[Hub]/) : Traits : Leg fat mass (right) :

chr3:93,537,290-94,472,527

Best TWAS P=2.64e-09 · Best GWAS P=4.32e-17 conditioned to 2.57e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Heart Atrial Appendage PROS1 0.31 0.16 enet 7 0.19 8.4e-09 5.8 -5.2 1.7e-07 -0.68 0.96 0.02 FALSE
2 METSIM Adipose STX19 0.06 0.09 lasso 3 0.08 1.8e-11 5.1 5.5 3.3e-08 0.50 1.00 0.00 FALSE
3 YFS Blood DHFRL1 0.07 0.04 lasso 9 0.04 4.1e-14 5.8 5.4 6.0e-08 0.54 1.00 0.00 FALSE
4 The Cancer Genome Atlas Breast Invasive Carcinoma STX19 0.04 0.02 lasso 1 0.01 5.5e-04 5.6 5.6 2.4e-08 0.64 0.02 0.77 FALSE
5 The Cancer Genome Atlas Glioblastoma Multiforme DHFRL1 0.20 0.12 lasso 8 0.11 3.7e-04 5.1 -5.2 2.2e-07 -0.44 0.01 0.09 FALSE
6 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DHFRL1 0.07 0.05 enet 17 0.05 2.5e-06 5.1 -5.8 5.3e-09 -0.54 0.05 0.91 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma STX19 0.35 0.11 enet 12 0.20 2.4e-22 5.6 5.7 9.4e-09 0.49 0.04 0.96 FALSE
8 The Cancer Genome Atlas Liver Hepatocellular Carcinoma STX19 0.15 0.08 lasso 1 0.05 1.8e-03 5.6 5.6 2.4e-08 0.64 0.02 0.54 FALSE
9 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma STX19 0.28 -0.01 enet 15 0.08 6.4e-04 5.6 5.2 1.6e-07 0.44 0.00 0.28 FALSE
10 The Cancer Genome Atlas Thyroid Carcinoma ARL13B 0.03 0.00 blup 39 0.00 2.1e-01 -6.3 6.0 2.6e-09 0.66 0.01 0.68 TRUE