Best TWAS P=3.86e-11 · Best GWAS P=8.09e-11 conditioned to 0.245
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -6.3 | -6.5 | 7.1e-11 | 0.63 | 0.05 | 0.91 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C3orf38 | 0.09 | 0.00 | lasso | 5 | 0.00 | 5.2e-01 | -2.4 | 5.4 | 7.3e-08 | -0.72 | 0.04 | 0.35 | FALSE |
| 3 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -6.3 | 6.3 | 2.5e-10 | -0.80 | 0.06 | 0.92 | FALSE |
| 4 | GTEx | Artery Tibial | C3orf38 | 0.11 | 0.03 | lasso | 6 | 0.04 | 3.7e-04 | -6.2 | 5.6 | 1.9e-08 | -0.70 | 0.06 | 0.87 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -6.5 | -6.5 | 6.8e-11 | 0.99 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -6.2 | 6.6 | 3.9e-11 | -0.91 | 0.06 | 0.94 | TRUE |
| 7 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -6.3 | 6.3 | 2.2e-10 | -0.80 | 0.06 | 0.92 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF654 | 0.09 | 0.01 | lasso | 7 | 0.06 | 2.7e-04 | -6.3 | -5.9 | 4.4e-09 | 0.74 | 0.05 | 0.65 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | C3orf38 | 0.09 | 0.07 | lasso | 6 | 0.04 | 2.8e-03 | -6.2 | 6.2 | 7.2e-10 | -0.78 | 0.06 | 0.86 | FALSE |
| 10 | GTEx | Testis | C3orf38 | 0.11 | 0.01 | enet | 12 | 0.00 | 1.9e-01 | -6.1 | 6.2 | 7.9e-10 | -0.42 | 0.08 | 0.44 | FALSE |
| 11 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -6.2 | 6.2 | 5.0e-10 | -0.80 | 0.07 | 0.93 | FALSE |
| 12 | GTEx | Uterus | ZNF654 | 0.29 | -0.01 | lasso | 4 | 0.01 | 1.7e-01 | -6.3 | -5.8 | 5.3e-09 | 0.71 | 0.04 | 0.59 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf38 | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -6.2 | 6.1 | 1.0e-09 | -0.80 | 0.02 | 0.67 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf38 | 0.02 | 0.01 | blup | 24 | 0.02 | 2.0e-03 | -6.2 | 6.1 | 1.1e-09 | -0.82 | 0.02 | 0.74 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -6.3 | 6.3 | 2.7e-10 | -0.79 | 0.02 | 0.79 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C3orf38 | 0.04 | 0.01 | blup | 24 | 0.03 | 5.7e-03 | -6.3 | 5.1 | 3.1e-07 | -0.77 | 0.01 | 0.59 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -6.3 | 6.3 | 2.7e-10 | -0.79 | 0.02 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | C3orf38 | 0.05 | 0.05 | blup | 24 | 0.05 | 1.1e-05 | -6.3 | 5.5 | 4.7e-08 | -0.76 | 0.02 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -6.3 | -6.3 | 2.1e-10 | 0.80 | 0.02 | 0.94 | FALSE |