2.4	-2.2	2.0	-0.5	0.8	1.7	0.7	-2.3	2.0	-2.4	-1.3	-2.4	-2.4
Pulse wave reflection index	1.6	2.0	3.6	-1.8	-1.9	0.5	-0.4	1.0	1.0	-1.2	-1.9	0.8	-1.7	-1.6	-1.8	-1.8
Medication: Amlodipine	1.6	2.3	5.8	1.7	1.6	-1.5	0.5	-1.7	-0.9	0.5	1.6	-1.2	1.6	2.4	1.6	1.6
Ever had bowel cancer screening	1.6	1.8	3.6	1.7	1.7	-0.8	0.7	0.5	-0.7	-0.7	1.9	-1.5	1.8	0.3	1.8	1.8
Alcohol drinker status: Previous	1.6	1.8	5.2	1.2	1.3	-1.8	-0.7	-0.5	-1.6	-1.0	1.0	-1.4	1.2	2.3	1.2	1.2
Schizophrenia vs Biploar Disorder	1.5	2.0	3.6	1.4	1.9	-1.4	0.8	-1.8	-1.2	0.7	1.5	-1.2	1.4	1.8	1.4	1.4
Triglycerides	1.5	2.5	6.2	-1.7	-1.0	1.1	1.5	-2.5	0.6	0.8	-1.4	2.4	-1.6	-1.3	-1.6	-1.6
Hair/balding pattern: Pattern 2	1.5	1.9	6.6	-1.5	-2.6	1.9	-0.7	1.0	1.0	0.2	-1.4	0.9	-1.5	-0.6	-1.5	-1.5
Depression (self-reported)	1.5	1.8	4.7	1.5	0.7	-1.1	-1.1	0.5	-1.8	0.1	1.3	-1.4	1.5	2.2	1.5	1.5
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	5.5	2.0	1.6	-1.2	-0.6	0.4	-2.2	0.9	2.2	-1.3	2.0	2.3	2.0	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.4	-1.4	-1.2	1.5	0.9	-0.2	0.7	0.9	-1.2	1.7	-1.4	-2.1	-1.4	-1.4
HDL Cholesterol	1.4	2.3	19.8	0.7	4.4	-0.3	0.8	2.4	0.4	0.7	0.6	0.0	0.7	0.5	0.7	0.7
Systolic Blood Pressure	1.4	7.1	12.7	2.9	3.2	-3.3	-1.0	-2.2	-2.4	-1.6	2.6	-2.3	2.8	3.6	2.9	2.9
Allergy or Eczema	1.4	3.6	6.2	2.5	1.1	-1.7	-1.5	-0.9	-2.2	0.2	2.5	-1.7	2.5	1.1	2.5	2.5
Sitting height	1.4	9.7	20.8	-4.0	-4.6	2.7	1.2	1.6	2.9	1.4	-3.8	2.2	-4.0	-0.6	-4.0	-4.0
Mouth/teeth dental problems	1.4	2.1	5.6	1.6	0.5	-0.1	0.6	0.8	-1.6	0.9	1.8	-2.1	1.5	2.4	1.5	1.5
Neuroticism score	1.4	3.0	5.7	-2.0	-1.0	1.6	-2.2	-0.8	1.6	-0.4	-2.1	2.4	-2.0	-0.7	-2.0	-2.0
Breastfed as a baby	1.4	1.7	2.5	-1.6	-1.3	1.0	-0.1	-1.5	1.3	-0.3	-1.5	0.9	-1.6	-1.6	-1.6	-1.6
Medication: Blood pressure	1.4	2.5	5.1	1.9	1.5	-1.6	1.6	0.3	-1.0	-0.6	1.6	-1.5	1.8	2.2	1.9	1.9
Blood Red Count	1.3	12.6	58.5	-3.3	-7.7	3.4	0.6	0.8	4.0	0.6	-3.7	3.0	-3.4	-3.0	-3.3	-3.3
Neuroticism	1.3	3.1	5.8	-2.0	-1.5	1.6	-2.0	0.5	1.9	-0.7	-2.3	2.4	-2.0	-0.5	-2.0	-2.0
Supplements: Zinc	1.3	1.5	2.5	1.6	0.9	-0.7	-1.5	1.3	-0.7	0.0	1.6	-0.9	1.6	0.6	1.6	1.6
Age at last live birth	1.3	1.9	6.3	1.5	1.9	-2.5	-0.2	-0.6	-0.5	-0.6	1.4	-1.7	1.5	0.7	1.5	1.5
Lupus	1.2	1.8	6.7	1.5	1.8	-1.1	0.5	0.2	-0.7	0.4	1.3	-0.6	1.5	2.6	1.5	1.5
Lung FEV1/FVC ratio	1.2	6.1	24.4	-2.6	-1.9	-0.8	-2.3	-4.9	-0.4	-2.5	-3.0	1.3	-2.6	-0.8	-2.6	-2.6
Falls in the last year	1.2	1.6	3.7	-1.5	-1.9	1.3	-0.1	0.4	0.5	0.3	-1.4	1.6	-1.5	-1.2	-1.5	-1.5
Prospective memory result	1.2	1.5	3.6	-1.4	-1.9	1.5	0.7	-0.8	0.8	0.3	-1.3	1.1	-1.4	-1.1	-1.4	-1.4
Glaucoma (self-reported)	1.2	1.4	4.0	1.1	0.9	-1.4	0.0	2.0	-0.9	-1.7	0.9	-1.2	1.1	0.8	1.1	1.1
Number of full sisters	1.2	1.4	3.3	0.8	1.6	-1.0	-1.5	-1.8	-1.8	-1.7	0.8	-0.4	0.8	0.7	0.8	0.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.9	-1.1	-0.7	1.1	-1.1	0.8	1.9	0.1	-1.2	2.0	-1.1	-1.4	-1.1	-1.1
Average weekly champagne plus white wine intake	1.2	1.6	8.9	-0.9	-3.0	1.2	1.1	0.2	0.8	2.1	-0.9	0.7	-0.9	0.4	-0.9	-0.9
Ulcerative Colitis	1.1	1.6	7.4	-1.0	-0.8	1.3	2.7	1.1	0.5	-0.4	-1.1	1.1	-1.1	-1.7	-1.0	-1.0
Lung FVC	1.1	5.8	10.0	3.1	1.5	-1.6	-1.1	0.9	-2.0	0.0	2.9	-3.2	3.1	2.8	3.1	3.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.1	1.9	1.1	-1.1	-1.4	-0.3	-2.3	0.9	2.0	-1.0	1.9	1.1	1.9	1.9
Number of full brothers	1.1	1.4	3.7	1.5	1.9	-0.5	0.1	0.8	-0.8	0.0	1.5	-0.9	1.5	1.1	1.5	1.5
Had major operations	1.1	1.3	10.2	0.3	0.1	1.2	3.2	1.9	0.5	1.1	0.3	-0.3	0.3	0.2	0.2	0.2
Back pain experienced in last month	1.1	1.6	4.3	-1.5	-0.8	1.1	1.1	-0.1	1.3	-0.1	-1.3	0.8	-1.5	-2.1	-1.5	-1.5
HbA1C	1.0	1.1	3.6	-1.1	-0.4	-0.8	-1.4	1.9	1.0	-0.4	-1.1	0.9	-1.1	-0.5	-1.1	-1.1
Impedance of leg (left)	1.0	4.9	8.0	2.7	2.8	-1.9	-0.4	0.7	-2.8	0.7	2.5	-1.5	2.7	2.5	2.7	2.7
Had menopause	1.0	1.3	3.5	-1.0	-1.3	1.0	1.9	-1.5	0.6	-0.6	-1.1	0.8	-1.0	-1.4	-1.0	-1.0
Hair/balding pattern: Pattern 3	1.0	1.5	3.9	0.9	1.4	-2.0	-0.8	-1.8	-1.2	-1.8	0.4	-1.2	0.9	0.8	0.9	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.3	1.2	1.3	-0.3	0.8	0.1	-0.5	0.7	1.2	-1.0	1.2	1.8	1.2	1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.7	-1.0	-0.8	1.3	-1.6	0.5	1.5	0.6	-1.2	1.5	-1.0	-0.1	-1.0	-1.0
Comparative body size at age 10	1.0	2.7	9.2	-1.4	-3.0	1.2	-2.1	-0.2	2.1	0.6	-1.4	1.8	-1.3	-1.6	-1.4	-1.4
Knee pain experienced in last month	1.0	1.6	2.7	-1.6	-1.4	1.0	1.6	-0.3	0.7	0.9	-1.3	1.0	-1.6	-0.4	-1.6	-1.6
Mineral and other dietary supplements	1.0	1.4	5.4	0.6	1.2	-1.7	-0.6	-0.9	-0.9	-2.3	0.5	-1.6	0.6	1.4	0.6	0.6
Number of self-reported non-cancer illnesses	1.0	1.8	3.4	1.6	1.8	-0.6	1.0	0.4	-1.3	1.0	1.8	-1.0	1.6	1.3	1.6	1.6
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.6	1.1	1.6	-0.9	-0.6	-1.1	-1.3	0.3	1.2	-1.0	1.1	1.4	1.1	1.1
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.7	1.0	1.1	-0.3	1.6	-0.1	-1.5	1.1	1.2	-0.7	1.0	1.5	1.0	1.0
Alzheimer’s Disease (in mother)	0.9	1.1	3.0	0.8	0.7	-1.6	-1.7	-1.7	-0.3	-0.9	0.6	-0.5	0.8	1.2	0.8	0.8
Irritable Bowel Disease (IBD)	0.9	2.2	7.8	-1.0	-0.1	2.2	2.1	2.8	1.4	0.4	-1.3	1.5	-1.0	-1.0	-1.0	-1.0
Ulcerative Colitis (UC)	0.9	1.8	5.5	-0.7	0.7	1.8	2.3	2.4	1.0	-0.1	-0.9	1.7	-0.8	-1.3	-0.8	-0.8
Primary Biliary Cirrhosis	0.9	1.3	2.9	-1.5	-1.4	0.3	0.4	-0.3	1.5	-0.7	-1.7	0.8	-1.4	-0.8	-1.4	-1.4
Medication: Metformin	0.9	1.3	2.3	1.4	-1.5	-0.7	0.7	0.4	-0.7	0.7	1.5	-1.2	1.4	1.4	1.4	1.4
Diabetes (mother)	0.9	1.1	6.2	-0.9	-2.5	0.5	0.3	-0.1	0.8	-0.5	-1.1	0.8	-0.9	-1.3	-0.9	-0.9
Impedance of leg (right)	0.9	4.5	7.3	2.6	2.6	-1.8	-0.9	0.9	-2.7	0.3	2.3	-1.6	2.6	2.2	2.6	2.6
Hypertension (Self-reported)	0.9	2.5	4.3	1.9	1.8	-1.3	1.9	-0.0	-1.4	-0.5	2.1	-1.6	1.8	1.2	1.9	1.9
Diabetes diagnosed by doctor	0.9	1.6	3.0	1.3	-1.7	-0.9	0.9	-0.7	-1.4	0.1	1.5	-1.2	1.3	1.7	1.3	1.3
Breast Cancer	0.8	2.0	4.7	1.9	0.7	-0.6	-0.9	0.7	-0.1	2.2	1.5	-0.4	1.9	1.5	1.9	1.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	5.4	0.8	-0.3	0.4	2.3	1.2	-0.4	1.1	1.0	-0.8	0.7	0.2	0.8	0.8
Angina	0.8	1.1	1.6	1.2	1.0	-1.1	-1.2	0.5	-0.3	-0.1	1.2	-1.1	1.2	1.3	1.2	1.2
Multivitamins +/- minerals	0.8	1.1	2.4	-1.1	-1.1	0.9	-0.0	0.3	1.6	0.6	-0.7	1.2	-1.1	-1.3	-1.1	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.5	0.9	2.1	-0.8	-1.3	-0.9	-0.3	0.4	0.8	0.2	0.9	1.8	0.9	0.9
Pain all over the body in last month	0.8	0.8	5.2	-0.0	0.5	1.8	0.1	-0.6	-0.5	2.3	0.2	1.3	-0.1	0.3	-0.1	-0.1
Pulse rate	0.8	1.3	2.1	1.5	0.9	-1.1	1.2	-0.6	-0.9	0.3	1.3	-1.2	1.5	0.8	1.5	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.7	0.9	0.8	-0.5	1.9	0.1	-0.2	1.3	1.1	-1.0	0.9	0.7	0.9	0.9
Medication: Aspirin	0.8	1.0	2.3	1.2	-0.1	-0.8	1.5	0.0	-1.0	0.8	1.2	-0.5	1.2	1.0	1.2	1.2
Average weekly red wine intake	0.8	1.2	6.8	1.0	0.2	-0.5	-1.6	0.1	-0.4	-0.1	0.9	-0.7	1.1	2.6	1.1	1.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.9	-0.5	0.2	1.4	2.0	-1.0	1.2	0.8	-0.8	1.2	-0.5	-0.3	-0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.0	-0.6	-1.0	1.6	-0.0	1.7	0.7	1.5	-0.8	1.0	-0.6	-1.0	-0.6	-0.6
Age started oral contraceptive pill	0.8	1.0	6.6	-0.8	-1.0	-0.5	0.8	-2.6	-0.2	-1.0	-1.0	0.6	-0.8	-0.3	-0.8	-0.8
Commuting to job workplace: Cycle	0.8	1.0	2.9	-0.7	-0.7	1.3	0.5	1.4	0.9	1.7	-0.7	1.4	-0.7	0.7	-0.7	-0.7
Impedance of whole body	0.8	4.0	7.0	2.3	2.6	-1.7	-0.3	1.1	-2.6	0.8	2.1	-1.5	2.3	2.1	2.4	2.4
Crohns Disease (2017)	0.7	1.5	6.6	-0.9	-0.8	1.7	1.3	2.6	1.4	1.0	-1.0	0.8	-0.8	-0.0	-0.8	-0.8
Average weekly spirits intake	0.7	0.8	4.9	-0.4	-0.4	-0.3	-2.0	0.8	0.7	-2.2	-0.5	-0.2	-0.4	-0.2	-0.4	-0.4
Current tobacco smoking	0.7	1.1	5.4	0.4	0.4	-1.0	-1.1	-1.9	-1.3	-2.3	0.4	-0.3	0.5	0.5	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	1.1	1.3	0.4	-0.2	1.1	-0.7	0.4	0.9	0.4	1.1	0.8	1.1	1.1
High blood pressure	0.7	2.0	3.5	1.7	1.6	-1.2	1.4	-0.0	-1.4	-0.5	1.9	-1.3	1.7	1.2	1.7	1.7
Medication: Atenolol	0.7	0.9	2.3	0.7	1.2	-0.9	1.3	-1.1	-1.4	-0.1	0.6	-0.3	0.7	1.5	0.7	0.7
Diabetes (self-reported)	0.7	1.1	2.1	1.1	-1.2	-1.1	1.3	-0.0	-1.0	-0.1	1.2	-0.8	1.1	1.4	1.1	1.1
Time employed in main current job	0.7	0.8	2.8	0.9	1.0	0.6	-1.4	0.2	-0.5	1.7	0.7	0.4	0.8	0.9	0.9	0.9
Mouth/teeth dental problems: Dentures	0.7	1.3	5.7	-0.9	-0.9	-0.3	-0.9	-0.7	0.6	-1.8	-1.0	0.7	-0.9	-2.4	-0.9	-0.9
Shortness of breath walking on level ground	0.7	0.8	3.7	-0.3	0.1	-1.0	-1.4	-1.9	0.2	-1.2	-0.2	0.7	-0.2	-1.4	-0.3	-0.3
Eye problems/disorders: None of the above	0.7	0.8	7.0	0.6	0.8	-0.3	-2.6	-0.4	0.0	-0.2	0.3	-0.6	0.6	0.1	0.6	0.6
Angina (self-reported)	0.7	0.9	1.5	1.1	0.9	-0.9	-1.1	0.5	-0.3	-0.1	1.1	-0.9	1.0	1.2	1.1	1.1
Medication: Gliclazide	0.7	0.8	5.4	-0.5	-2.3	1.4	1.0	-0.3	0.1	0.3	-0.5	0.8	-0.5	0.3	-0.5	-0.5
Body Mass Index (BMI) (2010)	0.6	0.8	3.9	-0.7	-0.2	-0.1	-0.0	0.5	1.6	-2.0	-0.9	0.0	-0.7	-0.9	-0.7	-0.7
LDL Cholesterol	0.6	1.0	1.8	-1.0	1.3	0.9	1.1	0.2	1.0	1.0	-0.7	1.3	-0.9	-1.0	-0.9	-0.9
Respiratory disease	0.6	1.4	4.7	1.2	1.3	-0.2	2.2	1.5	0.1	0.8	1.4	-0.6	1.2	0.8	1.2	1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	9.2	0.1	-3.0	0.2	1.5	1.1	-0.7	-0.2	0.3	-0.9	0.1	0.5	0.1	0.1
Average weekly fortified wine intake	0.6	0.7	1.7	1.1	0.8	-0.1	0.7	0.4	-0.1	1.3	1.0	0.4	1.0	0.8	1.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-0.7	-0.1	0.1	-0.7	-0.4	1.4	-0.0	-0.8	1.2	-0.7	-1.4	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.6	-1.0	-1.1	1.4	1.4	-1.2	2.2	0.6	-0.9	0.9	-1.0	-0.8	-1.0	-1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	0.7	0.4	-0.3	-1.1	0.7	-1.4	-0.7	0.5	-1.1	0.7	1.1	0.7	0.7
Qualifications: None of the above	0.6	1.3	2.8	-1.2	-0.5	1.0	-1.4	-0.7	0.4	-0.5	-1.3	1.7	-1.2	-1.6	-1.2	-1.2
Allergy	0.6	1.3	3.0	-1.4	-1.1	0.4	0.3	-0.5	1.7	-1.1	-1.6	0.7	-1.3	-1.0	-1.3	-1.3
Medication: Ramipril	0.6	0.7	2.5	0.3	-0.4	-1.3	0.5	-0.7	-1.6	-1.0	0.5	-0.9	0.3	1.4	0.3	0.3
Illnesses of mother	0.6	0.7	2.2	-0.5	-0.8	0.4	1.4	1.0	0.8	1.5	-0.5	0.1	-0.5	-1.2	-0.5	-0.5
Length of working week for main job	0.6	0.7	3.4	-0.8	0.4	-0.0	-1.8	-0.1	0.3	-0.9	-0.9	0.4	-0.8	-1.0	-0.8	-0.8
Headache pain in last month	0.6	1.0	4.4	1.0	2.1	-0.3	0.1	1.5	-0.8	-0.6	0.9	-0.5	1.0	0.5	1.0	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.9	-1.1	-1.2	1.3	-0.9	-0.4	0.4	0.8	-1.0	1.1	-1.1	-1.4	-1.1	-1.1
Chest pain or discomfort	0.6	0.9	3.2	0.7	1.4	-1.8	-0.2	-0.7	-1.2	-0.9	0.8	-0.9	0.7	0.8	0.7	0.7
Leg pain on walking	0.6	0.8	2.4	-0.4	0.5	-1.5	-1.5	-1.4	-1.2	-1.0	-0.3	-0.2	-0.3	0.2	-0.3	-0.3
Mood swings	0.6	1.0	4.5	-0.6	0.2	1.3	-0.7	0.5	2.1	0.7	-0.9	1.8	-0.6	-0.0	-0.6	-0.6
Loneliness, isolation	0.6	0.9	3.2	0.7	0.6	-1.2	-0.9	-1.8	-1.5	-0.3	0.6	-0.6	0.7	0.8	0.7	0.7
Financial situation satisfaction	0.6	0.7	4.3	-0.7	-0.6	0.1	-0.7	-2.1	0.3	-0.2	-0.8	0.9	-0.7	-0.8	-0.7	-0.7
Irritability	0.6	0.9	2.6	-1.0	-0.9	0.8	-0.8	0.1	1.4	-0.2	-1.0	1.6	-1.1	-0.2	-1.1	-1.1
Ever depressed for a whole week	0.6	0.7	1.7	1.0	0.5	0.4	-0.6	-0.7	-0.5	1.3	0.9	-0.7	1.0	1.0	1.0	1.0
Unable to work because of sickness or disability	0.6	0.8	4.4	0.5	0.8	-0.7	0.1	1.1	-2.1	-0.5	0.7	-1.2	0.5	0.5	0.5	0.5
Cholesterol lowering medication	0.6	0.9	3.3	0.1	1.2	-1.4	0.1	-1.4	-1.8	-1.4	0.4	-0.6	0.1	0.5	0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.1	-1.0	-0.9	0.4	1.0	1.1	0.1	-0.8	-1.0	0.9	-1.0	-0.2	-1.0	-1.0
Bipolar Disorder (2018)	0.5	0.7	4.5	0.4	0.2	0.5	-0.0	2.1	1.0	1.1	0.1	1.2	0.5	0.3	0.5	0.5
Depression (Nagel 2018)	0.5	0.7	3.1	-0.0	0.8	0.6	0.3	1.8	0.8	1.6	0.0	1.4	0.1	-0.4	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	7.1	0.6	0.2	-1.7	-1.1	-0.9	-0.9	-2.7	0.4	-0.8	0.6	-0.0	0.6	0.6
Blood Platelet Count	0.5	6.1	18.4	2.6	4.3	-0.5	4.0	-1.8	-1.1	2.1	2.5	-0.6	2.6	1.7	2.6	2.6
Waist Hip Ratio (WHR)	0.5	2.1	5.7	1.4	-0.3	-1.9	0.9	-1.5	-2.4	-0.7	1.4	-2.0	1.4	0.5	1.4	1.4
Diabetes (father)	0.5	0.6	2.3	-0.5	-0.9	-0.1	-1.5	1.0	0.8	-1.1	-0.4	0.4	-0.5	-0.9	-0.5	-0.5
Severe depression (siblings)	0.5	0.6	2.4	0.7	1.6	0.3	1.0	0.1	0.3	0.9	0.6	0.8	0.6	0.6	0.6	0.6
Hearing difficulty/problems with background noise	0.5	0.8	2.3	-1.1	-0.2	0.1	1.0	1.2	0.2	-1.5	-0.8	0.3	-1.0	-0.4	-1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.3	0.9	-0.2	0.5	-1.0	0.2	-0.0	1.5	0.8	-0.2	0.8	0.9	0.9	0.9
Heart attack	0.5	0.7	1.4	-1.0	-0.9	0.5	0.9	1.2	-0.0	-0.8	-0.9	0.8	-1.0	-0.1	-0.9	-0.9
Asthma	0.5	1.0	2.1	0.7	1.5	0.9	1.4	1.2	0.2	1.4	1.0	0.2	0.7	0.9	0.7	0.7
Medication: Lansoprazole	0.5	0.6	3.4	0.0	-0.8	1.0	0.6	1.9	0.8	0.9	0.0	-0.6	-0.0	0.3	0.0	0.0
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	0.7	0.7	-0.6	-1.5	-0.5	-0.4	-1.1	0.3	-1.0	0.7	1.6	0.7	0.7
Illnesses of father: Heart disease	0.5	0.7	2.3	-0.6	-0.4	1.3	0.1	0.5	0.9	1.0	-0.6	1.0	-0.6	-1.5	-0.6	-0.6
Commuting to job workplace: Walk	0.5	0.5	2.0	0.8	0.3	0.2	0.2	0.6	0.2	-0.0	0.8	-0.5	0.9	1.4	0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	-0.9	-0.9	-0.1	0.3	0.6	-1.2	-0.6	-0.7	-0.2	-0.9	-0.5	-0.9	-0.9
Breast cancer (self-reported)	0.5	0.5	1.9	0.4	0.7	-1.4	-0.4	-0.5	-1.3	-0.3	0.9	-0.9	0.4	-0.3	0.4	0.4
Medication: Aspirin	0.5	0.6	2.6	0.8	-0.6	-0.5	1.6	-0.4	-0.7	0.6	0.8	-0.3	0.8	0.7	0.8	0.8
Smoking status: Current	0.5	0.7	4.5	0.1	0.1	-0.7	-1.1	-1.4	-1.0	-2.1	0.2	-0.2	0.1	0.3	0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.3	1.1	-0.4	-0.3	-1.1	-1.0	-0.7	0.6	0.9	-1.3	1.1	1.5	1.1	1.1
Wears glasses or contact lenses	0.5	0.5	1.1	-0.9	-0.8	0.1	-1.0	-0.1	-0.4	-0.8	-1.0	0.3	-0.9	0.2	-0.9	-0.9
Hearing aid user	0.5	0.6	1.3	0.8	0.9	-0.2	0.7	0.3	-1.1	-0.0	0.8	-1.0	0.9	-0.1	0.9	0.9
Eye problems/disorders: Glaucoma	0.5	0.7	2.1	1.0	0.5	-0.7	0.8	1.4	-0.4	-0.4	0.8	-0.6	0.9	0.4	0.9	0.9
Alcohol drinker status: Never	0.5	0.6	2.4	-0.5	-0.3	1.5	-0.1	1.6	0.6	0.6	-0.3	0.9	-0.5	-0.3	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	4.2	0.1	0.4	-2.1	0.0	-0.2	-0.8	-1.6	-0.0	-0.6	0.1	-0.3	0.1	0.1
Supplements: Calcium	0.5	0.5	2.0	0.7	0.4	0.5	0.8	0.7	0.0	1.4	0.9	0.3	0.7	-0.2	0.7	0.7
Heart disease (siblings)	0.5	0.6	1.4	-0.8	0.1	1.0	0.8	0.0	0.9	1.2	-0.5	1.1	-0.8	-0.3	-0.8	-0.8
Prostate Cancer	0.4	0.6	2.8	0.2	0.6	0.5	-1.2	0.7	-0.1	1.3	0.2	0.4	0.2	1.7	0.2	0.2
Bipolar Disorder (2011)	0.4	0.4	1.6	-0.2	0.0	0.0	-0.1	1.3	0.8	0.6	-0.5	1.1	-0.2	-0.4	-0.2	-0.2
Rheumatoid Arthritis	0.4	0.5	1.3	-0.8	-1.1	0.8	-0.6	-0.5	0.8	0.2	-0.6	0.5	-0.8	-0.8	-0.8	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	4.5	0.0	0.9	-1.0	-0.9	0.9	0.2	-2.1	-0.1	-0.3	-0.0	-0.3	0.0	0.0
Relative age of first facial hair	0.4	0.9	2.9	0.7	0.7	-1.4	-0.9	-0.1	-0.9	-1.7	0.8	-1.2	0.8	0.5	0.7	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	0.4	-0.4	-0.6	1.3	-1.2	-0.7	-0.5	0.9	-0.4	0.4	-0.5	0.4	0.4
Pack years adult smoking proportion	0.4	0.6	3.7	0.1	-0.8	-0.6	-1.9	-0.9	-0.0	-1.5	-0.1	-0.1	0.2	0.1	0.1	0.1
Maternal smoking around birth	0.4	0.5	1.9	0.2	0.7	1.0	-0.9	-1.2	-0.1	1.4	0.1	0.4	0.3	1.0	0.2	0.2
Taking other prescription medications	0.4	0.6	1.8	0.6	0.7	-0.1	1.1	1.3	-1.1	0.8	0.8	-0.3	0.6	0.5	0.6	0.6
Alcohol usually taken with meals	0.4	0.6	2.7	0.7	-0.9	0.4	-1.3	-1.6	0.6	0.4	0.5	-0.3	0.7	0.6	0.7	0.7
Nervous feelings	0.4	0.7	4.2	0.4	0.4	0.4	-1.4	2.0	-0.1	0.0	0.1	0.3	0.3	1.4	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.7	-0.5	-0.6	0.6	1.3	-1.9	1.7	0.3	-0.6	0.4	-0.5	-0.7	-0.5	-0.5
Impedance of arm (right)	0.4	1.8	4.1	1.5	2.0	-0.9	-0.3	1.4	-1.9	0.4	1.3	-1.0	1.5	0.7	1.5	1.5
Happiness	0.4	0.5	2.2	-0.8	-0.2	0.0	-1.5	-0.0	0.3	-0.3	-0.9	0.4	-0.8	-0.2	-0.8	-0.8
Lung cancer (father)	0.4	0.5	2.2	-0.1	0.1	-0.4	1.5	0.1	-0.3	-1.2	-0.0	0.4	-0.1	-1.3	-0.1	-0.1
Gout (self-reported)	0.4	0.6	2.0	-0.4	0.5	-1.3	1.1	-1.1	-0.5	-1.4	-0.1	-0.0	-0.4	-0.5	-0.4	-0.4
Exposure to tobacco smoke outside home	0.4	0.6	4.3	-0.3	-0.3	0.9	2.1	0.7	0.5	-0.2	-0.1	0.2	-0.4	-0.9	-0.4	-0.4
Age at first live birth	0.4	0.6	2.8	0.6	1.4	-0.4	0.9	0.4	1.7	-0.1	0.5	-0.3	0.6	-1.0	0.6	0.6
Pulse wave peak to peak time	0.4	0.5	2.5	-0.1	-0.0	1.4	0.3	0.9	0.8	1.6	0.0	0.5	-0.1	0.7	-0.2	-0.2
Emphysema/chronic bronchitis	0.4	0.5	3.6	0.2	0.2	0.5	1.9	1.2	0.1	-0.4	0.3	0.0	0.2	0.7	0.2	0.2
Migraine (self-reported)	0.4	0.5	2.1	0.6	1.5	-0.5	-0.5	0.1	-1.2	-0.4	0.4	-0.3	0.6	1.0	0.6	0.6
Medication: Omeprazole	0.4	0.5	1.0	-0.7	-0.3	-0.9	0.5	0.6	0.2	-0.8	-0.8	0.5	-0.7	-1.0	-0.7	-0.7
Pulse rate, automated reading	0.4	1.4	5.4	1.1	0.7	-1.3	-0.0	-2.3	-1.6	-0.5	1.4	-1.1	1.1	0.4	1.1	1.1
Suffer from ‘nerves’	0.4	0.6	3.4	0.7	0.9	-0.6	-0.6	0.6	-0.0	0.1	0.4	0.5	0.7	1.9	0.7	0.7
Smoking status: Previous	0.4	0.7	3.3	0.9	0.7	-0.2	-0.2	0.3	-0.2	1.8	1.0	-0.3	0.9	0.4	0.9	0.9
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.9	-1.1	0.6	0.1	0.5	0.7	-0.6	-1.0	0.9	-0.9	0.4	-1.0	-1.0
Asthma (self-reported)	0.4	0.8	2.6	0.4	1.2	1.0	1.6	1.2	0.4	1.5	0.7	0.3	0.5	0.9	0.5	0.5
Osteoporosis (self-reported)	0.4	0.5	2.9	0.6	0.5	-0.6	1.7	-0.0	-0.7	0.2	0.5	0.1	0.7	0.1	0.7	0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	2.3	-0.5	-0.8	-0.5	0.9	-1.5	-0.1	-0.8	-0.1	0.0	-0.4	-0.2	-0.4	-0.4
Commuting to job workplace: Public transport	0.4	0.5	2.4	0.7	-0.0	0.8	0.9	0.4	0.4	0.4	0.8	-0.2	0.7	1.6	0.7	0.7
Ever smoked	0.4	0.8	2.8	0.8	0.8	-0.5	-0.6	0.9	-0.2	1.1	0.8	-0.7	0.9	1.7	0.8	0.8
Number of operations (self-reported)	0.4	0.6	4.1	0.6	0.7	-0.1	2.0	0.4	-0.2	0.5	1.0	-0.8	0.6	0.1	0.6	0.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.7	-1.2	-1.2	1.1	-0.8	0.1	1.0	0.6	-1.3	0.8	-1.2	-0.8	-1.2	-1.2
Coronary Artery Disease (CAD)	0.3	0.4	1.5	0.5	-0.1	-0.8	0.0	1.2	-0.9	-0.6	0.1	-0.9	0.4	-0.7	0.4	0.4
Neuroticism (2016)	0.3	0.5	2.5	0.5	0.9	-0.3	-1.6	0.0	0.5	0.3	-0.0	-0.1	0.4	1.3	0.4	0.4
Blood Eosinophil Count	0.3	2.4	4.2	1.9	2.1	-1.1	-0.6	0.5	-1.8	-0.5	2.0	-0.9	1.9	1.2	1.9	1.9
Smoking Status	0.3	0.8	5.9	0.0	0.2	-0.1	-1.3	-2.4	-1.2	-0.5	0.2	-0.3	0.0	0.6	0.0	0.0
Tanning	0.3	4.2	8.8	2.4	1.6	-1.6	-0.2	0.3	-3.0	0.2	2.5	-2.9	2.4	1.9	2.4	2.4
Number of treatments/medications taken	0.3	0.5	1.5	-0.7	-0.1	0.3	0.8	0.7	-0.1	-0.7	-0.5	0.8	-0.7	-1.2	-0.7	-0.7
Systolic blood pressure, automated reading	0.3	0.7	4.1	0.1	0.8	-1.1	0.1	-2.0	-0.0	-1.8	0.0	-0.0	0.1	0.1	0.1	0.1
Vitamin and mineral supplements	0.3	0.4	1.1	0.6	0.8	-1.0	0.2	-0.4	-0.3	-1.0	0.3	-1.0	0.6	0.4	0.6	0.6
Serious illness, injury or assault to yourself	0.3	0.3	1.6	-0.1	0.2	-0.3	-0.5	-0.5	-0.9	-0.7	0.4	-1.3	-0.1	-0.5	-0.1	-0.1
Past tobacco smoking	0.3	0.5	1.6	-0.7	-0.6	0.1	-0.2	-1.1	0.0	-1.2	-0.8	0.4	-0.7	-0.7	-0.7	-0.7
Forced vital capacity (FVC)	0.3	1.3	5.3	-0.2	-1.7	1.6	-0.4	2.3	0.6	2.1	-0.4	-0.2	-0.2	0.8	-0.2	-0.2
Medication: Simvastatin	0.3	0.5	1.4	0.6	0.9	-0.8	0.2	-0.7	-1.2	-0.4	0.9	-0.6	0.6	0.3	0.6	0.6
Fluid intelligence score	0.3	0.6	1.8	0.7	0.1	-1.3	-0.5	-0.3	-1.0	-1.3	0.4	-0.7	0.6	0.0	0.7	0.7
Illnesses of siblings	0.3	0.4	2.4	-0.4	-1.6	0.1	-1.1	-0.8	0.0	-0.1	-0.2	-0.1	-0.4	-0.0	-0.4	-0.4
Number of live births	0.3	0.5	2.4	-0.1	0.4	-1.1	1.0	-0.7	-0.7	-1.5	-0.1	-0.6	-0.1	0.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.2	-0.5	-1.5	1.2	-1.2	1.0	0.5	1.5	-0.8	0.3	-0.6	0.8	-0.6	-0.6
Noisy workplace	0.3	0.4	1.0	0.6	1.0	-0.0	-0.7	0.9	0.3	0.6	0.8	0.5	0.6	-0.6	0.6	0.6
Medication: Cholesterol lowering	0.3	0.5	1.1	0.8	1.0	-0.8	0.8	-0.1	-0.6	-0.4	0.9	-0.3	0.8	0.8	0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	4.1	-0.5	-1.8	0.9	-2.0	0.1	0.1	0.8	-0.8	-0.3	-0.5	0.5	-0.5	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	2.0	-0.2	-0.3	-1.0	0.0	-0.5	-0.4	-1.4	-0.4	-0.1	-0.2	-1.0	-0.2	-0.2
Impedance of arm (left)	0.3	1.4	3.2	1.4	1.4	-1.1	-0.3	1.0	-1.8	0.7	1.2	-0.8	1.4	0.8	1.4	1.4
Exposure to tobacco smoke at home	0.3	0.4	2.9	0.3	0.9	-0.4	-0.4	-1.7	-0.2	-0.1	0.4	0.0	0.2	-0.2	0.2	0.2
Loud music exposure frequency	0.3	0.3	1.2	0.0	0.0	0.4	1.0	0.9	1.1	0.4	0.0	-0.3	-0.0	-0.6	-0.0	-0.0
Birth weight	0.3	0.5	2.0	0.6	0.8	-0.7	-0.4	0.9	-0.8	-0.2	0.8	-1.4	0.7	0.2	0.6	0.6
Forced vital capacity (FVC), Best measure	0.3	0.9	2.9	-0.2	-1.7	1.2	-1.4	1.5	0.4	1.4	-0.4	-0.5	-0.2	0.7	-0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.4	0.6	0.7	-0.5	0.3	-1.2	-0.2	-0.6	0.4	0.2	0.5	-0.3	0.5	0.5
Medication: Allopurinol	0.3	0.4	0.8	-0.6	0.1	-0.7	-0.3	-0.9	0.3	-0.9	-0.7	0.5	-0.7	-0.0	-0.6	-0.6
Mean time to correctly identify matches	0.3	0.6	2.8	0.9	0.4	-0.2	-0.4	1.7	-0.9	-0.2	0.7	-0.7	0.9	0.1	0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	2.2	-0.0	-0.4	0.4	1.5	0.7	-0.6	-0.1	-0.2	0.7	-0.1	-0.4	-0.1	-0.1
Family relationship satisfaction	0.3	0.4	1.3	0.6	0.6	-0.1	1.1	0.2	-0.1	0.9	0.4	0.7	0.6	1.0	0.6	0.6
Eye problems/disorders: Cataract	0.3	0.4	1.5	-0.5	-0.6	0.3	1.2	-0.8	0.0	0.2	-0.3	1.0	-0.5	0.3	-0.5	-0.5
Medication for cholesterol	0.3	0.5	1.5	0.6	-0.1	0.7	-1.2	0.6	0.4	1.2	0.4	-0.3	0.6	1.0	0.6	0.6
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.9	1.0	-0.2	-0.4	0.0	-0.2	0.4	0.7	-0.2	0.9	0.2	0.9	0.9
Ever taken oral contraceptive pill	0.3	0.4	2.4	-0.4	0.1	-0.1	-1.6	0.7	-0.2	-0.8	-0.5	0.0	-0.4	0.5	-0.4	-0.4
Mother’s age at death	0.3	0.4	3.4	-0.0	-0.4	0.5	0.4	1.9	0.3	-0.9	-0.3	0.5	-0.0	-0.0	-0.0	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	-0.5	0.2	-0.4	-1.0	-0.5	0.7	-0.7	-0.7	-0.0	-0.5	-0.4	-0.5	-0.5
High cholesterol (Self-reported)	0.3	0.6	3.0	0.0	1.7	-0.4	0.2	-1.5	-0.8	-1.1	0.5	-0.0	0.0	-0.7	0.0	0.0
Medication: Bendroflumethiazide	0.3	0.4	3.7	0.0	0.4	-0.6	-0.2	-0.9	-0.4	-1.9	0.0	-0.3	-0.0	0.2	0.0	0.0
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-0.4	-0.0	0.5	1.1	1.2	0.1	-1.1	-0.1	-0.2	-0.3	-0.5	-0.4	-0.4
Myopia	0.3	0.4	1.5	0.5	0.0	-0.5	-0.6	1.2	-0.1	-0.4	0.3	-1.0	0.5	1.0	0.5	0.5
Pack years of smoking	0.3	0.4	2.0	-0.1	-1.0	-0.4	-1.3	-0.6	0.1	-1.4	-0.3	-0.1	-0.1	-0.1	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	4.3	0.7	0.6	-0.9	-0.3	0.3	-1.0	-2.1	0.4	-0.7	0.8	-0.2	0.8	0.8
Worry (Nagel 2018)	0.2	0.5	2.0	-0.3	-0.2	0.4	-1.0	1.4	1.0	-0.4	-0.6	1.2	-0.2	0.5	-0.2	-0.2
Major Depression (MDD)	0.2	0.3	1.3	0.3	-0.1	0.4	0.1	1.1	-0.6	0.5	0.3	-0.3	0.2	1.0	0.3	0.3
Fasting Glucose	0.2	0.2	1.4	-0.1	0.0	-0.1	-0.9	1.2	0.2	0.4	-0.3	-0.2	-0.0	0.3	-0.0	-0.0
Blood White Count	0.2	1.6	12.5	0.8	3.5	-1.3	1.2	0.7	-1.0	-0.4	0.9	0.2	0.8	-0.4	0.8	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.3	0.6	0.4	-0.5	0.1	0.8	0.4	-0.4	1.1	-0.3	0.1	-0.3	-0.3
Townsend deprivation index at recruitment	0.2	0.2	1.8	-0.1	0.2	-0.8	-1.3	0.5	-0.5	-0.2	0.2	-0.1	-0.0	-0.2	-0.0	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	-0.3	0.8	-0.4	-1.1	0.4	-0.2	-0.4	-0.2	0.4	-0.3	-0.7	-0.3	-0.3
Relative age voice broke	0.2	0.3	2.1	0.2	0.3	-0.7	-1.5	-0.3	-0.1	-0.6	0.2	-0.3	0.2	0.4	0.2	0.2
Stomach or abdominal pain in last month	0.2	0.2	1.0	-0.2	0.7	-0.4	-0.4	-0.2	-0.3	-1.0	0.1	0.3	-0.2	-0.4	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.3	-0.5	-0.6	-0.6	-0.4	-0.6	-0.2	-0.4	-0.0	-0.3	-0.9	-0.4	-0.4
Had other major operations	0.2	0.3	2.1	0.0	0.6	-0.3	1.5	0.3	0.8	0.1	0.2	-0.0	0.0	-0.1	0.0	0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	-0.4	-0.5	0.2	-0.8	-1.1	0.2	-0.6	-0.1	0.2	-0.3	-0.7	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.5	-0.4	1.2	0.3	1.2	0.9	0.2	-0.0	-0.3	0.4	-0.4	-0.3	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.6	0.9	1.3	-0.6	0.1	-1.2	-0.6	0.0	0.8	-0.2	0.9	0.0	0.9	0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.0	0.3	1.0	0.6	0.0	0.9	0.3	0.2	0.4	-0.3	0.3	-0.4	0.3	0.3
High blood pressure (siblings)	0.2	0.4	1.2	0.6	1.1	-0.5	0.6	0.8	-0.6	-0.3	0.3	-0.3	0.6	0.6	0.5	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	3.6	-0.2	-0.1	0.8	0.9	1.9	-0.0	0.4	0.1	0.5	-0.2	-0.1	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	-0.1	-0.7	0.1	1.0	0.7	-0.6	0.0	-0.1	-0.0	-0.1	0.5	-0.1	-0.1
Neck or shoulder pain in last month	0.2	0.3	2.1	0.2	1.5	-0.5	0.2	0.1	-0.1	-0.5	0.4	-0.6	0.2	-0.8	0.2	0.2
Heart disease (mother)	0.2	0.2	1.3	-0.1	0.4	0.5	0.6	-1.1	0.4	0.1	0.0	0.8	-0.1	0.3	-0.1	-0.1
Alcohol intake frequency.	0.2	0.4	1.3	0.6	1.1	0.2	-0.5	0.3	-0.7	-0.9	0.6	-0.2	0.7	0.5	0.7	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	-0.3	0.4	-0.1	-0.5	-0.0	0.1	-0.4	-0.4	0.4	-0.3	-1.1	-0.3	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	1.0	0.4	0.9	-0.1	0.3	0.4	-1.0	-0.6	0.7	-0.4	0.4	0.5	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.5	0.6	-0.3	0.6	-0.5	0.7	-0.4	-0.7	0.8	-0.5	-0.1	-0.5	-0.5
Medication: Blood pressure	0.2	0.4	1.0	0.7	0.2	-0.9	0.0	-0.4	-1.0	-0.8	0.7	-0.0	0.7	0.7	0.7	0.7
Average weekly beer plus cider intake	0.2	0.2	0.9	-0.6	0.6	-0.1	0.5	0.1	-1.0	-0.2	-0.2	0.1	-0.6	0.3	-0.6	-0.6
Diastolic blood pressure, automated reading	0.2	0.5	1.7	-0.7	-0.9	-0.0	1.3	-0.3	0.6	0.1	-0.6	0.1	-0.7	-1.1	-0.7	-0.7
Basal cell carcinoma (self-reported)	0.2	0.3	1.2	-0.2	-0.5	0.2	-0.5	0.2	0.6	1.1	-0.5	0.4	-0.2	0.8	-0.2	-0.2
Mean Putamen Volume	0.1	0.1	0.6	0.3	0.0	0.8	0.0	-0.1	-0.3	0.6	0.1	-0.0	0.2	0.7	0.3	0.3
Heel T-Score	0.1	0.7	2.3	0.8	0.0	-0.2	1.4	-0.3	1.5	0.5	0.7	-0.8	0.8	0.5	0.8	0.8
Cardiovascular Disease	0.1	0.2	0.9	0.2	0.9	-0.2	-0.0	0.4	-0.1	-0.5	0.3	-0.4	0.2	0.7	0.2	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	0.0	0.1	-0.7	0.5	0.1	-0.4	-0.4	-0.1	-0.3	0.0	0.2	0.0	0.0
Financial difficulties in last 2 years	0.1	0.2	1.3	-0.2	-1.2	0.1	-0.7	-0.5	-0.1	-0.4	-0.0	-0.1	-0.2	-0.4	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.7	-0.3	-0.3	0.3	0.1	1.3	0.2	-1.2	-0.6	-0.3	-0.3	0.5	-0.3	-0.3
Birth weight of first child	0.1	0.2	0.8	-0.1	0.4	-0.5	0.5	-0.5	-0.0	-0.4	-0.1	-0.9	-0.1	0.5	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.7	-0.1	-0.3	-0.2	0.2	-0.2	-0.2	-0.4	-0.5	-0.9	-0.1	0.6	-0.1	-0.1
Blood clot in the leg (DVT)	0.1	0.2	0.7	-0.1	0.2	0.2	-0.2	0.6	-0.8	0.1	0.0	-0.9	-0.2	0.1	-0.2	-0.2
Medication: Paracetamol	0.1	0.1	0.4	-0.1	0.5	-0.2	0.0	0.3	-0.4	0.0	0.2	-0.5	-0.1	-0.7	-0.1	-0.1
Number of children fathered	0.1	0.2	0.9	-0.2	0.2	-0.4	0.5	-0.6	-1.0	-0.1	-0.3	0.0	-0.2	0.3	-0.2	-0.2
Medication: Seretide 50 evohaler	0.1	0.2	0.5	-0.4	-0.4	0.5	0.0	-0.2	0.4	-0.7	-0.3	0.2	-0.4	-0.5	-0.4	-0.4
Overall health rating	0.1	0.3	1.1	0.1	0.9	-0.8	0.6	-0.3	-1.0	-0.9	0.4	0.0	0.1	-0.1	0.1	0.1
Friendships satisfaction	0.1	0.1	0.3	0.2	0.4	-0.5	-0.0	-0.3	-0.3	0.1	0.1	0.5	0.3	0.2	0.3	0.3
Medication: Paracetamol	0.1	0.1	0.6	-0.3	0.5	0.1	-0.0	-0.3	-0.4	0.2	0.0	-0.1	-0.3	-0.8	-0.3	-0.3
Illnesses of father: High blood pressure	0.1	0.2	0.9	0.2	0.3	0.3	-0.5	0.2	-0.3	0.7	0.1	-0.3	0.2	0.9	0.2	0.2
Pain experienced in last month	0.1	0.2	0.6	-0.0	-0.7	-0.7	-0.8	0.3	0.3	-0.7	-0.4	0.3	-0.1	0.5	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.7	-0.3	0.1	0.1	-0.3	0.5	-0.7	-0.1	-0.1	-0.8	-0.4	-0.2	-0.4	-0.4
Hair Pigment	0.0	1.1	7.1	0.7	1.3	-1.1	-0.4	-2.7	-0.4	-0.8	0.6	-0.7	0.7	0.7	0.7	0.7

Hub : Genes

PABPC1L

Models

Trait associations