Best TWAS P=4.37e-12 · Best GWAS P=4.49e-11 conditioned to 0.0852
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | AP3B1 | 0.07 | 0.01 | blup | 556 | 0.02 | 2.4e-04 | 2.9 | -5.2 | 1.8e-07 | 0.53 | 0.10 | 0.78 | FALSE |
2 | YFS | Blood | AP3B1 | 0.25 | 0.22 | lasso | 9 | 0.23 | 2.6e-74 | 5.4 | -5.7 | 1.5e-08 | 0.31 | 0.81 | 0.19 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -6.4 | -6.7 | 2.6e-11 | 0.86 | 0.02 | 0.90 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 5.8 | -5.4 | 6.1e-08 | 0.53 | 0.04 | 0.56 | FALSE |
5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 5.7 | -6.9 | 4.4e-12 | 0.80 | 0.02 | 0.91 | TRUE |
6 | The Cancer Genome Atlas | Thyroid Carcinoma | AP3B1 | 0.11 | 0.06 | lasso | 2 | 0.05 | 1.3e-05 | 5.4 | -5.2 | 2.3e-07 | 0.20 | 0.50 | 0.19 | FALSE |